The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder

Journal of Affective Disorders

Volumn 135, Issue 1-3, 2011, Pages 43-50

  Elvsåshagen, Torbjørn ^a,e   Vera, Elsa ^b   Bøen, Erlend ^a   Bratlie, Jorunn ^c   Andreassen, Ole A ^d,e   Josefsen, Dag ^d   Malt, Ulrik F ^a,e   Blasco, Maria A ^b   Boye, Birgitte ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF OSLO   (Norway)

Author keywords

Aging; Bipolar disorders; Depressive episode; Load of short telomeres; Telomere length

Indexed keywords

AMFEBUTAMONE; ESCITALOPRAM; FLUPENTIXOL; LAMOTRIGINE; LEVOTHYROXINE; LITHIUM; MIRTAZAPINE; PERPHENAZINE; QUETIAPINE; VALPROIC ACID; VENLAFAXINE;

ADULT; ALCOHOL ABUSE; ARTICLE; BIPOLAR II DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HYPOTHYROIDISM; MALE; PANIC; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SOCIAL PHOBIA; TELOMERE;

ADULT; AGING; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DEPRESSION; DEPRESSIVE DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKOCYTES, MONONUCLEAR; LONGITUDINAL STUDIES; MALE; MENTAL DISORDERS; TELOMERE; TELOMERE SHORTENING; TIME FACTORS;

EID: 80055021253     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2011.08.006     Document Type: Article

References (59)

1. S. Andersson, H.E. Barder, T. Hellvin, H. Lovdahl, and U.F. Malt Neuropsychological and electrophysiological indices of neurocognitive dysfunction in bipolar II disorder Bipolar Disord. 10 2008 888 899
2. J. Angst The bipolar spectrum Br. J. Psychiatry 190 2007 189 191
3. M. Armanios, J.K. Alder, E.M. Parry, B. Karim, M.A. Strong, and C.W. Greider Short telomeres are sufficient to cause the degenerative defects associated with aging Am. J. Hum. Genet. 85 2009 823 832
4. G. Aubert, and P.M. Lansdorp Telomeres and aging Physiol. Rev. 88 2008 557 579
5. L. Bendix, P.B. Horn, U.B. Jensen, I. Rubelj, and S. Kolvraa The load of short telomeres, estimated by a new method, Universal STELA, correlates with number of senescent cells Aging Cell 9 2010 383 397
6. M. Berk, F. Kapczinski, A.C. Andreazza, O.M. Dean, F. Giorlando, M. Maes, M. Yucel, C.S. Gama, S. Dodd, B. Dean, P.V. Magalhaes, P. Amminger, P. McGorry, and G.S. Malhi Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors Neurosci. Biobehav. Rev. 35 2011 804 817
7. E.H. Blackburn Switching and signaling at the telomere Cell 106 2001 661 673
8. M.A. Blasco Telomere length, stem cells and aging Nat. Chem. Biol. 3 2007 640 649
9. A. Canela, E. Vera, P. Klatt, and M.A. Blasco High-throughput telomere length quantification by FISH and its application to human population studies Proc. Natl. Acad. Sci. U.S.A. 104 2007 5300 5305
10. K. Collins, and J.R. Mitchell Telomerase in the human organism Oncogene 21 2002 564 579
11. C.W. Colton, and R.W. Manderscheid Congruencies in increased mortality rates, years of potential life lost, and causes of death among public mental health clients in eight states Prev. Chronic Dis. 3 2006 A42
12. A.K. Damjanovic, Y. Yang, R. Glaser, J.K. Kiecolt-Glaser, H. Nguyen, B. Laskowski, Y. Zou, D.Q. Beversdorf, and N.P. Weng Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients J. Immunol. 179 2007 4249 4254
13. M.R. DiMatteo, H.S. Lepper, and T.W. Croghan Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence Arch. Intern. Med. 160 2000 2101 2107
14. S. Dittmann, K. Hennig-Fast, S. Gerber, F. Seemuller, M. Riedel, W. Emanuel Severus, J. Langosch, R.R. Engel, H.J. Moller, and H.C. Grunze Cognitive functioning in euthymic bipolar I and bipolar II patients Bipolar Disord. 10 2008 877 887
15. R. Drake, K. Mueser, and G. McHugo Clinical rating scales: Alcohol Use Scale (AUS), Drug Use Scale (DUS), and Substance Abuse Treatment Scale (SAYS) L. Sederer, B. Dickey, Outcomes Assessment in Clinical Practice 1996 Williams & Wilkins Maryland 113 116
16. E.S. Epel, E.H. Blackburn, J. Lin, F.S. Dhabhar, N.E. Adler, J.D. Morrow, and R.M. Cawthon Accelerated telomere shortening in response to life stress Proc. Natl. Acad. Sci. U.S.A. 101 2004 17312 17315
17. E.S. Epel, J. Lin, F.H. Wilhelm, O.M. Wolkowitz, R. Cawthon, N.E. Adler, C. Dolbier, W.B. Mendes, and E.H. Blackburn Cell aging in relation to stress arousal and cardiovascular disease risk factors Psychoneuroendocrinology 31 2006 277 287
18. I. Eren, M. Naziroglu, and A. Demirdas Protective effects of lamotrigine, aripiprazole and escitalopram on depression-induced oxidative stress in rat brain Neurochem. Res. 32 2007 1188 1195
19. D.L. Evans, D.S. Charney, L. Lewis, R.N. Golden, J.M. Gorman, K.R. Krishnan, C.B. Nemeroff, J.D. Bremner, R.M. Carney, J.C. Coyne, M.R. Delong, N. Frasure-Smith, A.H. Glassman, P.W. Gold, I. Grant, L. Gwyther, G. Ironson, R.L. Johnson, A.M. Kanner, W.J. Katon, P.G. Kaufmann, F.J. Keefe, T. Ketter, T.P. Laughren, J. Leserman, C.G. Lyketsos, W.M. McDonald, B.S. McEwen, A.H. Miller, D. Musselman, C. O'Connor, J.M. Petitto, B.G. Pollock, R.G. Robinson, S.P. Roose, J. Rowland, Y. Sheline, D.S. Sheps, G. Simon, D. Spiegel, A. Stunkard, T. Sunderland, P. Tibbits Jr., and W.J. Valvo Mood disorders in the medically ill: scientific review and recommendations Biol. Psychiatry 58 2005 175 189
20. S.R. Ferron, M.A. Marques-Torrejon, H. Mira, I. Flores, K. Taylor, M.A. Blasco, and I. Farinas Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis J. Neurosci. 29 2009 14394 14407
21. I. Flores, A. Canela, E. Vera, A. Tejera, G. Cotsarelis, and M.A. Blasco The longest telomeres: a general signature of adult stem cell compartments Genes Dev. 22 2008 654 667
22. R.W. Frenck Jr., E.H. Blackburn, and K.M. Shannon The rate of telomere sequence loss in human leukocytes varies with age Proc. Natl. Acad. Sci. U.S.A. 95 1998 5607 5610
23. F. Fyhrquist, A. Tiitu, O. Saijonmaa, C. Forsblom, and P.H. Groop Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes J. Intern. Med. 267 2010 278 286
24. P.J. Goossens, E.G. Hartong, E.A. Knoppert-van der Klein, and T. van Achterberg Self-reported psychopathological symptoms and quality of life in outpatients with bipolar disorder Perspect. Psychiatr. Care 44 2008 275 284
25. L.Y. Hao, M. Armanios, M.A. Strong, B. Karim, D.M. Feldser, D. Huso, and C.W. Greider Short telomeres, even in the presence of telomerase, limit tissue renewal capacity Cell 123 2005 1121 1131
26. C.B. Harley, A.B. Futcher, and C.W. Greider Telomeres shorten during ageing of human fibroblasts Nature 345 1990 458 460
27. C.B. Harley, W. Liu, M. Blasco, E. Vera, W.H. Andrews, L.A. Briggs, and J.M. Raffaele A natural product telomerase activator as part of a health maintenance program Rejuvenation Res. 14 2011 45 56
28. N. Hartmann, M. Boehner, F. Groenen, and R. Kalb Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease Depress. Anxiety 27 2010 1111 1116
29. M.T. Hemann, M.A. Strong, L.Y. Hao, and C.W. Greider The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability Cell 107 2001 67 77
30. L. Kananen, I. Surakka, S. Pirkola, J. Suvisaari, J. Lonnqvist, L. Peltonen, S. Ripatti, and I. Hovatta Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls PLoS One 5 2010 e10826
31. F. Kapczinski, E. Vieta, A.C. Andreazza, B.N. Frey, F.A. Gomes, J. Tramontina, M. Kauer-Sant'anna, R. Grassi-Oliveira, and R.M. Post Allostatic load in bipolar disorder: implications for pathophysiology and treatment Neurosci. Biobehav. Rev. 32 2008 675 692
32. F. Kapczinski, F. Dal-Pizzol, A.L. Teixeira, P.V. Magalhaes, M. Kauer-Sant'Anna, F. Klamt, M.A. Pasquali, J. Quevedo, C.S. Gama, and R. Post A systemic toxicity index developed to assess peripheral changes in mood episodes Mol. Psychiatry 15 2010 784 786
33. L.V. Kessing, and P.K. Andersen Does the risk of developing dementia increase with the number of episodes in patients with depressive disorder and in patients with bipolar disorder? J. Neurol. Neurosurg. Psychiatry 75 2004 1662 1666
34. D.J. Kupfer The increasing medical burden in bipolar disorder JAMA 293 2005 2528 2530
35. K. Lasser, J.W. Boyd, S. Woolhandler, D.U. Himmelstein, D. McCormick, and D.H. Bor Smoking and mental illness: a population-based prevalence study JAMA 284 2000 2606 2610
36. A.D. Lopez, and C.C. Murray The global burden of disease, 1990-2020 Nat. Med. 4 1998 1241 1243
37. F.W. Lung, N.C. Chen, and B.C. Shu Genetic pathway of major depressive disorder in shortening telomeric length Psychiatr. Genet. 17 2007 195 199
38. S.L. McElroy, M.A. Frye, T. Suppes, D. Dhavale, P.E. Keck Jr., G.S. Leverich, L. Altshuler, K.D. Denicoff, W.A. Nolen, R. Kupka, H. Grunze, J. Walden, and R.M. Post Correlates of overweight and obesity in 644 patients with bipolar disorder J. Clin. Psychiatry 63 2002 207 213
39. M. McGrath, J.Y. Wong, D. Michaud, D.J. Hunter, and I. De Vivo Telomere length, cigarette smoking, and bladder cancer risk in men and women Cancer Epidemiol. Biomarkers Prev. 16 2007 815 819
40. J. McIlrath, S.D. Bouffler, E. Samper, A. Cuthbert, A. Wojcik, I. Szumiel, P.E. Bryant, A.C. Riches, A. Thompson, M.A. Blasco, R.F. Newbold, and P. Slijepcevic Telomere length abnormalities in mammalian radiosensitive cells Cancer Res. 61 2001 912 915
41. P. Monteleone, C. Serritella, V. Martiadis, and M. Maj Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders Bipolar Disord. 10 2008 95 100
42. S.A. Montgomery, and M. Asberg A new depression scale designed to be sensitive to change Br. J. Psychiatry 134 1979 382 389
43. T.W. Moorhead, J. McKirdy, J.E. Sussmann, J. Hall, S.M. Lawrie, E.C. Johnstone, and A.M. McIntosh Progressive gray matter loss in patients with bipolar disorder Biol. Psychiatry 62 2007 894 900
44. D. Ornish, J. Lin, J. Daubenmier, G. Weidner, E. Epel, C. Kemp, M.J. Magbanua, R. Marlin, L. Yglecias, P.R. Carroll, and E.H. Blackburn Increased telomerase activity and comprehensive lifestyle changes: a pilot study Lancet Oncol. 9 2008 1048 1057
45. U. Osby, L. Brandt, N. Correia, A. Ekbom, and P. Sparen Excess mortality in bipolar and unipolar disorder in Sweden Arch. Gen. Psychiatry 58 2001 844 850
46. E. Puterman, J. Lin, E. Blackburn, A. O'Donovan, N. Adler, and E. Epel The power of exercise: buffering the effect of chronic stress on telomere length PLoS One 5 2010 e10837
47. S. Rajaraman, J. Choi, P. Cheung, V. Beaudry, H. Moore, and S.E. Artandi Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo Proc. Natl. Acad. Sci. U.S.A. 104 2007 17747 17752
48. A. Sahay, and R. Hen Adult hippocampal neurogenesis in depression Nat. Neurosci. 10 2007 1110 1115
49. E. Samper, J.M. Flores, and M.A. Blasco Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc-/- mice with short telomeres EMBO Rep. 2 2001 800 807
50. R.J. Schloesser, J. Huang, P.S. Klein, and H.K. Manji Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder Neuropsychopharmacology 33 2008 110 133
51. L. Shao, L.T. Young, and J.F. Wang Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells Biol. Psychiatry 58 2005 879 884
52. D.V. Sheehan, Y. Lecrubier, K.H. Sheehan, P. Amorim, J. Janavs, E. Weiller, T. Hergueta, R. Baker, and G.C. Dunbar The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 J. Clin. Psychiatry 59 Suppl 20 1998 22 33
53. N.M. Simon, J.W. Smoller, K.L. McNamara, R.S. Maser, A.K. Zalta, M.H. Pollack, A.A. Nierenberg, M. Fava, and K.K. Wong Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging Biol. Psychiatry 60 2006 432 435
54. T. Suppes, G.S. Leverich, P.E. Keck, W.A. Nolen, K.D. Denicoff, L.L. Altshuler, S.L. McElroy, A.J. Rush, R. Kupka, M.A. Frye, M. Bickel, and R.M. Post The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients J. Affect. Disord. 67 2001 45 59
55. A.R. Tyrka, L.H. Price, H.T. Kao, B. Porton, S.A. Marsella, and L.L. Carpenter Childhood maltreatment and telomere shortening: preliminary support for an effect of early stress on cellular aging Biol. Psychiatry 67 2010 531 534
56. A.M. Valdes, T. Andrew, J.P. Gardner, M. Kimura, E. Oelsner, L.F. Cherkas, A. Aviv, and T.D. Spector Obesity, cigarette smoking, and telomere length in women Lancet 366 2005 662 664
57. O.M. Wolkowitz, E.S. Epel, V.I. Reus, and S.H. Mellon Depression gets old fast: do stress and depression accelerate cell aging? Depress. Anxiety 27 2010 327 338
58. H. Yamaguchi, R.T. Calado, H. Ly, S. Kajigaya, G.M. Baerlocher, S.J. Chanock, P.M. Lansdorp, and N.S. Young Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia N. Engl. J. Med. 352 2005 1413 1424
59. R.C. Young, J.T. Biggs, V.E. Ziegler, and D.A. Meyer A rating scale for mania: reliability, validity and sensitivity Br. J. Psychiatry 133 1978 429 435