Caspase inhibition augments Dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation

Neuroscience

Volumn 258, Issue , 2014, Pages 1-15

  Wani, W Y ^a   Sunkaria, A ^a   Sharma, D R ^a   Kandimalla, R J L ^a   Kaushal, A ^a   Gerace, E ^b   Chiarugi, A ^b   Gill, K D ^a  

^a POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Caspase inhibition; Dichlorvos; Organophosphate; Oxidative stress; PARP1 activation

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOPTOSIS INDUCING FACTOR; CASPASE; CASPASE INHIBITOR; DICHLORVOS; GLUTATHIONE; LACTATE DEHYDROGENASE; MANGANESE SUPEROXIDE DISMUTASE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL LEVEL; CELL NUCLEUS; CELL TRANSPORT; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; LIPID PEROXIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NERVE CELL NECROSIS; NEUROPROTECTION; OXIDATIVE STRESS; PC12 CELL; PRIORITY JOURNAL; PROTEIN CARBONYLATION;

2,4-DINITROPHENYL HYDRAZINE; 3-(4,5-DIMETHYLTHIAZOL-2-YL)-2,5-DIPHENYLTETRAZOLIUM BROMIDE; 4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC ACID; 4′,6-DIAMIDINO-2-PHENYLINDOLE; ACETYLCHOLINESTERASE; ACHE; AIF; APOPTOSIS-INDUCING FACTOR; BAF; BOC-ASPARTYL(OME)-FLUOROMETHYLKETONE; CASPASE INHIBITION; DAPI; DCFH-DA; DICHLORO-DIHYDRO-FLUORESCEIN DIACETATE; DICHLORVOS; DIHYDRODICHLOROFLUORESCEIN DIACETATE; DNPH; EDTA; EGTA; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHYLENE GLYCOL TETRAACETIC ACID; ETHYLENEDIAMINETETRAACETIC ACID; H2DCF-DA; HEPES; IC50; INHIBITORY CONCENTRATION 50; LACTATE DEHYDROGENASE; LDH; MALONDIALDEHYDE; MDA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY TRANSITION; MMP; MN-SUPEROXIDE DISMUTASE; MNSOD; MPT; MTT; OP; ORGANOPHOSPHATE; OXIDATIVE STRESS; PARP1; PARP1 ACTIVATION; PBS; PHOSPHATE-BUFFERED SALINE; POLY(ADP-RIBOSE) POLYMERASE-1; REACTIVE OXYGEN SPECIES; ROOM TEMPERATURE; ROS; RT;

ADENOSINE TRIPHOSPHATE; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS INDUCING FACTOR; CASPASE INHIBITORS; CELL DEATH; CELL SURVIVAL; DICHLORVOS; DOPAMINE; INSECTICIDES; NAD; NEURONS; OXIDATIVE STRESS; PC12 CELLS; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; RATS; REACTIVE OXYGEN SPECIES;

EID: 84890061147     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.11.004     Document Type: Article

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