메뉴 건너뛰기




Volumn 6, Issue 5, 2012, Pages 494-506

Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes

Author keywords

ANOVA; Breast cancer; DDFS; Epigenetics; ER; ES; EZH2; GEX; H3K27me3; IHC; Molecular subtypes; Polycomb; PR; PRC2; TMA

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; HISTONE H3; KI 67 ANTIGEN; MESSENGER RNA; TRANSCRIPTION FACTOR EZH2;

EID: 84866050864     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2012.06.002     Document Type: Article
Times cited : (139)

References (70)
  • 1
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann I.M., Halvorsen O.J., Collett K., Stefansson I.M., Straume O., Haukaas S.A., Salvesen H.B., Otte A.P., Akslen L.A. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J. Clin. Oncol. 2006, 24:268-273.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6    Salvesen, H.B.7    Otte, A.P.8    Akslen, L.A.9
  • 4
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of polycomb target genes unravels their roles in cell fate transitions
    • Bracken A.P., Dietrich N., Pasini D., Hansen K.H., Helin K. Genome-wide mapping of polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 2006, 20:1123-1136.
    • (2006) Genes Dev. , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 5
    • 0142105414 scopus 로고    scopus 로고
    • EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer
    • Bracken A.P., Pasini D., Capra M., Prosperini E., Colli E., Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J. 2003, 22:5323-5335.
    • (2003) EMBO J. , vol.22 , pp. 5323-5335
    • Bracken, A.P.1    Pasini, D.2    Capra, M.3    Prosperini, E.4    Colli, E.5    Helin, K.6
  • 6
    • 78651506355 scopus 로고    scopus 로고
    • High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients
    • Cai M.Y., Hou J.H., Rao H.L., Luo R.Z., Li M., Pei X.Q., Lin M.C., Guan X.Y., Kung H.F., Zeng Y.X., Xie D. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol. Med. 2011, 17:12-20.
    • (2011) Mol. Med. , vol.17 , pp. 12-20
    • Cai, M.Y.1    Hou, J.H.2    Rao, H.L.3    Luo, R.Z.4    Li, M.5    Pei, X.Q.6    Lin, M.C.7    Guan, X.Y.8    Kung, H.F.9    Zeng, Y.X.10    Xie, D.11
  • 10
    • 33644765912 scopus 로고    scopus 로고
    • Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer
    • Collett K., Eide G.E., Arnes J., Stefansson I.M., Eide J., Braaten A., Aas T., Otte A.P., Akslen L.A. Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer. Clin. Cancer Res. 2006, 12:1168-1174.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1168-1174
    • Collett, K.1    Eide, G.E.2    Arnes, J.3    Stefansson, I.M.4    Eide, J.5    Braaten, A.6    Aas, T.7    Otte, A.P.8    Akslen, L.A.9
  • 11
    • 80755144048 scopus 로고    scopus 로고
    • Decreased MicroRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion, and accumulation of the polycomb Ezh2 methyltransferase
    • Derfoul A., Juan A., Difilippantonio M.J., Palanisamy N., Ried T., Sartorelli V. Decreased MicroRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion, and accumulation of the polycomb Ezh2 methyltransferase. Carcinogenesis 2011, 32:1607-1614.
    • (2011) Carcinogenesis , vol.32 , pp. 1607-1614
    • Derfoul, A.1    Juan, A.2    Difilippantonio, M.J.3    Palanisamy, N.4    Ried, T.5    Sartorelli, V.6
  • 14
    • 0034017798 scopus 로고    scopus 로고
    • Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels. South Sweden breast cancer group, and South-East Sweden breast cancer group
    • Fernö M., Stål O., Baldetorp B., Hatschek T., Källström A.C., Malmström P., Nordenskjöld B., Rydén S. Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels. South Sweden breast cancer group, and South-East Sweden breast cancer group. Breast Cancer Res. Treat. 2000, 59:69-76.
    • (2000) Breast Cancer Res. Treat. , vol.59 , pp. 69-76
    • Fernö, M.1    Stål, O.2    Baldetorp, B.3    Hatschek, T.4    Källström, A.C.5    Malmström, P.6    Nordenskjöld, B.7    Rydén, S.8
  • 15
    • 79952766783 scopus 로고    scopus 로고
    • Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 Inhibition in breast cancer
    • Gonzalez M.E., Duprie M.L., Krueger H., Merajver S.D., Ventura A.C., Toy K.A., Kleer C.G. Histone methyltransferase EZH2 induces Akt-dependent genomic instability and BRCA1 Inhibition in breast cancer. Cancer Res. 2011, 71:2360-2370.
    • (2011) Cancer Res. , vol.71 , pp. 2360-2370
    • Gonzalez, M.E.1    Duprie, M.L.2    Krueger, H.3    Merajver, S.D.4    Ventura, A.C.5    Toy, K.A.6    Kleer, C.G.7
  • 20
    • 74249098871 scopus 로고    scopus 로고
    • Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma
    • He L.R., Liu M.Z., Li B.K., Rao H.L., Liao Y.J., Guan X.Y., Zeng Y.X., Xie D. Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer 2009, 9:461.
    • (2009) BMC Cancer , vol.9 , pp. 461
    • He, L.R.1    Liu, M.Z.2    Li, B.K.3    Rao, H.L.4    Liao, Y.J.5    Guan, X.Y.6    Zeng, Y.X.7    Xie, D.8
  • 25
    • 79953143376 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 in embryonic stem cells: an overview
    • Jones A., Wang H. Polycomb repressive complex 2 in embryonic stem cells: an overview. Protein Cell 2010, 1:1056-1062.
    • (2010) Protein Cell , vol.1 , pp. 1056-1062
    • Jones, A.1    Wang, H.2
  • 27
    • 84865146340 scopus 로고    scopus 로고
    • Jönsson, G., Staaf, J., Vallon-Christersson, J., Ringnér, M., Gruvberger-Saal, S.K., Saal, L.H., Holm, K., Hegardt, C., Arason, A., Fagerholm, R., Persson, C., Grabau, D., Johnsson, E., Lövgren, K., Magnusson, L., Heikkilä, P., Agnarsson, B.A., Johannsson, O.T., Malmström, P., Fernö, M., O
    • Jönsson, G., Staaf, J., Vallon-Christersson, J., Ringnér, M., Gruvberger-Saal, S.K., Saal, L.H., Holm, K., Hegardt, C., Arason, A., Fagerholm, R., Persson, C., Grabau, D., Johnsson, E., Lövgren, K., Magnusson, L., Heikkilä, P., Agnarsson, B.A., Johannsson, O.T., Malmström, P., Fernö, M., Olsson, H., Loman, N., Nevanlinna, H., Barkardottir, R.B., Borg, å. The retinoblastoma gene undergoes rearrangements in BRCA1-deficient basal-like breast cancer. Cancer Res., [Epub ahead of print]. http://dx.doi.org/10.1158/0008-5472.CAN-12-0097.
  • 30
    • 76349123384 scopus 로고    scopus 로고
    • The prognostic value of Ki67 is dependent on estrogen receptor status and histological grade in premenopausal patients with node-negative breast cancer
    • Klintman M., Bendahl P.O., Grabau D., Lovgren K., Malmstrom P., Ferno M. The prognostic value of Ki67 is dependent on estrogen receptor status and histological grade in premenopausal patients with node-negative breast cancer. Mod. Pathol. 2010, 23:251-259.
    • (2010) Mod. Pathol. , vol.23 , pp. 251-259
    • Klintman, M.1    Bendahl, P.O.2    Grabau, D.3    Lovgren, K.4    Malmstrom, P.5    Ferno, M.6
  • 33
    • 80052222327 scopus 로고    scopus 로고
    • Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers
    • Lee S.T., Li Z., Wu Z., Aau M., Guan P., Karuturi R.K., Liou Y.C., Yu Q. Context-specific regulation of NF-kappaB target gene expression by EZH2 in breast cancers. Mol. Cell 2011, 43:798-810.
    • (2011) Mol. Cell , vol.43 , pp. 798-810
    • Lee, S.T.1    Li, Z.2    Wu, Z.3    Aau, M.4    Guan, P.5    Karuturi, R.K.6    Liou, Y.C.7    Yu, Q.8
  • 36
    • 0035300764 scopus 로고    scopus 로고
    • S-phase fraction and urokinase plasminogen activator are better markers for distant recurrences than Nottingham Prognostic Index and histologic grade in a prospective study of premenopausal lymph node-negative breast cancer
    • Malmström P., Bendahl P.O., Boiesen P., Brunner N., Idvall I., Fernö M. S-phase fraction and urokinase plasminogen activator are better markers for distant recurrences than Nottingham Prognostic Index and histologic grade in a prospective study of premenopausal lymph node-negative breast cancer. J. Clin. Oncol. 2001, 19:2010-2019.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2010-2019
    • Malmström, P.1    Bendahl, P.O.2    Boiesen, P.3    Brunner, N.4    Idvall, I.5    Fernö, M.6
  • 37
    • 78751662908 scopus 로고    scopus 로고
    • The polycomb complex PRC2 and its mark in life
    • Margueron R., Reinberg D. The polycomb complex PRC2 and its mark in life. Nature 2011, 469:343-349.
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 48
    • 29344445843 scopus 로고    scopus 로고
    • Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder
    • Raman J.D., Mongan N.P., Tickoo S.K., Boorjian S.A., Scherr D.S., Gudas L.J. Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin. Cancer Res. 2005, 11:8570-8576.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 8570-8576
    • Raman, J.D.1    Mongan, N.P.2    Tickoo, S.K.3    Boorjian, S.A.4    Scherr, D.S.5    Gudas, L.J.6
  • 53
    • 43149123572 scopus 로고    scopus 로고
    • HER2 status in hormone receptor positive premenopausal primary breast cancer adds prognostic, but not tamoxifen treatment predictive, information
    • Rydén L., Landberg G., Stål O., Nordenskjöld B., Fernö M., Bendahl P.O. HER2 status in hormone receptor positive premenopausal primary breast cancer adds prognostic, but not tamoxifen treatment predictive, information. Breast Cancer Res. Treat. 2008, 109:351-357.
    • (2008) Breast Cancer Res. Treat. , vol.109 , pp. 351-357
    • Rydén, L.1    Landberg, G.2    Stål, O.3    Nordenskjöld, B.4    Fernö, M.5    Bendahl, P.O.6
  • 56
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing: knowns and unknowns
    • Simon J.A., Kingston R.E. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat. Rev. Mol. Cell Biol. 2009, 10:697-708.
    • (2009) Nat. Rev. Mol. Cell Biol. , vol.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 58
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann A., van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat. Rev. Cancer 2006, 6:846-856.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    van Lohuizen, M.2
  • 60
    • 83355161415 scopus 로고    scopus 로고
    • Landscape of somatic allelic imbalances and copy number alterations in HER2-amplified breast cancer
    • Staaf J., Jonsson G., Ringner M., Baldetorp B., Borg A. Landscape of somatic allelic imbalances and copy number alterations in HER2-amplified breast cancer. Breast Cancer Res. 2011, 13:R129.
    • (2011) Breast Cancer Res. , vol.13
    • Staaf, J.1    Jonsson, G.2    Ringner, M.3    Baldetorp, B.4    Borg, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.