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Volumn 15, Issue 13, 2014, Pages 1875-1887

Cardiac sodium channels and inherited electrophysiological disorders: An update on the pharmacotherapy

Author keywords

Brugada syndrome; Cardiac arrhythmias; Cardiac sodium channel; Long QT syndrome type 3; Pharmacotherapy

Indexed keywords

ANTIARRHYTHMIC AGENT; SODIUM CHANNEL;

EID: 84905842771     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2014.936380     Document Type: Review
Times cited : (9)

References (87)
  • 1
    • 40649084325 scopus 로고    scopus 로고
    • Cardiac sodium channels and inherited electrophysiologic disorders: A pharmacogenetic overview
    • Smits JP, Blom MT, Wilde AA, et al. Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview. Expert Opin Pharmacother 2008;9(4):537-49
    • (2008) Expert Opin Pharmacother , vol.9 , Issue.4 , pp. 537-549
    • Smits, J.P.1    Blom, M.T.2    Wilde, A.A.3
  • 2
    • 84866739941 scopus 로고    scopus 로고
    • Inherited calcium channelopathies in the pathophysiology of arrhythmias
    • Venetucci L, Denegri M, Napolitano C, et al. Inherited calcium channelopathies in the pathophysiology of arrhythmias. Nat Rev Cardiol 2012;9(10):561-75
    • (2012) Nat Rev Cardiol , vol.9 , Issue.10 , pp. 561-575
    • Venetucci, L.1    Denegri, M.2    Napolitano, C.3
  • 3
    • 84861481127 scopus 로고    scopus 로고
    • Potassium-channel mutations and cardiac arrhythmias-diagnosis and therapy
    • Giudicessi JR, Ackerman MJ. Potassium-channel mutations and cardiac arrhythmias-diagnosis and therapy. Nat Rev Cardiol 2012;9(6):319-32
    • (2012) Nat Rev Cardiol , vol.9 , Issue.6 , pp. 319-332
    • Giudicessi, J.R.1    Ackerman, M.J.2
  • 4
    • 67649547603 scopus 로고    scopus 로고
    • Sodium channel mutations and arrhythmias
    • Ruan Y, Liu N, Priori SG. Sodium channel mutations and arrhythmias. Nat Rev Cardiol 2009;6(5):337-48
    • (2009) Nat Rev Cardiol , vol.6 , Issue.5 , pp. 337-348
    • Ruan, Y.1    Liu, N.2    Priori, S.G.3
  • 5
    • 84880333897 scopus 로고    scopus 로고
    • Channelopathies from mutations in the cardiac sodium channel protein complex
    • Adsit GS, Vaidyanathan R, Galler CM, et al. Channelopathies from mutations in the cardiac sodium channel protein complex. J Mol Cell Cardiol 2013;61:34-43
    • (2013) J Mol Cell Cardiol , vol.61 , pp. 34-43
    • Adsit, G.S.1    Vaidyanathan, R.2    Galler, C.M.3
  • 6
    • 79954578382 scopus 로고    scopus 로고
    • Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel
    • Wilde AA, Brugada R. Phenotypical manifestations of mutations in the genes encoding subunits of the cardiac sodium channel. Circ Res 2011;108(7):884-97
    • (2011) Circ Res , vol.108 , Issue.7 , pp. 884-897
    • Wilde, A.A.1    Brugada, R.2
  • 7
    • 84880078317 scopus 로고    scopus 로고
    • Impact of genetics on the clinical management of channelopathies
    • Schwartz PJ, Ackerman MJ, George AL Jr, et al. Impact of genetics on the clinical management of channelopathies. J Am Coll Cardiol 2013;62(3):169-80
    • (2013) J Am Coll Cardiol , vol.62 , Issue.3 , pp. 169-180
    • Schwartz, P.J.1    Ackerman, M.J.2    George Jr., A.L.3
  • 8
    • 33645962855 scopus 로고    scopus 로고
    • Sodium channel variants in heart disease: Expanding horizons
    • Tan HL. Sodium channel variants in heart disease: expanding horizons. J Cardiovasc Electrophysiol 2006;17(Suppl 1):S151-S57
    • (2006) J Cardiovasc Electrophysiol , vol.17 , Issue.SUPPL. 1
    • Tan, H.L.1
  • 9
    • 72449157875 scopus 로고    scopus 로고
    • Cardiac ion channels in health and disease
    • Amin AS, Tan HL, Wilde AA. Cardiac ion channels in health and disease. Heart Rhythm 2010;7(1):117-26
    • (2010) Heart Rhythm , vol.7 , Issue.1 , pp. 117-126
    • Amin, A.S.1    Tan, H.L.2    Wilde, A.A.3
  • 11
    • 33845708766 scopus 로고    scopus 로고
    • Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD
    • Remme CA, Verkerk AO, Nuyens D, et al. Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD. Circulation 2006;114(24):2584-94
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2584-2594
    • Remme, C.A.1    Verkerk, A.O.2    Nuyens, D.3
  • 12
    • 84883461171 scopus 로고    scopus 로고
    • Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome a rare disease with high risk of sudden cardiac death
    • Bezzina CR, Barc J, Mizusawa Y, et al. Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet 2013;45(9):1044-9
    • (2013) Nat Genet , vol.45 , Issue.9 , pp. 1044-1049
    • Bezzina, C.R.1    Barc, J.2    Mizusawa, Y.3
  • 13
    • 84903591807 scopus 로고    scopus 로고
    • Brugada syndrome disease phenotype explained in apparently benign sodium channel mutations
    • Hoshi M, Du XX, Shinlapawittayatorn K, et al. Brugada syndrome disease phenotype explained in apparently benign sodium channel mutations. Circ Cardiovasc Genet 2014;7(2):123-31
    • (2014) Circ Cardiovasc Genet , vol.7 , Issue.2 , pp. 123-131
    • Hoshi, M.1    Du, X.X.2    Shinlapawittayatorn, K.3
  • 14
    • 22544432881 scopus 로고    scopus 로고
    • Brugada syndrome and fever: Genetic and molecular characterization of patients carrying SCN5A mutations
    • Keller DI, Rougier JS, Kucera JP, et al. Brugada syndrome and fever: genetic and molecular characterization of patients carrying SCN5A mutations. Cardiovasc Res 2005;67(3):510-19
    • (2005) Cardiovasc Res , vol.67 , Issue.3 , pp. 510-519
    • Keller, D.I.1    Rougier, J.S.2    Kucera, J.P.3
  • 15
    • 0032741905 scopus 로고    scopus 로고
    • Ionic mechanisms responsible for the electrocardiographic phenotype of the brugada syndrome are temperature dependent
    • Dumaine R, Towbin JA, Brugada P, et al. Ionic mechanisms responsible for the electrocardiographic phenotype of the brugada syndrome are temperature dependent. Circ Res 1999;85(9):803-9
    • (1999) Circ Res , vol.85 , Issue.9 , pp. 803-809
    • Dumaine, R.1    Towbin, J.A.2    Brugada, P.3
  • 16
    • 49049104417 scopus 로고    scopus 로고
    • Fever increases the risk for cardiac arrest in the Brugada syndrome
    • Amin AS, Meregalli PG, Bardai A, et al. Fever increases the risk for cardiac arrest in the Brugada syndrome. Ann Intern Med 2008;149(3):216-18
    • (2008) Ann Intern Med , vol.149 , Issue.3 , pp. 216-218
    • Amin, A.S.1    Meregalli, P.G.2    Bardai, A.3
  • 17
    • 84878268347 scopus 로고    scopus 로고
    • Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: Evidence from bench, bedside, and community
    • Bardai A, Amin AS, Blom MT, et al. Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community. Eur Heart J 2013;34(20):1506-16
    • (2013) Eur Heart J , vol.34 , Issue.20 , pp. 1506-1516
    • Bardai, A.1    Amin, A.S.2    Blom, M.T.3
  • 18
    • 84889856570 scopus 로고    scopus 로고
    • HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: Document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013
    • Priori SG, Wilde AA, Horie M, et al. HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm 2013;10(12):1932-63
    • (2013) Heart Rhythm , vol.10 , Issue.12 , pp. 1932-1963
    • Priori, S.G.1    Wilde, A.A.2    Horie, M.3
  • 19
    • 0030049208 scopus 로고    scopus 로고
    • Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle
    • Näbauer M, Beuckelmann D, Uberfuhr P, et al. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 1996;93:168-77
    • (1996) Circulation , vol.93 , pp. 168-177
    • Nabauer, M.1    Beuckelmann, D.2    Uberfuhr, P.3
  • 20
    • 0026466921 scopus 로고
    • Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. A multicenter report
    • Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992;20(6):1391-6
    • (1992) J Am Coll Cardiol , vol.20 , Issue.6 , pp. 1391-1396
    • Brugada, P.1    Brugada, J.2
  • 21
    • 0037027510 scopus 로고    scopus 로고
    • Proposed diagnostic criteria for the Brugada syndrome: Consensus report
    • Wilde AA. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation 2002;106(19):2514-19
    • (2002) Circulation , vol.106 , Issue.19 , pp. 2514-2519
    • Wilde, A.A.1
  • 22
    • 13444300924 scopus 로고    scopus 로고
    • Brugada syndrome: Report of the second consensus conference: Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association
    • Antzelevitch C, Brugada P, Borggrefe M, et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005;111(5):659-70
    • (2005) Circulation , vol.111 , Issue.5 , pp. 659-670
    • Antzelevitch, C.1    Brugada, P.2    Borggrefe, M.3
  • 23
    • 0032546384 scopus 로고    scopus 로고
    • Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
    • Chen Q, Kirsch GE, Zhang D, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature 1998;392:293-6
    • (1998) Nature , vol.392 , pp. 293-296
    • Chen, Q.1    Kirsch, G.E.2    Zhang, D.3
  • 24
    • 84905847429 scopus 로고    scopus 로고
    • Inherited arrhtyhmias database Available from Cited 11 April 2014
    • Inherited arrhtyhmias database. 2000. Available from: http://www.fsm.it/cardmoc/[Cited 11 April 2014]
    • (2000)
  • 25
    • 72449147774 scopus 로고    scopus 로고
    • An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing
    • Kapplinger JD, Tester DJ, Alders M, et al. An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm 2010;7(1):33-46
    • (2010) Heart Rhythm , vol.7 , Issue.1 , pp. 33-46
    • Kapplinger, J.D.1    Tester, D.J.2    Alders, M.3
  • 26
    • 0343819791 scopus 로고    scopus 로고
    • Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes
    • Deschenes I, Baroudi G, Berthet M, et al. Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes. Cardiovasc Res 2000;46:55-65
    • (2000) Cardiovasc Res , vol.46 , pp. 55-65
    • Deschenes, I.1    Baroudi, G.2    Berthet, M.3
  • 27
    • 0036063688 scopus 로고    scopus 로고
    • A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine
    • Valdivia CR, Ackerman MJ, Testerb DJ, et al. A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine. Cardiovasc Res 2002;55:279-89
    • (2002) Cardiovasc Res , vol.55 , pp. 279-289
    • Valdivia, C.R.1    Ackerman, M.J.2    Testerb, D.J.3
  • 28
    • 1542268995 scopus 로고    scopus 로고
    • A trafficking defective brugada syndrome-causing SCN5A mutation rescued by drugs
    • Valdivia CR, Tester DJ, Rok BA, et al. A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs. Cardiovasc Res 2004;62(1):53-62
    • (2004) Cardiovasc Res , vol.62 , Issue.1 , pp. 53-62
    • Valdivia, C.R.1    Tester, D.J.2    Rok, B.A.3
  • 29
    • 1042298047 scopus 로고    scopus 로고
    • Trafficking and functional expression of cardiac Na+ channels
    • Herfst LJ, Rook MB, Jongsma HJ. Trafficking and functional expression of cardiac Na+ channels. J Mol Cell Cardiol 2004;36(2):185-93
    • (2004) J Mol Cell Cardiol , vol.36 , Issue.2 , pp. 185-193
    • Herfst, L.J.1    Rook, M.B.2    Jongsma, H.J.3
  • 30
    • 33845796213 scopus 로고    scopus 로고
    • A sodium channel pore mutation causing Brugada syndrome
    • Pfahnl AE, Viswanathan PC, Weiss R, et al. A sodium channel pore mutation causing Brugada syndrome. Heart Rhythm 2007;4(1):46-53
    • (2007) Heart Rhythm , vol.4 , Issue.1 , pp. 46-53
    • Pfahnl, A.E.1    Viswanathan, P.C.2    Weiss, R.3
  • 31
    • 84867864853 scopus 로고    scopus 로고
    • Brugada phenocopy: New terminology and proposed classification
    • Baranchuk A, Nguyen T, Ryu MH, et al. Brugada phenocopy: new terminology and proposed classification. Ann Noninvasive Electrocardiol 2012;17(4):299-314
    • (2012) Ann Noninvasive Electrocardiol , vol.17 , Issue.4 , pp. 299-314
    • Baranchuk, A.1    Nguyen, T.2    Ryu, M.H.3
  • 32
    • 77954674875 scopus 로고    scopus 로고
    • The Brugada ECG pattern: A marker of channelopathy structural heart disease or neither? Toward a unifying mechanism of the Brugada syndrome
    • Hoogendijk MG, Opthof T, Postema PG, et al. The Brugada ECG pattern: a marker of channelopathy, structural heart disease, or neither? Toward a unifying mechanism of the Brugada syndrome. Circ Arrhythm Electrophysiol 2010;3(3):283-90
    • (2010) Circ Arrhythm Electrophysiol , vol.3 , Issue.3 , pp. 283-290
    • Hoogendijk, M.G.1    Opthof, T.2    Postema, P.G.3
  • 33
    • 0032879716 scopus 로고    scopus 로고
    • Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation
    • Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 1999;100(15):1660-6
    • (1999) Circulation , vol.100 , Issue.15 , pp. 1660-1666
    • Yan, G.X.1    Antzelevitch, C.2
  • 34
    • 34250763837 scopus 로고    scopus 로고
    • Heterogeneity and cardiac arrhythmias: An overview
    • Antzelevitch C. Heterogeneity and cardiac arrhythmias: an overview. Heart Rhythm 2007;4(7):964-72
    • (2007) Heart Rhythm , vol.4 , Issue.7 , pp. 964-972
    • Antzelevitch, C.1
  • 35
    • 77956180252 scopus 로고    scopus 로고
    • The pathophysiological mechanism underlying Brugada syndrome: Depolarization versus repolarization
    • Wilde AA, Postema PG, Di Diego JM, et al. The pathophysiological mechanism underlying Brugada syndrome: depolarization versus repolarization. J Mol Cell Cardiol 2010;49(4):543-53
    • (2010) J Mol Cell Cardiol , vol.49 , Issue.4 , pp. 543-553
    • Wilde, A.A.1    Postema, P.G.2    Di Diego, J.M.3
  • 36
    • 84900542677 scopus 로고    scopus 로고
    • Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome
    • Szel T, Antzelevitch C. Abnormal repolarization as the basis for late potentials and fractionated electrograms recorded from epicardium in experimental models of Brugada syndrome. J Am Coll Cardiol 2014;63(19):2037-45
    • (2014) J Am Coll Cardiol , vol.63 , Issue.19 , pp. 2037-2045
    • Szel, T.1    Antzelevitch, C.2
  • 37
    • 27844591399 scopus 로고    scopus 로고
    • Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: A combined electrophysiological, genetic, histopathologic, and computational study
    • Coronel R, Casini S, Koopmann TT, et al. Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study. Circulation 2005;112(18):2769-77
    • (2005) Circulation , vol.112 , Issue.18 , pp. 2769-2777
    • Coronel, R.1    Casini, S.2    Koopmann, T.T.3
  • 38
    • 67651128831 scopus 로고    scopus 로고
    • Slow and discontinuous conduction conspire in Brugada syndrome: A right ventricular mapping and stimulation study
    • Postema PG, van Dessel PF, de Bakker JM, et al. Slow and discontinuous conduction conspire in Brugada syndrome: a right ventricular mapping and stimulation study. Circ Arrhythm Electrophysiol 2008;1(5):379-86
    • (2008) Circ Arrhythm Electrophysiol , vol.1 , Issue.5 , pp. 379-386
    • Postema, P.G.1    Van Dessel, P.F.2    De Bakker, J.M.3
  • 39
    • 70349437385 scopus 로고    scopus 로고
    • Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities
    • Catalano O, Antonaci S, Moro G, et al. Magnetic resonance investigations in Brugada syndrome reveal unexpectedly high rate of structural abnormalities. Eur Heart J 2009;30(18):2241-8
    • (2009) Eur Heart J , vol.30 , Issue.18 , pp. 2241-2248
    • Catalano, O.1    Antonaci, S.2    Moro, G.3
  • 40
    • 84864493050 scopus 로고    scopus 로고
    • SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility
    • van Hoorn F, Campian ME, Spijkerboer A, et al. SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility. PLoS One 2012;7(8):e42037
    • (2012) PLoS One , vol.7 , Issue.8
    • Van Hoorn, F.1    Campian, M.E.2    Spijkerboer, A.3
  • 41
    • 0003096674 scopus 로고    scopus 로고
    • Cardiac connduction defects associate with mutations in SCN5A
    • Schott JJ, Alshinawi C, Kyndt F, et al. Cardiac connduction defects associate with mutations in SCN5A. Nat Genet 1999;23(1):20-1
    • (1999) Nat Genet , vol.23 , Issue.1 , pp. 20-21
    • Schott, J.J.1    Alshinawi, C.2    Kyndt, F.3
  • 42
    • 0242317397 scopus 로고    scopus 로고
    • Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A
    • Benson DW, Wang DW, Dyment M, et al. Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest 2003;112(7):1019-28
    • (2003) J Clin Invest , vol.112 , Issue.7 , pp. 1019-1028
    • Benson, D.W.1    Wang, D.W.2    Dyment, M.3
  • 43
    • 0037428063 scopus 로고    scopus 로고
    • A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill
    • Groenewegen WA. A cardiac sodium channel mutation cosegregates with a rare connexin40 genotype in familial atrial standstill. Circ Res 2002;92(1):14-22
    • (2002) Circ Res , vol.92 , Issue.1 , pp. 14-22
    • Groenewegen, W.A.1
  • 44
    • 65649123138 scopus 로고    scopus 로고
    • Molecular and clinical characterization of a novel SCN5A mutation associated with atrioventricular block and dilated cardiomyopathy
    • Ge J, Sun A, Paajanen V, et al. Molecular and clinical characterization of a novel SCN5A mutation associated with atrioventricular block and dilated cardiomyopathy. Circ Arrhythm Electrophysiol 2008;1(2):83-92
    • (2008) Circ Arrhythm Electrophysiol , vol.1 , Issue.2 , pp. 83-92
    • Ge, J.1    Sun, A.2    Paajanen, V.3
  • 45
    • 5644229494 scopus 로고    scopus 로고
    • SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia
    • McNair WP, Ku L, Taylor MR, et al. SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation 2004;110(15):2163-7
    • (2004) Circulation , vol.110 , Issue.15 , pp. 2163-2167
    • Mc Nair, W.P.1    Ku, L.2    Taylor, M.R.3
  • 46
    • 67651089884 scopus 로고    scopus 로고
    • Mechanisms and clinical management of inherited channelopathies: Long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome
    • Kaufman ES. Mechanisms and clinical management of inherited channelopathies: long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome. Heart Rhythm 2009;6(8 Suppl):S51-5
    • (2009) Heart Rhythm , vol.6 , Issue.8 SUPPL.
    • Kaufman, E.S.1
  • 48
    • 68949205869 scopus 로고    scopus 로고
    • Drugs and Brugada syndrome patients: Review of the literature recommendations, and an up-to-date website
    • Postema PG, Wolpert C, Amin AS, et al. Drugs and Brugada syndrome patients: review of the literature, recommendations, and an up-to-date website (http://www.brugadadrugs.org). Heart Rhythm 2009;6(9):1335-41
    • (2009) Heart Rhythm , vol.6 , Issue.9 , pp. 1335-1341
    • Postema, P.G.1    Wolpert, C.2    Amin, A.S.3
  • 49
    • 0026011647 scopus 로고
    • Mortality and morbidity in patients receiving encainide, flecainide or placebo
    • Echt D, Liebson P, Mitchell B, et al. Mortality and morbidity in patients receiving encainide, flecainide or placebo. N Engl J Med 1991;324(12):781-8
    • (1991) N Engl J Med , vol.324 , Issue.12 , pp. 781-788
    • Echt, D.1    Liebson, P.2    Mitchell, B.3
  • 50
    • 0029560055 scopus 로고
    • Interaction of ischaemia and encainide/flecainide treatment: A proposed mechanism for the increased mortality in CAST i
    • Greenberg H, Dwyer E, Hochman JS, et al. Interaction of ischaemia and encainide/flecainide treatment: a proposed mechanism for the increased mortality in CAST I. Br Heart J 1995;74:631-5
    • (1995) Br Heart J , vol.74 , pp. 631-635
    • Greenberg, H.1    Dwyer, E.2    Hochman, J.S.3
  • 51
    • 57749201111 scopus 로고    scopus 로고
    • Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes
    • Casini S, Verkerk AO, van Borren MM, et al. Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes. Cardiovasc Res 2009;81(1):72-81
    • (2009) Cardiovasc Res , vol.81 , Issue.1 , pp. 72-81
    • Casini, S.1    Verkerk, A.O.2    Van Borren, M.M.3
  • 52
    • 0035806895 scopus 로고    scopus 로고
    • Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes
    • Viswanathan PC, Bezzina CR, George AL, et al. Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes. Circulation 2001;104(10):1200-5
    • (2001) Circulation , vol.104 , Issue.10 , pp. 1200-1205
    • Viswanathan, P.C.1    Bezzina, C.R.2    George, A.L.3
  • 53
    • 68549104162 scopus 로고    scopus 로고
    • Brugada syndrome (sudden unexpected death syndrome): Perioperative and anesthetic management in oral and maxillofacial surgery
    • Theodotou N, Cillo JE Jr. Brugada syndrome (sudden unexpected death syndrome): perioperative and anesthetic management in oral and maxillofacial surgery. J Oral Maxillofac Surg 2009;67(9):2021-5
    • (2009) J Oral Maxillofac Surg , vol.67 , Issue.9 , pp. 2021-2025
    • Theodotou, N.1    Cillo Jr., J.E.2
  • 54
    • 80052323654 scopus 로고    scopus 로고
    • Anesthetic management of patients with Brugada syndrome: A case series and literature review
    • Kloesel B, Ackerman MJ, Sprung J, et al. Anesthetic management of patients with Brugada syndrome: a case series and literature review. Can J Anaesth 2011;58:824-36
    • (2011) Can J Anaesth , vol.58 , pp. 824-836
    • Kloesel, B.1    Ackerman, M.J.2    Sprung, J.3
  • 55
    • 34248575837 scopus 로고    scopus 로고
    • Brugada electrocardiographic pattern induced by cocaine toxicity
    • Bebarta VS, Summers S. Brugada electrocardiographic pattern induced by cocaine toxicity. Ann Emerg Med 2007;49(6):827-9
    • (2007) Ann Emerg Med , vol.49 , Issue.6 , pp. 827-829
    • Bebarta, V.S.1    Summers, S.2
  • 56
    • 0028051609 scopus 로고
    • Cocaethylene, a metabolite of cocaine and etanol, is a potent blocker of cardiac sodium channel
    • Xu Y-Q, Crumb WJ Jr, Clarkson CW. Cocaethylene, a metabolite of cocaine and etanol, is a potent blocker of cardiac sodium channel. J Pharmacol Exp Ther 1994;271(1):319-25
    • (1994) J Pharmacol Exp Ther , vol.271 , Issue.1 , pp. 319-325
    • Xu, Y.-Q.1    Crumb Jr., W.J.2    Clarkson, C.W.3
  • 57
    • 84879557389 scopus 로고    scopus 로고
    • Alcohol-induced ventricular fibrillation in a case of Brugada syndrome
    • Ohkubo K, Nakai T, Watanabe I. Alcohol-induced ventricular fibrillation in a case of Brugada syndrome. Europace 2013;15(7):1058
    • (2013) Europace , vol.15 , Issue.7 , pp. 1058
    • Ohkubo, K.1    Nakai, T.2    Watanabe, I.3
  • 58
    • 84891527042 scopus 로고    scopus 로고
    • Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome
    • Veerman CC, Verkerk AO, Blom MT, et al. Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome. Circ Arrhythm Electrophysiol 2013;6(5):1002-9
    • (2013) Circ Arrhythm Electrophysiol , vol.6 , Issue.5 , pp. 1002-1009
    • Veerman, C.C.1    Verkerk, A.O.2    Blom, M.T.3
  • 59
    • 0033762137 scopus 로고    scopus 로고
    • Infant case with a malignant form of Brugada syndrome
    • Suzuki H, Torigoe K, Numata O, et al. Infant case with a malignant form of Brugada syndrome. J Cardiovasc Electrophysiol 2000;11:1277-80
    • (2000) J Cardiovasc Electrophysiol , vol.11 , pp. 1277-1280
    • Suzuki, H.1    Torigoe, K.2    Numata, O.3
  • 60
    • 33745445929 scopus 로고    scopus 로고
    • Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome
    • Watanabe A, Fukushima Kusano K, Morita H, et al. Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome. Eur Heart J 2006;27(13):1579-83
    • (2006) Eur Heart J , vol.27 , Issue.13 , pp. 1579-1583
    • Watanabe, A.1    Fukushima Kusano, K.2    Morita, H.3
  • 61
    • 34249720430 scopus 로고    scopus 로고
    • Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation
    • Ohgo T, Okamura H, Noda T, et al. Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. Heart Rhythm 2007;4(6):695-700
    • (2007) Heart Rhythm , vol.4 , Issue.6 , pp. 695-700
    • Ohgo, T.1    Okamura, H.2    Noda, T.3
  • 62
    • 0029988521 scopus 로고    scopus 로고
    • Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome
    • Miyazaki T, Mitamura H, Miyoshi S, et al. Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 1996;27(5):1061-70
    • (1996) J Am Coll Cardiol , vol.27 , Issue.5 , pp. 1061-1070
    • Miyazaki, T.1    Mitamura, H.2    Miyoshi, S.3
  • 63
    • 66749131467 scopus 로고    scopus 로고
    • Electrical storm in Brugada syndrome successfully treated with orciprenaline; Effect of low-dose quinidine on the electrocardiogram
    • Kyriazis K, Bahlmann E, van der Schalk H, et al. Electrical storm in Brugada syndrome successfully treated with orciprenaline; effect of low-dose quinidine on the electrocardiogram. Europace 2009;11(5):665-6
    • (2009) Europace , vol.11 , Issue.5 , pp. 665-666
    • Kyriazis, K.1    Bahlmann, E.2    Van Der Schalk, H.3
  • 64
    • 0034823084 scopus 로고    scopus 로고
    • Quinidine induced electrocardiograpic normalization in two patients with Brugada syndrome
    • Alings M, Dekker L, Sadee A, et al. Quinidine induced electrocardiograpic normalization in two patients with Brugada syndrome. Pacing Clin Electrophysiol 2001;24:1420-2
    • (2001) Pacing Clin Electrophysiol , vol.24 , pp. 1420-1422
    • Alings, M.1    Dekker, L.2    Sadee, A.3
  • 65
    • 84870398579 scopus 로고    scopus 로고
    • Long-term efficacy of low doses of quinidine on malignant arrhythmias in Brugada syndrome with an implantable cardioverter-defibrillator: A case series and literature review
    • Marquez MF, Bonny A, Hernandez-Castillo E, et al. Long-term efficacy of low doses of quinidine on malignant arrhythmias in Brugada syndrome with an implantable cardioverter-defibrillator: a case series and literature review. Heart Rhythm 2012;9(12):1995-2000
    • (2012) Heart Rhythm , vol.9 , Issue.12 , pp. 1995-2000
    • Marquez, M.F.1    Bonny, A.2    Hernandez-Castillo, E.3
  • 66
    • 4644298458 scopus 로고    scopus 로고
    • Efficacy of quinidine in high-risk patients with Brugada syndrome
    • Belhassen B, Glick A, Viskin S. Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation 2004;110(13):1731-7
    • (2004) Circulation , vol.110 , Issue.13 , pp. 1731-1737
    • Belhassen, B.1    Glick, A.2    Viskin, S.3
  • 67
    • 2442495365 scopus 로고    scopus 로고
    • Hydroquinidine therapy in Brugada syndrome
    • Hermida JS, Denjoy I, Clerc J, et al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol 2004;43(10):1853-60
    • (2004) J Am Coll Cardiol , vol.43 , Issue.10 , pp. 1853-1860
    • Hermida, J.S.1    Denjoy, I.2    Clerc, J.3
  • 69
    • 33745727533 scopus 로고    scopus 로고
    • Effects of low-dose quinidine on ventricular tachyarrhythmias in patients with Brugada syndrome
    • Mizusawa Y, Sukarada H, Nishizaki M, et al. Effects of low-dose quinidine on ventricular tachyarrhythmias in patients with Brugada syndrome. J Cardiovasc Pharmacol 2006;47:359-64
    • (2006) J Cardiovasc Pharmacol , vol.47 , pp. 359-364
    • Mizusawa, Y.1    Sukarada, H.2    Nishizaki, M.3
  • 70
    • 45849153805 scopus 로고    scopus 로고
    • Succesful radiofrequency catheter ablation for electrical storm of ventricular fibrillation in a patient with Brugada syndrome
    • Nakagawa E, Takagi M, Tatsumi H, et al. Succesful radiofrequency catheter ablation for electrical storm of ventricular fibrillation in a patient with Brugada syndrome. Circ J 2008;72:1025-9
    • (2008) Circ J , vol.72 , pp. 1025-1029
    • Nakagawa, E.1    Takagi, M.2    Tatsumi, H.3
  • 71
    • 60749112095 scopus 로고    scopus 로고
    • Empiric quinidine therapy for asymptomatic Brugada syndrome: Time for a prospective registry
    • Viskin S, Wilde AA, Tan HL, et al. Empiric quinidine therapy for asymptomatic Brugada syndrome: time for a prospective registry. Heart Rhythm 2009;6(3):401-4
    • (2009) Heart Rhythm , vol.6 , Issue.3 , pp. 401-404
    • Viskin, S.1    Wilde, A.A.2    Tan, H.L.3
  • 72
    • 0035996742 scopus 로고    scopus 로고
    • Prevention of ventricular fibrillation by cilostazol, an oral phosphodiesterase inhibitor, in a patient with Brugada syndrome
    • Tsuchiya T, Ashikaga K, Honda T, et al. Prevention of ventricular fibrillation by cilostazol, an oral phosphodiesterase inhibitor, in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 2002;13:698-701
    • (2002) J Cardiovasc Electrophysiol , vol.13 , pp. 698-701
    • Tsuchiya, T.1    Ashikaga, K.2    Honda, T.3
  • 73
    • 33644786312 scopus 로고    scopus 로고
    • Failure of cilostazol in the prevention of ventricular fibrillation in a patient with Brugada syndrome
    • Abud A, Bagattin D, Goyeneche R, et al. Failure of cilostazol in the prevention of ventricular fibrillation in a patient with Brugada syndrome. J Cardiovasc Electrophysiol 2006;17:210-12
    • (2006) J Cardiovasc Electrophysiol , vol.17 , pp. 210-212
    • Abud, A.1    Bagattin, D.2    Goyeneche, R.3
  • 74
    • 84857640089 scopus 로고    scopus 로고
    • Pathophysiology of the cardiac late Na current and its potential as a drug target
    • Moreno JD, Clancy CE. Pathophysiology of the cardiac late Na current and its potential as a drug target. J Mol Cell Cardiol 2012;52(3):608-19
    • (2012) J Mol Cell Cardiol , vol.52 , Issue.3 , pp. 608-619
    • Moreno, J.D.1    Clancy, C.E.2
  • 75
    • 53049104215 scopus 로고    scopus 로고
    • Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome
    • Moss AJ, Zareba W, Schwarz KQ, et al. Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome. J Cardiovasc Electrophysiol 2008;19(12):1289-93
    • (2008) J Cardiovasc Electrophysiol , vol.19 , Issue.12 , pp. 1289-1293
    • Moss, A.J.1    Zareba, W.2    Schwarz, K.Q.3
  • 76
    • 84874409862 scopus 로고    scopus 로고
    • The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: Effect of ranolazine
    • Karwatowska-Prokopczuk E, Wang W, Cheng ML, et al. The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: effect of ranolazine. Europace 2013;15(3):429-36
    • (2013) Europace , vol.15 , Issue.3 , pp. 429-436
    • Karwatowska-Prokopczuk, E.1    Wang, W.2    Cheng, M.L.3
  • 77
    • 79960757657 scopus 로고    scopus 로고
    • Electrophysiologic basis for the antiarrhythmic actions of ranolazine
    • Antzelevitch C, Burashnikov A, Sicouri S, et al. Electrophysiologic basis for the antiarrhythmic actions of ranolazine. Heart Rhythm 2011;8(8):1281-90
    • (2011) Heart Rhythm , vol.8 , Issue.8 , pp. 1281-1290
    • Antzelevitch, C.1    Burashnikov, A.2    Sicouri, S.3
  • 78
    • 70449119097 scopus 로고    scopus 로고
    • Use-dependent block of cardiac late Na(+) current by ranolazine
    • Rajamani S, El-Bizri N, Shryock JC, et al. Use-dependent block of cardiac late Na(+) current by ranolazine. Heart Rhythm 2009;6(11):1625-31
    • (2009) Heart Rhythm , vol.6 , Issue.11 , pp. 1625-1631
    • Rajamani, S.1    El-Bizri, N.2    Shryock, J.C.3
  • 79
    • 84857988682 scopus 로고    scopus 로고
    • Ranolazine safely decreases ventricular and atrial fibrillation in Timothy syndrome (LQT8
    • Shah DP, Baez-Escudero JL, Weisberg IL, et al. Ranolazine safely decreases ventricular and atrial fibrillation in Timothy syndrome (LQT8). Pacing Clin Electrophysiol 2012;35(3):e62-4
    • (2012) Pacing Clin Electrophysiol , vol.35 , Issue.3
    • Shah, D.P.1    Baez-Escudero, J.L.2    Weisberg, I.L.3
  • 80
    • 84891735675 scopus 로고    scopus 로고
    • Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker
    • van den Berg MP, van den Heuvel F, van Tintelen JP, et al. Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker. Int J Cardiol 2014;171(1):90-2
    • (2014) Int J Cardiol , vol.171 , Issue.1 , pp. 90-92
    • Van Den Berg, M.P.1    Van Den Heuvel, F.2    Van Tintelen, J.P.3
  • 81
    • 84871691015 scopus 로고    scopus 로고
    • A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias
    • Belardinelli L, Liu G, Smith-Maxwell C, et al. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. J Pharmacol Exp Ther 2013;344(1):23-32
    • (2013) J Pharmacol Exp Ther , vol.344 , Issue.1 , pp. 23-32
    • Belardinelli, L.1    Liu, G.2    Smith-Maxwell, C.3
  • 82
    • 84879486271 scopus 로고    scopus 로고
    • Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967
    • Sicouri S, Belardinelli L, Antzelevitch C. Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967. Heart Rhythm 2013;10(7):1036-43
    • (2013) Heart Rhythm , vol.10 , Issue.7 , pp. 1036-1043
    • Sicouri, S.1    Belardinelli, L.2    Antzelevitch, C.3
  • 83
    • 67650218655 scopus 로고    scopus 로고
    • F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models
    • Vacher B, Pignier C, Letienne R, et al. F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models. Br J Pharmacol 2009;156(2):214-25
    • (2009) Br J Pharmacol , vol.156 , Issue.2 , pp. 214-225
    • Vacher, B.1    Pignier, C.2    Letienne, R.3
  • 84
    • 33747437950 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary
    • Fuster V, Ryden LE, Cannom DS, et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation-executive summary. Circulation 2006;114(7):700-52
    • (2006) Circulation , vol.114 , Issue.7 , pp. 700-752
    • Fuster, V.1    Ryden, L.E.2    Cannom, D.S.3
  • 85
    • 77649226980 scopus 로고    scopus 로고
    • Cardioversion of atrial fibrillation: The use of antiarrhythmic drugs
    • Schilling RJ. Cardioversion of atrial fibrillation: the use of antiarrhythmic drugs. Heart 2010;96(5):333-8
    • (2010) Heart , vol.96 , Issue.5 , pp. 333-338
    • Schilling, R.J.1
  • 86
    • 77949372054 scopus 로고    scopus 로고
    • Tachycardia due to atrial flutter with rapid 1:1 conduction following treatment of atrial fibrillation with flecainide
    • Taylor R, Gandhi MM, Lloyd G. Tachycardia due to atrial flutter with rapid 1:1 conduction following treatment of atrial fibrillation with flecainide. BMJ 2010;340:b4684
    • (2010) BMJ , vol.340
    • Taylor, R.1    Gandhi, M.M.2    Lloyd, G.3
  • 87
    • 0035112566 scopus 로고    scopus 로고
    • The Brugada Syndrome: Ionic basis and arrhythmia mechanisms
    • Antzelevitch C. The Brugada Syndrome: ionic basis and arrhythmia mechanisms. J Cardiovasc Electrophysiol 2001;12:268-72 Onderzoek
    • (2001) J Cardiovasc Electrophysiol , vol.12 , pp. 268-272
    • Antzelevitch, C.1


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