Exploring the therapeutic space around NAD+

Journal of Cell Biology

Volumn 199, Issue 2, 2012, Pages 205-209

  Houtkooper, Riekelt H ^a   Auwerx, Johan ^b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE;

ACQUIRED MITOCHONDRIAL DISEASE; ARTICLE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; INHERITED MITOCHONDRIAL DISEASE; METABOLIC DISORDER; METABOLISM; PRIORITY JOURNAL;

ADP-RIBOSYL CYCLASE; ENERGY METABOLISM; HUMANS; METABOLIC DISEASES; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NAD; POLY(ADP-RIBOSE) POLYMERASES; SIGNAL TRANSDUCTION; SIRTUINS;

EID: 84869121812     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201207019     Document Type: Article

References (45)

1. Altschul, R., A. Hoffer, and J.D. Stephen. 1955. Influence of nicotinic acid on serum cholesterol in man. Arch. Biochem. Biophys. 54:558-559. http:// dx.doi.org/10.1016/0003-9861(55)90070-9
2. Ames, B.N. 2006. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proc. Natl. Acad. Sci. USA. 103:17589-17594. http://dx.doi.org/ 10.1073/pnas.0608757103
3. Bai, P., C. Canto, A. Brunyánszki, A. Huber, M. Szántó, Y. Cen, H. Yamamoto, S.M. Houten, B. Kiss, H. Oudart, et al. 2011a. PARP-2 regulates SIRT1 expression and whole-body energy expenditure. Cell Metab. 13:450-460. http://dx.doi.org/10.1016/j.cmet.2011.03.013
4. Bai, P., C. Cantó, H. Oudart, A. Brunyánszki, Y. Cen, C. Thomas, H. Yamamoto, A. Huber, B. Kiss, R.H. Houtkooper, et al. 2011b. PARP-1 inhibitionincreases mitochondrial metabolism through SIRT1 activation. Cell Metab. 13:461-468. http://dx.doi.org/10.1016/j.cmet.2011.03.004
5. Barbosa, M.T., S.M. Soares, C.M. Novak, D. Sinclair, J.A. Levine, P. Aksoy, and E.N. Chini. 2007. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J. 21:3629-3639. http://dx.doi.org/10.1096/fj.07-8290com
6. Bass, T.M., D. Weinkove, K. Houthoofd, D. Gems, and L. Partridge. 2007. Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 128:546-552. http://dx.doi.org/10.1016/ j.mad.2007.07.007
7. Baur, J.A., K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, V.V. Prabhu, J.S. Allard, G. Lopez-Lluch, K. Lewis, et al. 2006. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444: 337-342. http://dx.doi.org/10.1038/nature05354
8. Berger, F., M.H. Ramírez-Hernández, and M. Ziegler. 2004. The new life of a centenarian: signalling functions of NAD(P). Trends Biochem. Sci. 29:111-118. http://dx.doi.org/10.1016/j.tibs.2004.01.007
9. Bieganowski, P., and C. Brenner. 2004. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell. 117:495-502. http://dx.doi.org/10.1016/S0092-8674(04)00416-7
10. Burnett, C., S. Valentini, F. Cabreiro, M. Goss, M. Somogyvári, M.D. Piper, M. Hoddinott, G.L. Sutphin, V. Leko, J.J. McElwee, et al. 2011. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 477:482-485. http://dx.doi.org/10.1038/nature10296
11. Cantó, C., and J. Auwerx. 2012. Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol. Rev. 64:166-187. http://dx.doi.org/ 10.1124/pr.110.003905
12. Cantó, C., Z. Gerhart-Hines, J.N. Feige, M. Lagouge, L. Noriega, J.C. Milne, P.J. Elliott, P. Puigserver, and J. Auwerx. 2009. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature. 458:1056-1060. http://dx.doi.org/10.1038/nature07813
13. Cantó, C., L.Q. Jiang, A.S. Deshmukh, C. Mataki, A. Coste, M. Lagouge, J.R. Zierath, and J. Auwerx. 2010. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab. 11:213-219. http://dx.doi.org/10.1016/j.cmet.2010.02.006
14. Cantó, C., R.H. Houtkooper, E. Pirinen, D.Y. Youn, M.H. Oosterveer, Y. Cen, P.J. Fernandez-Marcos, H. Yamamoto, P.A. Andreux, P. Cettour-Rose, et al. 2012. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 15:838-847. http://dx.doi.org/10.1016/j.cmet.2012.04.022
15. Chen, D., J. Bruno, E. Easlon, S.J. Lin, H.L. Cheng, F.W. Alt, and L. Guarente. 2008. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev. 22:1753-1757. http://dx.doi.org/10.1101/gad.1650608
16. Elvehjem, C., R. Madden, F. Strong, and D. Woolley. 1937. Relation of nicotinic acid and nicotinic acid amide to canine black tongue. J. Am. Chem. Soc. 59:1767-1768. http://dx.doi.org/10.1021/ja01288a509
17. Fernandez-Marcos, P.J., E.H. Jeninga, C. Canto, T. Harach, V.C. de Boer, P. Andreux, N. Moullan, E. Pirinen, H. Yamamoto, S.M. Houten, et al. 2012. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep. 2:425. http://dx.doi.org/10.1038/srep00425
18. Fulco, M., Y. Cen, P. Zhao, E.P. Hoffman, M.W. McBurney, A.A. Sauve, and V. Sartorelli. 2008. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell. 14:661-673. http://dx.doi.org/10.1016/j.devcel.2008.02.004
19. Guarente, L. 2008. Mitochondria-a nexus for aging, calorie restriction, and sirtuins? Cell. 132:171-176. http://dx.doi.org/10.1016/j.cell.2008.01.007
20. Haigis, M.C., and D.A. Sinclair. 2010. Mammalian sirtuins: biological insights and disease relevance. Annu. Rev. Pathol. 5:253-295. http://dx.doi.org/ 10.1146/annurev.pathol.4.110807.092250
21. Herranz, D., M. Muñoz-Martin, M. Cañamero, F. Mulero, B. Martinez-Pastor, O. Fernandez-Capetillo, and M. Serrano. 2010. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer. Nat Commun. 1:3. http://dx.doi.org/10.1038/ncomms1001
22. Hirschey, M.D., T. Shimazu, E. Goetzman, E. Jing, B. Schwer, D.B. Lombard, C.A. Grueter, C. Harris, S. Biddinger, O.R. Ilkayeva, et al. 2010. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464:121-125. http://dx.doi.org/10.1038/nature08778
23. Houtkooper, R.H., C. Cantó, R.J. Wanders, and J. Auwerx. 2010a. The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 31:194-223. http://dx.doi.org/10.1210/er.2009-0026
24. Houtkooper, R.H., R.W. Williams, and J. Auwerx. 2010b. Metabolic networks of longevity. Cell. 142:9-14. http://dx.doi.org/10.1016/j.cell.2010.06.029
25. Houtkooper, R.H., E. Pirinen, and J. Auwerx. 2012. Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell Biol. 13:225-238.
26. Howitz, K.T., K.J. Bitterman, H.Y. Cohen, D.W. Lamming, S. Lavu, J.G. Wood, R.E. Zipkin, P. Chung, A. Kisielewski, L.L. Zhang, et al. 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425:191-196. http://dx.doi.org/10.1038/nature01960
27. Imai, S., C.M. Armstrong, M. Kaeberlein, and L. Guarente. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 403:795-800. http://dx.doi.org/10.1038/35001622
28. Kim, H.J., J.H. Kim, S. Noh, H.J. Hur, M.J. Sung, J.T. Hwang, J.H. Park, H.J. Yang, M.S. Kim, D.Y. Kwon, and S.H. Yoon. 2011. Metabolomic analysis of livers and serum from high-fat diet induced obese mice. J. Proteome Res. 10:722-731. http://dx.doi.org/10.1021/pr100892r
29. Lagouge, M., C. Argmann, Z. Gerhart-Hines, H. Meziane, C. Lerin, F. Daussin, N. Messadeq, J. Milne, P. Lambert, P. Elliott, et al. 2006. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 127:1109-1122. http://dx.doi.org/ 10.1016/j.cell.2006.11.013
30. Lin, M.T., and M.F. Beal. 2006. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 443:787-795. http://dx.doi.org/ 10.1038/nature05292
31. Lin, J., C. Handschin, and B.M. Spiegelman. 2005. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1:361-370. http://dx.doi.org/10.1016/j.cmet.2005.05.004
32. Lin, S.J., P.A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science. 289:2126-2128. http://dx.doi.org/10.1126/science.289.5487.2126
33. Patti, M.E., and S. Corvera. 2010. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr. Rev. 31:364-395. http://dx.doi.org/10.1210/ er.2009-0027
34. Pearson, K.J., J.A. Baur, K.N. Lewis, L. Peshkin, N.L. Price, N. Labinskyy, W.R. Swindell, D. Kamara, R.K. Minor, E. Perez, et al. 2008. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8:157-168. http://dx.doi.org/10.1016/j.cmet.2008.06.011
35. Rouleau, M., A. Patel, M.J. Hendzel, S.H. Kaufmann, and G.G. Poirier. 2010. PARP inhibition: PARP1 and beyond. Nat. Rev. Cancer. 10:293-301. http://dx.doi.org/10.1038/nrc2812
36. Rutanen, J., N. Yaluri, S. Modi, J. Pihlajamäki, M. Vänttinen, P. Itkonen, S. Kainulainen, H. Yamamoto, M. Lagouge, D.A. Sinclair, et al. 2010. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. 59:829-835. http://dx.doi.org/10.2337/ db09-1191
37. Schug, T.T., and X. Li. 2011. Sirtuin 1 in lipid metabolism and obesity. Ann. Med. 43:198-211. http://dx.doi.org/10.3109/07853890.2010.547211
38. Timmers, S., E. Konings, L. Bilet, R.H. Houtkooper, T. van de Weijer, G.H. Goossens, J. Hoeks, S. van der Krieken, D. Ryu, S. Kersten, et al. 2011. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 14:612-622. http://dx.doi.org/10.1016/j.cmet.2011.10.002
39. Timmers, S., J. Auwerx, and P. Schrauwen. 2012. The journey of resveratrol from yeast to human. Aging (Albany NY). 4:146-158.
40. Tissenbaum, H.A., and L. Guarente. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature. 410:227-230. http://dx.doi.org/10.1038/35065638
41. Tunaru, S., J. Kero, A. Schaub, C. Wufka, A. Blaukat, K. Pfeffer, and S. Offermanns. 2003. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9:352-355. http://dx.doi.org/ 10.1038/nm824
42. van der Horst, A., and B.M. Burgering. 2007. Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol. 8:440-450. http://dx.doi.org/ 10.1038/nrm2190
43. Viscomi, C., E. Bottani, G. Civiletto, R. Cerutti, M. Moggio, G. Fagiolari, E.A. Schon, C. Lamperti, and M. Zeviani. 2011. In vivo correction of COX deficiency by activation of the AMPK/PGC-1α axis. Cell Metab. 14: 80-90. http://dx.doi.org/10.1016/j.cmet.2011.04.011
44. Wise, A., S.M. Foord, N.J. Fraser, A.A. Barnes, N. Elshourbagy, M. Eilert, D.M. Ignar, P.R. Murdock, K. Steplewski, A. Green, et al. 2003. Molecular identification of high and low affinity receptors for nicotinic acid. J. Biol. Chem. 278:9869-9874. http://dx.doi.org/10.1074/jbc.M210695200
45. Yoshino, J., K.F. Mills, M.J. Yoon, and S. Imai. 2011. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 14:528-536. http://dx.doi.org/ 10.1016/j.cmet.2011.08.014