Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 20, 2009, Pages 8192-8197

  Alian, Akram ^a   Griner, Sarah L ^a   Chiang, Vicki ^c   Tsiang, Manuel ^c   Jones, Gregg ^c   Birkus, Gabriel ^c   Geleziunas, Romas ^c   Leavitt, Andrew D ^a   Stroud, Robert M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GILEAD SCIENCES   (United States)

Author keywords

Covalent; Cross linking; Disulfide; DNA binding; Strand transfer

Indexed keywords

ANTIVIRUS AGENT; CYSTEINE; DISULFIDE; INTEGRASE; INTEGRASE INHIBITOR; TETRAMER; VIRUS DNA;

ARTICLE; CATALYSIS; DISULFIDE BOND; DNA PROTEIN COMPLEX; DRUG DNA BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION; PRIORITY JOURNAL; RETROVIRUS; THERMODYNAMICS; VIRUS DNA CELL DNA INTERACTION;

CATALYSIS; DISULFIDES; DNA, VIRAL; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 66249088004     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811919106     Document Type: Article

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