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Volumn 3, Issue 3, 2010, Pages 283-290

The Brugada ECG pattern a marker of channelopathy, structural heart disease, or neither? Toward a unifying mechanism of the Brugada syndrome

Author keywords

Arrhythmia; Brugada syndrome; Sodium channel; ST segment elevation; Structure

Indexed keywords

CALCIUM CHANNEL L TYPE; SODIUM CHANNEL; SODIUM CHANNEL NAV1.5; ION CHANNEL;

EID: 77954674875     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.110.937029     Document Type: Review
Times cited : (128)

References (88)
  • 1
    • 0026466921 scopus 로고
    • Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome: A multicenter report
    • Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report. J Am Coll Cardiol. 1992;20: 1391-1396.
    • (1992) J Am Coll Cardiol. , vol.20 , pp. 1391-1396
    • Brugada, P.1    Brugada, J.2
  • 5
    • 22544451292 scopus 로고    scopus 로고
    • Pathophysiological mechanisms of Brugada syndrome: Depolarization disorder, repolarization disorder, or more?
    • Meregalli PG, Wilde AAM, Tan HL. Pathophysiological mechanisms of Brugada syndrome: depolarization disorder, repolarization disorder, or more? Cardiovasc Res. 2005;67:367-378.
    • (2005) Cardiovasc Res. , vol.67 , pp. 367-378
    • Meregalli, P.G.1    Wilde, A.A.M.2    Tan, H.L.3
  • 6
    • 0025847714 scopus 로고
    • Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene
    • Keating M, Atkinson D, Dunn C, Timothy K, Vincent GM, Leppert M. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene. Science. 1991;252:704-706.
    • (1991) Science , vol.252 , pp. 704-706
    • Keating, M.1    Atkinson, D.2    Dunn, C.3    Timothy, K.4    Vincent, G.M.5    Leppert, M.6
  • 10
    • 1442356568 scopus 로고    scopus 로고
    • Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: Different incidences in familial and sporadic disease
    • Schulze-Bahr E, Eckardt L, Breithardt G, Seidl K, Wichter T, Wichter T, Borggrefe M, Haverkamp W. Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: different incidences in familial and sporadic disease. Hum Mutat. 2009;21:651-652.
    • (2009) Hum Mutat. , vol.21 , pp. 651-652
    • Schulze-Bahr, E.1    Eckardt, L.2    Breithardt, G.3    Seidl, K.4    Wichter, T.5    Wichter, T.6    Borggrefe, M.7    Haverkamp, W.8
  • 14
    • 34249686444 scopus 로고    scopus 로고
    • Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort
    • Koopmann TT, Beekman L, Alders M, Meregalli PG, Mannens MMAM, Moorman AFM, Wilde AAM, Bezzina CR. Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort. Heart Rhythm. 2007;4:752-755.
    • (2007) Heart Rhythm. , vol.4 , pp. 752-755
    • Koopmann, T.T.1    Beekman, L.2    Alders, M.3    Meregalli, P.G.4    Mmam, M.5    Afm, M.6    Aam, W.7    Bezzina, C.R.8
  • 15
    • 52749086867 scopus 로고    scopus 로고
    • Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome
    • Makiyama T, Akao M, Haruna Y, Tsuji K, Doi T, Ohno S, Nishio Y, Kita T, Horie M. Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome. Circ J. 2008;72:1705-1706.
    • (2008) Circ J. , vol.72 , pp. 1705-1706
    • Makiyama, T.1    Akao, M.2    Haruna, Y.3    Tsuji, K.4    Doi, T.5    Ohno, S.6    Nishio, Y.7    Kita, T.8    Horie, M.9
  • 18
    • 0030942181 scopus 로고    scopus 로고
    • Further characterization of the syndrome of right bundle branch block, ST segment elevation, and sudden cardiac death
    • Brugada J, Brugada P. Further characterization of the syndrome of right bundle branch block, ST segment elevation, and sudden cardiac death. J Cardiovasc Electrophysiol. 1997;8:325-331.
    • (1997) J Cardiovasc Electrophysiol. , vol.8 , pp. 325-331
    • Brugada, J.1    Brugada, P.2
  • 22
    • 2942596228 scopus 로고    scopus 로고
    • Vagal activity modulates spontaneous augmentation of ST elevation in the daily life of patients with Brugada syndrome
    • Mizumaki K, Fujiki A, Tsuneda T, Sakabe M, Nishida K, Sugao M, Inoue H. Vagal activity modulates spontaneous augmentation of ST elevation in the daily life of patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2004;15:667-673.
    • (2004) J Cardiovasc Electrophysiol. , vol.15 , pp. 667-673
    • Mizumaki, K.1    Fujiki, A.2    Tsuneda, T.3    Sakabe, M.4    Nishida, K.5    Sugao, M.6    Inoue, H.7
  • 26
    • 49049104417 scopus 로고    scopus 로고
    • Fever increases the risk for cardiac arrest in the Brugada syndrome
    • Amin AS, Meregalli PG, Bardai A, Wilde AAM, Tan HL. Fever increases the risk for cardiac arrest in the Brugada syndrome. Ann Intern Med. 2008;149:216-218.
    • (2008) Ann Intern Med. , vol.149 , pp. 216-218
    • Amin, A.S.1    Meregalli, P.G.2    Bardai, A.3    Aam, W.4    Tan, H.L.5
  • 27
    • 33845886948 scopus 로고    scopus 로고
    • Lethal ECG changes hidden by therapeutic hypothermia
    • Tan HL, Meregalli PG. Lethal ECG changes hidden by therapeutic hypothermia. Lancet. 2007;369:78.
    • (2007) Lancet , vol.369 , pp. 78
    • Tan, H.L.1    Meregalli, P.G.2
  • 28
    • 0029988521 scopus 로고    scopus 로고
    • Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome
    • Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Ogawa S, Aizawa Y. Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol. 1996;27: 1061-1070.
    • (1996) J Am Coll Cardiol. , vol.27 , pp. 1061-1070
    • Miyazaki, T.1    Mitamura, H.2    Miyoshi, S.3    Soejima, K.4    Ogawa, S.5    Aizawa, Y.6
  • 29
    • 0034823084 scopus 로고    scopus 로고
    • Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome
    • Alings M, Dekker LRC, Sadee A, Wilde AAM. Quinidine induced electrocardiographic normalization in two patients with Brugada syndrome. Pacing Clin Electrophysiol. 2001;24:1420-1422.
    • (2001) Pacing Clin Electrophysiol. , vol.24 , pp. 1420-1422
    • Alings, M.1    Lrc, D.2    Sadee, A.3    Wilde, A.A.M.4
  • 30
    • 0032869692 scopus 로고    scopus 로고
    • Effects of electrophysiologic-guided therapy with class IA antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome
    • Belhassen B, Viskin S, Fish R, Glick A, Setbon I, Eldar M. Effects of electrophysiologic-guided therapy with class IA antiarrhythmic drugs on the long-term outcome of patients with idiopathic ventricular fibrillation with or without the Brugada syndrome. J Cardiovasc Electrophysiol. 1999;10:1301-1312.
    • (1999) J Cardiovasc Electrophysiol. , vol.10 , pp. 1301-1312
    • Belhassen, B.1    Viskin, S.2    Fish, R.3    Glick, A.4    Setbon, I.5    Eldar, M.6
  • 31
    • 0038103597 scopus 로고    scopus 로고
    • Class 1 antiarrhythmic drugs: Quinidine, procainamide, disopyramide, lidocaine, mexiletine, tocainide, phenytoin, morcizine, flecainide, propafenone
    • Zipes DP, Jalife J, eds, Philadelphia, PA: WB Saunders Company
    • Stanton MS. Class 1 antiarrhythmic drugs: quinidine, procainamide, disopyramide, lidocaine, mexiletine, tocainide, phenytoin, morcizine, flecainide, propafenone. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. Philadelphia, PA: WB Saunders Company; 2000:890-903.
    • (2000) Cardiac Electrophysiology: From Cell to Bedside , pp. 890-903
    • Stanton, M.S.1
  • 33
    • 0032879716 scopus 로고    scopus 로고
    • Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation
    • Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation. 1999;100:1660-1666.
    • (1999) Circulation , vol.100 , pp. 1660-1666
    • Yan, G.X.1    Antzelevitch, C.2
  • 34
    • 0030049208 scopus 로고    scopus 로고
    • Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle
    • Näbauer M, Beuckelmann DJ, Ü berfuhr P, Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 1996;93:168-177.
    • (1996) Circulation , vol.93 , pp. 168-177
    • Näbauer, M.1    Beuckelmann, D.J.2    Überfuhr, P.3    Steinbeck, G.4
  • 35
    • 33750532715 scopus 로고    scopus 로고
    • Why the Brugada syndrome is not yet a disease: Syndromes, diseases, and genetic causality
    • Coronel R, Berecki G, Opthof T. Why the Brugada syndrome is not yet a disease: syndromes, diseases, and genetic causality. Cardiovasc Res. 2006;72:361-363.
    • (2006) Cardiovasc Res. , vol.72 , pp. 361-363
    • Coronel, R.1    Berecki, G.2    Opthof, T.3
  • 40
    • 0035693463 scopus 로고    scopus 로고
    • Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation
    • Shimizu W, Aiba T, Kurita T, Kamakura S. Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation. J Cardiovasc Electrophysiol. 2001;12:1418-1421.
    • (2001) J Cardiovasc Electrophysiol. , vol.12 , pp. 1418-1421
    • Shimizu, W.1    Aiba, T.2    Kurita, T.3    Kamakura, S.4
  • 46
    • 0035814749 scopus 로고    scopus 로고
    • Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people
    • Corrado D, Basso C, Buja G, Nava A, Rossi L, Thiene G. Right bundle branch block, right precordial ST-segment elevation, and sudden death in young people. Circulation. 2001;103:710-717.
    • (2001) Circulation , vol.103 , pp. 710-717
    • Corrado, D.1    Basso, C.2    Buja, G.3    Nava, A.4    Rossi, L.5    Thiene, G.6
  • 47
    • 0023003076 scopus 로고
    • The cardiac pathology of sudden, unexplained nocturnal death in Southeast Asian refugees
    • Kirschner RH, Eckner FAO, Baron RC. The cardiac pathology of sudden, unexplained nocturnal death in Southeast Asian refugees. JAMA. 1986; 256:2700-2705.
    • (1986) JAMA , vol.256 , pp. 2700-2705
    • Kirschner, R.H.1    Fao, E.2    Baron, R.C.3
  • 49
    • 0032519519 scopus 로고    scopus 로고
    • Arrhythmogenic right ventricular cardiomyopathy underlies syndrome of right bundle branch block, ST-segment elevation, and sudden death
    • Tada H, Aihara N, Ohe T, Yutani C, Hamada S, Miyanuma H, Takamiya M, Kamakura S. Arrhythmogenic right ventricular cardiomyopathy underlies syndrome of right bundle branch block, ST-segment elevation, and sudden death. Am J Cardiol. 1998;81:519-522.
    • (1998) Am J Cardiol. , vol.81 , pp. 519-522
    • Tada, H.1    Aihara, N.2    Ohe, T.3    Yutani, C.4    Hamada, S.5    Miyanuma, H.6    Takamiya, M.7    Kamakura, S.8
  • 50
    • 0034936418 scopus 로고    scopus 로고
    • Diagnosis and long-term follow-up of the Brugada syndrome in patients with idiopathic ventricular fibrillation
    • Remme CA, Wever EFD, Wilde AAM, Derksen R, Hauer RNW. Diagnosis and long-term follow-up of the Brugada syndrome in patients with idiopathic ventricular fibrillation. Eur Heart J. 2001;22:400-409.
    • (2001) Eur Heart J. , vol.22 , pp. 400-409
    • Remme, C.A.1    Efd, W.2    Aam, W.3    Derksen, R.4    Hauer, R.N.W.5
  • 52
    • 33644786429 scopus 로고    scopus 로고
    • Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome
    • DOI 10.1161/CIRCULATIONAHA.105.520999, PII 0000301720051213000006
    • Frustaci A, Priori SG, Pieroni M, Chimenti C, Napolitano C, Rivolta I, Sanna T, Bellocci F, Russo MA. Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome. Circulation. 2005;112: 3680-3687. (Pubitemid 43739507)
    • (2005) Circulation , vol.112 , Issue.24 , pp. 3680-3687
    • Frustaci, A.1    Priori, S.G.2    Pieroni, M.3    Chimenti, C.4    Napolitano, C.5    Rivolta, I.6    Sanna, T.7    Bellocci, F.8    Russo, M.A.9
  • 53
    • 0034909450 scopus 로고    scopus 로고
    • Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome
    • Takagi M, Aihara N, Kuribayashi S, Taguchi A, Shimizu W, Kurita T, Suyama K, Kamakura S, Hamada S, Takamiya M. Localized right ventricular morphological abnormalities detected by electron-beam computed tomography represent arrhythmogenic substrates in patients with the Brugada syndrome. Eur Heart J. 2001;22:1032-1041.
    • (2001) Eur Heart J. , vol.22 , pp. 1032-1041
    • Takagi, M.1    Aihara, N.2    Kuribayashi, S.3    Taguchi, A.4    Shimizu, W.5    Kurita, T.6    Suyama, K.7    Kamakura, S.8    Hamada, S.9    Takamiya, M.10
  • 56
  • 58
    • 0017807499 scopus 로고
    • Recording from the body surface of arrhythmogenic ventricular activity during the S-T segment
    • Berbari EJ, Scherlag BJ, Hope RR, Lazzara R. Recording from the body surface of arrhythmogenic ventricular activity during the S-T segment. Am J Cardiol. 1978;41:697-702.
    • (1978) Am J Cardiol. , vol.41 , pp. 697-702
    • Berbari, E.J.1    Scherlag, B.J.2    Hope, R.R.3    Lazzara, R.4
  • 59
    • 0023947438 scopus 로고
    • Quantitative analysis of the signal-averaged QRS in patients with arrhythmogenic right ventricular dysplasia
    • Blomstrom-Lundqvist C, Hirsch I, Olsson SB, Edvardsson N. Quantitative analysis of the signal-averaged QRS in patients with arrhythmogenic right ventricular dysplasia. Eur Heart J. 1988;9:301-312.
    • (1988) Eur Heart J. , vol.9 , pp. 301-312
    • Blomstrom-Lundqvist, C.1    Hirsch, I.2    Olsson, S.B.3    Edvardsson, N.4
  • 62
    • 33745122560 scopus 로고    scopus 로고
    • Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease
    • Das MK, Khan B, Jacob S, Kumar A, Mahenthiran J. Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease. Circulation. 2006;113:2495-2501.
    • (2006) Circulation , vol.113 , pp. 2495-2501
    • Das, M.K.1    Khan, B.2    Jacob, S.3    Kumar, A.4    Mahenthiran, J.5
  • 63
    • 53049089723 scopus 로고    scopus 로고
    • QRS fragmentation in standard ECG as a diagnostic marker of arrhythmogenic right ventricular dysplasia-cardiomyopathy
    • Peters S, TrÜmmel M, Koehler B. QRS fragmentation in standard ECG as a diagnostic marker of arrhythmogenic right ventricular dysplasia- cardiomyopathy. Heart Rhythm. 2008;5:1417-1421.
    • (2008) Heart Rhythm. , vol.5 , pp. 1417-1421
    • Peters, S.1    Trümmel, M.2    Koehler, B.3
  • 68
    • 2942547855 scopus 로고    scopus 로고
    • Results of ajmaline testing in patients with arrhythmogenic right ventricular dysplasia-cardiomyopathy
    • Peters S, TrÜmmel M, Denecke S, Koehler B. Results of ajmaline testing in patients with arrhythmogenic right ventricular dysplasia- cardiomyopathy. Int J Cardiol. 2004;95:207-210.
    • (2004) Int J Cardiol. , vol.95 , pp. 207-210
    • Peters, S.1    Trümmel, M.2    Denecke, S.3    Koehler, B.4
  • 70
    • 0028061307 scopus 로고
    • Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle
    • Cabo C, Pertsov AM, Baxter WT, Davidenko JM, Gray RA, Jalife J. Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle. Circ Res. 1994;75:1014-1028.
    • (1994) Circ Res. , vol.75 , pp. 1014-1028
    • Cabo, C.1    Pertsov, A.M.2    Baxter, W.T.3    Davidenko, J.M.4    Gray, R.A.5    Jalife, J.6
  • 71
    • 0031021775 scopus 로고    scopus 로고
    • Involvement of the calcium inward current in cardiac impulse propagation: Induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644
    • Rohr S, Kucera JP. Involvement of the calcium inward current in cardiac impulse propagation: induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644. Biophys J. 1997;72:754-766.
    • (1997) Biophys J. , vol.72 , pp. 754-766
    • Rohr, S.1    Kucera, J.P.2
  • 75
    • 33847285635 scopus 로고    scopus 로고
    • Abnormal expression of cardiac neural crest cells in heart development: A different hypothesis for the etiopathogenesis of Brugada syndrome
    • Elizari MV, Levi RL, Acunzo RS, Chiale PA, Civetta MM, Ferreiro M, Sicouri S. Abnormal expression of cardiac neural crest cells in heart development: a different hypothesis for the etiopathogenesis of Brugada syndrome. Heart Rhythm. 2007;4:359-365.
    • (2007) Heart Rhythm. , vol.4 , pp. 359-365
    • Elizari, M.V.1    Levi, R.L.2    Acunzo, R.S.3    Chiale, P.A.4    Civetta, M.M.5    Ferreiro, M.6    Sicouri, S.7
  • 76
    • 59649091757 scopus 로고    scopus 로고
    • Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-threatening ventricular arrhythmias
    • Boukens BJD, Christoffels VM, Coronel R, Moorman AFM. Developmental basis for electrophysiological heterogeneity in the ventricular and outflow tract myocardium as a substrate for life-threatening ventricular arrhythmias. Circ Res. 2009;104:19-31.
    • (2009) Circ Res. , vol.104 , pp. 19-31
    • Bjd, B.1    Christoffels, V.M.2    Coronel, R.3    Moorman, A.F.M.4
  • 77
    • 0011237735 scopus 로고
    • Quantitation of collagen in human myocardium
    • Oken D, Boucek R. Quantitation of collagen in human myocardium. Circ Res. 1957;5:357-361.
    • (1957) Circ Res. , vol.5 , pp. 357-361
    • Oken, D.1    Boucek, R.2
  • 78
    • 13244276345 scopus 로고    scopus 로고
    • Fat in the right ventricle of the normal heart
    • Tansey DK, Aly Z, Sheppard MN. Fat in the right ventricle of the normal heart. Histopathology. 2005;46:98-104.
    • (2005) Histopathology. , vol.46 , pp. 98-104
    • Tansey, D.K.1    Aly, Z.2    Sheppard, M.N.3
  • 79
    • 39749088814 scopus 로고    scopus 로고
    • Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge
    • Veeraraghavan R, Poelzing S. Mechanisms underlying increased right ventricular conduction sensitivity to flecainide challenge. Cardiovasc Res. 2008;77:749-756.
    • (2008) Cardiovasc Res. , vol.77 , pp. 749-756
    • Veeraraghavan, R.1    Poelzing, S.2
  • 84
    • 0030972734 scopus 로고    scopus 로고
    • Repolarization and the genesis of cardiac arrhythmias: Role of body surface mapping
    • Fontaine G, Anouate P, Fontaliran F. Repolarization and the genesis of cardiac arrhythmias: role of body surface mapping. Circulation. 1997;95: 2600-2602.
    • (1997) Circulation , vol.95 , pp. 2600-2602
    • Fontaine, G.1    Anouate, P.2    Fontaliran, F.3
  • 86
    • 0021246433 scopus 로고
    • Chronic oral toxicity and oncogenicity studies of flecainide, an antiarrhythmic, in rats and mice
    • Case MT, Sibinski LJ, Steffen GR. Chronic oral toxicity and oncogenicity studies of flecainide, an antiarrhythmic, in rats and mice. Toxicol Appl Pharmacol. 1984;73:232-242.
    • (1984) Toxicol Appl Pharmacol. , vol.73 , pp. 232-242
    • Case, M.T.1    Sibinski, L.J.2    Steffen, G.R.3
  • 87
    • 70349242035 scopus 로고    scopus 로고
    • Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes
    • Sato PY, Musa H, Coombs W, Guerrero-Serna G, Patino GA, Taffet SM, Isom LL, Delmar M. Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res. 2009;105:523-526.
    • (2009) Circ Res. , vol.105 , pp. 523-526
    • Sato, P.Y.1    Musa, H.2    Coombs, W.3    Guerrero-Serna, G.4    Patino, G.A.5    Taffet, S.M.6    Isom, L.L.7    Delmar, M.8


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