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Volumn 16, Issue 5, 2014, Pages 531-547

Advancing biomarker research: Utilizing 'Big Data' approaches for the characterization and prevention of bipolar disorder

Author keywords

Big Data; Biomarkers; Bipolar disorder; Integrated profiles; Prediction; Prodrome

Indexed keywords

BIOLOGICAL MARKER; N ACETYLASPARTIC ACID;

EID: 84905216459     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/bdi.12162     Document Type: Review
Times cited : (55)

References (124)
  • 2
    • 79957678800 scopus 로고    scopus 로고
    • Performance improvement CME: long-term treatment of bipolar disorder
    • McIntyre RS, Wagner KD. Performance improvement CME: long-term treatment of bipolar disorder. J Clin Psychiatry 2011; 72: e09.
    • (2011) J Clin Psychiatry , vol.72
    • McIntyre, R.S.1    Wagner, K.D.2
  • 3
    • 79960044482 scopus 로고    scopus 로고
    • Grand challenges in global mental health
    • Collins PY, Patel V, Joestl SS et al. Grand challenges in global mental health. Nature 2011; 475: 27-30.
    • (2011) Nature , vol.475 , pp. 27-30
    • Collins, P.Y.1    Patel, V.2    Joestl, S.S.3
  • 4
    • 78649938042 scopus 로고    scopus 로고
    • Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors
    • Berk M, Kapczinski F, Andreazza AC et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 2011; 35: 804-817.
    • (2011) Neurosci Biobehav Rev , vol.35 , pp. 804-817
    • Berk, M.1    Kapczinski, F.2    Andreazza, A.C.3
  • 7
    • 77955648973 scopus 로고    scopus 로고
    • Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence
    • López-Jaramillo C, Lopera-Vasquez J, Gallo A et al. Effects of recurrence on the cognitive performance of patients with bipolar I disorder: implications for relapse prevention and treatment adherence. Bipolar Disord 2010; 12: 557-567.
    • (2010) Bipolar Disord , vol.12 , pp. 557-567
    • López-Jaramillo, C.1    Lopera-Vasquez, J.2    Gallo, A.3
  • 8
    • 84860528248 scopus 로고    scopus 로고
    • Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies
    • Fusar-Poli P, Howes O, Bechdolf A, Borgwardt S. Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies. J Psychiatry Neurosci 2012; 37: 170-184.
    • (2012) J Psychiatry Neurosci , vol.37 , pp. 170-184
    • Fusar-Poli, P.1    Howes, O.2    Bechdolf, A.3    Borgwardt, S.4
  • 9
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group;
    • Biomarkers Definitions Working Group; Atkinson AJ, Colburn WA, DeGruttola VG et al. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69: 89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
    • Atkinson, A.J.1    Colburn, W.A.2    DeGruttola, V.G.3
  • 10
    • 67049134827 scopus 로고    scopus 로고
    • Metabolomics tools for identifying biomarkers for neuropsychiatric diseases
    • Quinones MP, Kaddurah-Daouk R. Metabolomics tools for identifying biomarkers for neuropsychiatric diseases. Neurobiol Dis 2009; 35: 165-176.
    • (2009) Neurobiol Dis , vol.35 , pp. 165-176
    • Quinones, M.P.1    Kaddurah-Daouk, R.2
  • 11
    • 0038823525 scopus 로고    scopus 로고
    • The endophenotype concept in psychiatry: etymology and strategic intentions
    • Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645.
    • (2003) Am J Psychiatry , vol.160 , pp. 636-645
    • Gottesman, I.I.1    Gould, T.D.2
  • 12
    • 84855896342 scopus 로고    scopus 로고
    • Early detection and intervention in bipolar affective disorder: targeting the development of the disorder
    • Howes OD, Falkenberg I. Early detection and intervention in bipolar affective disorder: targeting the development of the disorder. Curr Psychiatry Rep 2011; 13: 493-499.
    • (2011) Curr Psychiatry Rep , vol.13 , pp. 493-499
    • Howes, O.D.1    Falkenberg, I.2
  • 13
    • 80053332503 scopus 로고    scopus 로고
    • Strategies for the early recognition of bipolar disorder
    • Ketter TA. Strategies for the early recognition of bipolar disorder. J Clin Psychiatry 2011; 72: e22.
    • (2011) J Clin Psychiatry , vol.72
    • Ketter, T.A.1
  • 14
    • 77950331526 scopus 로고    scopus 로고
    • Baseline characteristics and outcomes in patients with first episode or multiple episodes of acute mania
    • Tohen M, Vieta E, Gonzalez-Pinto A, Reed C, Lin D. Baseline characteristics and outcomes in patients with first episode or multiple episodes of acute mania. J Clin Psychiatry 2010; 71: 255-261.
    • (2010) J Clin Psychiatry , vol.71 , pp. 255-261
    • Tohen, M.1    Vieta, E.2    Gonzalez-Pinto, A.3    Reed, C.4    Lin, D.5
  • 15
    • 79951474765 scopus 로고    scopus 로고
    • Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention
    • Berk M, Brnabic A, Dodd S et al. Does stage of illness impact treatment response in bipolar disorder? Empirical treatment data and their implication for the staging model and early intervention. Bipolar Disord 2011; 13: 87-98.
    • (2011) Bipolar Disord , vol.13 , pp. 87-98
    • Berk, M.1    Brnabic, A.2    Dodd, S.3
  • 16
    • 33645676093 scopus 로고    scopus 로고
    • Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial
    • Scott J, Paykel E, Morriss R et al. Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial. Br J Psychiatry 2006; 188: 313-320.
    • (2006) Br J Psychiatry , vol.188 , pp. 313-320
    • Scott, J.1    Paykel, E.2    Morriss, R.3
  • 17
    • 84873920431 scopus 로고    scopus 로고
    • Parsing trait and state effects of depression severity on neurocognition: evidence from a 26-year longitudinal study
    • Sarapas C, Shankman SA, Harrow M, Goldberg JF. Parsing trait and state effects of depression severity on neurocognition: evidence from a 26-year longitudinal study. J Abnorm Psychol 2012; 121: 830-837.
    • (2012) J Abnorm Psychol , vol.121 , pp. 830-837
    • Sarapas, C.1    Shankman, S.A.2    Harrow, M.3    Goldberg, J.F.4
  • 18
    • 84860366658 scopus 로고    scopus 로고
    • Depression in bipolar disorder versus major depressive disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions
    • Moreno C, Hasin DS, Arango C et al. Depression in bipolar disorder versus major depressive disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Bipolar Disord 2012; 14: 271-282.
    • (2012) Bipolar Disord , vol.14 , pp. 271-282
    • Moreno, C.1    Hasin, D.S.2    Arango, C.3
  • 19
    • 84858328536 scopus 로고    scopus 로고
    • Cognition in older adults with bipolar disorder versus major depressive disorder
    • Gildengers AG, Butters MA, Chisholm D et al. Cognition in older adults with bipolar disorder versus major depressive disorder. Bipolar Disord 2012; 14: 198-205.
    • (2012) Bipolar Disord , vol.14 , pp. 198-205
    • Gildengers, A.G.1    Butters, M.A.2    Chisholm, D.3
  • 20
    • 36749050920 scopus 로고    scopus 로고
    • Differentiating bipolar disorders from major depressive disorders: treatment implications
    • Muzina DJ, Kemp DE, McIntyre RS. Differentiating bipolar disorders from major depressive disorders: treatment implications. Ann Clin Psychiatry 2007; 19: 305-312.
    • (2007) Ann Clin Psychiatry , vol.19 , pp. 305-312
    • Muzina, D.J.1    Kemp, D.E.2    McIntyre, R.S.3
  • 21
    • 33644995450 scopus 로고    scopus 로고
    • Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblings
    • Kruger S, Alda M, Young LT, Goldapple K, Parikh S, Mayberg HS. Risk and resilience markers in bipolar disorder: brain responses to emotional challenge in bipolar patients and their healthy siblings. Am J Psychiatry 2006; 163: 257-264.
    • (2006) Am J Psychiatry , vol.163 , pp. 257-264
    • Kruger, S.1    Alda, M.2    Young, L.T.3    Goldapple, K.4    Parikh, S.5    Mayberg, H.S.6
  • 22
    • 84876117282 scopus 로고    scopus 로고
    • Brain structural and functional correlates of resilience to bipolar disorder
    • Frangou S. Brain structural and functional correlates of resilience to bipolar disorder. Front Hum Neurosci 2011; 5: 184.
    • (2011) Front Hum Neurosci , vol.5 , pp. 184
    • Frangou, S.1
  • 23
    • 84155183380 scopus 로고    scopus 로고
    • Advances in bipolar disorder: selected sessions from the 2011 International Conference on Bipolar Disorder
    • Kupfer DJ, Angst J, Berk M et al. Advances in bipolar disorder: selected sessions from the 2011 International Conference on Bipolar Disorder. Ann N Y Acad Sci 2011; 1242: 1-25.
    • (2011) Ann N Y Acad Sci , vol.1242 , pp. 1-25
    • Kupfer, D.J.1    Angst, J.2    Berk, M.3
  • 24
    • 84857123044 scopus 로고    scopus 로고
    • Circadian biomarkers, circadian genes and bipolar disorders
    • Milhiet V, Etain B, Boudebesse C, Bellivier F. Circadian biomarkers, circadian genes and bipolar disorders. J Physiol Paris 2011; 105: 183-189.
    • (2011) J Physiol Paris , vol.105 , pp. 183-189
    • Milhiet, V.1    Etain, B.2    Boudebesse, C.3    Bellivier, F.4
  • 25
    • 51349085199 scopus 로고    scopus 로고
    • Oxidative stress markers in bipolar disorder: a meta-analysis
    • Andreazza AC, Kauer-Sant'anna M, Frey BN et al. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord 2008; 111: 135-144.
    • (2008) J Affect Disord , vol.111 , pp. 135-144
    • Andreazza, A.C.1    Kauer-Sant'anna, M.2    Frey, B.N.3
  • 26
    • 33846889102 scopus 로고    scopus 로고
    • Serum S100B and antioxidant enzymes in bipolar patients
    • Andreazza AC, Cassini C, Rosa AR et al. Serum S100B and antioxidant enzymes in bipolar patients. J Psychiatr Res 2007; 41: 523-529.
    • (2007) J Psychiatr Res , vol.41 , pp. 523-529
    • Andreazza, A.C.1    Cassini, C.2    Rosa, A.R.3
  • 27
    • 78650788525 scopus 로고    scopus 로고
    • Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes
    • Curtis D, Vine AE, McQuillin A et al. Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes. Psychiatr Genet 2011; 21: 1-4.
    • (2011) Psychiatr Genet , vol.21 , pp. 1-4
    • Curtis, D.1    Vine, A.E.2    McQuillin, A.3
  • 28
    • 84860625277 scopus 로고    scopus 로고
    • Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders
    • Van Den Bossche MJ, Strazisar M, De Bruyne S et al. Identification of a CACNA2D4 deletion in late onset bipolar disorder patients and implications for the involvement of voltage-dependent calcium channels in psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 465-475.
    • (2012) Am J Med Genet B Neuropsychiatr Genet , vol.159 , pp. 465-475
    • Van Den Bossche, M.J.1    Strazisar, M.2    De Bruyne, S.3
  • 29
    • 84858295217 scopus 로고    scopus 로고
    • Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies
    • Chen D, Liu F, Yang C et al. Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies. J Affect Disord 2012; 138: 27-33.
    • (2012) J Affect Disord , vol.138 , pp. 27-33
    • Chen, D.1    Liu, F.2    Yang, C.3
  • 30
    • 82255192925 scopus 로고    scopus 로고
    • Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder
    • Kato T, Hayashi-Takagi A, Toyota T, Yoshikawa T, Iwamoto K. Gene expression analysis in lymphoblastoid cells as a potential biomarker of bipolar disorder. J Hum Genet 2011; 56: 779-783.
    • (2011) J Hum Genet , vol.56 , pp. 779-783
    • Kato, T.1    Hayashi-Takagi, A.2    Toyota, T.3    Yoshikawa, T.4    Iwamoto, K.5
  • 31
    • 80055021253 scopus 로고    scopus 로고
    • The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder
    • Elvsashagen T, Vera E, Boen E et al. The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder. J Affect Disord 2011; 135: 43-50.
    • (2011) J Affect Disord , vol.135 , pp. 43-50
    • Elvsashagen, T.1    Vera, E.2    Boen, E.3
  • 32
    • 84856888077 scopus 로고    scopus 로고
    • Olfactory acuity is associated with mood and function in a pilot study of stable bipolar disorder patients
    • Hardy C, Rosedale M, Messinger JW et al. Olfactory acuity is associated with mood and function in a pilot study of stable bipolar disorder patients. Bipolar Disord 2012; 14: 109-117.
    • (2012) Bipolar Disord , vol.14 , pp. 109-117
    • Hardy, C.1    Rosedale, M.2    Messinger, J.W.3
  • 33
    • 79551694657 scopus 로고    scopus 로고
    • Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q
    • Xu H, Cheng R, Juo SH et al. Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q. Am J Med Genet B Neuropsychiatr Genet 2011; 156: 168-176.
    • (2011) Am J Med Genet B Neuropsychiatr Genet , vol.156 , pp. 168-176
    • Xu, H.1    Cheng, R.2    Juo, S.H.3
  • 34
    • 80053988998 scopus 로고    scopus 로고
    • DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder
    • Nohesara S, Ghadirivasfi M, Mostafavi S et al. DNA hypomethylation of MB-COMT promoter in the DNA derived from saliva in schizophrenia and bipolar disorder. J Psychiatr Res 2011; 45: 1432-1438.
    • (2011) J Psychiatr Res , vol.45 , pp. 1432-1438
    • Nohesara, S.1    Ghadirivasfi, M.2    Mostafavi, S.3
  • 35
    • 84864955544 scopus 로고    scopus 로고
    • Genetic heterogeneity according to age at onset in bipolar disorder: a combined positional cloning and candidate gene approach
    • Dizier MH, Etain B, Lajnef M, et al. Genetic heterogeneity according to age at onset in bipolar disorder: a combined positional cloning and candidate gene approach. Am J Med Genet B Neuropsychiatr Genet 2012; 159B: 653-659.
    • (2012) Am J Med Genet B Neuropsychiatr Genet , vol.159 , pp. 653-659
    • Dizier, M.H.1    Etain, B.2    Lajnef, M.3
  • 36
    • 84861674715 scopus 로고    scopus 로고
    • Identification of sialyltransferase 8b as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26
    • McAuley EZ, Scimone A, Tiwari Y et al. Identification of sialyltransferase 8b as a generalized susceptibility gene for psychotic and mood disorders on chromosome 15q25-26. PLoS ONE 2012; 7: e38172.
    • (2012) PLoS ONE , vol.7
    • McAuley, E.Z.1    Scimone, A.2    Tiwari, Y.3
  • 37
    • 0242322769 scopus 로고    scopus 로고
    • Epigenetics and bipolar disorder: new opportunities and challenges
    • Petronis A. Epigenetics and bipolar disorder: new opportunities and challenges. Am J Med Genet C Semin Med Genet 2003; 123C: 65-75.
    • (2003) Am J Med Genet C Semin Med Genet , vol.123 , Issue.C , pp. 65-75
    • Petronis, A.1
  • 38
    • 79960332723 scopus 로고    scopus 로고
    • Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder
    • Carrard A, Salzmann A, Malafosse A, Karege F. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. J Affect Disord 2011; 132: 450-453.
    • (2011) J Affect Disord , vol.132 , pp. 450-453
    • Carrard, A.1    Salzmann, A.2    Malafosse, A.3    Karege, F.4
  • 39
    • 79958009147 scopus 로고    scopus 로고
    • Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder
    • Abdolmaleky HM, Yaqubi S, Papageorgis P et al. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res 2011; 129: 183-190.
    • (2011) Schizophr Res , vol.129 , pp. 183-190
    • Abdolmaleky, H.M.1    Yaqubi, S.2    Papageorgis, P.3
  • 41
    • 80055001196 scopus 로고    scopus 로고
    • A comprehensive review and model of putative prodromal features of bipolar affective disorder
    • Howes OD, Lim S, Theologos G, Yung AR, Goodwin GM, McGuire P. A comprehensive review and model of putative prodromal features of bipolar affective disorder. Psychol Med 2011; 41: 1567-1577.
    • (2011) Psychol Med , vol.41 , pp. 1567-1577
    • Howes, O.D.1    Lim, S.2    Theologos, G.3    Yung, A.R.4    Goodwin, G.M.5    McGuire, P.6
  • 42
    • 84870831020 scopus 로고    scopus 로고
    • Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder
    • Schulze TG, Akula N, Breuer R et al. Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder. World J Biol Psychiatry 2012; 1-9.
    • (2012) World J Biol Psychiatry , pp. 1-9
    • Schulze, T.G.1    Akula, N.2    Breuer, R.3
  • 44
    • 84877704720 scopus 로고    scopus 로고
    • Genetics of bipolar disorder
    • Craddock N, Sklar P. Genetics of bipolar disorder. Lancet 2013; 381: 1654-1662.
    • (2013) Lancet , vol.381 , pp. 1654-1662
    • Craddock, N.1    Sklar, P.2
  • 47
    • 43849111211 scopus 로고    scopus 로고
    • Reduced expression of glyoxalase-1 mRNA in mood disorder patients
    • Fujimoto M, Uchida S, Watanuki T et al. Reduced expression of glyoxalase-1 mRNA in mood disorder patients. Neurosci Lett 2008; 438: 196-199.
    • (2008) Neurosci Lett , vol.438 , pp. 196-199
    • Fujimoto, M.1    Uchida, S.2    Watanuki, T.3
  • 48
    • 84858433310 scopus 로고    scopus 로고
    • Personal omics profiling reveals dynamic molecular and medical phenotypes
    • Chen R, Mias GI, Li-Pook-Than J et al. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell 2012; 148: 1293-1307.
    • (2012) Cell , vol.148 , pp. 1293-1307
    • Chen, R.1    Mias, G.I.2    Li-Pook-Than, J.3
  • 49
    • 84864033725 scopus 로고    scopus 로고
    • Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression
    • Lee SA, Tsao TT, Yang KC et al. Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression. BMC Bioinformatics 2011; 12 (Suppl. 13): S20.
    • (2011) BMC Bioinformatics , vol.12 , Issue.SUPPL. 13
    • Lee, S.A.1    Tsao, T.T.2    Yang, K.C.3
  • 50
    • 79955603399 scopus 로고    scopus 로고
    • Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3
    • Focking M, Dicker P, English JA, Schubert KO, Dunn MJ, Cotter DR. Common proteomic changes in the hippocampus in schizophrenia and bipolar disorder and particular evidence for involvement of cornu ammonis regions 2 and 3. Arch Gen Psychiatry 2011; 68: 477-488.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 477-488
    • Focking, M.1    Dicker, P.2    English, J.A.3    Schubert, K.O.4    Dunn, M.J.5    Cotter, D.R.6
  • 51
    • 84865765591 scopus 로고    scopus 로고
    • Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders
    • Andreazza AC. Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders. Mol BioSyst 2012; 8: 2503-2512.
    • (2012) Mol BioSyst , vol.8 , pp. 2503-2512
    • Andreazza, A.C.1
  • 52
    • 66349135345 scopus 로고    scopus 로고
    • Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression
    • Behan AT, Byrne C, Dunn MJ, Cagney G, Cotter DR. Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression. Mol Psychiatry 2009; 14: 601-613.
    • (2009) Mol Psychiatry , vol.14 , pp. 601-613
    • Behan, A.T.1    Byrne, C.2    Dunn, M.J.3    Cagney, G.4    Cotter, D.R.5
  • 53
    • 73249130205 scopus 로고    scopus 로고
    • Metabolic profiling of human blood serum from treated patients with bipolar disorder employing 1H NMR spectroscopy and chemometrics
    • Sussulini A, Prando A, Maretto DA et al. Metabolic profiling of human blood serum from treated patients with bipolar disorder employing 1H NMR spectroscopy and chemometrics. Anal Chem 2009; 81: 9755-9763.
    • (2009) Anal Chem , vol.81 , pp. 9755-9763
    • Sussulini, A.1    Prando, A.2    Maretto, D.A.3
  • 54
    • 66349087823 scopus 로고    scopus 로고
    • Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics
    • Lindon JC, Nicholson JK. Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics. Annu Rev Anal Chem 2008; 1: 45-69.
    • (2008) Annu Rev Anal Chem , vol.1 , pp. 45-69
    • Lindon, J.C.1    Nicholson, J.K.2
  • 55
    • 33750475205 scopus 로고    scopus 로고
    • Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?
    • van der Greef J, Hankemeier T, McBurney RN. Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials? Pharmacogenomics 2006; 7: 1087-1094.
    • (2006) Pharmacogenomics , vol.7 , pp. 1087-1094
    • van der Greef, J.1    Hankemeier, T.2    McBurney, R.N.3
  • 56
    • 80355146928 scopus 로고    scopus 로고
    • Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia
    • Hope S, Dieset I, Agartz I et al. Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia. J Psychiatr Res 2011; 45: 1608-1616.
    • (2011) J Psychiatr Res , vol.45 , pp. 1608-1616
    • Hope, S.1    Dieset, I.2    Agartz, I.3
  • 57
    • 84869170166 scopus 로고    scopus 로고
    • Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation
    • Schwarz E, Guest PC, Rahmoune H et al. Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation. World J Biol Psychiatry 2012; 13: 627-632.
    • (2012) World J Biol Psychiatry , vol.13 , pp. 627-632
    • Schwarz, E.1    Guest, P.C.2    Rahmoune, H.3
  • 58
    • 78650446303 scopus 로고    scopus 로고
    • Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival
    • Herberth M, Koethe D, Levin Y et al. Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival. Proteomics 2011; 11: 94-105.
    • (2011) Proteomics , vol.11 , pp. 94-105
    • Herberth, M.1    Koethe, D.2    Levin, Y.3
  • 59
    • 80155139377 scopus 로고    scopus 로고
    • Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders
    • Goldstein BI, Collinger KA, Lotrich F et al. Preliminary findings regarding proinflammatory markers and brain-derived neurotrophic factor among adolescents with bipolar spectrum disorders. J Child Adolesc Psychopharmacol 2011; 21: 479-484.
    • (2011) J Child Adolesc Psychopharmacol , vol.21 , pp. 479-484
    • Goldstein, B.I.1    Collinger, K.A.2    Lotrich, F.3
  • 60
    • 84859886494 scopus 로고    scopus 로고
    • Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic-pituitary-adrenal axis and immune system
    • Duffy A, Lewitzka U, Doucette S, Andreazza A, Grof P. Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic-pituitary-adrenal axis and immune system. Early Interv Psychiatry 2012; 6: 128-137.
    • (2012) Early Interv Psychiatry , vol.6 , pp. 128-137
    • Duffy, A.1    Lewitzka, U.2    Doucette, S.3    Andreazza, A.4    Grof, P.5
  • 61
    • 84879317123 scopus 로고    scopus 로고
    • Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies
    • Modabbernia A, Taslimi S, Brietzke E, Ashrafi M. Cytokine alterations in bipolar disorder: a meta-analysis of 30 studies. Biol Psychiatry 2013; 74: 15-25.
    • (2013) Biol Psychiatry , vol.74 , pp. 15-25
    • Modabbernia, A.1    Taslimi, S.2    Brietzke, E.3    Ashrafi, M.4
  • 62
    • 84857050654 scopus 로고    scopus 로고
    • Inflammatory markers and their relationships with leptin and insulin from acute mania to full remission in bipolar disorder
    • Tsai SY, Chung KH, Wu JY, Kuo CJ, Lee HC, Huang SH. Inflammatory markers and their relationships with leptin and insulin from acute mania to full remission in bipolar disorder. J Affect Disord 2012; 136: 110-116.
    • (2012) J Affect Disord , vol.136 , pp. 110-116
    • Tsai, S.Y.1    Chung, K.H.2    Wu, J.Y.3    Kuo, C.J.4    Lee, H.C.5    Huang, S.H.6
  • 63
    • 34250318164 scopus 로고    scopus 로고
    • Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects
    • Machado-Vieira R, Andreazza AC, Viale CI et al. Oxidative stress parameters in unmedicated and treated bipolar subjects during initial manic episode: a possible role for lithium antioxidant effects. Neurosci Lett 2007; 421: 33-36.
    • (2007) Neurosci Lett , vol.421 , pp. 33-36
    • Machado-Vieira, R.1    Andreazza, A.C.2    Viale, C.I.3
  • 64
    • 67749122382 scopus 로고    scopus 로고
    • Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia
    • Wang JF, Shao L, Sun X, Young LT. Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia. Bipolar Disord 2009; 11: 523-529.
    • (2009) Bipolar Disord , vol.11 , pp. 523-529
    • Wang, J.F.1    Shao, L.2    Sun, X.3    Young, L.T.4
  • 65
    • 0037107008 scopus 로고    scopus 로고
    • Development and natural history of mood disorders
    • Costello EJ, Pine DS, Hammen C et al. Development and natural history of mood disorders. Biol Psychiatry 2002; 52: 529-542.
    • (2002) Biol Psychiatry , vol.52 , pp. 529-542
    • Costello, E.J.1    Pine, D.S.2    Hammen, C.3
  • 66
    • 77949397763 scopus 로고    scopus 로고
    • Pediatric bipolar disorder: evidence for prodromal states and early markers
    • Luby JL, Navsaria N. Pediatric bipolar disorder: evidence for prodromal states and early markers. J Child Psychol Psychiatry 2010; 51: 459-471.
    • (2010) J Child Psychol Psychiatry , vol.51 , pp. 459-471
    • Luby, J.L.1    Navsaria, N.2
  • 67
    • 75849156918 scopus 로고    scopus 로고
    • Elevated amygdala activity to sad facial expressions: a state marker of bipolar but not unipolar depression
    • Almeida JR, Versace A, Hassel S, Kupfer DJ, Phillips ML. Elevated amygdala activity to sad facial expressions: a state marker of bipolar but not unipolar depression. Biol Psychiatry 2010; 67: 414-421.
    • (2010) Biol Psychiatry , vol.67 , pp. 414-421
    • Almeida, J.R.1    Versace, A.2    Hassel, S.3    Kupfer, D.J.4    Phillips, M.L.5
  • 68
    • 42549084679 scopus 로고    scopus 로고
    • Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?
    • Ladouceur CD, Almeida JR, Birmaher B et al. Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder? J Am Acad Child Adolesc Psychiatry 2008; 47: 532-539.
    • (2008) J Am Acad Child Adolesc Psychiatry , vol.47 , pp. 532-539
    • Ladouceur, C.D.1    Almeida, J.R.2    Birmaher, B.3
  • 69
    • 79960289479 scopus 로고    scopus 로고
    • Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses
    • Houenou J, Frommberger J, Carde S et al. Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses. J Affect Disord 2011; 132: 344-355.
    • (2011) J Affect Disord , vol.132 , pp. 344-355
    • Houenou, J.1    Frommberger, J.2    Carde, S.3
  • 70
    • 81855221937 scopus 로고    scopus 로고
    • Neural correlates of cognitive flexibility in children at risk for bipolar disorder
    • Kim P, Jenkins SE, Connolly ME et al. Neural correlates of cognitive flexibility in children at risk for bipolar disorder. J Psychiatr Res 2012; 46: 22-30.
    • (2012) J Psychiatr Res , vol.46 , pp. 22-30
    • Kim, P.1    Jenkins, S.E.2    Connolly, M.E.3
  • 71
    • 84862221668 scopus 로고    scopus 로고
    • Differing amygdala responses to facial expressions in children and adults with bipolar disorder
    • Kim P, Thomas LA, Rosen BH et al. Differing amygdala responses to facial expressions in children and adults with bipolar disorder. Am J Psychiatry 2012; 169: 642-649.
    • (2012) Am J Psychiatry , vol.169 , pp. 642-649
    • Kim, P.1    Thomas, L.A.2    Rosen, B.H.3
  • 72
    • 84862195360 scopus 로고    scopus 로고
    • A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder
    • Weathers JD, Stringaris A, Deveney CM et al. A developmental study of the neural circuitry mediating motor inhibition in bipolar disorder. Am J Psychiatry 2012; 169: 633-641.
    • (2012) Am J Psychiatry , vol.169 , pp. 633-641
    • Weathers, J.D.1    Stringaris, A.2    Deveney, C.M.3
  • 73
    • 33645015083 scopus 로고    scopus 로고
    • Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study
    • Adler CM, Adams J, DelBello MP et al. Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study. Am J Psychiatry 2006; 163: 322-324.
    • (2006) Am J Psychiatry , vol.163 , pp. 322-324
    • Adler, C.M.1    Adams, J.2    DelBello, M.P.3
  • 74
    • 34547843470 scopus 로고    scopus 로고
    • Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness
    • Gogtay N, Ordonez A, Herman DH et al. Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness. J Child Psychol Psychiatry 2007; 48: 852-862.
    • (2007) J Child Psychol Psychiatry , vol.48 , pp. 852-862
    • Gogtay, N.1    Ordonez, A.2    Herman, D.H.3
  • 75
    • 84860000671 scopus 로고    scopus 로고
    • A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders
    • Saxena K, Tamm L, Walley A et al. A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders. J Child Adolesc Psychopharmacol 2012; 22: 112-119.
    • (2012) J Child Adolesc Psychopharmacol , vol.22 , pp. 112-119
    • Saxena, K.1    Tamm, L.2    Walley, A.3
  • 77
    • 84864443205 scopus 로고    scopus 로고
    • Mechanistic comparisons of functional domains across pediatric and adult bipolar disorder highlight similarities, as well as differences, influenced by the developing brain
    • Wegbreit E, Pavuluri M. Mechanistic comparisons of functional domains across pediatric and adult bipolar disorder highlight similarities, as well as differences, influenced by the developing brain. Isr J Psychiatry Relat Sci 2012; 49: 75-83.
    • (2012) Isr J Psychiatry Relat Sci , vol.49 , pp. 75-83
    • Wegbreit, E.1    Pavuluri, M.2
  • 78
    • 84861491134 scopus 로고    scopus 로고
    • Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system
    • Blond BN, Fredericks CA, Blumberg HP. Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system. Bipolar Disord 2012; 14: 340-355.
    • (2012) Bipolar Disord , vol.14 , pp. 340-355
    • Blond, B.N.1    Fredericks, C.A.2    Blumberg, H.P.3
  • 79
    • 75849125921 scopus 로고    scopus 로고
    • Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder
    • Versace A, Thompson WK, Zhou D et al. Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry 2010; 67: 422-431.
    • (2010) Biol Psychiatry , vol.67 , pp. 422-431
    • Versace, A.1    Thompson, W.K.2    Zhou, D.3
  • 80
    • 84876671670 scopus 로고    scopus 로고
    • The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder
    • Radua J, Surguladze SA, Marshall N et al. The impact of CACNA1C allelic variation on effective connectivity during emotional processing in bipolar disorder. Mol Psychiatry 2013; 18: 526-527.
    • (2013) Mol Psychiatry , vol.18 , pp. 526-527
    • Radua, J.1    Surguladze, S.A.2    Marshall, N.3
  • 81
    • 49949089662 scopus 로고    scopus 로고
    • A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder
    • 833-829, 857.
    • Phillips ML, Ladouceur CD, Drevets WC. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 2008; 13: 829, 833-829, 857.
    • (2008) Mol Psychiatry , vol.13 , pp. 829
    • Phillips, M.L.1    Ladouceur, C.D.2    Drevets, W.C.3
  • 82
    • 80053385384 scopus 로고    scopus 로고
    • Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4
    • Sklar P, Ripke S, Scott LJ et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 2011; 43: 977-983.
    • (2011) Nat Genet , vol.43 , pp. 977-983
    • Sklar, P.1    Ripke, S.2    Scott, L.J.3
  • 83
    • 0034194897 scopus 로고    scopus 로고
    • Eight-month functional outcome from mania following a first psychiatric hospitalization
    • Strakowski SM, Williams JR, Fleck DE, DelBello MP. Eight-month functional outcome from mania following a first psychiatric hospitalization. J Psychiatr Res 2000; 34: 193-200.
    • (2000) J Psychiatr Res , vol.34 , pp. 193-200
    • Strakowski, S.M.1    Williams, J.R.2    Fleck, D.E.3    DelBello, M.P.4
  • 84
    • 80053948906 scopus 로고    scopus 로고
    • P11 expression and PET in bipolar disorders
    • Zhang L, Li CT, Su TP et al. P11 expression and PET in bipolar disorders. J Psychiatr Res 2011; 45: 1426-1431.
    • (2011) J Psychiatr Res , vol.45 , pp. 1426-1431
    • Zhang, L.1    Li, C.T.2    Su, T.P.3
  • 85
    • 30344448578 scopus 로고    scopus 로고
    • Alterations in 5-HT1B receptor function by p11 in depression-like states
    • Svenningsson P, Chergui K, Rachleff I et al. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 2006; 311: 77-80.
    • (2006) Science , vol.311 , pp. 77-80
    • Svenningsson, P.1    Chergui, K.2    Rachleff, I.3
  • 86
    • 78650174790 scopus 로고    scopus 로고
    • Lower N-acetyl-aspartate levels in prefrontal cortices in pediatric bipolar disorder: a (1)H magnetic resonance spectroscopy study
    • Caetano SC, Olvera RL, Hatch JP et al. Lower N-acetyl-aspartate levels in prefrontal cortices in pediatric bipolar disorder: a (1)H magnetic resonance spectroscopy study. J Am Acad Child Adolesc Psychiatry 2011; 50: 85-94.
    • (2011) J Am Acad Child Adolesc Psychiatry , vol.50 , pp. 85-94
    • Caetano, S.C.1    Olvera, R.L.2    Hatch, J.P.3
  • 87
    • 27744593086 scopus 로고    scopus 로고
    • Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients
    • Sassi RB, Stanley JA, Axelson D et al. Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients. Am J Psychiatry 2005; 162: 2109-2115.
    • (2005) Am J Psychiatry , vol.162 , pp. 2109-2115
    • Sassi, R.B.1    Stanley, J.A.2    Axelson, D.3
  • 88
    • 52249085601 scopus 로고    scopus 로고
    • Neurocognitive endophenotypes (endophenocognitypes) from studies of relatives of bipolar disorder subjects: a systematic review
    • Balanza-Martinez V, Rubio C, Selva-Vera G et al. Neurocognitive endophenotypes (endophenocognitypes) from studies of relatives of bipolar disorder subjects: a systematic review. Neurosci Biobehav Rev 2008; 32: 1426-1438.
    • (2008) Neurosci Biobehav Rev , vol.32 , pp. 1426-1438
    • Balanza-Martinez, V.1    Rubio, C.2    Selva-Vera, G.3
  • 89
    • 83655192069 scopus 로고    scopus 로고
    • Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors
    • Beblo T, Sinnamon G, Baune BT. Specifying the neuropsychology of affective disorders: clinical, demographic and neurobiological factors. Neuropsychol Rev 2011; 21: 337-359.
    • (2011) Neuropsychol Rev , vol.21 , pp. 337-359
    • Beblo, T.1    Sinnamon, G.2    Baune, B.T.3
  • 90
    • 84855215309 scopus 로고    scopus 로고
    • Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder
    • Kurnianingsih YA, Kuswanto CN, McIntyre RS, Qiu A, Ho BC, Sim K. Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder. J Neural Transm 2011; 118: 1621-1639.
    • (2011) J Neural Transm , vol.118 , pp. 1621-1639
    • Kurnianingsih, Y.A.1    Kuswanto, C.N.2    McIntyre, R.S.3    Qiu, A.4    Ho, B.C.5    Sim, K.6
  • 91
    • 84866683481 scopus 로고    scopus 로고
    • Memory in early onset bipolar disorder and attention-deficit/hyperactivity disorder: similarities and differences
    • Udal AH, Øygarden B, Egeland J, Malt UF, Groholt B. Memory in early onset bipolar disorder and attention-deficit/hyperactivity disorder: similarities and differences. J Abnorm Child Psychol 2012; 40: 1179-1192.
    • (2012) J Abnorm Child Psychol , vol.40 , pp. 1179-1192
    • Udal, A.H.1    Øygarden, B.2    Egeland, J.3    Malt, U.F.4    Groholt, B.5
  • 92
  • 93
    • 67349191244 scopus 로고    scopus 로고
    • How to differentiate schizophrenia from bipolar disorder using cognitive assessment?
    • Demily C, Jacquet P, Marie-Cardine M. How to differentiate schizophrenia from bipolar disorder using cognitive assessment? Encephale 2009; 35: 139-145.
    • (2009) Encephale , vol.35 , pp. 139-145
    • Demily, C.1    Jacquet, P.2    Marie-Cardine, M.3
  • 94
    • 0035025139 scopus 로고    scopus 로고
    • Verbal fluency in patients with schizophrenia and affective psychoses and their first-degree relatives
    • Gilvarry CM, Russell A, Jones P, Sham P, Hemsley D, Murray RM. Verbal fluency in patients with schizophrenia and affective psychoses and their first-degree relatives. Psychol Med 2001; 31: 695-704.
    • (2001) Psychol Med , vol.31 , pp. 695-704
    • Gilvarry, C.M.1    Russell, A.2    Jones, P.3    Sham, P.4    Hemsley, D.5    Murray, R.M.6
  • 95
    • 10744224795 scopus 로고    scopus 로고
    • Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia
    • Zalla T, Joyce C, Szoke A et al. Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res 2004; 121: 207-217.
    • (2004) Psychiatry Res , vol.121 , pp. 207-217
    • Zalla, T.1    Joyce, C.2    Szoke, A.3
  • 97
    • 79952815943 scopus 로고    scopus 로고
    • Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder
    • Lewandowski KE, Cohen BM, Ongur D. Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder. Psychol Med 2011; 41: 225-241.
    • (2011) Psychol Med , vol.41 , pp. 225-241
    • Lewandowski, K.E.1    Cohen, B.M.2    Ongur, D.3
  • 98
    • 4444358568 scopus 로고    scopus 로고
    • Comorbidity in bipolar disorder: a framework for rational treatment selection
    • McIntyre RS, Konarski JZ, Yatham LN. Comorbidity in bipolar disorder: a framework for rational treatment selection. Hum Psychopharmacol 2004; 19: 369-386.
    • (2004) Hum Psychopharmacol , vol.19 , pp. 369-386
    • McIntyre, R.S.1    Konarski, J.Z.2    Yatham, L.N.3
  • 99
    • 29144512041 scopus 로고    scopus 로고
    • Mood and psychotic disorders and type 2 diabetes: a metabolic triad
    • McIntyre RS, Mancini DA, Pearce MM et al. Mood and psychotic disorders and type 2 diabetes: a metabolic triad. Can J Diabetes 2005; 29: 122-132.
    • (2005) Can J Diabetes , vol.29 , pp. 122-132
    • McIntyre, R.S.1    Mancini, D.A.2    Pearce, M.M.3
  • 100
    • 33646791481 scopus 로고    scopus 로고
    • Obesity in bipolar disorder and major depressive disorder: results from a National Community Health Survey on Mental Health and Well-Being
    • McIntyre RS, Konarski JZ, Wilkins K, Soczynska JK, Kennedy SH. Obesity in bipolar disorder and major depressive disorder: results from a National Community Health Survey on Mental Health and Well-Being. Can J Psychiatry 2006; 51: 274-280.
    • (2006) Can J Psychiatry , vol.51 , pp. 274-280
    • McIntyre, R.S.1    Konarski, J.Z.2    Wilkins, K.3    Soczynska, J.K.4    Kennedy, S.H.5
  • 102
    • 78649790730 scopus 로고    scopus 로고
    • A cohort study of the prevalence and impact of comorbid medical conditions in pediatric bipolar disorder
    • Jerrell JM, McIntyre RS, Tripathi A. A cohort study of the prevalence and impact of comorbid medical conditions in pediatric bipolar disorder. J Clin Psychiatry 2010; 71: 1518-1525.
    • (2010) J Clin Psychiatry , vol.71 , pp. 1518-1525
    • Jerrell, J.M.1    McIntyre, R.S.2    Tripathi, A.3
  • 104
    • 84859266814 scopus 로고    scopus 로고
    • Inflammatory cytokines as an underlying mechanism of the comorbidity between bipolar disorder and migraine
    • Brietzke E, Mansur RB, Grassi-Oliveira R, Soczynska JK, McIntyre RS. Inflammatory cytokines as an underlying mechanism of the comorbidity between bipolar disorder and migraine. Med Hypotheses 2012; 78: 601-605.
    • (2012) Med Hypotheses , vol.78 , pp. 601-605
    • Brietzke, E.1    Mansur, R.B.2    Grassi-Oliveira, R.3    Soczynska, J.K.4    McIntyre, R.S.5
  • 106
    • 79960764938 scopus 로고    scopus 로고
    • Mood disorders and obesity: understanding inflammation as a pathophysiological nexus
    • Soczynska JK, Kennedy SH, Woldeyohannes HO et al. Mood disorders and obesity: understanding inflammation as a pathophysiological nexus. Neuromolecular Med 2011; 13: 93-116.
    • (2011) Neuromolecular Med , vol.13 , pp. 93-116
    • Soczynska, J.K.1    Kennedy, S.H.2    Woldeyohannes, H.O.3
  • 109
    • 77952288596 scopus 로고    scopus 로고
    • Weight gain, obesity, and metabolic indices following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
    • Bond DJ, Kauer-Sant'anna M, Lam RW, Yatham LN. Weight gain, obesity, and metabolic indices following a first manic episode: prospective 12-month data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM). J Affect Disord 2010; 124: 108-117.
    • (2010) J Affect Disord , vol.124 , pp. 108-117
    • Bond, D.J.1    Kauer-Sant'anna, M.2    Lam, R.W.3    Yatham, L.N.4
  • 111
    • 84865476334 scopus 로고    scopus 로고
    • Can bipolar disorder be viewed as a multi-system inflammatory disease?
    • Leboyer M, Soreca I, Scott J et al. Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord 2012; 141: 1-10.
    • (2012) J Affect Disord , vol.141 , pp. 1-10
    • Leboyer, M.1    Soreca, I.2    Scott, J.3
  • 112
    • 33751210102 scopus 로고    scopus 로고
    • Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder
    • Ellenbogen MA, Hodgins S, Walker CD, Couture S, Adam S. Daytime cortisol and stress reactivity in the offspring of parents with bipolar disorder. Psychoneuroendocrinology 2006; 31: 1164-1180.
    • (2006) Psychoneuroendocrinology , vol.31 , pp. 1164-1180
    • Ellenbogen, M.A.1    Hodgins, S.2    Walker, C.D.3    Couture, S.4    Adam, S.5
  • 113
    • 75249083056 scopus 로고    scopus 로고
    • High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling
    • Ellenbogen MA, Santo JB, Linnen AM, Walker CD, Hodgins S. High cortisol levels in the offspring of parents with bipolar disorder during two weeks of daily sampling. Bipolar Disord 2010; 12: 77-86.
    • (2010) Bipolar Disord , vol.12 , pp. 77-86
    • Ellenbogen, M.A.1    Santo, J.B.2    Linnen, A.M.3    Walker, C.D.4    Hodgins, S.5
  • 114
    • 42049092538 scopus 로고    scopus 로고
    • A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes
    • Padmos RC, Hillegers MH, Knijff EM et al. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry 2008; 65: 395-407.
    • (2008) Arch Gen Psychiatry , vol.65 , pp. 395-407
    • Padmos, R.C.1    Hillegers, M.H.2    Knijff, E.M.3
  • 115
    • 85017296758 scopus 로고    scopus 로고
    • Translational bioinformatics embraces big data
    • Shah NH. Translational bioinformatics embraces big data. Yearb Med Inform 2012; 7: 130-134.
    • (2012) Yearb Med Inform , vol.7 , pp. 130-134
    • Shah, N.H.1
  • 116
    • 84859487243 scopus 로고    scopus 로고
    • U.S. science policy. Agencies rally to tackle big data
    • Mervis J. U.S. science policy. Agencies rally to tackle big data. Science 2012; 336: 22.
    • (2012) Science , vol.336 , pp. 22
    • Mervis, J.1
  • 117
    • 38149051880 scopus 로고    scopus 로고
    • The arrival of preemptive psychiatry
    • Insel TR. The arrival of preemptive psychiatry. Early Interv Psychiatry 2007; 1: 5-6.
    • (2007) Early Interv Psychiatry , vol.1 , pp. 5-6
    • Insel, T.R.1
  • 118
    • 84859385582 scopus 로고    scopus 로고
    • Recent progress in understanding pediatric bipolar disorder
    • Goldstein BI. Recent progress in understanding pediatric bipolar disorder. Arch Pediatr Adolesc Med 2012; 166: 362-371.
    • (2012) Arch Pediatr Adolesc Med , vol.166 , pp. 362-371
    • Goldstein, B.I.1
  • 119
    • 84872843420 scopus 로고    scopus 로고
    • Stigma and discrimination in people suffering with a mood disorder: a cross-sectional study
    • Lazowski L, Koller M, Stuart H, Milev R. Stigma and discrimination in people suffering with a mood disorder: a cross-sectional study. Depress Res Treat 2012; 2012: 1-9.
    • (2012) Depress Res Treat , vol.2012 , pp. 1-9
    • Lazowski, L.1    Koller, M.2    Stuart, H.3    Milev, R.4
  • 120
    • 84862175775 scopus 로고    scopus 로고
    • Tracking the development of bipolar disorder in childhood
    • Pliszka SR. Tracking the development of bipolar disorder in childhood. Am J Psychiatry 2012; 169: 557-559.
    • (2012) Am J Psychiatry , vol.169 , pp. 557-559
    • Pliszka, S.R.1
  • 121
    • 84863548955 scopus 로고    scopus 로고
    • Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs
    • Liu M, Wu Y, Chen Y et al. Large-scale prediction of adverse drug reactions using chemical, biological, and phenotypic properties of drugs. J Am Med Inform Assoc 2012; 19: e28-e35.
    • (2012) J Am Med Inform Assoc , vol.19
    • Liu, M.1    Wu, Y.2    Chen, Y.3
  • 122
    • 53849092347 scopus 로고    scopus 로고
    • Metabolic and cardiovascular adverse events associated with antipsychotic treatment in children and adolescents
    • McIntyre RS, Jerrell JM. Metabolic and cardiovascular adverse events associated with antipsychotic treatment in children and adolescents. Arch Pediatr Adolesc Med 2008; 162: 929-935.
    • (2008) Arch Pediatr Adolesc Med , vol.162 , pp. 929-935
    • McIntyre, R.S.1    Jerrell, J.M.2
  • 124
    • 84863224067 scopus 로고    scopus 로고
    • Development of biomarkers to chart all Alzheimer's disease stages: the royal road to cutting the therapeutic Gordian Knot
    • Hampel H, Lista S, Khachaturian ZS. Development of biomarkers to chart all Alzheimer's disease stages: the royal road to cutting the therapeutic Gordian Knot. Alzheimers Dement 2012; 8: 312-336.
    • (2012) Alzheimers Dement , vol.8 , pp. 312-336
    • Hampel, H.1    Lista, S.2    Khachaturian, Z.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.