Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish

Journal of Endocrinology

Volumn 222, Issue 2, 2014, Pages 229-241

  Marín Juez, Rubén ^a   Jong Raadsen, Susanne ^a   Yang, Shuxin ^b   Spaink, Herman P ^b  

^a ZF Screens BV ^*  (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Hyperinsulinemia; Immune suppression; Insulin resistance; ptpn6; Zebrafish

Indexed keywords

GLUCOSE; LEPTIN; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; RECOMBINANT HUMAN INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MEGADOSE; EMBRYO; GENE EXPRESSION PROFILING; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HYPERINSULINEMIA; HYPOGLYCEMIA; IMMUNOSUPPRESSIVE TREATMENT; INNATE IMMUNITY; INSULIN BLOOD LEVEL; INSULIN METABOLISM; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ZEBRA FISH;

HYPERINSULINEMIA; IMMUNE SUPPRESSION; INSULIN RESISTANCE; PTPN6; ZEBRAFISH;

ANIMALS; DISEASE MODELS, ANIMAL; GENE KNOCKDOWN TECHNIQUES; HUMANS; HYPERINSULINISM; IMMUNITY; INSULIN; INSULIN RESISTANCE; LARVA; LEPTIN; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; SIGNAL TRANSDUCTION; TRANSCRIPTOME; UP-REGULATION; ZEBRAFISH;

EID: 84905708208     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-14-0178     Document Type: Article

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