MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

EMBO Journal

Volumn 33, Issue 15, 2014, Pages 1667-1680

  Banzhaf Strathmann, Julia ^a   Benito, Eva ^b   May, Stephanie ^a   Arzberger, Thomas ^a,c,d   Tahirovic, Sabina ^a   Kretzschmar, Hans ^c   Fischer, André ^b,e   Edbauer, Dieter ^a,c,f  

^a GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^b EUROPEAN NEUROSCIENCE INSTITUTE   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

^f Adolf Butenandt Institute Biochemistry Ludwig Maximilians University Munich ^*  (Germany)

Author keywords

Alzheimer's disease; kinases; microRNA 125b; phosphatases; tau phosphorylation

Indexed keywords

CASPASE; CYCLIN DEPENDENT KINASE 5; DUAL SPECIFICITY PHOSPHATASE 6; LENTIVIRUS VECTOR; MICRORNA; MICRORNA 125B; MICRORNA 127; MICRORNA 134; MICRORNA 143; MICRORNA 16; MICRORNA 23B; MICRORNA 29A; MICRORNA 29B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PROTEIN BCL W; PROTEIN P35; TAU PROTEIN; UNCLASSIFIED DRUG;

AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CELL VIABILITY; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STATE DEPENDENT LEARNING; UPREGULATION; VERY ELDERLY;

ALZHEIMER'S DISEASE; KINASES; MICRORNA-125B; PHOSPHATASES; TAU PHOSPHORYLATION;

ALZHEIMER DISEASE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; COGNITION DISORDERS; DOWN-REGULATION; DUAL SPECIFICITY PHOSPHATASE 6; GENE KNOCKOUT TECHNIQUES; HIPPOCAMPUS; HUMANS; MEMORY; MICE; MICE, INBRED C57BL; MICRORNAS; NEURONS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; TAU PROTEINS;

EID: 84905406846     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201387576     Document Type: Article

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