Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin

Oncogene

Volumn 23, Issue 39, 2004, Pages 6621-6629

  Wagner, Klaus W ^a   Sapinoso, Lisa M ^a   El Rifai, Wa'el ^b   Frierson Jr , Henry F ^b   Butz, Nicole ^c   Mestan, Juergen ^c   Hofmann, Francesco ^c   Deveraux, Quinn L ^a   Hampton, Garret M ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apoptosis; DNA amplification; Gene expression; RNA interference; TRAIL DR5; UbcH10

Indexed keywords

DEATH RECEPTOR 5; PROTEIN UBCH10; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR AGONIST; UBIQUITIN CONJUGATING ENZYME; UNCLASSIFIED DRUG; PRIMER DNA; TNFRSF10B PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR; UBE2C PROTEIN, HUMAN;

ARTICLE; BLADDER CARCINOMA; BREAST CARCINOMA; CANCER INHIBITION; CARCINOMA; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA FINGERPRINTING; ENZYME INHIBITION; EPITHELIUM CELL; FIBROBLAST; GENE AMPLIFICATION; GENE IDENTIFICATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CARCINOMA; OVARY CARCINOMA; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; TUMOR DIFFERENTIATION; APOPTOSIS; CLASSIFICATION; DRUG ANTAGONISM; GENETICS; IMMUNOHISTOCHEMISTRY; NEOPLASM; NUCLEOTIDE SEQUENCE; PATHOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; GENE AMPLIFICATION; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASMS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; UBIQUITIN-CONJUGATING ENZYMES;

EID: 4444229048     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207861     Document Type: Article

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