메뉴 건너뛰기




Volumn 6, Issue 3, 2014, Pages 341-351

EZH2 as a potential target in cancer therapy

Author keywords

cancer; EZH2; histone lysine methyltransferase; PRC2; small molecule inhibitor

Indexed keywords

3-DEAZANEPLANOCIN; ADENOSINE; EZH2 PROTEIN, HUMAN; MOLECULAR LIBRARY; POLYCOMB REPRESSIVE COMPLEX 2;

EID: 84905826842     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.14.23     Document Type: Review
Times cited : (77)

References (90)
  • 1
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • Cao R, Wang L, Wang H et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298(5595), 1039-1043 (2002
    • (2002) Science , vol.298 , Issue.5595 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3
  • 2
    • 3042801308 scopus 로고    scopus 로고
    • SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex
    • Cao R, Zhang Y. SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 15(1), 57-67 (2004
    • (2004) Mol. Cell , vol.15 , Issue.1 , pp. 57-67
    • Cao, R.1    Zhang, Y.2
  • 3
    • 0037528708 scopus 로고    scopus 로고
    • Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement
    • Oguchi K, Takagi M, Tsuchida R et al. Missense mutation and defective function of ATM in a childhood acute leukemia patient with MLL gene rearrangement. Blood 101(9), 3622-3627 (2003
    • (2003) Blood , vol.101 , Issue.9 , pp. 3622-3627
    • Oguchi, K.1    Takagi, M.2    Tsuchida, R.3
  • 4
    • 0024723075 scopus 로고
    • Homeosis and the interaction of zeste and white in Drosophila
    • Wu CT, Jones RS, Lasko PF, Gelbart WM. Homeosis and the interaction of zeste and white in Drosophila. Mol. Gen. Genet. 218(3), 559-564 (1989
    • (1989) Mol. Gen. Genet , vol.218 , Issue.3 , pp. 559-564
    • Wu, C.T.1    Jones, R.S.2    Lasko, P.F.3    Gelbart, W.M.4
  • 5
    • 33646865180 scopus 로고    scopus 로고
    • Control of developmental regulators by Polycomb in human embryonic stem cells
    • Lee TI, Jenner RG, Boyer LA et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125(2), 301-313 (2006
    • (2006) Cell , vol.125 , Issue.2 , pp. 301-313
    • Lee, T.I.1    Jenner, R.G.2    Boyer, L.A.3
  • 6
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc. Natl Acad. Sci. USA 100(20), 11606-11611 (2003
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.20 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3
  • 7
    • 79959267832 scopus 로고    scopus 로고
    • Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
    • Takawa M, Masuda K, Kunizaki M et al. Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker. Cancer Sci. 102(7), 1298-1305 (2011
    • (2011) Cancer Sci , vol.102 , Issue.7 , pp. 1298-1305
    • Takawa, M.1    Masuda, K.2    Kunizaki, M.3
  • 8
    • 18644382388 scopus 로고    scopus 로고
    • The Polycomb group protein EZH2 is involved in progression of prostate cancer
    • Varambally S, Dhanasekaran SM, Zhou M et al. The Polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419(6907), 624-629 (2002
    • (2002) Nature , vol.419 , Issue.6907 , pp. 624-629
    • Varambally, S.1    Dhanasekaran, S.M.2    Zhou, M.3
  • 9
    • 77957282672 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma
    • Wagener N, Macher-Goeppinger S, Pritsch M et al. Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma. BMC Cancer 10, 524 (2010
    • (2010) BMC Cancer , vol.10 , Issue.524
    • Wagener, N.1    Macher-Goeppinger, S.2    Pritsch, M.3
  • 10
    • 79954435405 scopus 로고    scopus 로고
    • EZH2 Y641 mutations in follicular lymphoma
    • Bodor C, O'Riain C, Wrench D et al. EZH2 Y641 mutations in follicular lymphoma. Leukemia 25(4), 726-729 (2011
    • (2011) Leukemia , vol.25 , Issue.4 , pp. 726-729
    • Bodor, C.1    O'Riain, C.2    Wrench, D.3
  • 11
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • Ernst T, Chase AJ, Score J et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat. Genet. 42(8), 722-726 (2010
    • (2010) Nat. Genet , vol.42 , Issue.8 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 12
    • 84863165348 scopus 로고    scopus 로고
    • Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27
    • McCabe MT, Graves AP, Ganji G et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl Acad. Sci. USA 109(8), 2989-2994 (2012
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.8 , pp. 2989-2994
    • McCabe, M.T.1    Graves, A.P.2    Ganji, G.3
  • 13
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat. Genet. 42(2), 181-185 (2010
    • (2010) Nat. Genet , vol.42 , Issue.2 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3
  • 14
    • 0022490845 scopus 로고
    • 3-Deazaneplanocin: A new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60
    • Glazer RI, Hartman KD, Knode MC et al. 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochem. Biophys. Res. Commun. 135(2), 688-694 (1986
    • (1986) Biochem. Biophys. Res. Commun , vol.135 , Issue.2 , pp. 688-694
    • Glazer, R.I.1    Hartman, K.D.2    Knode, M.C.3
  • 15
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21(9), 1050-1063 (2007
    • (2007) Genes Dev , vol.21 , Issue.9 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3
  • 16
    • 67649371461 scopus 로고    scopus 로고
    • DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda TB, Cortez CC, Yoo CB et al. DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer Ther. 8(6), 1579-1588 (2009
    • (2009) Mol. Cancer Ther , vol.8 , Issue.6 , pp. 1579-1588
    • Miranda, T.B.1    Cortez, C.C.2    Yoo, C.B.3
  • 18
    • 84877815031 scopus 로고    scopus 로고
    • EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
    • Beguelin W, Popovic R, Teater M et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell 23(5), 677-692 (2013
    • (2013) Cancer Cell , vol.23 , Issue.5 , pp. 677-692
    • Beguelin, W.1    Popovic, R.2    Teater, M.3
  • 19
    • 84869012125 scopus 로고    scopus 로고
    • Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens
    • Diaz E, Machutta CA, Chen S et al. Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens. J. Biomol. Screen. 17(10), 1279-1292 (2012
    • (2012) J. Biomol. Screen , vol.17 , Issue.10 , pp. 1279-1292
    • Diaz, E.1    Machutta, C.A.2    Chen, S.3
  • 20
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 492(7427), 108-112 (2012
    • (2012) Nature , vol.492 , Issue.7427 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3
  • 21
    • 84877324084 scopus 로고    scopus 로고
    • Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
    • Knutson SK, Warholic NM, Wigle TJ et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc. Natl Acad. Sci. USA 110(19), 7922-7927 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.19 , pp. 7922-7927
    • Knutson, S.K.1    Warholic, N.M.2    Wigle, T.J.3
  • 22
    • 84867632489 scopus 로고    scopus 로고
    • A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
    • Knutson SK, Wigle TJ, Warholic NM et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat. Chem. Biol. 8(11), 890-896 (2012
    • (2012) Nat. Chem. Biol , vol.8 , Issue.11 , pp. 890-896
    • Knutson, S.K.1    Wigle, T.J.2    Warholic, N.M.3
  • 23
    • 84871841675 scopus 로고    scopus 로고
    • Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
    • Qi W, Chan H, Teng L et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc. Natl Acad. Sci. USA 109(52), 21360-21365 (2012
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.52 , pp. 21360-21365
    • Qi, W.1    Chan, H.2    Teng, L.3
  • 24
    • 84871248432 scopus 로고    scopus 로고
    • Identification of potent, selective, cell-active inhibitors of the histone lysine methyltransferase EZH2
    • Verma SK, Tian X, LaFrance LV et al. Identification of potent, selective, cell-active inhibitors of the histone lysine methyltransferase EZH2. ACS Med. Chem. Lett. 3(12), 1091-1096 (2012
    • (2012) ACS Med. Chem. Lett , vol.3 , Issue.12 , pp. 1091-1096
    • Verma, S.K.1    Tian, X.2    Lafrance, L.V.3
  • 25
    • 84888303259 scopus 로고    scopus 로고
    • Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth
    • Garapaty-Rao S, Nasveschuk C, Gagnon A et al. Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth. Chem. Biol. 20(11), 1329-1339 (2013
    • (2013) Chem. Biol , vol.20 , Issue.11 , pp. 1329-1339
    • Garapaty-Rao, S.1    Nasveschuk, C.2    Gagnon, A.3
  • 26
    • 84891603187 scopus 로고    scopus 로고
    • EZH2 mutations are frequent and represent an early event in follicular lymphoma
    • Bodor C, Grossmann V, Popov N et al. EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood 122(18), 3165-3168 (2013
    • (2013) Blood , vol.122 , Issue.18 , pp. 3165-3168
    • Bodor, C.1    Grossmann, V.2    Popov, N.3
  • 27
    • 84857942952 scopus 로고    scopus 로고
    • Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
    • Lohr JG, Stojanov P, Lawrence MS et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc. Natl Acad. Sci. USA 109(10), 3879-3884 (2012
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.10 , pp. 3879-3884
    • Lohr, J.G.1    Stojanov, P.2    Lawrence, M.S.3
  • 28
    • 80052029516 scopus 로고    scopus 로고
    • Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
    • Morin RD, Mendez-Lago M, Mungall AJ et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476(7360), 298-303 (2011
    • (2011) Nature , vol.476 , Issue.7360 , pp. 298-303
    • Morin, R.D.1    Mendez-Lago, M.2    Mungall, A.J.3
  • 29
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis E, Watson IR, Kryukov GV et al. A landscape of driver mutations in melanoma. Cell 150(2), 251-263 (2012
    • (2012) Cell , vol.150 , Issue.2 , pp. 251-263
    • Hodis, E.1    Watson, I.R.2    Kryukov, G.V.3
  • 30
    • 84866170767 scopus 로고    scopus 로고
    • Identification of somatic mutations in parathyroid tumors using whole-exome sequencing
    • Cromer MK, Starker LF, Choi M et al. Identification of somatic mutations in parathyroid tumors using whole-exome sequencing. J. Clin. Endocrinol. Metab. 97(9), E1774-E1781 (2012
    • (2012) J. Clin. Endocrinol. Metab , vol.97 , Issue.9
    • Cromer, M.K.1    Starker, L.F.2    Choi, M.3
  • 31
    • 80055101101 scopus 로고    scopus 로고
    • Temporal dissection of tumorigenesis in primary cancers
    • Durinck S, Ho C, Wang NJ et al. Temporal dissection of tumorigenesis in primary cancers. Cancer Discov. 1(2), 137-143 (2011
    • (2011) Cancer Discov , vol.1 , Issue.2 , pp. 137-143
    • Durinck, S.1    Ho, C.2    Wang, N.J.3
  • 32
    • 84878393452 scopus 로고    scopus 로고
    • EZH2 and CD79B mutational status over time in B-cell non-Hodgkin lymphomas detected by high-throughput sequencing using minimal samples
    • Saieg MA, Geddie WR, Boerner SL,Bailey D, Crump M, da Cunha SG. EZH2 and CD79B mutational status over time in B-cell non-Hodgkin lymphomas detected by high-throughput sequencing using minimal samples. Cancer Cytopathol. 121(7), 377-386 (2013
    • (2013) Cancer Cytopathol , vol.121 , Issue.7 , pp. 377-386
    • Saieg, M.A.1    Geddie, W.R.2    Boerner Slbailey, D.3    Crump, M.4    Da Cunha, S.G.5
  • 33
    • 83355173202 scopus 로고    scopus 로고
    • EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas
    • Ryan RJ, Nitta M, Borger D et al. EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. PLoS ONE 6(12), e28585 (2011
    • (2011) PLoS ONE , vol.6 , Issue.12
    • Ryan, R.J.1    Nitta, M.2    Borger, D.3
  • 34
    • 84872856782 scopus 로고    scopus 로고
    • Genetic heterogeneity of diffuse large B-cell lymphoma
    • Zhang J, Grubor V, Love CL et al. Genetic heterogeneity of diffuse large B-cell lymphoma. Proc. Natl Acad. Sci. USA 110(4), 1398-1403 (2013
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , Issue.4 , pp. 1398-1403
    • Zhang, J.1    Grubor, V.2    Love, C.L.3
  • 35
    • 84865684161 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
    • Krauthammer M, Kong Y, Ha BH et al. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat. Genet. 44(9), 1006-1014 (2012
    • (2012) Nat. Genet , vol.44 , Issue.9 , pp. 1006-1014
    • Krauthammer, M.1    Kong, Y.2    Ha, B.H.3
  • 36
    • 84866597616 scopus 로고    scopus 로고
    • A687V EZH2 is a gain-offunction mutation found in lymphoma patients
    • Majer CR, Jin L, Scott MP et al. A687V EZH2 is a gain-offunction mutation found in lymphoma patients. FEBS Lett. 586(19), 3448-3451 (2012
    • (2012) FEBS Lett , vol.586 , Issue.19 , pp. 3448-3451
    • Majer, C.R.1    Jin, L.2    Scott, M.P.3
  • 37
    • 79952167230 scopus 로고    scopus 로고
    • Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
    • Yap DB, Chu J, Berg T et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 117(8), 2451-2459 (2011
    • (2011) Blood , vol.117 , Issue.8 , pp. 2451-2459
    • Yap, D.B.1    Chu, J.2    Berg, T.3
  • 38
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wild-type plus mutant EZH2 drive tumorassociated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer CJ, Scott MP, Kuntz KW et al. Coordinated activities of wild-type plus mutant EZH2 drive tumorassociated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc. Natl Acad. Sci. USA 107(49), 20980-20985 (2010
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.49 , pp. 20980-20985
    • Sneeringer, C.J.1    Scott, M.P.2    Kuntz, K.W.3
  • 39
    • 80053279825 scopus 로고    scopus 로고
    • The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states
    • Wigle TJ, Knutson SK, Jin L et al. The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states. FEBS Lett. 585(19), 3011-3014 (2011
    • (2011) FEBS Lett , vol.585 , Issue.19 , pp. 3011-3014
    • Wigle, T.J.1    Knutson, S.K.2    Jin, L.3
  • 40
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • Barski A, Cuddapah S, Cui K et al. High-resolution profiling of histone methylations in the human genome. Cell 129(4), 823-837 (2007
    • (2007) Cell , vol.129 , Issue.4 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3
  • 41
    • 42149149895 scopus 로고    scopus 로고
    • Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo
    • Sarma K, Margueron R, Ivanov A, Pirrotta V, Reinberg D. Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol. Cell Biol. 28(8), 2718-2731 (2008
    • (2008) Mol. Cell Biol , vol.28 , Issue.8 , pp. 2718-2731
    • Sarma, K.1    Margueron, R.2    Ivanov, A.3    Pirrotta, V.4    Reinberg, D.5
  • 42
    • 84892366110 scopus 로고    scopus 로고
    • Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity
    • Ferrari KJ, Scelfo A, Jammula S et al. Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. Mol. Cell 53(1), 49-62 (2014
    • (2014) Mol. Cell , vol.53 , Issue.1 , pp. 49-62
    • Ferrari, K.J.1    Scelfo, A.2    Jammula, S.3
  • 43
    • 78650062951 scopus 로고    scopus 로고
    • EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
    • Velichutina I, Shaknovich R, Geng H et al. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood 116(24), 5247-5255 (2010
    • (2010) Blood , vol.116 , Issue.24 , pp. 5247-5255
    • Velichutina, I.1    Shaknovich, R.2    Geng, H.3
  • 44
    • 0037320925 scopus 로고    scopus 로고
    • Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
    • Su IH, Basavaraj A, Krutchinsky AN et al. Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat. Immunol. 4(2), 124-131 (2003
    • (2003) Nat. Immunol , vol.4 , Issue.2 , pp. 124-131
    • Su, I.H.1    Basavaraj, A.2    Krutchinsky, A.N.3
  • 45
    • 0034492916 scopus 로고    scopus 로고
    • Coexpression of BMI-1 and EZH2 Polycomb group genes in Reed-Sternberg cells of Hodgkin's disease
    • Raaphorst FM, van Kemenade FJ, Blokzijl T et al. Coexpression of BMI-1 and EZH2 Polycomb group genes in Reed-Sternberg cells of Hodgkin's disease. Am. J. Pathol. 157(3), 709-715 (2000
    • (2000) Am. J. Pathol , vol.157 , Issue.3 , pp. 709-715
    • Raaphorst, F.M.1    Van Kemenade, F.J.2    Blokzijl, T.3
  • 46
    • 84856596417 scopus 로고    scopus 로고
    • Inactivation of Polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms
    • Score J, Hidalgo-Curtis C, Jones AV et al. Inactivation of Polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/ myeloproliferative neoplasms. Blood 119(5), 1208-1213 (2012
    • (2012) Blood , vol.119 , Issue.5 , pp. 1208-1213
    • Score, J.1    Hidalgo-Curtis, C.2    Jones, A.V.3
  • 47
    • 84863781377 scopus 로고    scopus 로고
    • A somatic EZH2 mutation in childhood acute myeloid leukemia
    • Ernst T, Pflug A, Rinke J et al. A somatic EZH2 mutation in childhood acute myeloid leukemia. Leukemia 26(7), 1701-1703 (2012
    • (2012) Leukemia , vol.26 , Issue.7 , pp. 1701-1703
    • Ernst, T.1    Pflug, A.2    Rinke, J.3
  • 48
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX
    • Jankowska AM, Makishima H, Tiu RV et al. Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A. Blood 118(14), 3932-3941 (2011
    • (2011) EZH2, and DNMT3A. Blood , vol.118 , Issue.14 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3
  • 49
    • 79960227474 scopus 로고    scopus 로고
    • Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
    • Abdel-Wahab O, Pardanani A, Patel J et al. Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms. Leukemia 25(7), 1200-1202 (2011
    • (2011) Leukemia , vol.25 , Issue.7 , pp. 1200-1202
    • Abdel-Wahab, O.1    Pardanani, A.2    Patel, J.3
  • 50
    • 77957987676 scopus 로고    scopus 로고
    • Novel homo-and hemi-zygous mutations in EZH2 in myeloid malignancies
    • Makishima H, Jankowska AM, Tiu RV et al. Novel homo-and hemi-zygous mutations in EZH2 in myeloid malignancies. Leukemia 24(10), 1799-1804 (2010
    • (2010) Leukemia , vol.24 , Issue.10 , pp. 1799-1804
    • Makishima, H.1    Jankowska, A.M.2    Tiu, R.V.3
  • 51
    • 84856747744 scopus 로고    scopus 로고
    • Genetic inactivation of the Polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
    • Ntziachristos P, Tsirigos A, Van VP et al. Genetic inactivation of the Polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat. Med. 18(2), 298-301 (2012
    • (2012) Nat. Med , vol.18 , Issue.2 , pp. 298-301
    • Ntziachristos, P.1    Tsirigos, A.2    Van, V.P.3
  • 52
    • 84859295400 scopus 로고    scopus 로고
    • A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
    • Simon C, Chagraoui J, Krosl J et al. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. Genes Dev. 26(7), 651-656 (2012
    • (2012) Genes Dev , vol.26 , Issue.7 , pp. 651-656
    • Simon, C.1    Chagraoui, J.2    Krosl, J.3
  • 53
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann IM, Halvorsen OJ, Collett K et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J. Clin. Oncol. 24(2), 268-273 (2006
    • (2006) J. Clin. Oncol , vol.24 , Issue.2 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3
  • 54
    • 29344439946 scopus 로고    scopus 로고
    • Expression levels of the EZH2 Polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
    • Weikert S, Christoph F, Kollermann J et al. Expression levels of the EZH2 Polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int. J. Mol. Med. 16(2), 349-353 (2005
    • (2005) Int. J. Mol. Med , vol.16 , Issue.2 , pp. 349-353
    • Weikert, S.1    Christoph, F.2    Kollermann, J.3
  • 55
    • 19944397508 scopus 로고    scopus 로고
    • Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma
    • Sudo T, Utsunomiya T, Mimori K et al. Clinicopathological significance of EZH2 mRNA expression in patients with hepatocellular carcinoma. Br. J. Cancer 92(9), 1754-1758 (2005
    • (2005) Br. J. Cancer , vol.92 , Issue.9 , pp. 1754-1758
    • Sudo, T.1    Utsunomiya, T.2    Mimori, K.3
  • 56
    • 19944403215 scopus 로고    scopus 로고
    • Increased expression of the EZH2 Polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis
    • Breuer RH, Snijders PJ, Smit EF et al. Increased expression of the EZH2 Polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis. Neoplasia 6(6), 736-743 (2004
    • (2004) Neoplasia , vol.6 , Issue.6 , pp. 736-743
    • Breuer, R.H.1    Snijders, P.J.2    Smit, E.F.3
  • 57
    • 79957552560 scopus 로고    scopus 로고
    • Enhancer of zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98
    • Alajez NM, Shi W, Hui AB et al. Enhancer of zeste homolog 2 (EZH2) is overexpressed in recurrent nasopharyngeal carcinoma and is regulated by miR-26a, miR-101, and miR-98. Cell Death Dis. 1, e85 (2010
    • (2010) Cell Death Dis , vol.1
    • Alajez, N.M.1    Shi, W.2    Hui, A.B.3
  • 58
    • 79957568143 scopus 로고    scopus 로고
    • MiR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
    • Smits M, Nilsson J, Mir SE et al. miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget 1(8), 710-720 (2010
    • (2010) Oncotarget , vol.1 , Issue.8 , pp. 710-720
    • Smits, M.1    Nilsson, J.2    Mir, S.E.3
  • 59
    • 79551541972 scopus 로고    scopus 로고
    • Downregulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2
    • Smits M, Mir SE, Nilsson RJ et al. Downregulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2. PLoS ONE 6(1), e16282 (2011
    • (2011) PLoS ONE , vol.6 , Issue.1
    • Smits, M.1    Mir, S.E.2    Nilsson, R.J.3
  • 60
    • 78651411120 scopus 로고    scopus 로고
    • MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2
    • Lu J, He ML, Wang L et al. MiR-26a inhibits cell growth and tumorigenesis of nasopharyngeal carcinoma through repression of EZH2. Cancer Res. 71(1), 225-233 (2011
    • (2011) Cancer Res , vol.71 , Issue.1 , pp. 225-233
    • Lu, J.1    He, M.L.2    Wang, L.3
  • 61
    • 79952118835 scopus 로고    scopus 로고
    • Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer
    • Zhang B, Liu XX, He JR et al. Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis 32(1), 2-9 (2011
    • (2011) Carcinogenesis , vol.32 , Issue.1 , pp. 2-9
    • Zhang, B.1    Liu, X.X.2    He, J.R.3
  • 62
    • 65549083102 scopus 로고    scopus 로고
    • The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the Polycomb group protein EZH2
    • Friedman JM, Liang G, Liu CC et al. The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the Polycomb group protein EZH2. Cancer Res. 69(6), 2623-2629 (2009
    • (2009) Cancer Res , vol.69 , Issue.6 , pp. 2623-2629
    • Friedman, J.M.1    Liang, G.2    Liu, C.C.3
  • 63
    • 60749126576 scopus 로고    scopus 로고
    • Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcoma
    • Ciarapica R, Russo G, Verginelli F et al. Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcoma. Cell Cycle 8(1), 172-175 (2009
    • (2009) Cell Cycle , vol.8 , Issue.1 , pp. 172-175
    • Ciarapica, R.1    Russo, G.2    Verginelli, F.3
  • 64
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • Varambally S, Cao Q, Mani RS et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322(5908), 1695-1699 (2008
    • (2008) Science , vol.322 , Issue.5908 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3
  • 65
    • 33646596977 scopus 로고    scopus 로고
    • The gene for Polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer
    • Saramaki OR, Tammela TL, Martikainen PM, Vessella RL, Visakorpi T. The gene for Polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer. Genes Chromosomes Cancer 45(7), 639-645 (2006
    • (2006) Genes Chromosomes Cancer , vol.45 , Issue.7 , pp. 639-645
    • Saramaki, O.R.1    Tammela, T.L.2    Martikainen, P.M.3    Vessella, R.L.4    Visakorpi, T.5
  • 66
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 22(20), 5323-5335 (2003
    • (2003) EMBO J , vol.22 , Issue.20 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 67
    • 77957955244 scopus 로고    scopus 로고
    • Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation
    • Wilson BG, Wang X, Shen X et al. Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation. Cancer Cell 18(4), 316-328 (2010
    • (2010) Cancer Cell , vol.18 , Issue.4 , pp. 316-328
    • Wilson, B.G.1    Wang, X.2    Shen, X.3
  • 68
    • 84879773777 scopus 로고    scopus 로고
    • Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition
    • Amatangelo MD, Garipov A, Li H, Conejo-Garcia JR, Speicher DW, Zhang R. Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition. Cell Cycle 12(13), 2113-2119 (2013
    • (2013) Cell Cycle , vol.12 , Issue.13 , pp. 2113-2119
    • Amatangelo, M.D.1    Garipov, A.2    Li, H.3    Conejo-Garcia, J.R.4    Speicher, D.W.5    Zhang, R.6
  • 69
    • 84878741641 scopus 로고    scopus 로고
    • PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
    • Sato T, Kaneda A, Tsuji S et al. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci. Rep. 3, 1911 (2013
    • (2013) Sci. Rep , vol.3 , pp. 1911
    • Sato, T.1    Kaneda, A.2    Tsuji, S.3
  • 70
    • 84864746573 scopus 로고    scopus 로고
    • A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers
    • Lee RS, Stewart C, Carter SL et al. A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J. Clin. Invest. 122(8), 2983-2988 (2012
    • (2012) J. Clin. Invest , vol.122 , Issue.8 , pp. 2983-2988
    • Lee, R.S.1    Stewart, C.2    Carter, S.L.3
  • 71
    • 77951830343 scopus 로고    scopus 로고
    • Rhabdoid tumor: Gene expression clues to pathogenesis and potential therapeutic targets
    • Gadd S, Sredni ST, Huang CC, Perlman EJ. Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets. Lab. Invest. 90(5), 724-738 (2010
    • (2010) Lab. Invest , vol.90 , Issue.5 , pp. 724-738
    • Gadd, S.1    Sredni, S.T.2    Huang, C.C.3    Perlman, E.J.4
  • 72
    • 0034610395 scopus 로고    scopus 로고
    • Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice
    • Roberts CW, Galusha SA, McMenamin ME, Fletcher CD, Orkin SH. Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. Proc. Natl Acad. Sci. USA 97(25), 13796-13800 (2000
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.25 , pp. 13796-13800
    • Roberts, C.W.1    Galusha, S.A.2    McMenamin, M.E.3    Fletcher, C.D.4    Orkin, S.H.5
  • 73
    • 84875216002 scopus 로고    scopus 로고
    • SMARCB1 protein and mRNA loss is not caused by promoter and histone hypermethylation in epithelioid sarcoma
    • Papp G, Changchien YC, Peterfia B et al. SMARCB1 protein and mRNA loss is not caused by promoter and histone hypermethylation in epithelioid sarcoma. Mod. Pathol. 26(3), 393-403 (2013
    • (2013) Mod. Pathol , vol.26 , Issue.3 , pp. 393-403
    • Papp, G.1    Changchien, Y.C.2    Peterfia, B.3
  • 74
    • 84872810488 scopus 로고    scopus 로고
    • The spectrum of SWI/SNF mutations, ubiquitous in human cancers
    • Shain AH, Pollack JR. The spectrum of SWI/SNF mutations, ubiquitous in human cancers. PLoS ONE 8(1), e55119 (2013
    • (2013) PLoS ONE , vol.8 , Issue.1
    • Shain, A.H.1    Pollack, J.R.2
  • 75
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • van HG, Dalgliesh GL, Davies H et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat. Genet. 41(5), 521-523 (2009
    • (2009) Nat. Genet , vol.41 , Issue.5 , pp. 521-523
    • Van, H.G.1    Dalgliesh, G.L.2    Davies, H.3
  • 76
    • 80052266351 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    • Gui Y, Guo G, Huang Y et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat. Genet. 43(9), 875-878 (2011
    • (2011) Nat. Genet , vol.43 , Issue.9 , pp. 875-878
    • Gui, Y.1    Guo, G.2    Huang, Y.3
  • 77
    • 84864444165 scopus 로고    scopus 로고
    • Novel mutations target distinct subgroups of medulloblastoma
    • Robinson G, Parker M, Kranenburg TA et al. Novel mutations target distinct subgroups of medulloblastoma. Nature 488(7409), 43-48 (2012
    • (2012) Nature , vol.488 , Issue.7409 , pp. 43-48
    • Robinson, G.1    Parker, M.2    Kranenburg, T.A.3
  • 78
    • 84884532954 scopus 로고    scopus 로고
    • Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
    • Kim W, Bird GH, Neff T et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat. Chem. Biol. 9(10), 643-650 (2013
    • (2013) Nat. Chem. Biol , vol.9 , Issue.10 , pp. 643-650
    • Kim, W.1    Bird, G.H.2    Neff, T.3
  • 79
    • 84871052080 scopus 로고    scopus 로고
    • EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycombindependent
    • Xu K, Wu ZJ, Groner AC et al. EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycombindependent. Science 338(6113), 1465-1469 (2012
    • (2012) Science , vol.338 , Issue.6113 , pp. 1465-1469
    • Xu, K.1    Wu, Z.J.2    Groner, A.C.3
  • 80
    • 79955729316 scopus 로고    scopus 로고
    • Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy
    • Sasaki D, Imaizumi Y, Hasegawa H et al. Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy. Haematologica 96(5), 712-719 (2011
    • (2011) Haematologica , vol.96 , Issue.5 , pp. 712-719
    • Sasaki, D.1    Imaizumi, Y.2    Hasegawa, H.3
  • 81
    • 84866050864 scopus 로고    scopus 로고
    • Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes
    • Holm K, Grabau D, Lovgren K et al. Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes. Mol. Oncol. 6(5), 494-506 (2012
    • (2012) Mol. Oncol , vol.6 , Issue.5 , pp. 494-506
    • Holm, K.1    Grabau, D.2    Lovgren, K.3
  • 82
    • 84880803070 scopus 로고    scopus 로고
    • EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
    • Yan J, Ng SB, Tay JL et al. EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity. Blood 121(22), 4512-4520 (2013
    • (2013) Blood , vol.121 , Issue.22 , pp. 4512-4520
    • Yan, J.1    Ng, S.B.2    Tay, J.L.3
  • 83
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 414(6859), 105-111 (2001
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 84
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3(7), 730-737 (1997
    • (1997) Nat. Med , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 85
    • 34248169728 scopus 로고    scopus 로고
    • The Polycomb group protein Suz12 is required for embryonic stem cell differentiation
    • Pasini D, Bracken AP, Hansen JB, Capillo M, Helin K. The Polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol. Cell Biol. 27(10), 3769-3779 (2007
    • (2007) Mol. Cell Biol , vol.27 , Issue.10 , pp. 3769-3779
    • Pasini, D.1    Bracken, A.P.2    Hansen, J.B.3    Capillo, M.4    Helin, K.5
  • 86
    • 84859218238 scopus 로고    scopus 로고
    • Chromatin-modifying enzymes as modulators of reprogramming
    • Onder TT, Kara N, Cherry A et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 483(7391), 598-602 (2012
    • (2012) Nature , vol.483 , Issue.7391 , pp. 598-602
    • Onder, T.T.1    Kara, N.2    Cherry, A.3
  • 87
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 20(9), 1123-1136 (2006
    • (2006) Genes Dev , vol.20 , Issue.9 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 88
    • 84880857612 scopus 로고    scopus 로고
    • Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma
    • Natsume A, Ito M, Katsushima K et al. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res. 73(14), 4559-4570 (2013
    • (2013) Cancer Res , vol.73 , Issue.14 , pp. 4559-4570
    • Natsume, A.1    Ito, M.2    Katsushima, K.3
  • 89
    • 79951825513 scopus 로고    scopus 로고
    • Ovarian cancer stem celllike side populations are enriched following chemotherapy and overexpress EZH2
    • Rizzo S, Hersey JM, Mellor P et al. Ovarian cancer stem celllike side populations are enriched following chemotherapy and overexpress EZH2. Mol. Cancer Ther. 10(2), 325-335 (2011
    • (2011) Mol. Cancer Ther , vol.10 , Issue.2 , pp. 325-335
    • Rizzo, S.1    Hersey, J.M.2    Mellor, P.3
  • 90
    • 84879000598 scopus 로고    scopus 로고
    • Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
    • Kim E, Kim M, Woo DH et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. Cancer Cell 23(6), 839-852 (2013).
    • (2013) Cancer Cell , vol.23 , Issue.6 , pp. 839-852
    • Kim, E.1    Kim, M.2    Woo, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.