Brugada phenocopy: New terminology and proposed classification

Annals of Noninvasive Electrocardiology

Volumn 17, Issue 4, 2012, Pages 299-314

  Baranchuk, Adrian ^a   Nguyen, Timothy ^a   Ryu, Min Hyung ^a   Femenía, Francisco ^b   Zareba, Wojciech ^c   Wilde, Arthur A M ^d   Shimizu, Wataru ^e   Brugada, Pedro ^f   Pérez Riera, Andrés R ^g  

^a QUEEN S UNIVERSITY   (Canada)

^b HOSPITAL ESPAÑOL   (Argentina)

^c UNIVERSITY OF ROCHESTER   (United States)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^f FREE UNIVERSITY OF BRUSSELS   (Belgium)

^g FACULDADE DE MEDICINA DO ABC   (Brazil)

Author keywords

Brugada syndrome; Brugada syndrome mimicry; Brugada like ECG findings; Brugada like ECG pattern

Indexed keywords

AJMALINE; FLECAINIDE; PROCAINAMIDE;

BRUGADA SYNDROME; DISEASE CLASSIFICATION; ELECTROCARDIOGRAM; ELECTROCARDIOGRAPHY MONITORING; ELECTROLYTE DISTURBANCE; FAINTNESS; FEVER; HEART ARRHYTHMIA; HEART MUSCLE CELL; HUMAN; ISCHEMIA; MAMMAL CELL; MISSENSE MUTATION; PERICARDIAL DISEASE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SODIUM CHANNELOPATHY; ST SEGMENT ELEVATION;

EID: 84867864853     PISSN: 1082720X     EISSN: 1542474X     Source Type: Journal    
DOI: 10.1111/j.1542-474X.2012.00525.x     Document Type: Review

References (111)

1. Antzelevitch C, Brugada P, Borggrefe M, et al., Brugada syndrome: Report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005; 111: 659-670.
2. Riera ARP, Uchida AH, Schapachnik E, et al., Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy. Cardiol J 2010; 17: 130-135.
3. Arce M, Riera ARP, Femenia F, et al., Brugada electrocardiographic phenocopy in a patient with chronic Chagasic cardiomyopathy. Cardiol J 2010; 17: 525-527.
4. Wilde AA, Postema PG, DiDiego JM, et al., The pathophysiological mechanism underlying Brugada syndrome depolarization versus repolarization. J Mol Cell Cardiol 2010; 49: 543-553.
5. Hisamatsu K, Kusano KF, Morita H, et al., Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada Syndrome: Using body surface signal-averaged electrocardiography and body surface maps. J Cardiovasc Electrophysiol 2004; 15: 870-876.
6. Nagase S, Kusano KF, Morita H, et al., Epicardial electrogram of the right ventricular outflow tract in patients with the Brugada syndrome. J Am Coll Cardiol 2002; 39: 1992-1995.
7. Janse MJ, Kleber AG,. Electrophysiological changes and ventricular arrhythmias in the early phase of regional myocardial ischemia. Circ Res 1981; 49: 1069-1081.
8. Nademanee K, Veerakul G, Chandanamattha P, et al., Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium. Circulation 2011; 123: 1270-1279.
9. Elizari MV, Levi R, Acunzo RS, et al., Abnormal expression of cardiac neural crest cells in heart development: A different hypothesis for the etiopathogenesis of Brugada syndrome. Heart Rhythm 2007; 4: 359-365.
10. Shimizu W,. Acquired forms of the Brugada syndrome. J Electrocardiol 2005; 38: 22-25.
11. Abusin S,. Brugada ECG pattern precipitated by acute pneumonia: A case report. Cases J 2009; 2: 73.
12. Gavrielatos G, Letsas KP, Pappas LK, et al., Brugada electrocardiographic pattern induced during febrile state with marked leukocytosis. Pacing Clin Electrophysiol 2007; 30: 135-136.
13. Kalra S, Iskandar SB, Duggal S, et al., Fever-induced ST-segment elevation with a Brugada syndrome type electrocardiogram. Ann Intern Med 2008; 148: 82-84.
14. Karakitso D, Patrianakos A, Poularas J, et al., Brugada-like electrocardiographic pattern unmasked by fever in a critical care patient. Acta Anaesthesiol Scand 2006; 50: 1038-1039.
15. Kusaka K, Yamakawa J, Kawaura K, et al., Brugada-like electrocardiographic changes during influenza infection. J Int Med Res 2003; 31: 244-246.
16. Makaryus JN, Verbsky J, Schwartz S, et al., Fever associated with gastrointestinal shigellosis unmasks probable Brugada syndrome. Case Report Med 2009;492031.
17. Ott P, Freund NS,. Brugada-pattern EKG in a febrile patient. J Emerg Med 2007; 33: 281-282.
18. Ozben B, Caymaz O, Erdogan O,. Fever-induced precordial ST-segment elevation in a young man. Turk Kardiyoloji Dernegi Arsivi 2010; 38: 35-37.
19. Ozeke O, Aras D, Geyik B, et al., Brugada-type electrocardiographic pattern induced by fever. Indian Pacing Electrophysiol J 2005; 5: 146-148.
20. Patanè S, Marte F,. Revelation of Brugada electrocardiographic pattern during a febrile state associated with acute myocardial infarction. Int J Cardiol 2010; 144: e1-4.
21. Porres JM, Brugada J, Urbistondo V, et al., Fever unmasking the Brugada syndrome. Pacing Clin Electrophysiol 2002; 25: 1646-1648.
22. Saura D, Garcia-Alberola A, Carrillo P, et al., Brugada-like electrocardiographic pattern induced by fever. Pacing Clin Electrophysiol 2002; 25: 856-859.
23. Siniorakis E, Arvanitakis S, Psatheris G, et al., Recurrence of fever-related Brugada pattern and right ventricular functional correlates. Int J Cardiol 2010; 148: 370-372.
24. Suzuki T, Kohsaka S,. Brugada-type electrocardiographic changes in a febrile patient of African descent. Am J Med Sci 2006; 332: 97-99.
25. Tsarouhas K, Papalexis P, Kafantaris I, et al., Electrocardiographic findings compatible with Brugada syndrome in a patient with febrile respiratory infection. Hippokratia 2010; 14: 221-223.
26. Unlu M, Bengi F, Amasyali B, et al., Brugada-like electrocardiographic changes induced by fever. EMJ 2007; 24: e4.
27. Amin AS, Meregalli PG, Bardai A, et al., Fever increases the risk of cardiac arrest in the Brugada syndrome. Ann Int Medicine 2008; 149: 216-218.
28. Baranchuk A, Simpson CS,. Brugada syndrome coinciding with fever and pandemic (H1N1) influenza. CMAJ 2011; 183: 582.
29. Dumaine R, Towbin JA, Brugada P, et al., Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. Circ Res 1999; 85: 803-809.
30. Keller DI, Rougier JS, Kucera JP, et al., Brugada syndrome and fever: Genetic and molecular characterization of patients carrying SCN5A mutations. Cardiovasc Res 2005; 67: 510-519.
31. Meregalli P, Ruijter J, Hofman N, et al., Diagnostic value of flecainide testing in unmasking SCN5A-related Brugada syndrome. J Cardiovasc Electrophysiol 2006; 17: 857-864.
32. Junttila MJ, Gonzalez M, Lizotte E, et al., Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Circulation 2008; 117: 1890-1893.
33. Postema PG, Wolpert C, Amin AS, et al., Drugs and Brugada syndrome patients: Review of the literature, recommendations and an up-to-date website (http://www.brugadadrugs.org). Heart Rhythm 2009; 6: 1335-1341.
34. Noda T, Shimizu W, Taguchi A, et al., ST-segment elevation and ventricular fibrillation without coronary spasm by intracoronary injection of acetylcholine and/or ergonovine maleate in patients with Brugada syndrome. J Am Coll Cardiol 2002; 40: 1841-1847.
35. Habuchi Y, Furukawa T, Tanaka H, et al., Ethanol inhibition of Ca2+ and Na +currents in the guinea-pig heart. Eur J Pharmcol 1995; 292: 143-149.
36. Shimada M, Miyazaki T, Miyoshi S, et al., Sustained monomorphic ventricular tachycardia in a patient with Brugada syndrome. Jpn Circ J 1996; 60: 364-370.
37. Akhtar M, Goldschlager NF,. Brugada electrocardiographic pattern due to tricyclic antidepressant overdose. J Electrocardiol 2006; 39: 336-339.
38. Bebarta VS, Waksman JC,. Amitriptyline-induced Brugada pattern fails to respond to sodium bicarbonate. Clin Toxicol 2007; 45: 186-188.
39. Bebarta VS, Summers S,. Brugada electrocardiographic pattern induced by cocaine toxicity. Ann Emerg Med 2007; 49: 827-829.
40. Bolognesi R, Tsialtas D, Vasini P, et al., Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose. Am J Cardiol 1997; 79: 242-245.
41. Palaniswamy C, Selvaraj DR, Chugh T, et al., Brugada electrocardiographic pattern induced by amitriptyline overdose. Am J Ther 2010; 17: 529-532.
42. Roberts-Thomson KC, Teo KS, Young GD,. Drug-induced Brugada syndrome with ST-T wave alternans and long QT. Intern Med J 2007; 37: 199-200.
43. Rouleau F, Asfar P, Boulet S, et al., Transient ST segment elevation in right precordial leads induced by psychotropic drugs: Relationship to the Brugada syndrome. J Cardiovasc Electrophysiol 2001; 12: 61-65.
44. Goldgran-Toledano D, Sideris G, Kevorkian JP,. Overdose of cyclic antidepressants and the Brugada syndrome. N Engl J Med 2002; 346: 1591-1592.
45. Babaliaros VC, Hurst JW,. Tricyclic antidepressants and the Brugada syndrome: An example of Brugada waves appearing after the administration of desipramine. Clin Cardiol 2002; 25: 395-398.
46. Chow BJ, Gollob M, Birnie D,. Brugada syndrome precipitated by a tricyclic antidepressant. Heart 2005; 91: 651.
47. Sheikh M, Kanjwal K, Kasmani R, et al., Simultaneous ST-segment elevation in inferior and precordial leads following ingestion of a lethal dose of desipramine: A novel Brugada-like EKG pattern. J Interv Card Electrophysiol 2010; 28: 35-38.
48. Tada H, Sticherling C, Oral H, Morady F,. Brugada syndrome mimicked by tricyclic antidepressants overdose. J Cardiovasc Electrophysiol 2001; 12: 275.
49. Pirotte MJ, Mueller JG, Poprawski T,. A case report of Brugada-type electrocardiographic changes in a patient taking lithium. Am J Emerg Med 2008; 26: e1-3.
50. Wright D, Salehian O,. Brugada-type electrocardiographic changes induced by long-term lithium use. Circulation 2010; 122: e418-419.
51. Phillips N, Priestley M, Denniss AR, et al., Brugada-type electrocardiographic pattern induced by epidural bupivacaine. Anesth Analg 2003; 97: 264-267.
52. Vernooy K, Delhaas T, Cremer Ol, et al., Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. Heart Rhythm 2006; 3: 131-137.
53. Riezzo I, Centini F, Neri M, et al., Brugada-like EKG pattern and myocardial effects in a chronic propofol abuser. Clin Toxicol 2009; 47: 358-363.
54. Weiner JB, Haddad EV, Raj SR,. Recovery following propofol-associated Brugada electrocardiogram. Pacing Clin Electrophysiol 2010; 33: e39-42.
55. Littmann L, Monroe MH, Svenson RH,. Brugada-type electrocardiographic pattern induced by cocaine. Mayo Clin Proc 2000; 75: 845-849.
56. Ortega-Carnicer J, Bertos-Polo J, Gutierrez-Tirado C,. Aborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion. J Electrocariol 2001; 34: 345-349.
57. Robertson KE, Martin TN, Rae AP,. Brugada-pattern ECG and cardiac arrest in cocaine toxicity: Reading between the white lines. Heart 2010; 96: 643-644.
58. Chinushi M, Tagawa M, Izumi D, et al., Pilsicainide-induced ST segment depression in two patients with variant forms of Brugada-type electrocardiographic abnormalities. Pacing Clin Electrophysiol 2009; 32: 811-815.
59. Paul G, Yusuf S, Sharma S,. Unmasking of the Brugada syndrome phenotype during the acute phase of amiodarone infusion. Circulation 2006; 114: e489-491.
60. Al Aloul B, Adabag AS, Houghland MA, et al., Brugada pattern electrocardiogram associated with supratherapeutic phenytoin levels and the risk of sudden death. Pacing Clin Electrophysiol 2007; 30: 713-715.
61. Stirnimann G, Severine P, Abriel H, et al., Brugada syndrome ECG provoked by the selective serotonin reuptake inhibitor fluvoxamine. Europace 2010; 12: 282-283.
62. Sawhney V, Thomas G, Webster P, et al., Resolution of Brugada-pattern ECG after withdrawal of the selective serotonin reuptake inhibitor paroxetine. Heart 2010; 96: 1165-1166.
63. Kiran HS, Ravikumar YS, Jayasheelan MR, et al., Brugada like pattern in ECG with drug overdose. J Assoc Physicians India 2010; 58: 120-122.
64. Meert A, Vermeersch N, Beckers R, et al., Brugada-like ECG pattern induced by tricyclic antidepressants. Eur J Emerg Med 2010; 17: 325-327.
65. Copetti R, Proclemer A, Pillinini PP,. Brugada-like ECG abnormalities during thioridazine overdose. Br J Clin Pharmacol 2005; 59: 608.
66. Rollin A, Maury P, Guilbeau-Frugier C, et al., Transient ST elevation after ketamine intoxication: A new cause of acquired Brugada ECG pattern. J Card Elect 2010; 22: 91-94.
67. Cole JB, Sattiraju S, Bilden EF, et al., Isolated Tramadol overdose associated with Brugada ECG pattern. Pacing Clin Electrophysiol 2010 Oct 7 [E-pub ahead of print], doi: 10.1111/j.1540-8159.2010.02924.x.
68. Sharma AN, Hexdall AH, Chang EK, et al., Diphenhydramine-induced wide complex dysrthythmia responds to treatment with sodium bicarbonate. Am J Emerg Med 2003; 21: 212-215.
69. Levine M, Lovecchio F,. Diphenhydramine-induced Brugada pattern. Resuscitation 2010; 81: 503-504.
70. Lopez-Barbeito B, Llis M, Delgado V, et al., Diphenhydramine overdose and Brugada sign. Pacing Clin Electrophysiol 2005; 28: 730-732.
71. Daccarett M, Freih M, Machado C,. Acute cannabis intoxication mimicking Brugada-like ST segment abnormalities. Int J Cardiol 2007; 119: 235-236.
72. Ansari E, Cook JR,. Profound hypothermia mimicking a Brugada type ECG. J Electrocardiol 2003; 36: 257-260.
73. Bonnemeier H, Mauser W, Schunkert H,. Images in cardiovascular medicine. Brugada-like ECG pattern in severe hypothermia. Circulation 2008; 118: 977-978.
74. Irani F, Kasmani R, Kanjwal Y,. Hyperkalemia and cocaine induced dynamic Brugada-type electrocardiogram. Eur J Emerg Med 2009; 17: 113-115.
75. Khalil Y, Siddique SM, Hoang NT,. A Brugada-pattern electrocardiogram and adrenal insufficiency. Ann Intern Med 2010; 153: 849-851.
76. Kovacic JC, Kuchar DL,. Brugada pattern electrocardiographic changes associated with profound electrolyte disturbance. Pacing Clin Electrophysiol 2004; 27: 1020-1023.
77. Kurisu S, Inoue I, Kawagoe T,. Brugada-like electrocardiographic pattern due to hyperkalemia. Clin Cardiol 2009; 32: E23.
78. Kutsuzawa D, Arimoto T, Watanabe T, et al., Persistent abnormal value of late potential in Brugada syndrome associated with hypokalemia. Ann Noninvasive Electrocardiol 2011; 16: 104-106.
79. Mehta S, Parameswaran AC, Greenspan A, et al., Hypercalcemia due to rhabdomyolysis mimicking Brugada syndrome. Pacing Clin Electrophysiol 2009; 32: e14-15.
80. Mok N, Tong C, Yuen H,. Concomitant-acquired long QT and Brugada syndromes associated with indapamide-induced hypokalemia and hyponatremia. Pacing Clin Electrophysiol 2008; 31: 772-775.
81. Ortega-Carnicer J, Benezet J, Ruiz-Lorenzo F, et al., Transient Brugada-type electrocardiographic abnormalities in renal failure reversed by dialysis. Resuscitation 2002; 55: 215-219.
82. Ortega-Carnicer J, Benezet J, Calderon-Jimenez P, et al., Hypothermia-induced Brugada-like electrocardiogram pattern. J Electrocardiol 2008; 41: 690-692.
83. Tamene A, Sattiraju S, Wang K, et al., Brugada-like electrocardiography pattern induced by severe hyponatraemia. Europace 2010; 12: 905-907.
84. Tanawuttiwat T, Harindhanavudhi T, Bhan A, et al., Hyperkalemia-induced Brugada pattern: An unusual manifestation. J Cardiovasc Med 2010; 11: 285-287.
85. Tsai CF, Wu DJ, Lin MC, et al., A Brugada-pattern electrocardiogram and thyrotoxic periodic paralysis. Ann Intern Med 2010; 153: 848-849.
86. Kataoka H,. Electrocardiographic patterns of the Brugada Syndrome in 2 young patients with pectus excavatum. J Electrocardiol 2002; 35: 169-171.
87. Nakazato Y, Ohmura T, Shimada I, et al., Brugada-like precordial ST elevation on ECG by anterior mediastinal infective mass lesion. Indian Pacing Electrophysiol J 2003; 3: 184.
88. Sasaki A, Nakazato Y,. Brugada-like electrocardiogram detected after reconstructive operation for oesophageal cancer. Europace 2010; 12: 1542.
89. Tarin N, Farre J, Rubio JM, et al., Brugada-like electrocardiographic pattern in a patient with a mediastinal tumor. Pacing Clin Electrophysiol 1999; 22: 1264-1266.
90. Tomcsanyi J, Simor T, Papp L,. Haemopericardium and Brugada-like ECG pattern in rheumatoid arthritis. Heart 2002; 87: 234.
91. Eggebrecht H, Wieneke H, Erbel R,. Image of the month. Brugada-like ECG pattern in a patient with isolated right ventricular infarction. Herz 2009; 34: 327.
92. Nakazato Y, Kurata T, Yamaguchi H,. ST segment elevation in the precordial leads mimicking Brugada syndrome. Heart 2000; 83: 216.
93. Itoh E, Suzuki K, Tanabe Y,. A case of vasospastic angina presenting Brugada-type ECG abnormalities. Jpn Circ J 1999; 63: 493-495.
94. Tomcsanyi J, Zsoldos A, Bozsik B,. Brugada-like acute myocardial infarction. Heart 2003; 89: 1199.
95. Bramos D, Koutras K, Kollias G, et al., Cardiac amyloidosis and Brugada-like ECG pattern. Int J Cardiol 2009; 145: 249-251.
96. Kim YH, Lim HE, Kim SH, et al., Brugada-like ST-segment abnormalities associated with myocardial involvement of hematologic diseases. Pacing Clin Electrophysiol 2008; 31: 761-764.
97. Nayyar S, Nair M,. Brugada pattern in toxic myocarditis due to severe aluminum phosphide poisoning. Pacing Clin Electrophysiol 2009; 32: e16-17.
98. Brito MR, Miranda CES, Rabelo W, et al., Type 1 electrocardiographic Brugada pattern in a woman with Chagas disease: A case report. Europace 2010; 12: 1345-1346.
99. Ozeke O, Selcuk MT, Topaloglu S, et al., Brugada-like early repolarisation pattern associated with acute pericarditis. EMJ 2006; 23: e64.
100. Rudnik-Schoneborn S, Schaupp M, Lindner A, et al., Brugada-like cardiac disease in myotonic dystrophy type 2: Report of two unrelated patients. Eur J Neurol 2010; 18: 191-194.
101. Kaiser E, Pastore CA, Moffa PJ,. Ebstein's anomaly with Brugada-like electrocardiogram pattern: a critical view. Cardiology 2010; 17: 415.
102. Rangaraj R, Moorthy N, Patil SS, et al., Brugada-type electrocardiographic pattern induced by electrocution. Indian Pacing Electrophysiol J 2009; 9: 56-59.
103. Littmann L, Monoroe MH, Taylor III L, et al., The hyperkalemic Brugada sign. J Electrocardiol 2007; 40: 53-59.
104. Yan GX, Antzelevitch C,. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-Segment elevation. Circulation 1999; 100: 1660-1666.
105. Antzelevitch C,. The Brugada syndrome. Diagnostic criteria and cellular mechanisms. Eur Heart J 2001; 22: 356-363.
106. Nishida K, Fujiki A, Mizumaki K, et al., Canine model of Brugada syndrome using regional epicardial cooling of the right ventricular outflow tract. J Cardiovasc Electrophysiol 2004; 15: 936-941.
107. Baranchuk A, Rosas F, Morillo CA,. Enfermedad de Chagas en países desarrollados: mito o realidad (Chagas' disease in developed countries: myth or reality). In, Rosas F, Vanegas D, Cabrales M, (eds): Enfermedad de Chagas, Bogotá, Sociedad Colombiana de Cardiología. Bogota, Colombia, Sociedad Española de Cardiologia, 2007, pp. 217-219.
108. Chiale PA, Przybylski J, Laiño RA, et al., Electrocardiographic changes evoked by ajmaline in chronic Chagas' disease without manifest myocarditis. Am J Cardiol 1982; 49: 14-20.
109. Takagi M, Aihara N, Kuribayashi S, et al., Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome. Eur Heart J 2001; 22: 1032-1041.
110. Wahbi K, Fressart V, Bécane HM, et al., High prevalence of Brugada syndrome in patients with Steinert's disease. Medgen 2009; 21: 423.
111. Teijeiro R, Garro HA, Acunzo RS, et al., Recording of high V1-V3 precordial leads may be essential to the diagnosis of Brugada syndrome during the ajmaline test. J Cardiovasc Pharmacol Ther 2006; 11: 153-155.