A phosphatase-independent gain-of-function mutation in PTEN triggers aberrant cell growth in astrocytes through an autocrine IGF-1 loop

Oncogene

Volumn 33, Issue 32, 2014, Pages 4114-4122

  Fernandez S ^a   Genis, L ^a   Torres Aleman I ^a  

^a INSTITUTO CAJAL   (Spain)

Author keywords

gain of function; glioma; IGF 1; PKA; PTEN

Indexed keywords

ANIMALS; ASTROCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; MICE, SCID; MUTATION; NEOPLASM TRANSPLANTATION; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; PTEN PHOSPHOHYDROLASE; REACTIVE OXYGEN SPECIES;

EID: 84905823470     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.376     Document Type: Article

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