Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-κB activation in mouse embryonic stem cells

Free Radical Biology and Medicine

Volumn 49, Issue 6, 2010, Pages 976-983

  Tan, Mingjia ^a   Zhu, Yueming ^b   Kovacev, Jordan ^c   Zhao, Yongchao ^a   Pan, Zhen Qiang ^c   Spitz, Douglas R ^b   Sun, Yi ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; E3 ligase; Free radicals; NF B; Protein ubiquitination; Radiosensitization; ROS; SAG

Indexed keywords

I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN RBX2; PROTEIN ROC2; PROTEIN SAG; REACTIVE OXYGEN METABOLITE; RING FINGER PROTEIN; STEM CELL FACTOR; SUPEROXIDE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL KILLING; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE DISRUPTION; GENE EXPRESSION; INTRACELLULAR MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; RADIATION; RADIOSENSITIZATION; STEADY STATE; UBIQUITINATION;

EID: 77955510624     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.05.030     Document Type: Article

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