F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models

British Journal of Pharmacology

Volumn 156, Issue 2, 2009, Pages 214-225

  Vacher, B ^a   Pignier, C ^a   Letienne R ^a   Verscheure, Y ^a   Le Grand, B ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Anti anginal drugs; Cardiac ischaemia; F 15845; Persistent sodium current

Indexed keywords

3 [3 (2 METHOXYPHENYLTHIO 2 METHYLPROPYL)]AMINO 3,4 DIHYDRO 2H 1,5 BENZOXATHIEPINE BROMHYDRATE; F 15845; SODIUM; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VERATRIDINE; VOLTAGE GATED SODIUM CHANNEL 1.5; 3 (3 (2 METHOXYPHENYLTHIO) 2 METHYLPROPYL)AMINO 3,4 DIHYDRO 2H 1,5 BENZOXATHIEPINE; 3-(3-(2-METHOXYPHENYLTHIO)-2-METHYLPROPYL)AMINO-3,4-DIHYDRO-2H-1,5-BENZOXATHIEPINE; BENZOTHIEPIN DERIVATIVE;

ANGINA PECTORIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; FEMALE; GUINEA PIG; HEART ELECTROPHYSIOLOGY; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RABBIT; SODIUM CURRENT; STEADY STATE; ACTION POTENTIAL; ANIMAL; CHEMICALLY INDUCED DISORDER; DOG; DRUG EFFECT; HEART MUSCLE CELL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACTION POTENTIALS; ANGINA PECTORIS; ANIMALS; BENZOTHIEPINS; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; ION CHANNEL GATING; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RABBITS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; VERATRIDINE;

EID: 67650218655     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2008.00062.x     Document Type: Article

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