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Volumn 99, Issue 8, 2014, Pages 1277-1284

Targeting acute myeloid leukemia stem cells: A review and principles for the development of clinical trials

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 9H PURIN 9 YL) 5 [[[3 [2 (5 TERT BUTYL 1H BENZIMIDAZOL 2 YL) ETHYL] CYCLOBUTYL] (ISOPROPYL) AMINO] METHYL] TETRAHYDROFURAN 3, 4 DIOL; 2 (6 AMINO 9H PURIN 9 YL) 5 [[[3 [2 (5 TERT BUTYL 1H BENZIMIDAZOL 2 YL)ETHYL]CYCLOBUTYL](ISOPROPYL)AMINO]METHYL]TETRAHYDROFURAN 3,4 DIOL; ABC TRANSPORTER; ALPHA INTERFERON; ANTIGEN; BCR ABL PROTEIN; BETA CATENIN; BORTEZOMIB; C KIT PROTEIN; C TYPE LECTIN LIKE MOLECULE 1; CD123 ANTIGEN; CD47 ANTIGEN; CD96 ANTIGEN; GEMTUZUMAB OZOGAMICIN; HERMES ANTIGEN; IMATINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENALIDOMIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 75; MONOCLONAL ANTIBODY 78; MONOCLONAL ANTIBODY 80; NOTCH RECEPTOR; PARTHENOLIDE; PROTEIN; PROTEIN BCL 2; PROTEIN KINASE SRC; REGULATOR PROTEIN; RITUXIMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN; ANTINEOPLASTIC AGENT;

EID: 84905179547     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2013.085209     Document Type: Review
Times cited : (93)

References (108)
  • 1
    • 84868196033 scopus 로고    scopus 로고
    • Current treatment of acute myeloid leukemia
    • Roboz GJ. Current treatment of acute myeloid leukemia. Curr Opin Oncol. 2012; 24(6): 711-9.
    • (2012) Curr Opin Oncol , vol.24 , Issue.6 , pp. 711-719
    • Roboz, G.J.1
  • 2
    • 84866990365 scopus 로고    scopus 로고
    • Remission induction in acute myeloid leukemia
    • Stein EM, Tallman MS. Remission induction in acute myeloid leukemia. Int J Hematol. 2012; 96(2): 164-70.
    • (2012) Int J Hematol , vol.96 , Issue.2 , pp. 164-170
    • Stein, E.M.1    Tallman, M.S.2
  • 3
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature. 2001; 414(6859): 105-11.
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 4
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE. Stem cell concepts renew cancer research. Blood. 2008; 112(13): 4793-807.
    • (2008) Blood , vol.112 , Issue.13 , pp. 4793-4807
    • Dick, J.E.1
  • 5
    • 33751210076 scopus 로고    scopus 로고
    • The cancer stem cell hypothesis: A work in progress
    • Tan BT, Park CY, Ailles LE, Weissman IL. The cancer stem cell hypothesis: a work in progress. Lab Invest. 2006; 86(12): 1203-7.
    • (2006) Lab Invest , vol.86 , Issue.12 , pp. 1203-1207
    • Tan, B.T.1    Park, C.Y.2    Ailles, L.E.3    Weissman, I.L.4
  • 6
    • 35848968478 scopus 로고    scopus 로고
    • Evaluating Therapeutic Efficacy against Cancer Stem Cells: New Challenges Posed by a New Paradigm
    • Wang JC. Evaluating Therapeutic Efficacy against Cancer Stem Cells: New Challenges Posed by a New Paradigm. Cell Stem Cell. 2007; 1(5): 497-501.
    • (2007) Cell Stem Cell , vol.1 , Issue.5 , pp. 497-501
    • Wang, J.C.1
  • 7
    • 78651140052 scopus 로고
    • The role of tumor stem-cells in regrowth of the tumor following drastic applications
    • Makino S. The role of tumor stem-cells in regrowth of the tumor following drastic applications. Acta Unio Int Contra Cancrum. 1959; 15(Suppl 1): 196-8.
    • (1959) Acta Unio Int Contra Cancrum , vol.15 , Issue.SUPPL. 1 , pp. 196-198
    • Makino, S.1
  • 8
  • 9
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells
    • Hamburger AW, Salmon SE. Primary bioassay of human tumor stem cells. Science. 1977; 197(4302): 461-3.
    • (1977) Science , vol.197 , Issue.4302 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 11
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994; 367(6464): 645-8.
    • (1994) Nature , vol.367 , Issue.6464 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3    Murdoch, B.4    Hoang, T.5    Caceres-Cortes, J.6
  • 12
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med. 1997; 3(7): 730-7.
    • (1997) Nat Med , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 13
    • 24344506258 scopus 로고    scopus 로고
    • Cancer stem cells: Lessons from leukemia
    • Wang JC, Dick JE. Cancer stem cells: lessons from leukemia. Trends Cell Biol. 2005; 15(9): 494-501.
    • (2005) Trends Cell Biol , vol.15 , Issue.9 , pp. 494-501
    • Wang, J.C.1    Dick, J.E.2
  • 14
    • 0030911358 scopus 로고    scopus 로고
    • Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice
    • Bhatia M, Wang JC, Kapp U, Bonnet D, Dick JE. Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci USA. 1997; 94(10): 5320-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.10 , pp. 5320-5325
    • Bhatia, M.1    Wang, J.C.2    Kapp, U.3    Bonnet, D.4    Dick, J.E.5
  • 15
    • 0035228050 scopus 로고    scopus 로고
    • Distinct classes of human stem cells that differ in proliferative and self-renewal potential
    • Guenechea G, Gan OI, Dorrell C, Dick JE. Distinct classes of human stem cells that differ in proliferative and self-renewal potential. Nat Immunol. 2001; 2(1): 75-82.
    • (2001) Nat Immunol , vol.2 , Issue.1 , pp. 75-82
    • Guenechea, G.1    Gan, O.I.2    Dorrell, C.3    Dick, J.E.4
  • 16
    • 0942266035 scopus 로고    scopus 로고
    • Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment
    • Mazurier F, Gan OI, McKenzie JL, Doedens M, Dick JE. Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment. Blood. 2004; 103(2): 545-52.
    • (2004) Blood , vol.103 , Issue.2 , pp. 545-552
    • Mazurier, F.1    Gan, O.I.2    McKenzie, J.L.3    Doedens, M.4    Dick, J.E.5
  • 17
    • 3242754448 scopus 로고    scopus 로고
    • Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in selfrenewal capacity
    • Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in selfrenewal capacity. Nat Immunol. 2004; 5(7): 738-43.
    • (2004) Nat Immunol , vol.5 , Issue.7 , pp. 738-743
    • Hope, K.J.1    Jin, L.2    Dick, J.E.3
  • 18
    • 0038011863 scopus 로고    scopus 로고
    • Stem cells: Self-renewal writ in blood
    • Dick JE. Stem cells: Self-renewal writ in blood. Nature. 2003; 423(6937): 231-3.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 231-233
    • Dick, J.E.1
  • 19
    • 13244287709 scopus 로고    scopus 로고
    • Complexity of the human acute myeloid leukemia stem cell compartment: Implications for therapy
    • Dick JE. Complexity of the human acute myeloid leukemia stem cell compartment: implications for therapy. Biol Blood Marrow Transplant. 2005; 11(2 Suppl 2): 9-11.
    • (2005) Biol Blood Marrow Transplant , vol.11 , Issue.2 SUPPL. 2 , pp. 9-11
    • Dick, J.E.1
  • 20
    • 0000989518 scopus 로고    scopus 로고
    • Detection and characterization of primitive malignant and normal progenitors in patients with acute myelogenous leukemia using long-term coculture with supportive feeder layers and cytokines
    • Ailles LE, Gerhard B, Hogge DE. Detection and characterization of primitive malignant and normal progenitors in patients with acute myelogenous leukemia using long-term coculture with supportive feeder layers and cytokines. Blood. 1997; 90(7): 2555-64.
    • (1997) Blood , vol.90 , Issue.7 , pp. 2555-2564
    • Ailles, L.E.1    Gerhard, B.2    Hogge, D.E.3
  • 21
    • 0032402173 scopus 로고    scopus 로고
    • Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(-)/HLA-DR
    • Blair A, Hogge DE, Sutherland HJ. Most acute myeloid leukemia progenitor cells with long-term proliferative ability in vitro and in vivo have the phenotype CD34(+)/CD71(-)/HLA-DR. Blood. 1998; 92 (11): 4325-35.
    • (1998) Blood , vol.92 , Issue.11 , pp. 4325-4335
    • Blair, A.1    Hogge, D.E.2    Sutherland, H.J.3
  • 22
    • 78650950098 scopus 로고    scopus 로고
    • Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rgammac-deficient mice
    • Sarry JE, Murphy K, Perry R, et al. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rgammac-deficient mice. J Clin Invest. 2011; 121(1): 384-95.
    • (2011) J Clin Invest , vol.121 , Issue.1 , pp. 384-395
    • Sarry, J.E.1    Murphy, K.2    Perry, R.3
  • 23
    • 80052468964 scopus 로고    scopus 로고
    • Stem cell gene expression programs influence clinical outcome in human leukemia
    • Eppert K, Takenaka K, Lechman ER, Waldron L, Nilsson B, van Galen P, et al. Stem cell gene expression programs influence clinical outcome in human leukemia. Nat Med. 2011; 17(9): 1086-93.
    • (2011) Nat Med , vol.17 , Issue.9 , pp. 1086-1093
    • Eppert, K.1    Takenaka, K.2    Lechman, E.R.3    Waldron, L.4    Nilsson, B.5    van Galen, P.6
  • 24
    • 84863910743 scopus 로고    scopus 로고
    • Recent advances in acute myeloid leukemia stem cell biology
    • Horton SJ, Huntly BJ. Recent advances in acute myeloid leukemia stem cell biology. Haematologica. 2012; 97(7): 966-74.
    • (2012) Haematologica , vol.97 , Issue.7 , pp. 966-974
    • Horton, S.J.1    Huntly, B.J.2
  • 25
    • 0030988803 scopus 로고    scopus 로고
    • Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo
    • Blair A, Hogge DE, Ailles LE, Lansdorp PM, Sutherland HJ. Lack of expression of Thy-1 (CD90) on acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo. Blood. 1997; 89(9): 3104-12.
    • (1997) Blood , vol.89 , Issue.9 , pp. 3104-3112
    • Blair, A.1    Hogge, D.E.2    Ailles, L.E.3    Lansdorp, P.M.4    Sutherland, H.J.5
  • 26
    • 0033815950 scopus 로고    scopus 로고
    • The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells
    • Jordan CT, Upchurch D, Szilvassy SJ, Guzman ML, Howard DS, Pettigrew AL, et al. The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells. Leukemia. 2000; 14(10): 1777-84.
    • (2000) Leukemia , vol.14 , Issue.10 , pp. 1777-1784
    • Jordan, C.T.1    Upchurch, D.2    Szilvassy, S.J.3    Guzman, M.L.4    Howard, D.S.5    Pettigrew, A.L.6
  • 27
    • 0032745463 scopus 로고    scopus 로고
    • Detection of cytogenetic aberrations both in CD90 (Thy-1)-positive and (Thy-1)-negative stem cell (CD34) subfractions of patients with acute and chronic myeloid leukemias
    • Brendel C, Mohr B, Schimmelpfennig C, Müller J, Bornhäuser M, Schmidt M, et al. Detection of cytogenetic aberrations both in CD90 (Thy-1)-positive and (Thy-1)-negative stem cell (CD34) subfractions of patients with acute and chronic myeloid leukemias. Leukemia. 1999; 13(11): 1770-5.
    • (1999) Leukemia , vol.13 , Issue.11 , pp. 1770-1775
    • Brendel, C.1    Mohr, B.2    Schimmelpfennig, C.3    Müller, J.4    Bornhäuser, M.5    Schmidt, M.6
  • 28
    • 0036234659 scopus 로고    scopus 로고
    • Unique molecular and cellular features of acute myelogenous leukemia stem cells
    • Jordan CT. Unique molecular and cellular features of acute myelogenous leukemia stem cells. Leukemia. 2002; 16(4): 559-62.
    • (2002) Leukemia , vol.16 , Issue.4 , pp. 559-562
    • Jordan, C.T.1
  • 29
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001; 98(8): 2301-7.
    • (2001) Blood , vol.98 , Issue.8 , pp. 2301-2307
    • Guzman, M.L.1    Neering, S.J.2    Upchurch, D.3    Grimes, B.4    Howard, D.S.5    Rizzieri, D.A.6
  • 30
    • 84875143073 scopus 로고    scopus 로고
    • BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
    • Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell. 2013; 12(3): 329-41.
    • (2013) Cell Stem Cell , vol.12 , Issue.3 , pp. 329-341
    • Lagadinou, E.D.1    Sach, A.2    Callahan, K.3    Rossi, R.M.4    Neering, S.J.5    Minhajuddin, M.6
  • 33
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille TC, Cleary ML. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 2006; 10(4): 257-68.
    • (2006) Cancer Cell , vol.10 , Issue.4 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 34
    • 0141483064 scopus 로고    scopus 로고
    • Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    • Passegue E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics? Proc Natl Acad Sci USA. 2003; 100 Suppl 1: 11842-9.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.SUPPL. 1 , pp. 11842-11849
    • Passegue, E.1    Jamieson, C.H.2    Ailles, L.E.3    Weissman, I.L.4
  • 36
    • 77950451485 scopus 로고    scopus 로고
    • Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction
    • Taussig DC, Vargaftig J, Miraki-Moud F, Griessinger E, Sharrock K, Luke T, et al. Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction. Blood. 2010; 115(10): 1976-84.
    • (2010) Blood , vol.115 , Issue.10 , pp. 1976-1984
    • Taussig, D.C.1    Vargaftig, J.2    Miraki-Moud, F.3    Griessinger, E.4    Sharrock, K.5    Luke, T.6
  • 37
    • 84862839849 scopus 로고    scopus 로고
    • Minimal residual disease detection defined as the malignant fraction of the total primitive stem cell compartment offers additional prognostic information in acute myeloid leukaemia
    • Terwijn M, Kelder A, Snel AN, Rutten AP, Scholtern WJ, Oussoren YJ, et al. Minimal residual disease detection defined as the malignant fraction of the total primitive stem cell compartment offers additional prognostic information in acute myeloid leukaemia. Int J Lab Hematol. 2012; 34 (4): 432-41.
    • (2012) Int J Lab Hematol , vol.34 , Issue.4 , pp. 432-441
    • Terwijn, M.1    Kelder, A.2    Snel, A.N.3    Rutten, A.P.4    Scholtern, W.J.5    Oussoren, Y.J.6
  • 38
    • 78651416188 scopus 로고    scopus 로고
    • Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia
    • Goardon N, Marchi E, Atzberger A, Quek L, Schuh A, Soneji S, et al. Coexistence of LMPP-like and GMP-like leukemia stem cells in acute myeloid leukemia. Cancer Cell. 2011; 19(1): 138-52.
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 138-152
    • Goardon, N.1    Marchi, E.2    Atzberger, A.3    Quek, L.4    Schuh, A.5    Soneji, S.6
  • 39
    • 4344688843 scopus 로고    scopus 로고
    • MRD parameters using immunophenotypic detection methods are highly reliable in predicting survival in acute myeloid leukaemia
    • Feller N, van der Pol MA, van Stijn A, Weijers GW, Westra AH, Evertse BW, et al. MRD parameters using immunophenotypic detection methods are highly reliable in predicting survival in acute myeloid leukaemia. Leukemia. 2004; 18(8): 1380-90.
    • (2004) Leukemia , vol.18 , Issue.8 , pp. 1380-1390
    • Feller, N.1    van der Pol, M.A.2    van Stijn, A.3    Weijers, G.W.4    Westra, A.H.5    Evertse, B.W.6
  • 40
    • 0035885973 scopus 로고    scopus 로고
    • Early immunophenotypical evaluation of minimal residual disease in acute myeloid leukemia identifies different patient risk groups and may contribute to postinduction treatment stratification
    • San Miguel JF, Vidriales MB, Lopez-Berges C, Díaz-Mediavilla J, Gutiérrez N, Cañizo C, et al. Early immunophenotypical evaluation of minimal residual disease in acute myeloid leukemia identifies different patient risk groups and may contribute to postinduction treatment stratification. Blood. 2001; 98(6): 1746-51.
    • (2001) Blood , vol.98 , Issue.6 , pp. 1746-1751
    • San Miguel, J.F.1    Vidriales, M.B.2    Lopez-Berges, C.3    Díaz-Mediavilla, J.4    Gutiérrez, N.5    Cañizo, C.6
  • 41
    • 0034554848 scopus 로고    scopus 로고
    • Level of minimal residual disease after consolidation therapy predicts outcome in acute myeloid leukemia
    • Venditti A, Buccisano F, Del Poeta G, Maurillo L, Tamburini A, Cox C, et al. Level of minimal residual disease after consolidation therapy predicts outcome in acute myeloid leukemia. Blood. 2000; 96(12): 3948-52.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3948-3952
    • Venditti, A.1    Buccisano, F.2    Del Poeta, G.3    Maurillo, L.4    Tamburini, A.5    Cox, C.6
  • 42
    • 5444223232 scopus 로고    scopus 로고
    • Determination of relapse risk based on assessment of minimal residual disease during complete remission by multiparameter flow cytometry in unselected patients with acute myeloid leukemia
    • Kern W, Voskova D, Schoch C, Hiddemann W, Schnittger S, Haferlach T. Determination of relapse risk based on assessment of minimal residual disease during complete remission by multiparameter flow cytometry in unselected patients with acute myeloid leukemia. Blood. 2004; 104 (10): 3078-85.
    • (2004) Blood , vol.104 , Issue.10 , pp. 3078-3085
    • Kern, W.1    Voskova, D.2    Schoch, C.3    Hiddemann, W.4    Schnittger, S.5    Haferlach, T.6
  • 43
    • 84865406961 scopus 로고    scopus 로고
    • Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: A report from Children's Oncology Group
    • Loken MR, Alonzo TA, Pardo L, Gerbing RB, Raimondi SC, Hirsch BA, et al. Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's Oncology Group. Blood. 2012; 120(8): 1581-8.
    • (2012) Blood , vol.120 , Issue.8 , pp. 1581-1588
    • Loken, M.R.1    Alonzo, T.A.2    Pardo, L.3    Gerbing, R.B.4    Raimondi, S.C.5    Hirsch, B.A.6
  • 44
    • 70349579540 scopus 로고    scopus 로고
    • Minimal residual disease levels assessed by NPM1 mutationspecific RQ-PCR provide important prognostic information in AML
    • Schnittger S, Kern W, Tschulik C, Weiss T, Dicker F, Falini B, et al. Minimal residual disease levels assessed by NPM1 mutationspecific RQ-PCR provide important prognostic information in AML. Blood. 2009; 114(11): 2220-31.
    • (2009) Blood , vol.114 , Issue.11 , pp. 2220-2231
    • Schnittger, S.1    Kern, W.2    Tschulik, C.3    Weiss, T.4    Dicker, F.5    Falini, B.6
  • 45
    • 84880991962 scopus 로고    scopus 로고
    • MRD-directed risk stratification treatment may improve outcomes of t(8; 21) AML in the first complete remission: Results from the AML05 multicenter trial
    • Zhu HH, Zhang XH, Qin YZ, Liu DH, Jiang H, Chen H, et al. MRD-directed risk stratification treatment may improve outcomes of t(8; 21) AML in the first complete remission: results from the AML05 multicenter trial. Blood. 2013; 121(20): 4056-62.
    • (2013) Blood , vol.121 , Issue.20 , pp. 4056-4062
    • Zhu, H.H.1    Zhang, X.H.2    Qin, Y.Z.3    Liu, D.H.4    Jiang, H.5    Chen, H.6
  • 46
    • 34447646569 scopus 로고    scopus 로고
    • Aberrant marker expression patterns on the CD34+CD38-stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission
    • van Rhenen A, Moshaver B, Kelder A, Feller N, Nieuwint AW, Zweegman S, et al. Aberrant marker expression patterns on the CD34+CD38-stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission. Leukemia. 2007; 21(8): 1700-7.
    • (2007) Leukemia , vol.21 , Issue.8 , pp. 1700-1707
    • van Rhenen, A.1    Moshaver, B.2    Kelder, A.3    Feller, N.4    Nieuwint, A.W.5    Zweegman, S.6
  • 47
    • 0037606054 scopus 로고    scopus 로고
    • Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML)
    • Guan Y, Gerhard B, Hogge DE. Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML). Blood. 2003; 101(8): 3142-9.
    • (2003) Blood , vol.101 , Issue.8 , pp. 3142-3149
    • Guan, Y.1    Gerhard, B.2    Hogge, D.E.3
  • 48
    • 35948984135 scopus 로고    scopus 로고
    • Chemotherapy-resistant human AML stem cells home to and engraft within the bonemarrow endosteal region
    • Ishikawa F, Yoshida S, Saito Y, Hijikata A, Kitamura H, Tanaka S, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bonemarrow endosteal region. Nat Biotechnol. 2007; 25(11): 1315-21.
    • (2007) Nat Biotechnol , vol.25 , Issue.11 , pp. 1315-1321
    • Ishikawa, F.1    Yoshida, S.2    Saito, Y.3    Hijikata, A.4    Kitamura, H.5    Tanaka, S.6
  • 49
    • 0029840432 scopus 로고    scopus 로고
    • Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture
    • Terpstra W, Ploemacher RE, Prins A, van Lom K, Pouwels K, Wognum AW, et al. Fluorouracil selectively spares acute myeloid leukemia cells with long-term growth abilities in immunodeficient mice and in culture. Blood. 1996; 88(6): 1944-50.
    • (1996) Blood , vol.88 , Issue.6 , pp. 1944-1950
    • Terpstra, W.1    Ploemacher, R.E.2    Prins, A.3    van Lom, K.4    Pouwels, K.5    Wognum, A.W.6
  • 50
    • 0034662606 scopus 로고    scopus 로고
    • Human acute myeloid leukemia CD34+/CD38-progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities
    • Costello RT, Mallet F, Gaugler B, Sainty D, Arnoulet C, Gastaut JA, Olive D. Human acute myeloid leukemia CD34+/CD38-progenitor cells have decreased sensitivity to chemotherapy and Fas-induced apoptosis, reduced immunogenicity, and impaired dendritic cell transformation capacities. Cancer Res. 2000; 60(16): 4403-11.
    • (2000) Cancer Res , vol.60 , Issue.16 , pp. 4403-4411
    • Costello, R.T.1    Mallet, F.2    Gaugler, B.3    Sainty, D.4    Arnoulet, C.5    Gastaut, J.A.6    Olive, D.7
  • 51
    • 16844363378 scopus 로고    scopus 로고
    • The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
    • Guzman ML, Rossi RM, Karnischky L, Li X, Peterson DR, Howard DS, Jordan CT. The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood. 2005; 105(11): 4163-9.
    • (2005) Blood , vol.105 , Issue.11 , pp. 4163-4169
    • Guzman, M.L.1    Rossi, R.M.2    Karnischky, L.3    Li, X.4    Peterson, D.R.5    Howard, D.S.6    Jordan, C.T.7
  • 52
    • 84884982900 scopus 로고    scopus 로고
    • Sequential administration of the high affinity CXCR4 antagonist BKT140 promotes megakaryopoiesis and platelet production
    • Abraham M, Weiss ID, Wald H, Nagler A, Beider K, Eizenberg O, Peled A. Sequential administration of the high affinity CXCR4 antagonist BKT140 promotes megakaryopoiesis and platelet production. Br J Haematol. 2013; 163(2): 248-59.
    • (2013) Br J Haematol , vol.163 , Issue.2 , pp. 248-259
    • Abraham, M.1    Weiss, I.D.2    Wald, H.3    Nagler, A.4    Beider, K.5    Eizenberg, O.6    Peled, A.7
  • 53
    • 79952092993 scopus 로고    scopus 로고
    • Leukemia stem cells and microenvironment: Biology and therapeutic targeting
    • Konopleva MY, Jordan CT. Leukemia stem cells and microenvironment: biology and therapeutic targeting. J Clin Oncol. 2011; 29 (5): 591-9.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 591-599
    • Konopleva, M.Y.1    Jordan, C.T.2
  • 54
    • 0034525530 scopus 로고    scopus 로고
    • Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML)
    • Guan Y, Hogge DE. Proliferative status of primitive hematopoietic progenitors from patients with acute myelogenous leukemia (AML). Leukemia. 2000; 14(12): 2135-41.
    • (2000) Leukemia , vol.14 , Issue.12 , pp. 2135-2141
    • Guan, Y.1    Hogge, D.E.2
  • 55
    • 23644455476 scopus 로고    scopus 로고
    • Drug therapy for acute myeloid leukemia
    • Tallman MS, Gilliland DG, Rowe JM. Drug therapy for acute myeloid leukemia. Blood. 2005; 106(4): 1154-63.
    • (2005) Blood , vol.106 , Issue.4 , pp. 1154-1163
    • Tallman, M.S.1    Gilliland, D.G.2    Rowe, J.M.3
  • 56
    • 33747045287 scopus 로고    scopus 로고
    • Strategies to eliminate cancer stem cells: Clinical implications
    • Huff CA, Matsui WH, Smith BD, Jones RJ. Strategies to eliminate cancer stem cells: clinical implications. Eur J Cancer. 2006; 42 (9): 1293-7.
    • (2006) Eur J Cancer , vol.42 , Issue.9 , pp. 1293-1297
    • Huff, C.A.1    Matsui, W.H.2    Smith, B.D.3    Jones, R.J.4
  • 57
    • 0036090222 scopus 로고    scopus 로고
    • Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
    • Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, et al. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002; 99(1): 319-25.
    • (2002) Blood , vol.99 , Issue.1 , pp. 319-325
    • Graham, S.M.1    Jorgensen, H.G.2    Allan, E.3    Pearson, C.4    Alcorn, M.J.5    Richmond, L.6
  • 58
    • 0036265158 scopus 로고    scopus 로고
    • Quantitative assessment of gene expression in highly purified hematopoietic cells using real-time reverse transcriptase polymerase chain reaction
    • Raaijmakers MH, van Emst L, de Witte T, Mensink E, Raymakers RA. Quantitative assessment of gene expression in highly purified hematopoietic cells using real-time reverse transcriptase polymerase chain reaction. Exp Hematol. 2002; 30(5): 481-7.
    • (2002) Exp Hematol , vol.30 , Issue.5 , pp. 481-487
    • Raaijmakers, M.H.1    van Emst, L.2    de Witte, T.3    Mensink, E.4    Raymakers, R.A.5
  • 59
    • 0036163796 scopus 로고    scopus 로고
    • ABC transporters as phenotypic markers and functional regulators of stem cells
    • Bunting KD. ABC transporters as phenotypic markers and functional regulators of stem cells. Stem Cells. 2002; 20(1): 11-20.
    • (2002) Stem Cells , vol.20 , Issue.1 , pp. 11-20
    • Bunting, K.D.1
  • 60
    • 7244232706 scopus 로고    scopus 로고
    • Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump
    • Burger H, van Tol H, Boersma AW, Brok M, Wiemer EA, Stoter G, Nooter K. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004; 104(9): 2940-2.
    • (2004) Blood , vol.104 , Issue.9 , pp. 2940-2942
    • Burger, H.1    van Tol, H.2    Boersma, A.W.3    Brok, M.4    Wiemer, E.A.5    Stoter, G.6    Nooter, K.7
  • 61
    • 0037443754 scopus 로고    scopus 로고
    • MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models
    • Mahon FX, Belloc F, Lagarde V, Chollet C, Moreau-Gaudry F, Reiffers J, et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. Blood. 2003; 101(6): 2368-73.
    • (2003) Blood , vol.101 , Issue.6 , pp. 2368-2373
    • Mahon, F.X.1    Belloc, F.2    Lagarde, V.3    Chollet, C.4    Moreau-Gaudry, F.5    Reiffers, J.6
  • 62
    • 0027277061 scopus 로고
    • BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia
    • Bedi A, Zehnbauer BA, Collector MI, Barber JP, Zicha MS, Sharkis SJ, Jones RJ. BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia. Blood. 1993; 81(11): 2898-902.
    • (1993) Blood , vol.81 , Issue.11 , pp. 2898-2902
    • Bedi, A.1    Zehnbauer, B.A.2    Collector, M.I.3    Barber, J.P.4    Zicha, M.S.5    Sharkis, S.J.6    Jones, R.J.7
  • 63
    • 24944450475 scopus 로고    scopus 로고
    • Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors
    • Angstreich GR, Matsui W, Huff CA, Vala MS, Barber J, Hawkins AL, et al. Effects of imatinib and interferon on primitive chronic myeloid leukaemia progenitors. Br J Haematol. 2005; 130(3): 373-81.
    • (2005) Br J Haematol , vol.130 , Issue.3 , pp. 373-381
    • Angstreich, G.R.1    Matsui, W.2    Huff, C.A.3    Vala, M.S.4    Barber, J.5    Hawkins, A.L.6
  • 64
    • 78049528573 scopus 로고    scopus 로고
    • Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial
    • Mahon FX, Rea D, Guilhot J, Huguet F, Nicolini F, Legros L, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol. 2010; 11(11): 1029-35.
    • (2010) Lancet Oncol , vol.11 , Issue.11 , pp. 1029-1035
    • Mahon, F.X.1    Rea, D.2    Guilhot, J.3    Huguet, F.4    Nicolini, F.5    Legros, L.6
  • 66
    • 30444449874 scopus 로고    scopus 로고
    • Multiple myeloma stem cells and plasma cells display distinct drug sensitivities
    • Matsui W, Huff CA, Wang QJ, Barber JP, Smith BD, Jones RJ. Multiple myeloma stem cells and plasma cells display distinct drug sensitivities. Blood. 2004; 104: 679A-A.
    • (2004) Blood , vol.104 , pp. 679
    • Matsui, W.1    Huff, C.A.2    Wang, Q.J.3    Barber, J.P.4    Smith, B.D.5    Jones, R.J.6
  • 67
    • 33746319879 scopus 로고    scopus 로고
    • Rituximab treatment provides no clinical benefit in patients with pretreated advanced multiple myeloma
    • Zojer N, Kirchbacher K, Vesely M, Hubl W, Ludwig H. Rituximab treatment provides no clinical benefit in patients with pretreated advanced multiple myeloma. Leuk Lymphoma. 2006; 47(6): 1103-9.
    • (2006) Leuk Lymphoma , vol.47 , Issue.6 , pp. 1103-1109
    • Zojer, N.1    Kirchbacher, K.2    Vesely, M.3    Hubl, W.4    Ludwig, H.5
  • 68
    • 0036140240 scopus 로고    scopus 로고
    • CD20-directed serotherapy in patients with multiple myeloma: Biologic considerations and therapeutic applications
    • Treon SP, Pilarski LM, Belch AR, Kelliher A, Preffer FI, Shima CS, et al. CD20-directed serotherapy in patients with multiple myeloma: biologic considerations and therapeutic applications. J Immunother. 2002; 25(1): 72-81.
    • (2002) J Immunother , vol.25 , Issue.1 , pp. 72-81
    • Treon, S.P.1    Pilarski, L.M.2    Belch, A.R.3    Kelliher, A.4    Preffer, F.I.5    Shima, C.S.6
  • 69
    • 2342535230 scopus 로고    scopus 로고
    • Cancer stem cells: Are we missing the target?
    • Jones RJ, Matsui WH, Smith BD. Cancer stem cells: are we missing the target? J Natl Cancer Inst. 2004; 96(8): 583-5.
    • (2004) J Natl Cancer Inst , vol.96 , Issue.8 , pp. 583-585
    • Jones, R.J.1    Matsui, W.H.2    Smith, B.D.3
  • 70
    • 83555166140 scopus 로고    scopus 로고
    • Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML
    • de Jonge HJ, Woolthuis CM, Vos AZ, Mulder A, van den Berg E, Kluin PM, et al. Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML. Leukemia. 2011; 25(12): 1825-33.
    • (2011) Leukemia , vol.25 , Issue.12 , pp. 1825-1833
    • de Jonge, H.J.1    Woolthuis, C.M.2    Vos, A.Z.3    Mulder, A.4    van den Berg, E.5    Kluin, P.M.6
  • 71
    • 25144433295 scopus 로고    scopus 로고
    • High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival
    • van Rhenen A, Feller N, Kelder A, Westra AH, Rombouts E, Zweegman S, et al. High stem cell frequency in acute myeloid leukemia at diagnosis predicts high minimal residual disease and poor survival. Clin Cancer Res. 2005; 11(18): 6520-7.
    • (2005) Clin Cancer Res , vol.11 , Issue.18 , pp. 6520-6527
    • van Rhenen, A.1    Feller, N.2    Kelder, A.3    Westra, A.H.4    Rombouts, E.5    Zweegman, S.6
  • 72
    • 84855610965 scopus 로고    scopus 로고
    • Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance
    • Ran D, Schubert M, Taubert I, Eckstein V, Bellos F, Jauch A, et al. Heterogeneity of leukemia stem cell candidates at diagnosis of acute myeloid leukemia and their clinical significance. Exp Hematol. 2012; 40(2): 155-65. e1.
    • (2012) Exp Hematol , vol.40 , Issue.2 , pp. 155-165
    • Ran, D.1    Schubert, M.2    Taubert, I.3    Eckstein, V.4    Bellos, F.5    Jauch, A.6
  • 73
    • 78650444882 scopus 로고    scopus 로고
    • Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia
    • Gentles AJ, Plevritis SK, Majeti R, Alizadeh AA. Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA. 2010; 304(24): 2706-15.
    • (2010) JAMA , vol.304 , Issue.24 , pp. 2706-2715
    • Gentles, A.J.1    Plevritis, S.K.2    Majeti, R.3    Alizadeh, A.A.4
  • 74
    • 70449413732 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes
    • Ran D, Schubert M, Pietsch L, Taubert I, Wuchter P, Eckstein V, et al. Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes. Exp Hematol. 2009; 37(12): 1423-34.
    • (2009) Exp Hematol , vol.37 , Issue.12 , pp. 1423-1434
    • Ran, D.1    Schubert, M.2    Pietsch, L.3    Taubert, I.4    Wuchter, P.5    Eckstein, V.6
  • 75
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R, Chao MP, Alizadeh AA, Pang WW, Jaiswal S, Gibbs KD, et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009; 138(2): 286-99.
    • (2009) Cell , vol.138 , Issue.2 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3    Pang, W.W.4    Jaiswal, S.5    Gibbs, K.D.6
  • 76
    • 66549121284 scopus 로고    scopus 로고
    • Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities
    • Horton SJ, Walf-Vorderwulbecke V, Chatters SJ, Sebire NJ, de Boer J, Williams O. Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities. Blood. 2009; 113(20): 4922-9.
    • (2009) Blood , vol.113 , Issue.20 , pp. 4922-4929
    • Horton, S.J.1    Walf-Vorderwulbecke, V.2    Chatters, S.J.3    Sebire, N.J.4    de Boer, J.5    Williams, O.6
  • 78
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006; 12(10): 1167-74.
    • (2006) Nat Med , vol.12 , Issue.10 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 79
    • 67649200331 scopus 로고    scopus 로고
    • Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells
    • Jin L, Lee EM, Ramshaw HS, Busfield SJ, Peoppl AG, Wilkinson L, et al. Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell. 2009; 5(1): 31-42.
    • (2009) Cell Stem Cell , vol.5 , Issue.1 , pp. 31-42
    • Jin, L.1    Lee, E.M.2    Ramshaw, H.S.3    Busfield, S.J.4    Peoppl, A.G.5    Wilkinson, L.6
  • 80
    • 34948839959 scopus 로고    scopus 로고
    • The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells
    • van Rhenen A, van Dongen GA, Kelder A, Rombouts EJ, Feller N, Moshaver B, et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells. Blood. 2007; 110(7): 2659-66.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2659-2666
    • van Rhenen, A.1    van Dongen, G.A.2    Kelder, A.3    Rombouts, E.J.4    Feller, N.5    Moshaver, B.6
  • 81
  • 82
    • 84887333212 scopus 로고    scopus 로고
    • The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cell by chemotherapeutic agents
    • Dos Santos C, McDonald T, Ho YW, Liu H, Lina A, Forman SJ, et al. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cell by chemotherapeutic agents. Blood. 2013; 122(11): 1900-13.
    • (2013) Blood , vol.122 , Issue.11 , pp. 1900-1913
    • Dos Santos, C.1    McDonald, T.2    Ho, Y.W.3    Liu, H.4    Lina, A.5    Forman, S.J.6
  • 83
    • 77749294821 scopus 로고    scopus 로고
    • Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells
    • Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasawa M, Tanaka S, Takagi S, et al. Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells. Sci Transl Med. 2010; 2(17): 17ra9.
    • (2010) Sci Transl Med , vol.2 , Issue.17
    • Saito, Y.1    Kitamura, H.2    Hijikata, A.3    Tomizawa-Murasawa, M.4    Tanaka, S.5    Takagi, S.6
  • 84
    • 84877729772 scopus 로고    scopus 로고
    • A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo
    • Saito Y, Yuki H, Kuratani M, Hashizume Y, Takagi S, Honma T, et al. A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo. Sci Transl Med. 2013; 5(181): 181ra52.
    • (2013) Sci Transl Med , vol.5 , Issue.181
    • Saito, Y.1    Yuki, H.2    Kuratani, M.3    Hashizume, Y.4    Takagi, S.5    Honma, T.6
  • 85
    • 84864452783 scopus 로고    scopus 로고
    • Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist
    • Shih AY, Schairer A, Barrett CL, Geron I, Court Recart AC, Goff D, et al. Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist. Blood. 2011; 118: 1613.
    • (2011) Blood , vol.118 , pp. 1613
    • Shih, A.Y.1    Schairer, A.2    Barrett, C.L.3    Geron, I.4    Court Recart, A.C.5    Goff, D.6
  • 86
    • 84904368509 scopus 로고    scopus 로고
    • Phase II Study of Bortezomib as a Single Agent in Patients with Previously Untreated or Relapsed/Refractory Acute Myeloid Leukemia Ineligible for Intensive Therapy
    • Sarlo C, Buccisano F, Maurillo L, Cefalo M, Di Caprio L, Cicconi L, et al. Phase II Study of Bortezomib as a Single Agent in Patients with Previously Untreated or Relapsed/Refractory Acute Myeloid Leukemia Ineligible for Intensive Therapy. Leuk Res Treatment. 2013; 2013: 705714.
    • (2013) Leuk Res Treatment , vol.2013 , pp. 705714
    • Sarlo, C.1    Buccisano, F.2    Maurillo, L.3    Cefalo, M.4    Di Caprio, L.5    Cicconi, L.6
  • 88
    • 84886825064 scopus 로고    scopus 로고
    • SGNCD33A: A novel CD33-targeting antibodydrug conjugate using a pyrrolobenzodiazepine dimer is active in models of drugresistant AML
    • Kung Sutherland MS, Walter RB, Jeffrey SC, Burke PJ, Yu C, Kostner H, et al. SGNCD33A: a novel CD33-targeting antibodydrug conjugate using a pyrrolobenzodiazepine dimer is active in models of drugresistant AML. Blood. 2013; 122(8): 1455-63.
    • (2013) Blood , vol.122 , Issue.8 , pp. 1455-1463
    • Kung Sutherland, M.S.1    Walter, R.B.2    Jeffrey, S.C.3    Burke, P.J.4    Yu, C.5    Kostner, H.6
  • 89
    • 84879320732 scopus 로고    scopus 로고
    • Anti-CD33-antibodies labelled with the alpha-emitter Bismuth-213 kill CD33-positive acute myeloid leukaemia cells specifically by activation of caspases and break radio-and chemoresistance by inhibition of the antiapoptotic proteins X-linked inhibitor of apoptosis protein and B-cell lymphoma-extra large
    • Friesen C, Roscher M, Hormann I, Leib O, Marx S, Moreno J, Miltner E. Anti-CD33-antibodies labelled with the alpha-emitter Bismuth-213 kill CD33-positive acute myeloid leukaemia cells specifically by activation of caspases and break radio-and chemoresistance by inhibition of the antiapoptotic proteins X-linked inhibitor of apoptosis protein and B-cell lymphoma-extra large. Eur J Cancer. 2013; 49(11): 2542-54.
    • (2013) Eur J Cancer , vol.49 , Issue.11 , pp. 2542-2554
    • Friesen, C.1    Roscher, M.2    Hormann, I.3    Leib, O.4    Marx, S.5    Moreno, J.6    Miltner, E.7
  • 90
    • 84876116790 scopus 로고    scopus 로고
    • T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct
    • Aigner M, Feulner J, Schaffer S, Kischel R, Kufer P, Schneider K, et al. T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct. Leukemia. 2013; 27(5): 1107-15.
    • (2013) Leukemia , vol.27 , Issue.5 , pp. 1107-1115
    • Aigner, M.1    Feulner, J.2    Schaffer, S.3    Kischel, R.4    Kufer, P.5    Schneider, K.6
  • 91
    • 0037085927 scopus 로고    scopus 로고
    • A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors
    • Feuring-Buske M, Frankel AE, Alexander RL, Gerhard B, Hogge DE. A diphtheria toxin-interleukin 3 fusion protein is cytotoxic to primitive acute myeloid leukemia progenitors but spares normal progenitors. Cancer Res. 2002; 62(6): 1730-6.
    • (2002) Cancer Res , vol.62 , Issue.6 , pp. 1730-1736
    • Feuring-Buske, M.1    Frankel, A.E.2    Alexander, R.L.3    Gerhard, B.4    Hogge, D.E.5
  • 92
    • 20644469046 scopus 로고    scopus 로고
    • Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: Pharmacokinetics, pharmacodynamics, and clinical activity
    • Marcucci G, Stock W, Dai G, Klisovic RB, Liu S, Klisovic MI, et al. Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity. J Clin Oncol. 2005; 23(15): 3404-11.
    • (2005) J Clin Oncol , vol.23 , Issue.15 , pp. 3404-3411
    • Marcucci, G.1    Stock, W.2    Dai, G.3    Klisovic, R.B.4    Liu, S.5    Klisovic, M.I.6
  • 93
    • 33744552602 scopus 로고    scopus 로고
    • A Phase II study of Bcl-2 antisense (oblimersen sodium) combined with gemtuzumab ozogamicin in older patients with acute myeloid leukemia in first relapse
    • Moore J, Seiter K, Kolitz J, Stock W, Giles F, Kalaycio M, et al. A Phase II study of Bcl-2 antisense (oblimersen sodium) combined with gemtuzumab ozogamicin in older patients with acute myeloid leukemia in first relapse. Leuk Res. 2006; 30(7): 777-83.
    • (2006) Leuk Res , vol.30 , Issue.7 , pp. 777-783
    • Moore, J.1    Seiter, K.2    Kolitz, J.3    Stock, W.4    Giles, F.5    Kalaycio, M.6
  • 94
    • 0034050268 scopus 로고    scopus 로고
    • Monoclonal antibodies to the myeloid stem cells: Therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate
    • Bernstein ID. Monoclonal antibodies to the myeloid stem cells: therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate. Leukemia. 2000; 14(3): 474-5.
    • (2000) Leukemia , vol.14 , Issue.3 , pp. 474-475
    • Bernstein, I.D.1
  • 95
    • 28844456971 scopus 로고    scopus 로고
    • Hematopoietic stem cells express multiple myeloid markers: Implications for the origin and targeted therapy of acute myeloid leukemia
    • Taussig DC, Pearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G, et al. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood. 2005; 106(13): 4086-92.
    • (2005) Blood , vol.106 , Issue.13 , pp. 4086-4092
    • Taussig, D.C.1    Pearce, D.J.2    Simpson, C.3    Rohatiner, A.Z.4    Lister, T.A.5    Kelly, G.6
  • 96
    • 84859899567 scopus 로고    scopus 로고
    • Acute myeloid leukemia stem cells and CD33-targeted immunotherapy
    • Walter RB, Appelbaum FR, Estey EH, Bernstein ID. Acute myeloid leukemia stem cells and CD33-targeted immunotherapy. Blood. 2012; 119(26): 6198-208.
    • (2012) Blood , vol.119 , Issue.26 , pp. 6198-6208
    • Walter, R.B.1    Appelbaum, F.R.2    Estey, E.H.3    Bernstein, I.D.4
  • 97
    • 0035397980 scopus 로고    scopus 로고
    • Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse
    • Sievers EL, Larson RA, Stadtmauer EA, Estey E, Löwenberg B, Dombret H, et al. Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol. 2001; 19(13): 3244-54.
    • (2001) J Clin Oncol , vol.19 , Issue.13 , pp. 3244-3254
    • Sievers, E.L.1    Larson, R.A.2    Stadtmauer, E.A.3    Estey, E.4    Löwenberg, B.5    Dombret, H.6
  • 98
    • 0034900174 scopus 로고    scopus 로고
    • Approval summary: Gemtuzumab ozogamicin in relapsed acute myeloid leukemia
    • Bross PF, Beitz J, Chen G, Chen XH, Duffy E, Kieffer L, et al. Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia. Clin Cancer Res. 2001; 7(6): 1490-6.
    • (2001) Clin Cancer Res , vol.7 , Issue.6 , pp. 1490-1496
    • Bross, P.F.1    Beitz, J.2    Chen, G.3    Chen, X.H.4    Duffy, E.5    Kieffer, L.6
  • 99
    • 84881305790 scopus 로고    scopus 로고
    • A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
    • Petersdorf SH, Kopecky KJ, Slovak M, Willman C, Nevill T, Brandwein J, et al. A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia. Blood. 2013; 121(24): 4854-60.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4854-4860
    • Petersdorf, S.H.1    Kopecky, K.J.2    Slovak, M.3    Willman, C.4    Nevill, T.5    Brandwein, J.6
  • 100
    • 79952099282 scopus 로고    scopus 로고
    • Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: Results of the MRC AML15 trial
    • Burnett AK, Hills RK, Milligan D, Kjeldsen L, Kell J, Russell NH, et al. Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial. J Clin Oncol. 2011; 29(4): 369-77.
    • (2011) J Clin Oncol , vol.29 , Issue.4 , pp. 369-377
    • Burnett, A.K.1    Hills, R.K.2    Milligan, D.3    Kjeldsen, L.4    Kell, J.5    Russell, N.H.6
  • 101
    • 84859911350 scopus 로고    scopus 로고
    • Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): A randomised, open-label, phase 3 study
    • Castaigne S, Pautas C, Terré C, Raffoux E, Bordessoule D, Bastie JN, et al. Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study. Lancet. 2012; 379(9825): 1508-16.
    • (2012) Lancet , vol.379 , Issue.9825 , pp. 1508-1516
    • Castaigne, S.1    Pautas, C.2    Terré, C.3    Raffoux, E.4    Bordessoule, D.5    Bastie, J.N.6
  • 102
    • 84861733011 scopus 로고    scopus 로고
    • Addition of Gemtuzumab Ozogamycin to Chemotherapy Improves Event-Free Survival but Not Overall Survival of AML Patients with Intermediate Cytogenetics Not Eligible for Allogeneic Transplantation. Results of the GOELAMS AML 2006 IR Study
    • Delaunay J, Recher C, Pigneux A, Witz F, Vey N, Blanchet O, et al. Addition of Gemtuzumab Ozogamycin to Chemotherapy Improves Event-Free Survival but Not Overall Survival of AML Patients with Intermediate Cytogenetics Not Eligible for Allogeneic Transplantation. Results of the GOELAMS AML 2006 IR Study. Blood. 2011; 118: 37.
    • (2011) Blood , vol.118 , pp. 37
    • Delaunay, J.1    Recher, C.2    Pigneux, A.3    Witz, F.4    Vey, N.5    Blanchet, O.6
  • 103
    • 84863522871 scopus 로고    scopus 로고
    • Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia
    • Burnett AK, Russell NH, Hills RK, Kell J, Freeman S, Kjeldsen L, et al. Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia. J Clin Oncol. 2012; 30(32): 3924-31.
    • (2012) J Clin Oncol , vol.30 , Issue.32 , pp. 3924-3931
    • Burnett, A.K.1    Russell, N.H.2    Hills, R.K.3    Kell, J.4    Freeman, S.5    Kjeldsen, L.6
  • 104
    • 84880245095 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in acute myeloid leukemia: A remarkable saga about an active drug
    • Rowe JM, Lowenberg B. Gemtuzumab ozogamicin in acute myeloid leukemia: a remarkable saga about an active drug. Blood. 2013; 121(24): 4838-41.
    • (2013) Blood , vol.121 , Issue.24 , pp. 4838-4841
    • Rowe, J.M.1    Lowenberg, B.2
  • 105
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012; 481(7382): 506-10.
    • (2012) Nature , vol.481 , Issue.7382 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3    Miller, C.A.4    Koboldt, D.C.5    Welch, J.S.6
  • 106
    • 0026668478 scopus 로고
    • Varying intensity of postremission therapy in acute myeloid leukemia
    • Cassileth PA, Lynch E, Hines JD, Oken MM, Mazza JJ, Bennett JM, et al. Varying intensity of postremission therapy in acute myeloid leukemia. Blood. 1992; 79(8): 1924-30.
    • (1992) Blood , vol.79 , Issue.8 , pp. 1924-1930
    • Cassileth, P.A.1    Lynch, E.2    Hines, J.D.3    Oken, M.M.4    Mazza, J.J.5    Bennett, J.M.6
  • 107
    • 1542753653 scopus 로고    scopus 로고
    • 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TADHAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): A randomized trial of the German AML Cooperative Group
    • Buchner T, Hiddemann W, Berdel WE, Wörmann B, Schoch C, Fonatsch C, et al. 6-Thioguanine, cytarabine, and daunorubicin (TAD) and high-dose cytarabine and mitoxantrone (HAM) for induction, TAD for consolidation, and either prolonged maintenance by reduced monthly TAD or TADHAM-TAD and one course of intensive consolidation by sequential HAM in adult patients at all ages with de novo acute myeloid leukemia (AML): a randomized trial of the German AML Cooperative Group. J Clin Oncol. 2003; 21(24): 4496-504.
    • (2003) J Clin Oncol , vol.21 , Issue.24 , pp. 4496-4504
    • Buchner, T.1    Hiddemann, W.2    Berdel, W.E.3    Wörmann, B.4    Schoch, C.5    Fonatsch, C.6
  • 108
    • 0028926870 scopus 로고
    • A prospective evaluation of the roles of allogeneic marrow transplantation and low-dose monthly maintenance chemotherapy in the treatment of adult acute myelogenous leukemia (AML): A Southwest Oncology Group study
    • Hewlett J, Kopecky KJ, Head D, Eyre HJ, Elias L, Kingsbury L, et al. A prospective evaluation of the roles of allogeneic marrow transplantation and low-dose monthly maintenance chemotherapy in the treatment of adult acute myelogenous leukemia (AML): a Southwest Oncology Group study. Leukemia. 1995; 9(4): 562-9.
    • (1995) Leukemia , vol.9 , Issue.4 , pp. 562-569
    • Hewlett, J.1    Kopecky, K.J.2    Head, D.3    Eyre, H.J.4    Elias, L.5    Kingsbury, L.6


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