Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

PLoS Genetics

Volumn 10, Issue 7, 2014, Pages

  Chalkiadaki, Angeliki ^a   Igarashi, Masaki ^a   Nasamu, Armiyaw Sebastian ^a   Knezevic, Jovana ^a   Guarente, Leonard ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SIRTUIN 1; UTROPHIN; DYSTROPHIN; PPARGC1A PROTEIN, MOUSE; SIRT1 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; ENDURANCE TRAINING; FAST MUSCLE FIBER; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; MOUSE; MUSCLE ATROPHY; NONHUMAN; SKELETAL MUSCLE; SLOW MUSCLE FIBER; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEUROMUSCULAR SYNAPSE; PATHOLOGY; PATHOPHYSIOLOGY; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; DYSTROPHIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; MICE, INBRED MDX; MUSCLE FIBERS, SLOW-TWITCH; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE; NEUROMUSCULAR JUNCTION; SIRTUIN 1; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 84905483293     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004490     Document Type: Article

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