-
1
-
-
9744227183
-
Ubiquitin: Structures, functions, mechanisms
-
Pickart CM, Eddins MJ. Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta. 2004;1695:55-72.
-
(2004)
Biochim Biophys Acta
, vol.1695
, pp. 55-72
-
-
Pickart, C.M.1
Eddins, M.J.2
-
2
-
-
67349256160
-
Ubiquitin-like protein activation by E1 enzymes: The apex for downstream signalling pathways
-
Schulman BA, Harper JW. Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways. Nat Rev Mol Cell Biol. 2009;10:319-31.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 319-331
-
-
Schulman, B.A.1
Harper, J.W.2
-
3
-
-
0842303313
-
Back to the Future with Ubiquitin
-
DOI 10.1016/S0092-8674(03)01074-2
-
Pickart CM. Back to the future with ubiquitin. Cell. 2004;116:181-90. (Pubitemid 38167311)
-
(2004)
Cell
, vol.116
, Issue.2
, pp. 181-190
-
-
Pickart, C.M.1
-
4
-
-
79953197650
-
Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease
-
Dammer EB, Na CH, Xu P, et al. Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease. J Biol Chem. 2011;286:10457-65.
-
(2011)
J Biol Chem
, vol.286
, pp. 10457-10465
-
-
Dammer, E.B.1
Na, C.H.2
Xu, P.3
-
5
-
-
77957943643
-
Protein ubiquitylation in pancreatic cancer
-
Bonacci T, Roignot J, Soubeyran P. Protein ubiquitylation in pancreatic cancer. Sci World J. 2010;10:1462-72.
-
(2010)
Sci World J
, vol.10
, pp. 1462-1472
-
-
Bonacci, T.1
Roignot, J.2
Soubeyran, P.3
-
6
-
-
0036395180
-
Ubiquitin-dependent proteolysis: Its role in human diseases and the design of therapeutic strategies
-
DOI 10.1016/S1096-7192(02)00146-4, PII S1096719202001464
-
Sakamoto KM. Ubiquitin-dependent proteolysis: its role in human disease and the design of therapeutic strategies. Mol Genet Metab. 2002;77:44-56. (Pubitemid 35178514)
-
(2002)
Molecular Genetics and Metabolism
, vol.77
, Issue.1-2
, pp. 44-56
-
-
Sakamoto, K.M.1
-
7
-
-
0038189900
-
Therapeutic anti-cancer targets upstream of the proteasome
-
DOI 10.1016/S0305-7372(03)00083-5
-
Nalepa G, Wade Harper J. Therapeutic anti-cancer targets upstream of the proteasome. Cancer Treat Rev. 2003;29:49-57. (Pubitemid 36626292)
-
(2003)
Cancer Treatment Reviews
, vol.29
, Issue.SUPPL. 1
, pp. 49-57
-
-
Nalepa, G.1
Harper, J.W.2
-
8
-
-
0025967290
-
UBA1: An essential yeast gene encoding ubiquitin-activating enzyme
-
McGrath JP, Jentsch S, Varshavsky A. UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme. EMBO J. 1991;10:227-36. (Pubitemid 21905286)
-
(1991)
EMBO Journal
, vol.10
, Issue.1
, pp. 227-236
-
-
McGrath, J.P.1
Jentsch, S.2
Varshavsky, A.3
-
9
-
-
84878350063
-
Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer
-
Voutsadakis IA. Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer. Mol Biol Rep. 2013;40:2019-34.
-
(2013)
Mol Biol Rep
, vol.40
, pp. 2019-2034
-
-
Voutsadakis, I.A.1
-
10
-
-
8844237615
-
Polyubiquitin chains: Polymeric protein signals
-
DOI 10.1016/j.cbpa.2004.09.009, PII S1367593104001413
-
Pickart CM, Fushman D. Polyubiquitin chains: polymeric protein signals. Curr Opin Chem Biol. 2004;8:610-6. (Pubitemid 39535722)
-
(2004)
Current Opinion in Chemical Biology
, vol.8
, Issue.6
, pp. 610-616
-
-
Pickart, C.M.1
Fushman, D.2
-
11
-
-
0034915764
-
Mechanisms underlying ubiquitination
-
DOI 10.1146/annurev.biochem.70.1.503
-
Pickart CM. Mechanisms underlying ubiquitination. Annu Rev Biochem. 2001;70:503-33. (Pubitemid 32663902)
-
(2001)
Annual Review of Biochemistry
, vol.70
, pp. 503-533
-
-
Pickart, C.M.1
-
14
-
-
0030695478
-
Pathways of ubiquitin conjugation
-
Haas AL, Siepmann TJ. Pathways of ubiquitin conjugation. FASEB J. 1997;11:1257-68. (Pubitemid 27527889)
-
(1997)
FASEB Journal
, vol.11
, Issue.14
, pp. 1257-1268
-
-
Haas, A.L.1
Siepmann, T.J.2
-
15
-
-
2642559887
-
Targeting E3 ubiquitin ligases for cancer therapy
-
Sun Y. Targeting E3 ubiquitin ligases for cancer therapy. Cancer Biol Ther. 2003;2:623-9.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 623-629
-
-
Sun, Y.1
-
16
-
-
77955185636
-
A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis
-
Maine GN, Li H, Zaidi IW, Basrur V, Elenitoba-Johnson KS, Burstein E. A bimolecular affinity purification method under denaturing conditions for rapid isolation of a ubiquitinated protein for mass spectrometry analysis. Nat Protoc. 2010;5:1447-59.
-
(2010)
Nat Protoc
, vol.5
, pp. 1447-1459
-
-
Maine, G.N.1
Li, H.2
Zaidi, I.W.3
Basrur, V.4
Elenitoba-Johnson, K.S.5
Burstein, E.6
-
17
-
-
33750946999
-
Narrative review: Potein degradation and human diseases: The ubiquitin connection
-
Reinstein E, Ciechanover A. Narrative review: protein degradation and human diseases: the ubiquitin connection. Ann Intern Med. 2006;145:676-84. (Pubitemid 46768844)
-
(2006)
Annals of Internal Medicine
, vol.145
, Issue.9
, pp. 676-684
-
-
Reinstein, E.1
Ciechanover, A.2
-
18
-
-
0025960565
-
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1
-
Handley PM, Mueckler M, Siegel NR, Ciechanover A, Schwartz AL. Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1. Proc Natl Acad Sci USA. 1991;88:258-62. (Pubitemid 21914466)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.1
, pp. 258-262
-
-
Handley, P.M.1
Mueckler, M.2
Siegel, N.R.3
Ciechanover, A.4
Schwartz, A.L.5
-
19
-
-
84875917767
-
The ubiquitin-proteasomal system is critical for multiple myeloma: Implications in drug discovery
-
Cao B, Mao X. The ubiquitin-proteasomal system is critical for multiple myeloma: implications in drug discovery. Am J Blood Res. 2011;1:46-56.
-
(2011)
Am J Blood Res
, vol.1
, pp. 46-56
-
-
Cao, B.1
Mao, X.2
-
20
-
-
77950421253
-
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
-
Xu GW, Ali M, Wood TE, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 2010;115:2251-9.
-
(2010)
Blood
, vol.115
, pp. 2251-2259
-
-
Xu, G.W.1
Ali, M.2
Wood, T.E.3
-
21
-
-
34548188010
-
UBE1L2, a novel E1 enzyme specific for ubiquitin
-
DOI 10.1074/jbc.C700111200
-
Pelzer C, Kassner I, Matentzoglu K, Singh RK, Wollscheid HP, Scheffner M, Schmidtke G, Groettrup M. UBE1L2, a novel E1 enzyme specific for ubiquitin. J Biol Chem. 2007;282:23010-4. (Pubitemid 47311897)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.32
, pp. 23010-23014
-
-
Pelzer, C.1
Kassner, I.2
Matentzoglu, K.3
Singh, R.K.4
Wollscheid, H.-P.5
Scheffner, M.6
Schmidtke, G.7
Groettrup, M.8
-
22
-
-
67449091213
-
What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?
-
Michelle C, Vourc HP, Mignon L, Andres CR. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? J Mol Evol. 2009;68:616-28.
-
(2009)
J Mol Evol
, vol.68
, pp. 616-628
-
-
Michelle, C.1
Vourc, H.P.2
Mignon, L.3
Andres, C.R.4
-
23
-
-
77951651753
-
The family of ubiquitin-conjugating enzymes (E2s): Deciding between life and death of proteins
-
Van Wijk SJ, Timmers HT. The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins. FASEB J. 2010;24:981-93.
-
(2010)
FASEB J
, vol.24
, pp. 981-993
-
-
Van Wijk, S.J.1
Timmers, H.T.2
-
24
-
-
0035958926
-
In vitro assembly and recognition of Lys-63 polyubiquitin chains
-
Hofmann RM, Pickart CM. In vitro assembly and recognition of Lys-63 polyubiquitin chains. J Biol Chem. 2001;276:27936-43.
-
(2001)
J Biol Chem
, vol.276
, pp. 27936-27943
-
-
Hofmann, R.M.1
Pickart, C.M.2
-
25
-
-
42649124278
-
Anatomy of the E2 ligase fold: Implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation
-
Burroughs AM, Jaffee M, Iyer LM, Aravind L. Anatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation. J Struct Biol. 2008;162:205-18.
-
(2008)
J Struct Biol
, vol.162
, pp. 205-218
-
-
Burroughs, A.M.1
Jaffee, M.2
Iyer, L.M.3
Aravind, L.4
-
26
-
-
84863602520
-
Ubiquitin-conjugating enzyme UBE2C: Molecular biology, role in tumorigenesis, and potential as a biomarker
-
Hao Z, Zhang H, Cowell J. Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker. Tumour Biol. 2012;33:723-30.
-
(2012)
Tumour Biol
, vol.33
, pp. 723-730
-
-
Hao, Z.1
Zhang, H.2
Cowell, J.3
-
27
-
-
79959908728
-
Emerging roles for Lys11-linked polyubiquitin in cellular regulation
-
Bremm A, Komander D. Emerging roles for Lys11-linked polyubiquitin in cellular regulation. Trends Biochem Sci. 2011;36:355-63.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 355-363
-
-
Bremm, A.1
Komander, D.2
-
28
-
-
4444229048
-
Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin
-
DOI 10.1038/sj.onc.1207861
-
Wagner KW, Sapinoso LM, El-Rifai W, Frierson HF, Butz N, Mestan J, Hofmann F, Deveraux QL, Hampton GM. Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin. Oncogene. 2004;23:6621-9. (Pubitemid 39265525)
-
(2004)
Oncogene
, vol.23
, Issue.39
, pp. 6621-6629
-
-
Wagner, K.W.1
Sapinoso, L.M.2
El-Rifai, W.3
Frierson Jr., H.F.4
Butz, N.5
Mestan, J.6
Hofmann, F.7
Deveraux, Q.L.8
Hampton, G.M.9
-
29
-
-
34547171850
-
The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition
-
DOI 10.1593/neo.07385
-
Tedesco D, Zhang J, Trinh L, Lalehzadeh G, Meisner R, Yamaguchi KD, Ruderman DL, Dinter H, Zajchowski DA. The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition. Neoplasia. 2007;9:601-13. (Pubitemid 47121834)
-
(2007)
Neoplasia
, vol.9
, Issue.7
, pp. 601-613
-
-
Tedesco, D.1
Zhang, J.2
Trinh, L.3
Lalehzadehz, G.4
Meisner, R.5
Yamaguchi, K.D.6
Ruderman, D.L.7
Dinter, H.8
Zajchowski, D.A.9
-
30
-
-
40949135212
-
Rad6B is a positive regulator of beta-catenin stabilization
-
DOI 10.1158/0008-5472.CAN-07-2111
-
Shekhar MP, Gerard B, Pauley RJ, Williams BO, Tait L. Rad6B is a positive regulator of beta-catenin stabilization. Cancer Res. 2008;68:1741-50. (Pubitemid 351416559)
-
(2008)
Cancer Research
, vol.68
, Issue.6
, pp. 1741-1750
-
-
Shekhar, M.P.V.1
Gerard, B.2
Pauley, R.J.3
Williams, B.O.4
Tait, L.5
-
31
-
-
0035719960
-
Wnt signaling in breast cancer: Have we come full circle?
-
DOI 10.1186/bcr321
-
Brown AM. Wnt signaling in breast cancer: have we come full circle? Breast Cancer Res. 2001;3:351-5. (Pubitemid 34196359)
-
(2001)
Breast Cancer Research
, vol.3
, Issue.6
, pp. 351-355
-
-
Brown, A.M.C.1
-
32
-
-
84878350063
-
Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer
-
Voutsadakis Ioannis A. Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer. Mol Biol Rep. 2013;40:2019-34.
-
(2013)
Mol Biol Rep
, vol.40
, pp. 2019-2034
-
-
Voutsadakis Ioannis, A.1
-
33
-
-
4744350876
-
Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo
-
DOI 10.1074/jbc.M403362200
-
Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP. Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. J Biol Chem. 2004;279:42169-81. (Pubitemid 39313666)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.40
, pp. 42169-42181
-
-
Saville, M.K.1
Sparks, A.2
Xirodimas, D.P.3
Wardrop, J.4
Stevenson, L.F.5
Bourdon, J.-C.6
Woods, Y.L.7
Lane, D.P.8
-
34
-
-
0033591363
-
Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha
-
Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. J Biol Chem. 1999;274:14823-30.
-
(1999)
J Biol Chem
, vol.274
, pp. 14823-14830
-
-
Gonen, H.1
Bercovich, B.2
Orian, A.3
Carrano, A.4
Takizawa, C.5
Yamanaka, K.6
Pagano, M.7
Iwai, K.8
Ciechanover, A.9
-
35
-
-
21344469230
-
Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue
-
DOI 10.1158/0008-5472.CAN-05-0201
-
Chen L, Madura K. Increased proteasome activity, ubiquitin-conjugating enzymes, and eEF1A translation factor detected in breast cancer tissue. Cancer Res. 2005;65:5599-606. (Pubitemid 40911160)
-
(2005)
Cancer Research
, vol.65
, Issue.13
, pp. 5599-5606
-
-
Chen, L.1
Madura, K.2
-
36
-
-
0022975275
-
The protein substrate binding site of the ubiquitin-protein ligase system
-
Hershko A, Heller H, Eytan E, Reiss Y. The protein substrate binding site of the ubiquitin-protein ligase system. J Biol Chem. 1986;261:11992-9. (Pubitemid 17202754)
-
(1986)
Journal of Biological Chemistry
, vol.261
, Issue.26
, pp. 11992-11999
-
-
Hershko, A.1
Heller, H.2
Eytan, E.3
Reiss, Y.4
-
37
-
-
0023768491
-
Ubiquitin-mediated protein degradation
-
Hershko A. Ubiquitin-mediated protein degradation. J Biol Chem. 1988;263:15237-40.
-
(1988)
J Biol Chem
, vol.263
, pp. 15237-15240
-
-
Hershko, A.1
-
38
-
-
33745674468
-
Drug discovery in the ubiquitin-proteasome system
-
Nalepa G, Rolfe M, Harper JW. Drug discovery in the ubiquitin-proteasome system. Nat Rev Drug Discov. 2006;5:596-613.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 596-613
-
-
Nalepa, G.1
Rolfe, M.2
Harper, J.W.3
-
39
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev. 2002;82:373-428. (Pubitemid 34654457)
-
(2002)
Physiological Reviews
, vol.82
, Issue.2
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
40
-
-
67349132223
-
Physiological functions of the HECT family of ubiquitin ligases
-
Rotin D, Kumar S. Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol. 2009;10:398-409.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 398-409
-
-
Rotin, D.1
Kumar, S.2
-
41
-
-
64749098830
-
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
-
Soucy TA, Smith PG, Milhollen MA, et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009;458:732-6.
-
(2009)
Nature
, vol.458
, pp. 732-736
-
-
Soucy, T.A.1
Smith, P.G.2
Milhollen, M.A.3
-
42
-
-
84859787749
-
New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies
-
Grande E, Earl J, Fuentes R, Carrato A. New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies. Expert Rev Anticancer Ther. 2012;12:457-67.
-
(2012)
Expert Rev Anticancer Ther
, vol.12
, pp. 457-467
-
-
Grande, E.1
Earl, J.2
Fuentes, R.3
Carrato, A.4
-
43
-
-
33748521536
-
E3 ubiquitin ligases as cancer targets and biomarkers
-
DOI 10.1593/neo.06376
-
Sun Y. E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia. 2006;8:645-54. (Pubitemid 44379791)
-
(2006)
Neoplasia
, vol.8
, Issue.8
, pp. 645-654
-
-
Sun, Y.1
-
44
-
-
1542515338
-
A census of human cancer genes
-
Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R, Rahman N, Stratton MR. A census of human cancer genes. Nat Rev Cancer. 2004;4:177-83. (Pubitemid 38337497)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.3
, pp. 177-183
-
-
Futreal, P.A.1
Coin, L.2
Marshall, M.3
Down, T.4
Hubbard, T.5
Wooster, R.6
Rahman, N.7
Stratton, M.R.8
-
45
-
-
84867534504
-
Radiosensitization of cancer cells by inactivation of cullin-RING E3 ubiquitin ligases
-
Wei Dongping, Morgan Meredith A, Sun Yi. Radiosensitization of cancer cells by inactivation of cullin-RING E3 ubiquitin ligases. Transl Oncol. 2012;5:305-12.
-
(2012)
Transl Oncol
, vol.5
, pp. 305-312
-
-
Dongping, W.1
Morgan, M.A.2
Yi, S.3
-
46
-
-
0033279836
-
SCF and cullin/RING H2-based ubiquitin ligases
-
DOI 10.1146/annurev.cellbio.15.1.435
-
Deshaies RJ. SCF and cullin/ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol. 1999;15:435-67. (Pubitemid 32250383)
-
(1999)
Annual Review of Cell and Developmental Biology
, vol.15
, pp. 435-467
-
-
Deshaies, R.J.1
-
47
-
-
0034871084
-
SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: Molecular cloning, biochemical properties, and biological functions
-
Sun Y, Tan M, Duan H, Swaroop M. SAG/ROC/Rbx/Hrt, a zinc RING finger gene family: molecular cloning, biochemical properties, and biological functions. Antioxid Redox Signal. 2001;3:635-50. (Pubitemid 32785986)
-
(2001)
Antioxidants and Redox Signaling
, vol.3
, Issue.4
, pp. 635-650
-
-
Sun, Y.1
Tan, M.2
Duan, H.3
Swaroop, M.4
-
48
-
-
77955883766
-
Regulation of Skp2 expression and activity and its role in cancer progression
-
Chan CH, Lee SW, Wang J, Lin HK. Regulation of Skp2 expression and activity and its role in cancer progression. Sci World J. 2010;10:1001-15.
-
(2010)
Sci World J
, vol.10
, pp. 1001-1015
-
-
Chan, C.H.1
Lee, S.W.2
Wang, J.3
Lin, H.K.4
-
49
-
-
4444318673
-
The SCF ubiquitin ligase: Insights into a molecular machine
-
DOI 10.1038/nrm1471
-
Cardozo T, Pagano M. The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol. 2004;5:739-51. (Pubitemid 39208183)
-
(2004)
Nature Reviews Molecular Cell Biology
, vol.5
, Issue.9
, pp. 739-751
-
-
Cardozo, T.1
Pagano, M.2
-
50
-
-
80052069445
-
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
-
Lipkowitz S, Weissman AM. RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat Rev Cancer. 2011;11:629-43.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 629-643
-
-
Lipkowitz, S.1
Weissman, A.M.2
-
51
-
-
0037325853
-
Deregulated degradation of the cdk inhibitor p27 and malignant transformation
-
DOI 10.1016/S1044-579X(02)00098-6, PII S1044579X02000986
-
Bloom J, Pagano M. Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol. 2003;13:41-7. (Pubitemid 36269179)
-
(2003)
Seminars in Cancer Biology
, vol.13
, Issue.1
, pp. 41-47
-
-
Bloom, J.1
Pagano, M.2
-
52
-
-
38549086019
-
FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
-
DOI 10.1038/nrc2290, PII NRC2290
-
Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer. 2008;8:83-93. (Pubitemid 351161321)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.2
, pp. 83-93
-
-
Welcker, M.1
Clurman, B.E.2
-
53
-
-
26444480631
-
Mechanisms of tumor suppression by the SCF(Fbw7)
-
Minella AC, Clurman BE. Mechanisms of tumor suppression by the SCF(Fbw7). Cell Cycle. 2005;4:1356-9.
-
(2005)
Cell Cycle
, vol.4
, pp. 1356-1359
-
-
Minella, A.C.1
Clurman, B.E.2
-
54
-
-
35148842479
-
FBXW7/hCDC4 is a general tumor suppressor in human cancer
-
DOI 10.1158/0008-5472.CAN-07-1320
-
Akhoondi S, Sun D, Von Der Lehr N, et al. FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res. 2007;67:9006-12. (Pubitemid 47535882)
-
(2007)
Cancer Research
, vol.67
, Issue.19
, pp. 9006-9012
-
-
Akhoondi, S.1
Sun, D.2
Von Der, L.N.3
Apostolidou, S.4
Klotz, K.5
Maljukova, A.6
Cepeda, D.7
Fiegl, H.8
Dofou, D.9
Marth, C.10
Mueller-Holzner, E.11
Corcoran, M.12
Dagnell, M.13
Nejad, S.Z.14
Nayer, B.N.15
Zali, M.R.16
Hansson, J.17
Egyhazi, S.18
Petersson, F.19
Sangfelt, P.20
Nordgren, H.21
Grander, D.22
Reed, S.I.23
Widschwendter, M.24
Sangfelt, O.25
Spruck, C.26
more..
-
55
-
-
0027358723
-
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
-
DOI 10.1016/0092-8674(93)90384-3
-
Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell. 1993;75:495-505. (Pubitemid 23335075)
-
(1993)
Cell
, vol.75
, Issue.3
, pp. 495-505
-
-
Scheffner, M.1
Huibregtse, J.M.2
Vierstra, R.D.3
Howley, P.M.4
-
56
-
-
78049315806
-
Ubiquitin becomes ubiquitous in cancer: Emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets
-
Shi Dingding, Grossman Steven R. Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets. Cancer Biol Ther. 2010;10:737-47.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 737-747
-
-
Dingding, S.1
Grossman, S.R.2
-
57
-
-
34249028003
-
HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP
-
DOI 10.1038/sj.onc.1210130, PII 1210130
-
Shai A, Nguyen ML, Wagstaff J, Jiang Y-H, Lambert PF. HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP. Oncogene. 2007;26:3321-8. (Pubitemid 46788889)
-
(2007)
Oncogene
, vol.26
, Issue.23
, pp. 3321-3328
-
-
Shai, A.1
Nguyen, M.L.2
Wagstaff, J.3
Jiang, Y.-H.4
Lambert, P.F.5
-
58
-
-
34247221276
-
Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6
-
DOI 10.1038/sj.onc.1210188, PII 1210188
-
Camus S, Menendez S, Cheok CF, Stevenson LF, Lain S, Lane DP. Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6. Oncogene. 2007;26:4059-70. (Pubitemid 46920172)
-
(2007)
Oncogene
, vol.26
, Issue.28
, pp. 4059-4070
-
-
Camus, S.1
Menendez, S.2
Cheok, C.F.3
Stevenson, L.F.4
Lain, S.5
Lane, D.P.6
-
59
-
-
0036968468
-
Cell cycle regulatory E3 ubiquitin ligases as anticancer targets
-
DOI 10.1016/S1368-7646(02)00121-8, PII S1368764602001218
-
Pray TR, Parlati F, Huang J, Wong BR, Payan DG, Bennett MK, Issakani SD, Molineaux S, Demo SD. Cell cycle regulatory E3 ubiquitin ligases as anti cancer targets. Drug Resist Updat. 2002;5:249-58. (Pubitemid 36132806)
-
(2002)
Drug Resistance Updates
, vol.5
, Issue.6
, pp. 249-258
-
-
Pray, T.R.1
Parlati, F.2
Huang, J.3
Wong, B.R.4
Payan, D.G.5
Bennett, M.K.6
Issakani, S.D.7
Molineaux, S.8
Demo, S.D.9
-
60
-
-
1942437663
-
Regulating the p53 system through ubiquitination
-
DOI 10.1038/sj.onc.1207411
-
Yang Y, Li CC, Weissman AM. Regulating the p53 system through ubiquitination. Oncogene. 2004;23:2096-106. (Pubitemid 38496739)
-
(2004)
Oncogene
, vol.23
, Issue.11 REV. ISS. 1
, pp. 2096-2106
-
-
Yang, Y.1
Li, C.-C.H.2
Weissman, A.M.3
-
61
-
-
35148826938
-
Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm
-
DOI 10.1016/j.ccr.2007.10.001, PII S153561080700270X
-
Soussi T, Wiman KG. Shaping genetic alterations in human cancer: the p53 mutation paradigm. Cancer Cell. 2007;12:303-12. (Pubitemid 47539312)
-
(2007)
Cancer Cell
, vol.12
, Issue.4
, pp. 303-312
-
-
Soussi, T.1
Wiman, K.G.2
-
62
-
-
0037317840
-
Inhibiting the p53-MDM2 interaction: An important target for cancer therapy
-
DOI 10.1038/nrc991
-
Chene P. Inhibiting the p53-MDM2 interaction: an important target for cancer therapy. Nat Rev Cancer. 2003;3:102-9. (Pubitemid 37328877)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.2
, pp. 102-109
-
-
Chene, P.1
-
63
-
-
0031569413
-
cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene
-
DOI 10.1006/geno.1996.4582
-
Kumar S, Harvey KF, Kinoshita M, Copeland NG, Noda M, Jenkins NA. cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene. Genomics. 1997;40:435-43. (Pubitemid 27136996)
-
(1997)
Genomics
, vol.40
, Issue.3
, pp. 435-443
-
-
Kumar, S.1
Harvey, K.F.2
Kinoshita, M.3
Copeland, N.G.4
Noda, M.5
Jenkins, N.A.6
-
64
-
-
33845991111
-
NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN
-
DOI 10.1016/j.cell.2006.11.039, PII S0092867406015480
-
Wang X, Trotman LC, Koppie T, et al. NEDD4-1 is a protooncogenic ubiquitin ligase for PTEN. Cell. 2007;128:129-39. (Pubitemid 46048884)
-
(2007)
Cell
, vol.128
, Issue.1
, pp. 129-139
-
-
Wang, X.1
Trotman, L.C.2
Koppie, T.3
Alimonti, A.4
Chen, Z.5
Gao, Z.6
Wang, J.7
Erdjument-Bromage, H.8
Tempst, P.9
Cordon-Cardo, C.10
Pandolfi, P.P.11
Jiang, X.12
-
65
-
-
33845977965
-
Ubiquitination Regulates PTEN Nuclear Import and Tumor Suppression
-
DOI 10.1016/j.cell.2006.11.040, PII S0092867406015492
-
Trotman LC, Wang X, Alimonti A, et al. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell. 2007;128:141-56. (Pubitemid 46048885)
-
(2007)
Cell
, vol.128
, Issue.1
, pp. 141-156
-
-
Trotman, L.C.1
Wang, X.2
Alimonti, A.3
Chen, Z.4
Teruya-Feldstein, J.5
Yang, H.6
Pavletich, N.P.7
Carver, B.S.8
Cordon-Cardo, C.9
Erdjument-Bromage, H.10
Tempst, P.11
Chi, S.-G.12
Kim, H.-J.13
Misteli, T.14
Jiang, X.15
Pandolfi, P.P.16
-
66
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGFbeta receptor for degradation
-
DOI 10.1016/S1097-2765(00)00134-9
-
Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell. 2000;6:1365-75. (Pubitemid 32045929)
-
(2000)
Molecular Cell
, vol.6
, Issue.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
67
-
-
0034711290
-
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
-
DOI 10.1074/jbc.C000580200
-
Lin X, Liang M, Feng XH. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor -beta signaling. J Biol Chem. 2000;275:36818-22. (Pubitemid 32002092)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.47
, pp. 36818-36822
-
-
Lin, X.1
Liang, M.2
Feng, X.-H.3
-
68
-
-
0037115624
-
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma
-
Fukuchi M, Fukai Y, Masuda N, Miyazaki T, Nakajima M, Sohda M, Manda R, Tsukada K, Kato H, Kuwano H. High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Res. 2002;62:7162-5. (Pubitemid 36025230)
-
(2002)
Cancer Research
, vol.62
, Issue.24
, pp. 7162-7165
-
-
Fukuchi, M.1
Fukai, Y.2
Masuda, N.3
Miyazaki, T.4
Nakajima, M.5
Sohda, M.6
Manda, R.7
Tsukada, K.8
Kato, H.9
Kuwano, H.10
-
69
-
-
1942469596
-
A central role for the ring finger protein RNF11 in ubiquitin-mediated proteolysis via interactions with E2s and E3s
-
DOI 10.1038/sj.onc.1207380
-
Connor MK, Seth A. A central role for the ring finger protein RNF11 in ubiquitin-mediated proteolysis via interactions with E2s and E3s. Oncogene. 2004;23:2089-95. (Pubitemid 38496738)
-
(2004)
Oncogene
, vol.23
, Issue.11 REV. ISS. 1
, pp. 2089-2095
-
-
Connor, M.K.1
Seth, A.2
-
70
-
-
0037204990
-
Signal transduction by the TGF-beta superfamily
-
Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science. 2002;296:1646-7.
-
(2002)
Science
, vol.296
, pp. 1646-1647
-
-
Attisano, L.1
Wrana, J.L.2
-
71
-
-
6344260070
-
The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
-
DOI 10.1038/sj.emboj.7600398
-
Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, Camonis J, Atfi A. The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J. 2004;23:3780-92. (Pubitemid 39389709)
-
(2004)
EMBO Journal
, vol.23
, Issue.19
, pp. 3780-3792
-
-
Seo, S.R.1
Lallemand, F.2
Ferrand, N.3
Pessah, M.4
L'Hoste, S.5
Camonis, J.6
Atfi, A.7
-
72
-
-
20444439172
-
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases
-
DOI 10.1074/jbc.M414027200
-
Moren A, Imamura T, Miyazono K, Heldin CH, Moustakas A. Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J Biol Chem. 2005;280:22115-23. (Pubitemid 40827867)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.23
, pp. 22115-22123
-
-
Moren, A.1
Imamura, T.2
Miyazono, K.3
Heldin, C.-H.4
Moustakas, A.5
-
73
-
-
4644312604
-
Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)
-
DOI 10.1038/sj.onc.1207885
-
Komuro A, Imamura T, Saitoh M, Yoshida Y, Yamori T, Miyazono K, Miyazawa K. Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Oncogene. 2004;23:6914-23. (Pubitemid 39279992)
-
(2004)
Oncogene
, vol.23
, Issue.41
, pp. 6914-6923
-
-
Komuro, A.1
Imamura, T.2
Saitoh, M.3
Yoshida, Y.4
Yamori, T.5
Miyazono, K.6
Miyazawa, K.7
-
74
-
-
18844429239
-
Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells
-
DOI 10.1038/sj.onc.1208497
-
Chen C, Sun X, Ran Q, Wilkinson KD, Murphy TJ, Simons JW, Dong JT. Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene. 2005;24:3319-27. (Pubitemid 40695113)
-
(2005)
Oncogene
, vol.24
, Issue.20
, pp. 3319-3327
-
-
Chen, C.1
Sun, X.2
Ran, Q.3
Wilkinson, K.D.4
Murphy, T.J.5
Simons, J.W.6
Dong, J.-T.7
-
75
-
-
65649086740
-
Overexpression of WWP1 is associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma
-
Chen C, Zhou Z, Sheehan CE, Slodkowska E, Sheehan CB, Boguniewicz A, Ross JS. Overexpression of WWP1 is associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma. Int J Cancer. 2009;124:2829-36.
-
(2009)
Int J Cancer
, vol.124
, pp. 2829-2836
-
-
Chen, C.1
Zhou, Z.2
Sheehan, C.E.3
Slodkowska, E.4
Sheehan, C.B.5
Boguniewicz, A.6
Ross, J.S.7
-
76
-
-
33847401446
-
Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
-
DOI 10.1038/sj.onc.1209924, PII 1209924
-
Laine A, Ronai Z. Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. Oncogene. 2007;26:1477-83. (Pubitemid 46340811)
-
(2007)
Oncogene
, vol.26
, Issue.10
, pp. 1477-1483
-
-
Laine, A.1
Ronai, Z.2
-
77
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
DOI 10.1038/20459
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271-5. (Pubitemid 29246458)
-
(1999)
Nature
, vol.399
, Issue.6733
, pp. 271-275
-
-
Maxwell, P.H.1
Wlesener, M.S.2
Chang, G.-W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
78
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000;2:423-7.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
79
-
-
83655196994
-
Role of VHL gene mutation in human renal cell carcinoma
-
Arjumand W, Sultana S. Role of VHL gene mutation in human renal cell carcinoma. Tumour Biol. 2012;33:9-16.
-
(2012)
Tumour Biol
, vol.33
, pp. 9-16
-
-
Arjumand, W.1
Sultana, S.2
-
80
-
-
0037709883
-
Von Hippel-Lindau disease
-
DOI 10.1016/S0140-6736(03)13643-4
-
Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM, Oldfield EH. von Hippel-Lindau disease. Lancet. 2003;361(9374):2059-67. (Pubitemid 36695052)
-
(2003)
Lancet
, vol.361
, Issue.9374
, pp. 2059-2067
-
-
Lonser, R.R.1
Glenn, G.M.2
Walther, M.3
Chew, E.Y.4
Libutti, S.K.5
Linehan, W.M.6
Oldfield, E.H.7
-
81
-
-
63649086487
-
Targeting the ubiquitin system in cancer therapy
-
Hoeller D, Dikic I. Targeting the ubiquitin system in cancer therapy. Nature. 2009;458:438-44.
-
(2009)
Nature
, vol.458
, pp. 438-444
-
-
Hoeller, D.1
Dikic, I.2
-
82
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
DOI 10.1074/jbc.275.12.8945
-
Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem. 2000;275:8945-51. (Pubitemid 30180252)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.12
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
83
-
-
17344365851
-
Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families
-
DOI 10.1086/301749
-
Ford D, Easton DF, Stratton M, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The breast cancer linkage consortium. Am J Hum Genet. 1998;62:676-89. (Pubitemid 28164626)
-
(1998)
American Journal of Human Genetics
, vol.62
, Issue.3
, pp. 676-689
-
-
Ford, D.1
Easton, D.F.2
Stratton, M.3
Narod, S.4
Goldgar, D.5
Devilee, P.6
Bishop, D.T.7
Weber, B.8
Lenoir, G.9
Chang-Claude, J.10
Sobol, H.11
Teare, M.D.12
Struewing, J.13
Arason, A.14
Scherneck, S.15
Peto, J.16
Rebbeck, T.R.17
Tonin, P.18
Neuhausen, S.19
Barkardottir, R.20
Eyfjord, J.21
Lynch, H.22
Ponder, B.A.J.23
Gayther, S.A.24
Birch, J.M.25
Lindblom, A.26
Stoppa-Lyonnet, D.27
Bignon, Y.28
Borg, A.29
Hamann, U.30
Haites, N.31
Scott, R.J.32
Maugard, C.M.33
Vasen, H.34
Seitz, S.35
Cannon-Albright, L.A.36
Schofield, A.37
Zelada-Hedman, M.38
more..
-
84
-
-
0035805582
-
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation
-
Hashizume R, Fukuda M, Maeda I, Nishikawa H, Oyake D, Yabuki Y, Ogata H, Ohta T. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem. 2001;276:14537-40.
-
(2001)
J Biol Chem
, vol.276
, pp. 14537-14540
-
-
Hashizume, R.1
Fukuda, M.2
Maeda, I.3
Nishikawa, H.4
Oyake, D.5
Yabuki, Y.6
Ogata, H.7
Ohta, T.8
-
85
-
-
0035942190
-
Cancer-predisposing mutations within the RING domain of BRCA1: Loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
-
DOI 10.1073/pnas.081068398
-
Ruffner H, Joazeiro CA, Hemmati D, Hunter T, Verma IM. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc Natl Acad Sci U S A. 2001;98:5134-9. (Pubitemid 32397095)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.9
, pp. 5134-5139
-
-
Ruffner, H.1
Joazeiro, C.A.P.2
Hemmati, D.3
Hunter, T.4
Verma, I.M.5
-
86
-
-
0037076672
-
Autoubiquitination of the BRCA1-BARD1 RING ubiquitin ligase
-
DOI 10.1074/jbc.M201252200
-
Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ. Auto-ubiquitination of the BRCA1-BARD1 RING ubiquitin ligase. J Biol Chem. 2002;277:22085-92. (Pubitemid 34952363)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.24
, pp. 22085-22092
-
-
Chen, A.1
Kleiman, F.E.2
Manley, J.L.3
Ouchi, T.4
-
87
-
-
36448996703
-
Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
-
DOI 10.1038/nrc2054, PII NRC2054
-
Fackenthal JD, Olopade OI. Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer. 2007;7:937-48. (Pubitemid 350165853)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.12
, pp. 937-948
-
-
Fackenthal, J.D.1
Olopade, O.I.2
-
88
-
-
63549126247
-
The contribution of BRCA1 and BRCA2 to ovarian cancer
-
Ramus SJ, Gayther SA. The contribution of BRCA1 and BRCA2 to ovarian cancer. Mol Oncol. 2009;3:138-50.
-
(2009)
Mol Oncol
, vol.3
, pp. 138-150
-
-
Ramus, S.J.1
Gayther, S.A.2
-
89
-
-
40149110668
-
The ubiquitin E3 ligase activity of BRCA1 and its biological functions
-
Wu W, Koike A, Takeshita T, Ohta T. The ubiquitin E3 ligase activity of BRCA1 and its biological functions. Cell Div. 2008;3:1.
-
(2008)
Cell Div
, vol.3
, pp. 1
-
-
Wu, W.1
Koike, A.2
Takeshita, T.3
Ohta, T.4
-
90
-
-
84874886341
-
Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase
-
Sun Y, Li H. Functional characterization of SAG/RBX2/ROC2/RNF7, an antioxidant protein and an E3 ubiquitin ligase. Protein Cell. 2013;4:103-16.
-
(2013)
Protein Cell
, vol.4
, pp. 103-116
-
-
Sun, Y.1
Li, H.2
-
91
-
-
0034213598
-
Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: Chip profiling implicates its role in cell cycle regulation
-
Swaroop M, Wang Y, Miller P, Duan H, Jatkoe T, Madore SJ, Sun Y. Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. Oncogene. 2000;19:2855-66. (Pubitemid 30386422)
-
(2000)
Oncogene
, vol.19
, Issue.24
, pp. 2855-2866
-
-
Swaroop, M.1
Wang, Y.2
Miller, P.3
Duan, H.4
Jatkoe, T.5
Madore, S.J.6
Sun, Y.7
-
92
-
-
77955510624
-
Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells
-
Tan M, Zhu Y, Kovacev J, Zhao Y, Pan ZQ, Spitz DR, Sun Y. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radic Biol Med. 2010;49:976-83.
-
(2010)
Free Radic Biol Med
, vol.49
, pp. 976-983
-
-
Tan, M.1
Zhu, Y.2
Kovacev, J.3
Zhao, Y.4
Pan, Z.Q.5
Spitz, D.R.6
Sun, Y.7
-
93
-
-
33845583328
-
beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection
-
DOI 10.1593/neo.06568
-
Tan M, Gallegos JR, Gu Q, Huang Y, Li J, Jin Y, Lu H, Sun Y. SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection. Neoplasia. 2006;8:1042-54. (Pubitemid 44936154)
-
(2006)
Neoplasia
, vol.8
, Issue.12
, pp. 1042-1054
-
-
Tan, M.1
Gallegos, J.R.2
Gu, Q.3
Huang, Y.4
Li, J.5
Jin, Y.6
Lu, H.7
Sun, Y.8
-
94
-
-
39849098721
-
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation
-
DOI 10.1038/sj.onc.1210780, PII 1210780
-
Tan M, Gu Q, He H, Pamarthy D, Semenza GL, Sun Y. SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1 alpha ubiquitination and degradation. Oncogene. 2008;27:1404-11. (Pubitemid 351317467)
-
(2008)
Oncogene
, vol.27
, Issue.10
, pp. 1404-1411
-
-
Tan, M.1
Gu, Q.2
He, H.3
Pamarthy, D.4
Semenza, G.L.5
Sun, Y.6
-
95
-
-
34548846689
-
SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-α/NF-kappaB
-
DOI 10.1083/jcb.200612067
-
Gu Q, Bowden TG, Normolle D, Sun Y. SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage dependent targeting of c-Jun/AP1 and IkB/NF-kB. J Cell Biol. 2007;178:1009-23. (Pubitemid 47443323)
-
(2007)
Journal of Cell Biology
, vol.178
, Issue.6
, pp. 1009-1023
-
-
Gu, Q.1
Bowden, G.T.2
Normolle, D.3
Sun, Y.4
-
96
-
-
76049102305
-
Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target
-
Jia L, Yang J, Hao X, Zheng M, He H, Xiong X, Xu L, Sun Y. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. Clin Cancer Res. 2010;16:814-24.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 814-824
-
-
Jia, L.1
Yang, J.2
Hao, X.3
Zheng, M.4
He, H.5
Xiong, X.6
Xu, L.7
Sun, Y.8
-
97
-
-
58149295169
-
Targeting the ubiquitin-proteasome system for cancer therapy
-
Yang Y, Kitagaki J, Wang H, Hou DX, Perantoni AO. Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 2009;100:24-8.
-
(2009)
Cancer Sci
, vol.100
, pp. 24-28
-
-
Yang, Y.1
Kitagaki, J.2
Wang, H.3
Hou, D.X.4
Perantoni, A.O.5
-
99
-
-
34249711818
-
Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2
-
DOI 10.1074/jbc.M610879200
-
Singh RK, Iyappan S, Scheffner M. Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. J Biol Chem. 2007;282:10901-7. (Pubitemid 47100746)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.15
, pp. 10901-10907
-
-
Singh, R.K.1
Iyappan, S.2
Scheffner, M.3
-
100
-
-
31544460359
-
Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway
-
DOI 10.1158/0008-5472.CAN-05-1123
-
Desai SD, Haas AL, Wood LM, Tsai YC, Pestka S, Rubin EH, Saleem A, Nur-E-Kamal A, Liu LF. Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway. Cancer Res. 2006;66:921-8. (Pubitemid 43165959)
-
(2006)
Cancer Research
, vol.66
, Issue.2
, pp. 921-928
-
-
Desai, S.D.1
Haas, A.L.2
Wood, L.M.3
Tsai, Y.-C.4
Pestka, S.5
Rubin, E.H.6
Saleem, A.7
Nur-E-Kamal, A.8
Liu, L.F.9
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