Troxerutin improves hepatic lipid homeostasis by restoring NAD +-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice

Biochemical Pharmacology

Volumn 91, Issue 1, 2014, Pages 74-86

  Zhang, Zi Feng ^a   Fan, Shao Hua ^a   Zheng, Yuan Lin ^a   Lu, Jun ^a   Wu, Dong Mei ^a   Shan, Qun ^a   Hu, Bin ^a  

^a JIANGSU NORMAL UNIVERSITY   (China)

Author keywords

Hepatic lipid homeostasis; Lipin 1; NAFLD; SirT1; Troxerutin

Indexed keywords

4 HYDROXYNONENAL; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE PEROXIDASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIPID; LIPIN 1; LIPIN 1 ALPHA; LIPIN 1 BETA; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; SIRTUIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TROXERUTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; FATTY ACID OXIDATION; FATTY LIVER; HEPATIC LIPID HOMEOSTASIS; HYPERGLYCEMIA; HYPERLIPIDEMIA; LIPID DIET; LIPID HOMEOSTASIS; LIPID LIVER LEVEL; LIPOGENESIS; LIVER INJURY; MALE; MATING TYPE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EX527 (PUBCHEM CID 5113032); HEPATIC LIPID HOMEOSTASIS; LIPIN 1; NAD(+); NAFLD; SIRT1; TROXERUTIN; TROXERUTIN (PUBCHEM CID 9896814);

ANIMALS; DIET, HIGH-FAT; FATTY LIVER; HYDROXYETHYLRUTOSIDE; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED ICR; NAD; NUCLEAR PROTEINS; OBESITY; OXIDATIVE STRESS; PHOSPHATIDATE PHOSPHATASE; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 84905447695     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.07.002     Document Type: Article

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