Fine mapping of candidate regions for bipolar disorder provides strong evidence for susceptibility loci on chromosomes 7q

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 156, Issue 2, 2011, Pages 168-176

  Xu, Haiyan ^a,b,d   Cheng, Rong ^a,b   Juo, Suh Hang ^a,b,c   Liu, Jianjun ^b,e   Loth, Jo Ellen ^a   Endicott, Jean ^a   Gilliam, Conrad ^a,b,f   Baron, Miron ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Kaohsiung Medical University ^*  (United States)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e GENOME INSTITUTE OF SINGAPORE   (Singapore)

^f UNIVERSITY OF CHICAGO   (United States)

Author keywords

Bipolar; Follow up; Genome scan; Linkage

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; BIPOLAR DISORDER; CHROMOSOME 10Q; CHROMOSOME 13Q; CHROMOSOME 14Q; CHROMOSOME 17Q; CHROMOSOME 2; CHROMOSOME 4Q; CHROMOSOME 7Q; CHROMOSOME 8Q; GENE LOCUS; GENE MAPPING; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL;

ALGORITHMS; BIPOLAR DISORDER; CHROMOSOMES, HUMAN, PAIR 7; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC LINKAGE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LOD SCORE; MODELS, GENETIC; PEDIGREE; PHYSICAL CHROMOSOME MAPPING;

EID: 79551694657     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.31151     Document Type: Article

References (31)

1. Adams P. 1994. LABMAN and LINKMAN: A data management system specifically designed for genome searches of complex diseases. Genet Epidemiol 11(1): 87-98.
2. Aita VM, Liu J, Knowles JA, Terwilliger JD, Baltazar R, Grunn A, Loth JE, Kanyas K, Lerer B, Endicott J, et al. 1999. A comprehensive linkage analysis of chromosome 21q22 supports prior evidence for a putative bipolar affective disorder locus. Am J Hum Genet 64(1): 210-217.
3. Badner JA, Gershon ES. 2002. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7(4): 405-411.
4. Baron M. 2002. Manic-depression genes and the new millennium: Poised for discovery. Mol Psychiatry 7(4): 342-358.
5. Baron M, Endicott J, Lerer B, Loth JE, Alexander JR, Simon R, Sharpe L, Gibbon M, Hasin D, Lilliston B. 1994. A pedigree series for mapping disease genes in bipolar affective disorder: Sampling, assessment, and analytic considerations. Psychiatr Genet 4(1): 43-55.
6. Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nothen MM, et al. 2008. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry 13:197-207.
7. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, Bougueleret L, Barry C, Tanaka H, La Rosa P, et al. 2002. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 99(21): 13675-13680.
8. Cottingham RW, Jr., Idury RM, Schaffer AA. 1993. Faster sequential genetic linkage computations. Am J Hum Genet 53(1): 252-263.
9. Craddock N, Forty L. 2006. Genetics of affective (mood) disorders. Eur J Hum Genet 14(6): 660-668.
10. Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, et al. 2003. Genomewide linkage analyses of bipolar disorder: A new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. Am J Hum Genet 73(1): 107-114.
11. Endicott J, Spitzer RL. 1978. A diagnostic interview: The schedule for affective disorders and schizophrenia. Arch Gen Psychiatry 35(7): 837-844.
12. Gershon ES, Liu C, Badner JA. 2008. Genome-wide association in bipolar. Mol Psychiatry 13(1): 1-2.
13. Goring HH, Terwilliger JD. 2000. Linkage analysis in the presence of errors I: Complex-valued recombination fractions and complex phenotypes. Am J Hum Genet 66(3): 1095-1106.
14. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES. 2003. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72(5): 1131-1140.
15. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, et al. 2002. A high-resolution recombination map of the human genome. Nat Genet 31(3): 241-247.
16. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58(6): 1347-1363.
17. Lander E, Kruglyak L. 1995. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11(3): 241-247.
18. Liu J, Juo SH, Terwilliger JD, Grunn A, Tong X, Brito M, Loth JE, Kanyas K, Lerer B, Endicott J, et al. 2001. A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22. Am J Med Genet 105(2): 189-194.
19. Liu J, Juo SH, Dewan A, Grunn A, Tong X, Brito M, Park N, Loth JE, Kanyas K, Lerer B, et al. 2003. Evidence for a putative bipolar disorder locus on 2p 13- 16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q 11-12. Mol Psychiatry 8(3): 333-342.
20. O'Connell JR, Weeks DE. 1998. PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63(1): 259-266.
21. Ott J. 1989. Statistical properties of the haplotype relative risk. Genet Epidemiol 6(1): 127-130.
22. Park N, Juo SH, Cheng R, Liu J, Loth JE, Lilliston B, Nee J, Grunn A, Kanyas K, Lerer B, et al. 2004. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry 9(12): 1091-1099.
23. Psychiatric GWAS Consortium Coordinating Committee. 2009. Genomewide association studies: History, rationale, and prospects for psychiatric disorders. Am J Psychiatry 166(5): 540-556.
24. Schumacher J, Jamra RA, Freudenberg J, Becker T, Ohlraun S, Otte AC, Tullius M, Kovalenko S, Bogaert AV, Maier W, et al. 2004. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry 9(2): 203-207.
25. Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Jr., Craddock N, DePaulo JR, Baron M, Gershon ES, et al. 2003. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet 73(1): 49-62.
26. Sklar P, Smoller JW, Fan J, Ferraira MA, Perlis RH, Chambert K, Nimgaonkar VL, McQueen MB, Faraone SV, Kirby A, et al. 2008. Whole-genome association study of bipolar disorder. Mol Psychiatry 13:558-569.
27. Spitzer RL, Endicott J, Robins E. 1978. Research diagnostic criteria: Rationale and reliability. Arch Gen Psychiatry 35(6): 773-782.
28. Taylor L, Faraone SV, Tsuang MT. 2002. Family, twin, and adoption studies of bipolar disease. Curr Psychiatry Rep 4(2): 130-133.
29. The Wellcome Trust Case Control Consortium. 2007. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 447:661-683.
30. Venken T, Claes S, Sluijs S, Paterson AD, van Duijn C, Adolfsson R, Del-Favero J, Van Broeckhoven C. 2005. Genomewide scan for affective disorder susceptibility Loci in families of a northern Swedish isolated population. Am J Hum Genet 76(2): 237-248.
31. Weeks DE, Ott J, Lathrop GM. 1990. SLINK: a general simulation program for linkage analysis. (Abstract); p A204. Available at .