메뉴 건너뛰기




Volumn 28, Issue 8, 2014, Pages 1316-1328

Endogenous ω-3 polyunsaturated fatty acid production confers resistance to obesity, dyslipidemia, and diabetes in mice

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE 1; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEUKOTRIENE B4; LIPID; LIVER X RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; CADHERIN; FATH PROTEIN, MOUSE;

EID: 84905241884     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2014-1011     Document Type: Article
Times cited : (53)

References (63)
  • 1
    • 0642342752 scopus 로고    scopus 로고
    • The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase
    • Kang JX. The importance of omega-6/omega-3 fatty acid ratio in cell function. The gene transfer of omega-3 fatty acid desaturase. World Rev Nutr Diet. 2003;92:23-36.
    • (2003) World Rev Nutr Diet , vol.92 , pp. 23-36
    • Kang, J.X.1
  • 2
    • 0035752179 scopus 로고    scopus 로고
    • Evolutionary aspects of diet and essential fatty acids
    • Simopoulos AP. Evolutionary aspects of diet and essential fatty acids. World Rev Nutr Diet. 2001;88:18-27.
    • (2001) World Rev Nutr Diet , vol.88 , pp. 18-27
    • Simopoulos, A.P.1
  • 3
    • 0036097472 scopus 로고    scopus 로고
    • β-Cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia
    • Biarnés M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E. β-Cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes. 2002;51: 66-72.
    • (2002) Diabetes , vol.51 , pp. 66-72
    • Biarnés, M.1    Montolio, M.2    Nacher, V.3    Raurell, M.4    Soler, J.5    Montanya, E.6
  • 4
    • 80054009428 scopus 로고    scopus 로고
    • Effect of high-fat diets on body composition, lipid metabolism and insulin sensitivity, and the role of exercise on these parameters
    • Coelho DF, Pereira-Lancha LO, Chaves DS, et al. Effect of high-fat diets on body composition, lipid metabolism and insulin sensitivity, and the role of exercise on these parameters. Braz J Med Biol Res. 2011;44:966-972.
    • (2011) Braz J Med Biol Res , vol.44 , pp. 966-972
    • Coelho, D.F.1    Pereira-Lancha, L.O.2    Chaves, D.S.3
  • 5
    • 84893022065 scopus 로고    scopus 로고
    • Update on cardiometabolic health effects of ω-3 fatty acids
    • Kromhout D, de Goede J. Update on cardiometabolic health effects of ω-3 fatty acids. Curr Opin Lipidol. 2014;25:85-90.
    • (2014) Curr Opin Lipidol , vol.25 , pp. 85-90
    • Kromhout, D.1    de Goede, J.2
  • 6
    • 0019293677 scopus 로고
    • Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974
    • Kromann N, Green A. Epidemiological studies in the Upernavik district, Greenland. Incidence of some chronic diseases 1950-1974. Acta Med Scand. 1980;208:401-406.
    • (1980) Acta Med Scand , vol.208 , pp. 401-406
    • Kromann, N.1    Green, A.2
  • 7
    • 0027988668 scopus 로고
    • Lower prevalence of impaired glucose tolerance and diabetes associated with daily seal oil or salmon consumption among Alaska Natives
    • Adler AI, Boyko EJ, Schraer CD, Murphy NJ. Lower prevalence of impaired glucose tolerance and diabetes associated with daily seal oil or salmon consumption among Alaska Natives. Diabetes Care. 1994;17:1498-1501.
    • (1994) Diabetes Care , vol.17 , pp. 1498-1501
    • Adler, A.I.1    Boyko, E.J.2    Schraer, C.D.3    Murphy, N.J.4
  • 9
    • 14744280322 scopus 로고    scopus 로고
    • N-3 long-chain polyunsaturated fatty acids in type 2 diabetes: A review
    • Nettleton JA, Katz R. n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J Am Diet Assoc. 2005;105:428-440.
    • (2005) J Am Diet Assoc , vol.105 , pp. 428-440
    • Nettleton, J.A.1    Katz, R.2
  • 10
    • 33750141751 scopus 로고    scopus 로고
    • Fish intake, contaminants, and human health: Evaluating the risks and the benefits
    • Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006;296: 1885-1899.
    • (2006) JAMA , vol.296 , pp. 1885-1899
    • Mozaffarian, D.1    Rimm, E.B.2
  • 11
    • 0036177755 scopus 로고    scopus 로고
    • A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age
    • Birch EE, Hoffman DR, Castañeda YS, Fawcett SL, Birch DG, Uauy RD. A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. Am J Clin Nutr. 2002;75:570-580.
    • (2002) Am J Clin Nutr , vol.75 , pp. 570-580
    • Birch, E.E.1    Hoffman, D.R.2    Castañeda, Y.S.3    Fawcett, S.L.4    Birch, D.G.5    Uauy, R.D.6
  • 12
    • 0032770870 scopus 로고    scopus 로고
    • Blood lipid concentrations of docosahexaenoic and arachidonic acids at birth determine their relative postnatal changes in term infants fed breast milk or formula
    • Guesnet P, Pugo-Gunsam P, Maurage C, et al. Blood lipid concentrations of docosahexaenoic and arachidonic acids at birth determine their relative postnatal changes in term infants fed breast milk or formula. Am J Clin Nutr. 1999;70:292-298.
    • (1999) Am J Clin Nutr , vol.70 , pp. 292-298
    • Guesnet, P.1    Pugo-Gunsam, P.2    Maurage, C.3
  • 14
    • 23844453049 scopus 로고    scopus 로고
    • Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with omega-3 polyunsaturated fatty acids
    • Fontani G, Corradeschi F, Felici A, et al. Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with omega-3 polyunsaturated fatty acids. Eur J Clin Invest. 2005; 35:499-507.
    • (2005) Eur J Clin Invest , vol.35 , pp. 499-507
    • Fontani, G.1    Corradeschi, F.2    Felici, A.3
  • 15
    • 84950170958 scopus 로고    scopus 로고
    • Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors
    • Hill AM, Buckley JD, Murphy KJ, Howe PR. Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors. Am J Clin Nutr. 2007;85:1267-1274.
    • (2007) Am J Clin Nutr , vol.85 , pp. 1267-1274
    • Hill, A.M.1    Buckley, J.D.2    Murphy, K.J.3    Howe, P.R.4
  • 16
    • 0036730666 scopus 로고    scopus 로고
    • Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome
    • Risérus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002;25:1516-1521.
    • (2002) Diabetes Care , vol.25 , pp. 1516-1521
    • Risérus, U.1    Arner, P.2    Brismar, K.3    Vessby, B.4
  • 17
    • 0037224545 scopus 로고    scopus 로고
    • The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus
    • Belury MA, Mahon A, Banni S. The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr. 2003;133:257S-260S.
    • (2003) J Nutr , vol.133
    • Belury, M.A.1    Mahon, A.2    Banni, S.3
  • 18
    • 33747068377 scopus 로고    scopus 로고
    • Factorial study of the effect of n-3 fatty acid supplementation and atorvastatin on the kinetics of HDL apolipoproteins A-I and A-II in men with abdominal obesity
    • Chan DC, Watts GF, Nguyen MN, Barrett PH. Factorial study of the effect of n-3 fatty acid supplementation and atorvastatin on the kinetics of HDL apolipoproteins A-I and A-II in men with abdominal obesity. Am J Clin Nutr. 2006;84:37-43.
    • (2006) Am J Clin Nutr , vol.84 , pp. 37-43
    • Chan, D.C.1    Watts, G.F.2    Nguyen, M.N.3    Barrett, P.H.4
  • 19
    • 1142310943 scopus 로고    scopus 로고
    • Transgenic mice: Fat-1 mice convert n-6 to n-3 fatty acids
    • Kang JX, Wang J, Wu L, Kang ZB. Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature. 2004;427:504.
    • (2004) Nature , vol.427 , pp. 504
    • Kang, J.X.1    Wang, J.2    Wu, L.3    Kang, Z.B.4
  • 20
    • 0032814457 scopus 로고    scopus 로고
    • Regulation of gene expression by dietary fat
    • Jump DB, Clarke SD. Regulation of gene expression by dietary fat. Annu Rev Nutr. 1999;19:63-90.
    • (1999) Annu Rev Nutr , vol.19 , pp. 63-90
    • Jump, D.B.1    Clarke, S.D.2
  • 21
    • 0036213141 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids and regulation of gene transcription
    • Jump DB. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol. 2002;13:155-164.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 155-164
    • Jump, D.B.1
  • 22
    • 84950170953 scopus 로고
    • Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages
    • Suzukawa M, Abbey M, Howe PR, Nestel PJ. Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages. J Lipid Res. 1995;36:473-484.
    • (1995) J Lipid Res , vol.36 , pp. 473-484
    • Suzukawa, M.1    Abbey, M.2    Howe, P.R.3    Nestel, P.J.4
  • 24
    • 84867892916 scopus 로고    scopus 로고
    • Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat dietinduced non-alcoholic fatty liver disease
    • Kim EH, Bae JS, Hahm KB, Cha JY. Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 mice ameliorate high-fat dietinduced non-alcoholic fatty liver disease. Biochem Pharmacol. 2012;84:1359-1365.
    • (2012) Biochem Pharmacol , vol.84 , pp. 1359-1365
    • Kim, E.H.1    Bae, J.S.2    Hahm, K.B.3    Cha, J.Y.4
  • 25
    • 78650060401 scopus 로고    scopus 로고
    • Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice
    • White PJ, Arita M, Taguchi R, Kang JX, Marette A. Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice. Diabetes. 2010; 59:3066-3073.
    • (2010) Diabetes , vol.59 , pp. 3066-3073
    • White, P.J.1    Arita, M.2    Taguchi, R.3    Kang, J.X.4    Marette, A.5
  • 26
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 27
    • 0020534084 scopus 로고
    • Isolation of mouse liver cells: Perfusion technique and metabolic evaluation
    • Edström S, Ekman L, Ternell M, Lundholm K. Isolation of mouse liver cells: perfusion technique and metabolic evaluation. Eur Surg Res. 1983;15:97-102.
    • (1983) Eur Surg Res , vol.15 , pp. 97-102
    • Edström, S.1    Ekman, L.2    Ternell, M.3    Lundholm, K.4
  • 28
    • 38649096259 scopus 로고    scopus 로고
    • Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR γ in promoting steatosis
    • Zhou J, Febbraio M, Wada T, et al. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR γ in promoting steatosis. Gastroenterology. 2008;134:556-567.
    • (2008) Gastroenterology , vol.134 , pp. 556-567
    • Zhou, J.1    Febbraio, M.2    Wada, T.3
  • 29
    • 0028321529 scopus 로고
    • Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
    • Kliewer SA, Forman BM, Blumberg B, et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA. 1994;91:7355-7359.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7355-7359
    • Kliewer, S.A.1    Forman, B.M.2    Blumberg, B.3
  • 30
    • 38949216025 scopus 로고    scopus 로고
    • Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylatio
    • Hosooka T, Noguchi T, Kotani K, et al. Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation. Nat Med. 2008;14:188-193.
    • (2008) Nat Med , vol.14 , pp. 188-193
    • Hosooka, T.1    Noguchi, T.2    Kotani, K.3
  • 31
    • 34447130778 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
    • Choi CS, Fillmore JJ, Kim JK, et al. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest. 2007;117:1995-2003.
    • (2007) J Clin Invest , vol.117 , pp. 1995-2003
    • Choi, C.S.1    Fillmore, J.J.2    Kim, J.K.3
  • 32
    • 33746625086 scopus 로고    scopus 로고
    • Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
    • Hudert CA, Weylandt KH, Lu Y, et al. Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci USA. 2006;103:11276-11281.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11276-11281
    • Hudert, C.A.1    Weylandt, K.H.2    Lu, Y.3
  • 33
    • 67650473883 scopus 로고    scopus 로고
    • Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid
    • He C, Qu X, Cui L, Wang J, Kang JX. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci USA. 2009;106:11370-11375.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 11370-11375
    • He, C.1    Qu, X.2    Cui, L.3    Wang, J.4    Kang, J.X.5
  • 34
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407:908-913.
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 35
    • 77449096697 scopus 로고    scopus 로고
    • Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance
    • Ye R, Jung DY, Jun JY, et al. Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. Diabetes. 2010;59:6-16.
    • (2010) Diabetes , vol.59 , pp. 6-16
    • Ye, R.1    Jung, D.Y.2    Jun, J.Y.3
  • 36
    • 53249093993 scopus 로고    scopus 로고
    • Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure
    • Knauf C, Cani PD, Ait-Belgnaoui A, et al. Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure. Endocrinology. 2008; 149:4768-4777.
    • (2008) Endocrinology , vol.149 , pp. 4768-4777
    • Knauf, C.1    Cani, P.D.2    Ait-Belgnaoui, A.3
  • 37
    • 77449141236 scopus 로고    scopus 로고
    • Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic β-cells and islets enhance insulin secretion and confer protection against cytokineinduced cell death
    • Wei D, Li J, Shen M, et al. Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic β-cells and islets enhance insulin secretion and confer protection against cytokineinduced cell death. Diabetes. 2010;59:471-478.
    • (2010) Diabetes , vol.59 , pp. 471-478
    • Wei, D.1    Li, J.2    Shen, M.3
  • 38
    • 2142756699 scopus 로고    scopus 로고
    • LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1
    • Wang Y, Kurdi-Haidar B, Oram JF. LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1. J Lipid Res. 2004;45:972-980.
    • (2004) J Lipid Res , vol.45 , pp. 972-980
    • Wang, Y.1    Kurdi-Haidar, B.2    Oram, J.F.3
  • 39
    • 33646588329 scopus 로고    scopus 로고
    • Liver X receptor agonist TO- 901317 upregulates SCD1 expression in renal proximal straight tubule
    • Zhang Y, Zhang X, Chen L, et al. Liver X receptor agonist TO- 901317 upregulates SCD1 expression in renal proximal straight tubule. Am J Physiol Renal Physiol. 2006;290:F1065-F1073.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Zhang, Y.1    Zhang, X.2    Chen, L.3
  • 40
    • 33746266935 scopus 로고    scopus 로고
    • Glucose regulates LXR α subcellular localization and function in rat pancreatic β-cells
    • Helleboid-Chapman A, Helleboid S, Jakel H, et al. Glucose regulates LXR α subcellular localization and function in rat pancreatic β-cells. Cell Res. 2006;16:661-670.
    • (2006) Cell Res , vol.16 , pp. 661-670
    • Helleboid-Chapman, A.1    Helleboid, S.2    Jakel, H.3
  • 41
    • 33846208252 scopus 로고    scopus 로고
    • The nuclear receptor LXR is a glucose sensor
    • Mitro N, Mak PA, Vargas L, et al. The nuclear receptor LXR is a glucose sensor. Nature. 2007;445:219-223.
    • (2007) Nature , vol.445 , pp. 219-223
    • Mitro, N.1    Mak, P.A.2    Vargas, L.3
  • 42
    • 84874806070 scopus 로고    scopus 로고
    • Mechanisms of insulin resistance in obesity
    • Ye J. Mechanisms of insulin resistance in obesity. Front Med. 2013; 7:14-24.
    • (2013) Front Med , vol.7 , pp. 14-24
    • Ye, J.1
  • 43
    • 49749141035 scopus 로고    scopus 로고
    • Antiinflammatory properties of omega-3 fatty acids in critical illness: Novel mechanisms and an integrative perspective
    • Singer P, Shapiro H, Theilla M, Anbar R, Singer J, Cohen J. Antiinflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective. Intensive Care Med. 2008;34:1580-1592.
    • (2008) Intensive Care Med , vol.34 , pp. 1580-1592
    • Singer, P.1    Shapiro, H.2    Theilla, M.3    Anbar, R.4    Singer, J.5    Cohen, J.6
  • 44
    • 12544256898 scopus 로고    scopus 로고
    • Effects of dietary n-3 polyunsaturated fatty acids on T-cell membrane composition and function
    • Switzer KC, McMurray DN, Chapkin RS. Effects of dietary n-3 polyunsaturated fatty acids on T-cell membrane composition and function. Lipids. 2004;39:1163-1170.
    • (2004) Lipids , vol.39 , pp. 1163-1170
    • Switzer, K.C.1    McMurray, D.N.2    Chapkin, R.S.3
  • 45
    • 0642311983 scopus 로고    scopus 로고
    • Importance of the ratio of omega-6/omega-3 essential fatty acids: Evolutionary aspects
    • Simopoulos AP. Importance of the ratio of omega-6/omega-3 essential fatty acids: evolutionary aspects. World Rev Nutr Diet. 2003;92:1-22.
    • (2003) World Rev Nutr Diet , vol.92 , pp. 1-22
    • Simopoulos, A.P.1
  • 46
    • 0037534877 scopus 로고    scopus 로고
    • Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    • Leaf A, Kang JX, Xiao YF, Billman GE. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation. 2003;107:2646-2652.
    • (2003) Circulation , vol.107 , pp. 2646-2652
    • Leaf, A.1    Kang, J.X.2    Xiao, Y.F.3    Billman, G.E.4
  • 47
    • 84880578189 scopus 로고    scopus 로고
    • Omega-3 fatty acids: Mechanisms underlying 'protective effects' in atherosclerosis
    • Chang CL, Deckelbaum RJ. Omega-3 fatty acids: mechanisms underlying 'protective effects' in atherosclerosis. Curr Opin Lipidol. 2013;24:345-350.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 345-350
    • Chang, C.L.1    Deckelbaum, R.J.2
  • 48
    • 33749154105 scopus 로고    scopus 로고
    • Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review
    • Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis. 2006;189:19-30.
    • (2006) Atherosclerosis , vol.189 , pp. 19-30
    • Balk, E.M.1    Lichtenstein, A.H.2    Chung, M.3    Kupelnick, B.4    Chew, P.5    Lau, J.6
  • 49
    • 20044387026 scopus 로고    scopus 로고
    • IKK-β links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR, et al. IKK-β links inflammation to obesity-induced insulin resistance. Nat Med. 2005;11:191-198.
    • (2005) Nat Med , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 50
    • 34250840799 scopus 로고    scopus 로고
    • Hepatic tumor necrosis factor signaling and nuclear factor-κB: Effects on liver homeostasis and beyond
    • Wullaert A, van Loo G, Heyninck K, Beyaert R. Hepatic tumor necrosis factor signaling and nuclear factor-κB: effects on liver homeostasis and beyond. Endocr Rev. 2007;28:365-386.
    • (2007) Endocr Rev , vol.28 , pp. 365-386
    • Wullaert, A.1    van Loo, G.2    Heyninck, K.3    Beyaert, R.4
  • 51
    • 69449097633 scopus 로고    scopus 로고
    • The protein kinase IKKepsilon regulates energy balance in obese mice
    • Chiang SH, Bazuine M, Lumeng CN, et al. The protein kinase IKKepsilon regulates energy balance in obese mice. Cell. 2009;138: 961-975.
    • (2009) Cell , vol.138 , pp. 961-975
    • Chiang, S.H.1    Bazuine, M.2    Lumeng, C.N.3
  • 52
    • 18644382785 scopus 로고    scopus 로고
    • The clinical significance of PPAR γ agonism
    • Campbell IW. The clinical significance of PPAR γ agonism. Curr Mol Med. 2005;5:349-363.
    • (2005) Curr Mol Med , vol.5 , pp. 349-363
    • Campbell, I.W.1
  • 53
    • 0842263981 scopus 로고    scopus 로고
    • The biology of peroxisome proliferator-activated receptors: Relationship with lipid metabolism and insulin sensitivity
    • Ferré P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes. 2004;53(suppl 1):S43-S50.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Ferré, P.1
  • 54
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med. 2002;53:409-435.
    • (2002) Annu Rev Med , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 55
    • 0037143752 scopus 로고    scopus 로고
    • Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    • Ntambi JM, Miyazaki M, Stoehr JP, et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA. 2002;99:11482-11486.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11482-11486
    • Ntambi, J.M.1    Miyazaki, M.2    Stoehr, J.P.3
  • 56
    • 84860476011 scopus 로고    scopus 로고
    • Omega 3 fatty acids and GPR120
    • Oh DY, Olefsky JM. Omega 3 fatty acids and GPR120. Cell Metab. 2012;15:564-565.
    • (2012) Cell Metab , vol.15 , pp. 564-565
    • Oh, D.Y.1    Olefsky, J.M.2
  • 57
    • 84858285593 scopus 로고    scopus 로고
    • Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
    • Ichimura A, Hirasawa A, Poulain-Godefroy O, et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012;483:350-354.
    • (2012) Nature , vol.483 , pp. 350-354
    • Ichimura, A.1    Hirasawa, A.2    Poulain-Godefroy, O.3
  • 58
    • 17844388556 scopus 로고    scopus 로고
    • Endocannabinoid control of food intake and energy balance
    • Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci. 2005;8:585-589.
    • (2005) Nat Neurosci , vol.8 , pp. 585-589
    • Di Marzo, V.1    Matias, I.2
  • 59
    • 25844460609 scopus 로고    scopus 로고
    • Activation of the peripheral endocannabinoid system in human obesity
    • Engeli S, Böhnke J, Feldpausch M, et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes. 2005;54: 2838-2843.
    • (2005) Diabetes , vol.54 , pp. 2838-2843
    • Engeli, S.1    Böhnke, J.2    Feldpausch, M.3
  • 60
    • 72949087988 scopus 로고    scopus 로고
    • Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis
    • Rahman MM, Bhattacharya A, Banu J, Kang JX, Fernandes G. Endogenous n-3 fatty acids protect ovariectomy induced bone loss by attenuating osteoclastogenesis. J Cell Mol Med. 2009;13:1833-1844.
    • (2009) J Cell Mol Med , vol.13 , pp. 1833-1844
    • Rahman, M.M.1    Bhattacharya, A.2    Banu, J.3    Kang, J.X.4    Fernandes, G.5
  • 61
    • 55749110745 scopus 로고    scopus 로고
    • Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 β phosphorylation
    • Lu Y, Nie D, Witt WT, et al. Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 β phosphorylation. Mol Cancer Ther. 2008;7: 3203-3211.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3203-3211
    • Lu, Y.1    Nie, D.2    Witt, W.T.3
  • 62
    • 34848875143 scopus 로고    scopus 로고
    • Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids
    • Nowak J, Weylandt KH, Habbel P, et al. Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids. Carcinogenesis. 2007;28:1991-1995.
    • (2007) Carcinogenesis , vol.28 , pp. 1991-1995
    • Nowak, J.1    Weylandt, K.H.2    Habbel, P.3
  • 63
    • 84954358310 scopus 로고    scopus 로고
    • Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis
    • Weylandt KH, Nadolny A, Kahlke L, et al. Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis. Biochim Biophys Acta. 2008; 1782:634-641.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 634-641
    • Weylandt, K.H.1    Nadolny, A.2    Kahlke, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.