Insulin-like growth factors in central nervous system tumors

Journal of Neuro-Oncology

Volumn 35, Issue 3, 1997, Pages 315-325

  Glick, Roberta P ^a,c   Lichtor, Terry ^b   Unterman, Terry G ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^c Jr Hospital of Cook County   (United States)

Author keywords

Antisense; Binding proteins; Brain tumors; Gene therapy; Insulin like growth factors; Somatomedins

Indexed keywords

ANTINEOPLASTIC AGENT; BINDING PROTEIN; COMPLEMENTARY DNA; GLUCOSE TRANSPORTER; SEX HORMONE; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOCRINE EFFECT; BRAIN TUMOR; CELL TRANSFORMATION; CONTROLLED STUDY; GENE TECHNOLOGY; GENE THERAPY; GLIOMA; HORMONAL REGULATION; HUMAN; HUMAN CELL; INTRATUMORAL DRUG ADMINISTRATION; MENINGIOMA; NONHUMAN; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BRAIN NEOPLASMS; HUMANS; SOMATOMEDINS;

EID: 0030772251     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005876819455     Document Type: Article

References (100)

1. Froesch RG, Busby WH, Schwander J, et al: Actions of insulin-like growth factors. Ann Rev Physiol 47:443-467, 1985
2. McMorris FA, Smith TM, DeSalvo S et al: Insulin-like growth factor I/somato-medin C: a potent inducer of oligodendrocyte development. Proc Natl Acad Sci USA 82: 7126-30, 1986
3. Rechler MM, Nissley SP: The nature and regulation of the receptors for insulin-like growth factors. Annu Rev Physiol 47: 425-442, 1985
4. Zapf J, Schoenle E, Froesch ER: Insulin-like growth factors I and II: some biological actions and receptor binding characteristics of two purified constituents of non-supressible insulin-like activity of human serum. Eur J Biochem 87: 285-296, 1978
5. Zapf J, Schmid C, Froesch ER: Biological and immunological properties of insulin-like growth factors (IGF) I and II. Clin Endocrinol Metab 13: 3-30, 1984
6. Rotwein P, Burgess SK, Milbrandt JD et al: Differential expression of insulin-like growth factor genes in rat CNS. Proc Natl Acad Sci USA 85: 265-9, 1988
7. Sandberg AC, Engberg C, Lake M et al: Expression of insulin-like growth factor I and insulin-like growth factor II genes in the human fetal and adult brain and in gliomas. Neurosci Lett 93: 114-119, 1988
8. Haselbachler G K, Schwab ME, Pasi A, Humbel RE: Insulin like growth factor II (IGF II) in human brain: regional distribution of IGF II and higher molecular mass forms. Proc Natl Acad Sci USA 82: 2153-2157, 1985
9. Baskin DG, Wilcox BJ, Figelwicz DP et al: Insulin and insulin-like growth factors in the CNS. Trends Neurosci 11: 107-111, 1988
10. Sara VR, Carlsson-Skiwut C: The role of the insulin-like growth factors in the regulation of brain development. Prog Brain Res 73: 87-99, 1988
11. Sara VR, Hall K, Misaki M et al: Ontogenesis of somatomedin and insulin receptors in the human fetus. J Clin Invest 71: 1084-1094, 1983
12. Lesniak M A, Hill JM, Kiess W, et al: Receptors for insulin-like growth factors I and II: autoradiographic localization in rat brain and comparison to receptors for insulin. Endocrinology 123: 2089-2099, 1989
13. Sara VR, Hall K, Von Holtz H, et al: Evidence for the presence of specific receptors of insulin-like growth factors I (IGF-I) and 2 (IGF-2 and insulin throughout the adult human brain. Neurosci Lett 34: 39-44, 1982
14. Lenoir D, Honegger P: Insulin-like growth factor I (IGF-1) stimulates DNA synthesis in fetal rat brain cell cultures. Brain Res 283: 2055-213, 1983
15. Mill JF, Chao MV, Ishh DN: Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation. Proc Natl Acad Sci USA 82: 7126-7130, 1985
16. Lim R, Miller JF, Hicklin JF, Holm A, GinsbergBH: Mitogenic activity of glial maturation factor. Exp Cell Res 159: 334-343, 1985
17. Shemer J, Raizada MK, Masters BA, Ota A, LeRoith D: Insulin-like growth factor I receptors in neuronal and glial cells. J Biol Chem 262: 7693-7699, 1987
18. Kadle R, Suskang C, Adle R, Suskang C, Roberson EC, Fellows RE: Identification of an insulin-like factor in astrocyte conditioned medium. Brain Res 460: 60-67, 1988
19. Balottie R, Nielson FC, Pringle N, Kowalski A, Richardson WD Van Obberghen E, Gammeltoft S: Insulin-like growth factor I in cultured rat astrocytes: expression of the gene, and receptor tyrosine kinase. EMBO J 6: 3633-3639, 1987
20. Shambaugh G, Unterman TG, Glick RP, Kelly GC, Radosevich JA: Neonatal rat cerebellar cells: a model for study of production and regulation of IGF-II in the CNS. In Proc of the 2nd Internat. Symposium on IGFs, San Francisco, CA, p 157, 1991
21. Unterman TG, Simmons R, Glick RP, Ogata ES: Circulating levels of insulin, insulin-like growth factor (IGF)-I and -II and IGF binding proteins (IGFBPs) in the small for gestational age fetal rat. Endocrinology 132: 327-336, 1993
22. Blatt J, White , Dienes S et al: Production of an insulin-like growth factor by osteosarcoma. Biochem Biophys Res Commun 123: 373-336, 1984
23. Huff KK, Kaufman D, Gabbay KH et al: Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells. Cancer Res 46:4613-4619, 1990
24. Jaques G, Rotsch M, Wegamnn C et al: Production of immunoreactive insulin-like growth factor I and response to exogenous IGF-I in small cell lung cancer cell lines. Exp Cell Res 176: 336-343, 1988
25. Scott J, Cowell J, Robertson ME et al: Insulin-like growth factor-II production in Wilm's tumour and embryonic tissues. Nature 317: 260-262 (letter), 1985
26. Tricoli JV, Rall LB, Karakousis C et al: Enhanced levels of insulin-like growth factor messenger mRNA in human colon carcinomas and liposarcomas. Cancer Res 46: 6169-6173, 1986
27. Prager D, Li H-S, Asa S, Melmed S: Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant. Proc Natl Acad Sci USA 91: 2181-85, 1994
28. Peterson JE, Jelinek T, Kaleko M, Siddle K, Weber MJ: Phosphorylation and activation of the IGF-I receptor in src-transformed cells. J Biol Chem 269: 27315-27321, 1994
29. Bates P, Fisher R, Ward A, Richardson L, Hill DJ, Graham CF: Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II). Br J Cancer 72: 1189-1193, 1995
30. Ward A , Bates P, Fisher R, Richardson L, Graham CF: Disproportionate growth in mice with Igf-2 transgenes. Proc Natl Acad Sci USA 91: 10365-10369, 1994
31. Kaleko M, Rutter WJ, Miller AD: Overexpression of the human IGF-I receptor promotes ligand-dependent neoplastic transformation. Mol Cell Biol 10: 464-473, 1990
32. Sturm MA, Conover CA, Pham H et al: Insulin-like growth factor receptors and binding protein in rat neuroblastoma cells. Endocrinology 124: 388-396, 1989
33. El-Badry OM, Romanus JA, Helman LJ et al: Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II. J Clin Invest 84: 829-839, 1989
34. Kiess W, Lee L, Graham D et al: Rat C6 glial cell synthesize insulin-like growth factor I (IGF-I) and express IGF-I receptors and IGF-II/mannose 6-phosphate receptors. Endocrinology 124: 1727-1736, 1989
35. Trojan J, Blossey B, Johnson T et al: Loss of tumorigenicity of rat glioblastoma directed by episome based antisense cDNA transcription of insulin-like growth factor-I. Proc Natl Acad Sci USA 89: 4874-4878, 1992
36. Lichtor T, Kurakus MA, Gurney ME: Differential expression of insulin-like growth factor II in human meningiomas. Neurosurgery 29: 405-410, 1991
37. Gammeltoft S, Ballotti R, Kowalski A, Westermark B, Van Obberghen E: Expression of two types of receptor for insulin-like growth factors in human malignant glioma. Cancer Res 48: 1233-1237, 1988
38. Antoniades HN, Galalnopoulos T, Neveill-Goldne J, Maxwell M: Expression of IGFs I and II and their receptor mRNAs in primary astrocytomas and meningiomas: in vivo studies using in situ hybridization and immunohistochemistry. Int J Cancer 50: 215-222, 1992
39. Grundberger G, Lowe W, McElduff A, and Glick RP: Insulin Receptor of Human Cerebral Gliomas. J Clin Invest 77: 997-1005, 1986
40. Glick RP, Gettleman R, Patel K, Tsibris J, Unterman TG: Insulin and insulin-like growth factor I in brain tumors: binding and in vitro effects. Neurosurgery 24: 791-797, 1989
41. Prisell P, Persson L, Boethius J, Sara V: Somatomedins in tumor cyst fluid, CSF, and tumor cytosol in patients with glial tumors. Acta Neurochir Wien 89: 48-52, 1987
42. Glick RP, Unterman TG, Hollis R: Radioimmunoassay of insulin-like growth factors in cyst fluid of central nervous system tumors. J Neurosurg 74: 972-978, 1991
43. Glick RP, Unterman TG, Van Der Woude M, Blaydes L: Insulin and insulin-like growth factors in CNS tumors. V. Production of IGFs I and II in vitro. J Neurosurg 77: 445-50, 1992
44. Glick RP, Unterman T: Radioimmunoassay of IGF-I and II in the CSF of Patients with Pituitary and other CNS Tumors. Neurosurg 36: 556-564, 1994
45. Ballard J, Baxter R, Binoux M et al: Reports on the nomenclature of the IGF binding proteins. J Clin Endocrinol Metab 817: 818-819, 1970
46. Baxter R, Martin J: Binding proteins for the insulin-like growth factors, structure, regulation, and function. Prog Growth Factor Res 1: 49-68, 1989
47. Busby R, Klapper D, Clemmons D: Purification of a 31,000 dalton insulin like factor binding protein from amniotic fluid. J Biol Chem 263: 14203-14210, 1988
48. Yeoh S, Baxter R: Metabolic regulation of the growth hormone independent insulin-like growth factor binding protein in human plasma. Acta Endocrinol 119: 465-473, 1988
49. Tseng L, Brown A, Yang Y et al: The fetal rat binding protein for insulin like growth factors is expressed in the choroid plexus and CSF of rats. Mol Endocrinol 3: 1559-69, 1989
50. Romanus J, Terrel J, Yang Y et al: Insulin-like growth factor carrier proteins in neonatal and adult rat serum are immunologically different: demonstration using a new radioimmunoassay for the carrier protein from BRL-3A rat liver cells. Endocrinol 118: 1743-1758, 1986
51. Shimasaki S, Uchiyama F, Shimonaka M et al: Molecular cloning of the cDNA encoding a novel insulin-like growth factor-binding protein from rat and human. Mol Endocrinol 4: 1451-58, 1990
52. Mohan S, Bautista C, Wergdal, Baylink J: Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell conditioned medium; a potential local regulator of IGF action. Proc Natl Acad Sci USA 86: 8338-8342, 1990
53. Shimasaki S, Ling N: Identification and molecular characterization of insulin-like binding protein (IGF BP)-1, -2, -3, -4, -5 and -6. Prog Growth Factor Res 3: 243-266, 1991
54. Hintz R: Plasma forms of somatomedin and the binding protein phenomenoa. Clin Endocrinol Metab 13: 31-42, 1984
55. DeMellow J, Baxter R: Growth hormone dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I stimulated DNA synthesis in human skin fibroblasts. Biochem Biophys Res Commun 156: 199-204, 1988
56. Elgin R, Busby W, Clemmons D: An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I. Proc Natl Acad Sci USA 84: 3254-3258
57. Unterman TG, Glick RP, Waites G, Bell S: Production of insulin like growth factor binding proteins by human central nervous system tumors. Cancer Res 51: 3030-3036, 1991
58. Muller HL, Oh Y, Gargosky SE, Lehrnbecher T et al: Concentrations of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3), IGF, and IGFBP-3 protease activity in cerebrospinal fluid of children with leukemia, central nervous system tumor, or meningitis. J Clin Endocrinol Metab 77: 1113-1119, 1993
59. Huff K, Knabbe C, Linsay R et al: Multihormonal regulation of insulin-like growth factor-I related protein in MCF-7 human breast cancer cells. Mol Endocrinol 2: 200-208, 1988
60. Clemmons D, Camacho-Hubner C, Coronado C, Osborne K: Insulin like growth factor binding protein secretion by breast carcinoma cell lines: correlation with estrogen receptor status. Endocrinology 127: 2679-2688, 1990
61. Rausing A, Ybo W, Stenflo J: Intracranial meningioma: a population study often years. Acta Neurol Scand 46: 102-110, 1970
62. Bickerstaff ER, Small J, Guest I: The relapsing course of certain meningiomas in relation to pregnancy and menstruation. J Neurol Neurosurg Psychiatry 21: 89-91, 1958
63. Rand C, Andler M: Tumors of the brain complicating pregnancy. Arch Neurol Psychiatry 63: 1-41, 1950
64. Olson J, Beck D, Schlechte J et al: Effect of the antiprogesterone RU-38486 in meningioma implanted into nude mice. J Neurosurg 66: 584-587, 1987
65. Koper J, Foekens J, Braakman R et al: Effects of progesterone on the response to epidermal growth factor and other growth factors in cultured human meningioma cells. Cancer Res 50: 2604-2607, 1990
66. Jay JR, MacLaughlin D, Riley K et al: Modulation of meningioma cell growth by sex steroid hormones in vitro. J Neurosurg 62: 757-762, 1985
67. Weisman A, VillemureT, Kelly P:Regulation of DNA synthesis and growth of cells derived from primary human meningiomas. Cancer Res 46: 2545-2550, 1986
68. Schoenberg B, Christine B, Whisnat J: Nervous system neoplasms and primary malignancies of other sites: the unique association between meningiomas and breast cancer. Neurology NY 25: 705-712, 1975
69. Glick RP, Molteni A, Fors EM: Hormone binding in brain tumors. Neurosurgery 13: 513-519, 1983
70. DiChiro G, DeLaPaz RL, Brooks RA, Sokoloff L, Kornblith P, Smith B, Patronas N, Kufta C, Kessler P, Johnson G, Manning R, Wolf A: Glucose utilization of cerebral gliomas measured by 18-flurodeoxyglucose and positron emission tomography. Neurology 32: 1323-1329, 1984
71. DiChiro G, Hatazawa J: Glucose utilitzation by intracranial meningioma as an index of tumor agressivity and probability of recurrence. A PET Study. Radiology 164: 512, 1987
72. Watanabe A, Tanaka R, Takeda N, Washiyama K: DNA systhesis, blood flow and glucose utilization in experimental rat brain tumors. J Neurosurg 70: 86-91, 1989
73. Bell GI, Kayano T, Buse J, Burant C, Taleda J, Lin D, Fukumoto H, Seino S: Molecular biology of mammalian glucose transporters. Diabetes Care 13: 198-208, 1990
74. Flier J, Mueckler M, McCall A, Lodish H: Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. J Clin Invest 79: 657-661, 1987
75. Kalaria R, Gracina S, Schmidley JW, Perry G, Harik S: The glucose transporter of the human brain and blood brain barrier. Ann Neurol 24: 757-764, 1988
76. Pardridge W, Boado R, Farrell C: Brain-type glucose transporter (Glut-1) is selectively localized to the blood brain barrier. Studies with quantitative Western blotting and in situ hybridization. J Biol Chem 265: 18035-18040, 1990
77. Maher F, Vanycci S, Takeda J, Simpson I: Expression of mouse GLUT 3 and human GLUT 3 glucose transporter proteins in brain. Biochem Biophys Res Commun 182: 703-711, 1992
78. Gerhart D, Broderius M, Borson N, Dreives L: Neurons and microvessels express brain glucose transporter protein GLUT 3. Proc Natl Acad Sci 89: 733-737, 1992
79. Masters BA, Raizada MK: Insulin-like Growth Factor I Receptors and IGF-I actions in Neuronal Cultures from the Brain. Annals NY Acad Sci 692: 89-101, 1993
80. Werner H, Raizada M, Muss L, Foyt H, Simpson I, Roberts C, LeRoith D: Regulation of rat brain/Hep G2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. Endocrinology 125: 314-320, 1989
81. Glick RP, Untermann TG, Lacson R: Identification of insulin like growth factor (IGF) and glucose transporter-1 and -3 mRNA in CNS tumors. Regulatory Peptides 48: 251-256, 1993
82. Goldstein G: The glucose transporter and blood brain barrier of human brain tumors. Ann Neurol 28: 758-765, 1990
83. Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, Imura H, Shigemoto R, Kikuchi H: Distribution of glucose transporters in human brain tumors. Cancer Res 53: 3972-3979, 1992
84. Hall W, Flores E, Low W: Antisense oligonucleotides of central nervous sytem tumors. Neurosurg 38: 376-383, 1996
85. Trojan J, Johnson TR, Rudin SD, Ilan JU, Tykocinski M, Ilan J: Treatment and prevention of rat glioblastoma directed by immunogenic antisense IGF-1 tumor transfectants. Science 259: 94-97, 1993
86. Trojan J, Blossey BK, Johnson TR, Rudin SD, Tykoncinski M, Ilan JU, Ilan J: Loss of tumorogenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin like growth factor 1. Proc Natl Acad Sci USA 89: 4874-4878, 1992
87. Resnicoff M, Sell C, Rubini M, Coppola D, Ambrose D, Baserga R, Rubin R: Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 54: 2218-2222, 1994
88. Baserga R : The insulin-like growth factor 1 receptor: A key to tumor growth? Cancer research 55: 249-252, 1995
89. Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kahuria S, Chen E, Jakobs S, Francke U, Ramachandran J, Fujita-Yamaguchi Y: Insulin-like growth factor 1 receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 5: 2503-2512, 1986
90. Sell C, Rubini M, Rubin R, Liu J-P, Efstratiadis A, Baserga R: Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type-1 IGF receptor. Proc Natl Acad Sci USA 90: 11217-11221, 1993
91. Sell C, Dumenil G, Deveaud C, Miura M, Coppola D, De Angelis T, Rubin R, Efstratiadis A, Baserga R: Effect of a null mutation of the type 1 IGF receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol 14: 3604-3612, 1994
92. Glick RP, Lichtor T, Taylor C, Griffitt W, Resnicoff M, Baserga R: Stimulation of Anti-tumor Immune Responses by Anti-sense IGF-IR Oligonucleotides. Proc of 2nd Biennial Tumor Satellite Symposium, Montreal, 1996, p 15
93. Macaulay VM: Insulin-like growth factors and cancer. Br J Cancer 65: 311-320, 1992
94. Pastan I, Fitzgerald D: Recombinant toxins for cancer treatment. Science 254: 1173-1177, 1991
95. Kunwar S, Pai LH, Pastan I: Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells. J Neurosurg 79: 569-576, 1993
96. Flier J, Usher Pk, Moses A: Monoclonal antibody to the type I IGF-I receptor blocks IGF-I receptor mediation DNA synthesis. Proc Natl Acad Sci 83: 664-668, 1986
97. Snelling L, Miyamoto CT, Bender H, Brady LW et al: Epidermal growth factor receptor 425 monoclonal antibodies radiolabled with iodine-125 in the adjuvant treatment of high grade astrocytomas. Hybridoma 14: 111-114, 1995
98. Dadparvar S, Krishna L, Miyamoto C, Brady LW et al: Indium-111-labeled anti-EGFr-425 scintigraphy in the detection of malignant gliomas. Cancer 73: 884-889, 1994
99. 125I-Insulin-like growth factor-I binding to human meningiomas and on proliferation of meningioma cells. J Neurosurg 80: 502-509, 1994
100. Stoll BA: The growth hormone/insulin like growth factor axis and breast cancer rish. Breast 2: 130-133, 1993