Effects of low-dose quinidine on ventricular tachyarrhythmias in patients with Brugada syndrome: Low-dose quinidine therapy as an adjunctive treatment

Journal of Cardiovascular Pharmacology

Volumn 47, Issue 3, 2006, Pages 359-364

  Mizusawa, Yuka ^a   Sakurada, Harumizu ^a   Nishizaki, Mitsuhiro ^b   Hiraoka, Masayasu ^c  

^a TOKYO METROPOLITAN HIROO HOSPITAL   (Japan)

^b Yokohama Minami Kyosai Hospital   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Brugada syndrome; Electrophysiologic study; Quinidine sulfate; Serum quinidine concentration; Ventricular fibrillation

Indexed keywords

AMIODARONE; CILOSTAZOL; COLESTYRAMINE; QUINIDINE SULFATE; ANTIARRHYTHMIC AGENT; QUINIDINE;

ADULT; AGED; ARTICLE; BRUGADA SYNDROME; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEFIBRILLATOR; DEVICE REMOVAL; DIARRHEA; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; DRUG TREATMENT FAILURE; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; FOLLOW UP; HEART VENTRICLE TACHYCARDIA; HUMAN; IMPLANT; LOW DRUG DOSE; MALE; NONHUMAN; PREVENTIVE MEDICINE; PRIORITY JOURNAL; PROPHYLAXIS; RECURRENT DISEASE; ELECTROCARDIOGRAPHY; FEMALE; HEART BUNDLE BRANCH BLOCK; HEART VENTRICLE FIBRILLATION; MIDDLE AGED; SYNDROME;

ADULT; AGED; ANTI-ARRHYTHMIA AGENTS; BUNDLE-BRANCH BLOCK; DEFIBRILLATORS, IMPLANTABLE; ELECTRIC STIMULATION; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; QUINIDINE; SYNDROME; TACHYCARDIA, VENTRICULAR; VENTRICULAR FIBRILLATION;

EID: 33745727533     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000206437.27854.65     Document Type: Article

References (15)

1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol. 1992;20:1391-1396.
2. Gussak I, Antzelevitch C, Bjerregaard P, et al. The Brugada syndrome: clinical, electrophysiologic and genetic aspects. J Am Coll Cardiol. 1999;33:5-15.
3. Priori SG, Napolitano C, Gasparini M, et al. Natural history of Brugada syndrome: insights for risk stratification and management. Circulation. 2002;105:1342-1347.
4. Brugada J, Brugada R, Antzelevitch C, et al. Long-term follow-up of individuals with the electrocardiographic pattern of right bundle-branch block and ST segment elevation in precordial leads V1 to V3. Circulation. 2002;105:73-78.
5. Yan G, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation. 1999;100:1660-1666.
6. Antzelevitch C. The Brugada syndrome. J Cardiovasc Electrophysiol. 1998;9:513-516.
7. Belhassen B, Viskin S, Fish R, et al. Effects of electrophysiologic- guided therapy with Class IA antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome. J Cardiovasc Electrophysiol. 1999;10:1301-1312.
8. Hermida JS, Denjoy I, Clerc J, et al. Hydroquinidine therapy in Brugada syndrome. J Am Coll Cardiol. 2004;43:1853-1860.
9. Belhassen B, Glick A, Viskin S. Efficacy of quinidine in high-risk patients with Brugada syndrome. Circulation. 2004;110:1731-1737.
10. Kodama I, Aizawa Y, Ogawa S, et al. Guidelines for drug treatment of arrhythmias (JCS 2004) [in Japanese]. Circ J. 2004;68(Suppl IV):981-1078.
11. Wilde AAM, Antzelevitch C, Borggrefe M, et al. For the study group on the molecular basis of arrhythmias of the European society of cardiology: proposed diagnosis criteria for the Brugada syndrome: consensus report. Circulation. 2002;106:2514-2519.
12. Belhassen B, Shapira I, Sheps D. Programmed ventricular stimulation using up to two extrastimuli and repetition of double extrastimulation for induction of ventricular tachycardia: a new highly sensitive and specific protocol. Am J Cardiol. 1990;65:615-622.
13. Brugada J, Brugada R, Brugada P. Determinants of sudden cardiac death in individuals with the electrocardiographic pattern of Brugada syndrome and no previous cardiac arrest. Circulation. 2003;108:3092-3096.
14. Tsuchiya T, Ashikaga K, Honda T, et al. Prevention of ventricular fibrillation by cilostazol, an oral phosphodiesterase inhibitor, in a patient with Brugada syndrome. J Cardiovasc Electrophysiol. 2002;13:698-701.
15. Gasparini M, Priori SG, Mantica M, et al. Programmed electrical stimulation in Brugada syndrome. J Cardiovasc Electrophysiol. 2002;13:880-887.