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Volumn 33, Issue 2-3, 2014, Pages 747-756

Circulating tumour cells - A bona fide cause of metastatic cancer

Author keywords

Circulating tumour cells; Disseminated tumour cells; Dormancy; Metastasis

Indexed keywords

ANIMAL; GENETICS; HUMAN; METABOLISM; METASTASIS; MORTALITY; NEOPLASM; PATHOLOGY; TUMOR EMBOLISM; TUMOR MICROENVIRONMENT;

EID: 84905109889     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-014-9502-8     Document Type: Review
Times cited : (30)

References (90)
  • 1
    • 67650354361 scopus 로고    scopus 로고
    • Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer
    • doi:10.1093/annonc/mdn786
    • Cohen, S. J., Punt, C. J., Iannotti, N., Saidman, B. H., Sabbath, K. D., Gabrail, N. Y., et al. (2009). Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer. Annals of Oncology, 20(7), 1223-1229. doi:10.1093/annonc/mdn786.
    • (2009) Annals of Oncology , vol.20 , Issue.7 , pp. 1223-1229
    • Cohen, S.J.1    Punt, C.J.2    Iannotti, N.3    Saidman, B.H.4    Sabbath, K.D.5    Gabrail, N.Y.6
  • 3
    • 84857613654 scopus 로고    scopus 로고
    • High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients
    • doi:10.1093/annonc/mdr263
    • Pierga, J. Y., Hajage, D., Bachelot, T., Delaloge, S., Brain, E., Campone, M., et al. (2012). High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients. Annals of Oncology, 23(3), 618-624. doi:10.1093/annonc/mdr263.
    • (2012) Annals of Oncology , vol.23 , Issue.3 , pp. 618-624
    • Pierga, J.Y.1    Hajage, D.2    Bachelot, T.3    Delaloge, S.4    Brain, E.5    Campone, M.6
  • 5
    • 33846814619 scopus 로고    scopus 로고
    • Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival
    • doi:10.1158/1078-0432.CCR-05-2821
    • Hayes, D. F., Cristofanilli, M., Budd, G. T., Ellis, M. J., Stopeck, A., Miller, M. C., et al. (2006). Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clinical Cancer Research, 12(14 Pt 1), 4218-4224. doi:10.1158/1078-0432.CCR-05-2821.
    • (2006) Clinical Cancer Research , vol.12 , Issue.14 PART 1 , pp. 4218-4224
    • Hayes, D.F.1    Cristofanilli, M.2    Budd, G.T.3    Ellis, M.J.4    Stopeck, A.5    Miller, M.C.6
  • 6
    • 62849099048 scopus 로고    scopus 로고
    • Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: A reanalysis of IMMC38 trial data
    • doi:10.1016/S1470-2045(08)70340-1
    • Scher, H. I., Jia, X., de Bono, J. S., Fleisher, M., Pienta, K. J., Raghavan, D., et al. (2009). Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data. Lancet Oncology, 10(3), 233-239. doi:10.1016/S1470-2045(08)70340-1.
    • (2009) Lancet Oncology , vol.10 , Issue.3 , pp. 233-239
    • Scher, H.I.1    Jia, X.2    De Bono, J.S.3    Fleisher, M.4    Pienta, K.J.5    Raghavan, D.6
  • 7
    • 84875458848 scopus 로고    scopus 로고
    • Circulating tumor cells (CTCs) in breast cancer: A diagnostic tool for prognosis and molecular analysis
    • doi:10.3978/j.issn.1000-9604.2012.11.03
    • Dong, X., Alpaugh, K. R., & Cristofanilli, M. (2012). Circulating tumor cells (CTCs) in breast cancer: a diagnostic tool for prognosis and molecular analysis. Chinese Journal of Cancer Research, 24(4), 388-398. doi:10.3978/j.issn.1000-9604.2012.11.03.
    • (2012) Chinese Journal of Cancer Research , vol.24 , Issue.4 , pp. 388-398
    • Dong, X.1    Alpaugh, K.R.2    Cristofanilli, M.3
  • 9
    • 84860390470 scopus 로고    scopus 로고
    • Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment
    • doi:10. 1186/bcr2907
    • Giuliano, M., Giordano, A., Jackson, S., Hess, K. R., De Giorgi, U., Mego, M., et al. (2011). Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment. Breast Cancer Research, 13(3), R67. doi:10. 1186/bcr2907.
    • (2011) Breast Cancer Research , vol.13 , Issue.3
    • Giuliano, M.1    Giordano, A.2    Jackson, S.3    Hess, K.R.4    De Giorgi, U.5    Mego, M.6
  • 10
    • 84863105627 scopus 로고    scopus 로고
    • Circulating tumour cells in non-metastatic breast cancer: A prospective study
    • doi:10.1016/S1470-2045(12)70209-7
    • Lucci, A., Hall, C. S., Lodhi, A. K., Bhattacharyya, A., Anderson, A. E., Xiao, L., et al. (2012). Circulating tumour cells in non-metastatic breast cancer: a prospective study. Lancet Oncology, 13(7), 688-695. doi:10.1016/S1470-2045(12)70209-7.
    • (2012) Lancet Oncology , vol.13 , Issue.7 , pp. 688-695
    • Lucci, A.1    Hall, C.S.2    Lodhi, A.K.3    Bhattacharyya, A.4    Anderson, A.E.5    Xiao, L.6
  • 11
    • 84873817306 scopus 로고    scopus 로고
    • Relationship among circulating tumor cells, CEA and overall survival in patients with metastatic colorectal cancer
    • doi:10.1093/annonc/mds336
    • Aggarwal, C., Meropol, N. J., Punt, C. J., Iannotti, N., Saidman, B. H., Sabbath, K. D., et al. (2013). Relationship among circulating tumor cells, CEA and overall survival in patients with metastatic colorectal cancer. Annals of Oncology, 24(2), 420-428. doi:10.1093/annonc/mds336.
    • (2013) Annals of Oncology , vol.24 , Issue.2 , pp. 420-428
    • Aggarwal, C.1    Meropol, N.J.2    Punt, C.J.3    Iannotti, N.4    Saidman, B.H.5    Sabbath, K.D.6
  • 12
    • 84870050058 scopus 로고    scopus 로고
    • Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer
    • doi:10.1158/2159-8290.CD-12-0222
    • Miyamoto, D. T., Lee, R. J., Stott, S. L., Ting, D. T., Wittner, B. S., Ulman, M., et al. (2012). Androgen receptor signaling in circulating tumor cells as a marker of hormonally responsive prostate cancer. Cancer Discovery, 2(11), 995-1003. doi:10.1158/2159-8290.CD-12-0222.
    • (2012) Cancer Discovery , vol.2 , Issue.11 , pp. 995-1003
    • Miyamoto, D.T.1    Lee, R.J.2    Stott, S.L.3    Ting, D.T.4    Wittner, B.S.5    Ulman, M.6
  • 13
    • 0000110505 scopus 로고
    • A case of cancer in which cells similar to those in the tumours were seen in the blood after death
    • Ashworth, T. R. (1869). A case of cancer in which cells similar to those in the tumours were seen in the blood after death. Australian Medical Journal, 14, 146-147.
    • (1869) Australian Medical Journal , vol.14 , pp. 146-147
    • Ashworth, T.R.1
  • 14
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • doi:10. 1016/j.cell.2011.09.024
    • Valastyan, S., & Weinberg, R. A. (2011). Tumor metastasis: molecular insights and evolving paradigms. Cell, 147(2), 275-292. doi:10. 1016/j.cell.2011.09.024.
    • (2011) Cell , vol.147 , Issue.2 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 15
    • 0036990103 scopus 로고    scopus 로고
    • The organ microenvironment and cancer metastasis
    • doi:10.1046/j.1432-0436.2002.700904.x
    • Fidler, I. J. (2002). The organ microenvironment and cancer metastasis. Differentiation, 70(9-10), 498-505. doi:10.1046/j.1432-0436.2002.700904.x.
    • (2002) Differentiation , vol.70 , Issue.9-10 , pp. 498-505
    • Fidler, I.J.1
  • 16
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget, S. (1889). The distribution of secondary growths in cancer of the breast. Lancet, 1, 571-573.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 17
    • 84880270290 scopus 로고    scopus 로고
    • Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay
    • doi:10.1038/nbt.2576
    • Baccelli, I., Schneeweiss, A., Riethdorf, S., Stenzinger, A., Schillert, A., Vogel, V., et al. (2013). Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay. Nature Biotechnology, 31(6), 539-544. doi:10.1038/nbt.2576.
    • (2013) Nature Biotechnology , vol.31 , Issue.6 , pp. 539-544
    • Baccelli, I.1    Schneeweiss, A.2    Riethdorf, S.3    Stenzinger, A.4    Schillert, A.5    Vogel, V.6
  • 19
    • 84861194016 scopus 로고    scopus 로고
    • EMT as the ultimate survival mechanism of cancer cells
    • doi:10.1016/j.semcancer.2012.02.013
    • Tiwari, N., Gheldof, A., Tatari, M., & Christofori, G. (2012). EMT as the ultimate survival mechanism of cancer cells. Seminars in Cancer Biology, 22(3), 194-207. doi:10.1016/j.semcancer.2012.02.013.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.3 , pp. 194-207
    • Tiwari, N.1    Gheldof, A.2    Tatari, M.3    Christofori, G.4
  • 20
    • 84866325625 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition under control: Global programs to regulate epithelial plasticity
    • doi:10.1016/j.semcancer.2012.05.003
    • Nieto, M. A., & Cano, A. (2012). The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity. Seminars in Cancer Biology, 22(5-6), 361-368. doi:10.1016/j.semcancer.2012.05. 003.
    • (2012) Seminars in Cancer Biology , vol.22 , Issue.5-6 , pp. 361-368
    • Nieto, M.A.1    Cano, A.2
  • 21
    • 0026806148 scopus 로고
    • Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients
    • Lindemann, F., Schlimok, G., Dirschedl, P., Witte, J., & Riethmuller, G. (1992). Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet, 340(8821), 685-689.
    • (1992) Lancet , vol.340 , Issue.8821 , pp. 685-689
    • Lindemann, F.1    Schlimok, G.2    Dirschedl, P.3    Witte, J.4    Riethmuller, G.5
  • 23
    • 58149165081 scopus 로고    scopus 로고
    • Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer
    • doi:10.1158/1078-0432.CCR-08-0872
    • de Bono, J. S., Scher, H. I., Montgomery, R. B., Parker, C., Miller, M. C., Tissing, H., et al. (2008). Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clinical Cancer Research, 14(19), 6302-6309. doi:10.1158/1078-0432.CCR-08-0872.
    • (2008) Clinical Cancer Research , vol.14 , Issue.19 , pp. 6302-6309
    • De Bono, J.S.1    Scher, H.I.2    Montgomery, R.B.3    Parker, C.4    Miller, M.C.5    Tissing, H.6
  • 24
    • 84864764730 scopus 로고    scopus 로고
    • Relationship between lymphocytopenia and circulating tumor cells as prognostic factors for overall survival in metastatic breast cancer
    • doi:10.1016/j.clbc.2012.04.004
    • De Giorgi, U., Mego, M., Scarpi, E., Giuliano, M., Giordano, A., Reuben, J. M., et al. (2012). Relationship between lymphocytopenia and circulating tumor cells as prognostic factors for overall survival in metastatic breast cancer. Clinical Breast Cancer, 12(4), 264-269. doi:10.1016/j.clbc.2012.04.004.
    • (2012) Clinical Breast Cancer , vol.12 , Issue.4 , pp. 264-269
    • De Giorgi, U.1    Mego, M.2    Scarpi, E.3    Giuliano, M.4    Giordano, A.5    Reuben, J.M.6
  • 25
    • 84868106386 scopus 로고    scopus 로고
    • Circulating tumor cells in small-cell lung cancer: A predictive and prognostic factor
    • doi:10.1093/annonc/mds138
    • Hiltermann, T. J., Pore, M. M., van den Berg, A., Timens, W., Boezen, H. M., Liesker, J. J., et al. (2012). Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor. Annals of Oncology, 23(11), 2937-2942. doi:10.1093/annonc/mds138.
    • (2012) Annals of Oncology , vol.23 , Issue.11 , pp. 2937-2942
    • Hiltermann, T.J.1    Pore, M.M.2    Van Den Berg, A.3    Timens, W.4    Boezen, H.M.5    Liesker, J.J.6
  • 26
    • 84856862054 scopus 로고    scopus 로고
    • Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer
    • doi:10.1200/JCO.2010.33.3716
    • Hou, J. M., Krebs, M. G., Lancashire, L., Sloane, R., Backen, A., Swain, R. K., et al. (2012). Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer. Journal of Clinical Oncology, 30(5), 525-532. doi:10.1200/JCO.2010.33.3716.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.5 , pp. 525-532
    • Hou, J.M.1    Krebs, M.G.2    Lancashire, L.3    Sloane, R.4    Backen, A.5    Swain, R.K.6
  • 27
    • 84856973299 scopus 로고    scopus 로고
    • High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: A longitudinal analysis
    • doi:10.1088/1478-3975/9/1/016004
    • Nieva, J., Wendel, M., Luttgen, M. S., Marrinucci, D., Bazhenova, L., Kolatkar, A., et al. (2012). High-definition imaging of circulating tumor cells and associated cellular events in non-small cell lung cancer patients: a longitudinal analysis. Physical Biology, 9(1), 016004. doi:10.1088/1478-3975/9/ 1/016004.
    • (2012) Physical Biology , vol.9 , Issue.1 , pp. 016004
    • Nieva, J.1    Wendel, M.2    Luttgen, M.S.3    Marrinucci, D.4    Bazhenova, L.5    Kolatkar, A.6
  • 28
    • 0031655802 scopus 로고    scopus 로고
    • Multistep nature of metastatic inefficiency: Dormancy of solitary cells after successful extravasation and limited survival of early micrometastases
    • Luzzi, K. J., MacDonald, I. C., Schmidt, E. E., Kerkvliet, N., Morris, V. L., Chambers, A. F., et al. (1998). Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases. American Journal of Pathology, 153(3), 865-873. doi:10.1016/S0002-9440(10)65628-3. (Pubitemid 28419039)
    • (1998) American Journal of Pathology , vol.153 , Issue.3 , pp. 865-873
    • Luzzi, K.J.1    MacDonald, I.C.2    Schmidt, E.E.3    Kerkvliet, N.4    Morris, V.L.5    Chambers, A.F.6    Groom, A.C.7
  • 29
    • 84857808707 scopus 로고    scopus 로고
    • Time course and pattern of metastasis of cutaneous melanoma differ between men and women
    • doi:10.1371/journal.pone.0032955
    • Mervic, L. (2012). Time course and pattern of metastasis of cutaneous melanoma differ between men and women. PLoS ONE, 7(3), e32955. doi:10.1371/journal.pone.0032955.
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Mervic, L.1
  • 30
    • 84858629953 scopus 로고    scopus 로고
    • Factors influencing the hormone receptor and HER2 levels in breast cancer: A population-based analysis
    • doi:10.1159/000336812
    • Tas, F. (2012). Factors influencing the hormone receptor and HER2 levels in breast cancer: a population-based analysis. Onkologie, 35(3), 95-98. doi:10.1159/000336812.
    • (2012) Onkologie , vol.35 , Issue.3 , pp. 95-98
    • Tas, F.1
  • 31
    • 84878814203 scopus 로고    scopus 로고
    • Detection of cancer before distant metastasis
    • doi:10.1186/1471-2407-13-283
    • Coumans, F. A., Siesling, S., & Terstappen, L. W. (2013). Detection of cancer before distant metastasis. BMC Cancer, 13(1), 283. doi:10.1186/1471-2407-13-283.
    • (2013) BMC Cancer , vol.13 , Issue.1 , pp. 283
    • Coumans, F.A.1    Siesling, S.2    Terstappen, L.W.3
  • 32
    • 0035879873 scopus 로고    scopus 로고
    • Real-time observation of micrometastasis formation in the living mouse liver using a green fluorescent protein gene-tagged rat tongue carcinoma cell line
    • DOI 10.1002/ijc.1318
    • Ito, S., Nakanishi, H., Ikehara, Y., Kato, T., Kasai, Y., Ito, K., et al. (2001). Real-time observation of micrometastasis formation in the living mouse liver using a green fluorescent protein gene-tagged rat tongue carcinoma cell line. International Journal of Cancer, 93(2), 212-217. doi:10.1002/ijc.1318. (Pubitemid 32574277)
    • (2001) International Journal of Cancer , vol.93 , Issue.2 , pp. 212-217
    • Ito, S.1    Nakanishi, H.2    Ikehara, Y.3    Kato, T.4    Kasai, Y.5    Ito, K.6    Akiyama, S.7    Nakao, A.8    Tatematsu, M.9
  • 33
    • 0034443811 scopus 로고    scopus 로고
    • Metastasis of cancer: A conceptual history from antiquity to the 1990s
    • Weiss, L. (2000). Metastasis of cancer: a conceptual history from antiquity to the 1990s. Cancer and Metastasis Reviews, 19(3-4), I-XI. 193-383
    • (2000) Cancer and Metastasis Reviews , vol.19 , Issue.3-4
    • Weiss, L.1
  • 34
    • 84896395959 scopus 로고    scopus 로고
    • New frontiers in circulating tumor cell analysis: A reference guide for biomolecular profiling toward translational clinical use
    • doi:10.1002/ijc.28516
    • Becker, T. M., Caixeiro, N. J., Lim, S. H., Tognela, A., Kienzle, N., Scott, K. F., et al. (2014). New frontiers in circulating tumor cell analysis: a reference guide for biomolecular profiling toward translational clinical use. International Journal of Cancer, 134(11), 2523-2533. doi:10.1002/ijc.28516.
    • (2014) International Journal of Cancer , vol.134 , Issue.11 , pp. 2523-2533
    • Becker, T.M.1    Caixeiro, N.J.2    Lim, S.H.3    Tognela, A.4    Kienzle, N.5    Scott, K.F.6
  • 35
    • 78049485312 scopus 로고    scopus 로고
    • M30 neoepitope expression in epithelial cancer: Quantification of apoptosis in circulating tumor cells by cell search analysis
    • doi:10.1158/1078-0432.CCR-10-1449
    • Rossi, E., Basso, U., Celadin, R., Zilio, F., Pucciarelli, S., Aieta, M., et al. (2010). M30 neoepitope expression in epithelial cancer: quantification of apoptosis in circulating tumor cells by cell search analysis. Clinical Cancer Research, 16(21), 5233-5243. doi:10.1158/1078-0432.CCR-10-1449.
    • (2010) Clinical Cancer Research , vol.16 , Issue.21 , pp. 5233-5243
    • Rossi, E.1    Basso, U.2    Celadin, R.3    Zilio, F.4    Pucciarelli, S.5    Aieta, M.6
  • 37
    • 84860601923 scopus 로고    scopus 로고
    • Single cell profiling of circulating tumor cells: Transcriptional heterogeneity and diversity from breast cancer cell lines
    • doi:10.1371/journal.pone.0033788
    • Powell, A. A., Talasaz, A. H., Zhang, H., Coram, M. A., Reddy, A., Deng, G., et al. (2012). Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS ONE, 7 (5), e33788. doi:10.1371/journal.pone.0033788.
    • (2012) PLoS ONE , vol.7 , Issue.5
    • Powell, A.A.1    Talasaz, A.H.2    Zhang, H.3    Coram, M.A.4    Reddy, A.5    Deng, G.6
  • 39
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • doi:10.1038/nrc2618
    • Joyce, J. A., & Pollard, J. W. (2009). Microenvironmental regulation of metastasis. Nature Reviews Cancer, 9(4), 239-252. doi:10.1038/nrc2618.
    • (2009) Nature Reviews Cancer , vol.9 , Issue.4 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 40
    • 0026494476 scopus 로고
    • Platelets and cancer metastasis: A causal relationship?
    • Honn, K. V., Tang, D. G., & Crissman, J. D. (1992). Platelets and cancer metastasis: a causal relationship? Cancer and Metastasis Reviews, 11(3-4), 325-351.
    • (1992) Cancer and Metastasis Reviews , vol.11 , Issue.3-4 , pp. 325-351
    • Honn, K.V.1    Tang, D.G.2    Crissman, J.D.3
  • 41
    • 11144230059 scopus 로고    scopus 로고
    • Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells
    • DOI 10.1182/blood-2004-06-2272
    • Palumbo, J. S., Talmage, K. E., Massari, J. V., La Jeunesse, C. M., Flick, M. J., Kombrinck, K. W., et al. (2005). Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood, 105(1), 178-185. doi:10.1182/blood-2004-06- 2272. (Pubitemid 40053080)
    • (2005) Blood , vol.105 , Issue.1 , pp. 178-185
    • Palumbo, J.S.1    Talmage, K.E.2    Massari, J.V.3    La, J.C.M.4    Flick, M.J.5    Kombrinck, K.W.6    Jirouskova, M.7    Degen, J.L.8
  • 42
    • 75549085422 scopus 로고    scopus 로고
    • Inhibition of platelet GPIb alpha and promotion of melanoma metastasis
    • doi:10.1038/jid.2009.278
    • Erpenbeck, L., Nieswandt, B., Schon, M., Pozgajova, M., & Schon, M. P. (2010). Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. Journal of Investigative Dermatology, 130(2), 576-586. doi:10.1038/jid.2009.278.
    • (2010) Journal of Investigative Dermatology , vol.130 , Issue.2 , pp. 576-586
    • Erpenbeck, L.1    Nieswandt, B.2    Schon, M.3    Pozgajova, M.4    Schon, M.P.5
  • 43
    • 0029887296 scopus 로고    scopus 로고
    • TNF promotes metastasis by impairing natural killer cell activity
    • DOI 10.1002/(SICI)1097-0215(19960503)66:3<388
    • Hafner, M., Orosz, P., Kruger, A., & Mannel, D. N. (1996). TNF promotes metastasis by impairing natural killer cell activity. International Journal of Cancer, 66(3), 388-392. doi:10.1002/(SICI)1097-0215(19960503)66: 3〈388::AID-IJC20〉3.0.CO;2-6. (Pubitemid 26166200)
    • (1996) International Journal of Cancer , vol.66 , Issue.3 , pp. 388-392
    • Hafner, M.1    Orosz, P.2    Kruger, A.3    Mannel, D.N.4
  • 44
    • 84896523466 scopus 로고    scopus 로고
    • Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer
    • doi:10.1158/0008-5472.CAN-13-1885
    • Steinert, G., Scholch, S., Niemietz, T., Iwata, N., Garcia, S. A., Behrens, B., et al. (2014). Immune escape and survival mechanisms in circulating tumor cells of colorectal cancer. Cancer Research, 74(6), 1694-1704. doi:10.1158/0008-5472.CAN-13-1885.
    • (2014) Cancer Research , vol.74 , Issue.6 , pp. 1694-1704
    • Steinert, G.1    Scholch, S.2    Niemietz, T.3    Iwata, N.4    Garcia, S.A.5    Behrens, B.6
  • 45
    • 80054108831 scopus 로고    scopus 로고
    • Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome
    • doi:10.1182/blood-2011-07-368514
    • Shao, B., Wahrenbrock, M. G., Yao, L., David, T., Coughlin, S. R., Xia, L., et al. (2011). Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood, 118(15), 4015-4023. doi:10.1182/blood-2011-07-368514.
    • (2011) Blood , vol.118 , Issue.15 , pp. 4015-4023
    • Shao, B.1    Wahrenbrock, M.G.2    Yao, L.3    David, T.4    Coughlin, S.R.5    Xia, L.6
  • 46
    • 0033396058 scopus 로고    scopus 로고
    • Cancer, coagulation, and anticoagulation
    • Letai, A., & Kuter, D. J. (1999). Cancer, coagulation, and anticoagulation. The Oncologist, 4(6), 443-449. (Pubitemid 30013178)
    • (1999) Oncologist , vol.4 , Issue.6 , pp. 443-449
    • Letai, A.1    Kuter, D.J.2
  • 47
    • 77954860342 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer: Parallels between normal development and tumor progression
    • doi:10.1007/s10911-010-9178-9
    • Micalizzi, D. S., Farabaugh, S. M., & Ford, H. L. (2010). Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. Journal of Mammary Gland Biology and Neoplasia, 15(2), 117-134. doi:10.1007/s10911-010-9178-9.
    • (2010) Journal of Mammary Gland Biology and Neoplasia , vol.15 , Issue.2 , pp. 117-134
    • Micalizzi, D.S.1    Farabaugh, S.M.2    Ford, H.L.3
  • 48
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • doi:10.1038/35000025
    • Cano, A., Perez-Moreno, M. A., Rodrigo, I., Locascio, A., Blanco, M. J., del Barrio, M. G., et al. (2000). The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biology, 2 (2), 76-83. doi:10.1038/35000025.
    • (2000) Nature Cell Biology , vol.2 , Issue.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    Del Barrio, M.G.6
  • 49
    • 84862495767 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition, the tumor microenvironment, andmetastatic behavior of epithelial malignancies
    • Talbot, L. J., Bhattacharya, S. D., & Kuo, P. C. (2012). Epithelial-mesenchymal transition, the tumor microenvironment, andmetastatic behavior of epithelial malignancies. International Journal of Biochemistry and Molecular Biology, 3(2), 117-136.
    • (2012) International Journal of Biochemistry and Molecular Biology , vol.3 , Issue.2 , pp. 117-136
    • Talbot, L.J.1    Bhattacharya, S.D.2    Kuo, P.C.3
  • 50
    • 79957894183 scopus 로고    scopus 로고
    • mRNA and microRNA expression profiles in circulating tumor cells and primary tumors of metastatic breast cancer patients
    • doi:10.1158/1078-0432.CCR-11-0255
    • Sieuwerts, A. M., Mostert, B., Bolt-de Vries, J., Peeters, D., de Jongh, F. E., Stouthard, J. M., et al. (2011). mRNA and microRNA expression profiles in circulating tumor cells and primary tumors of metastatic breast cancer patients. Clinical Cancer Research, 17(11), 3600-3618. doi:10.1158/1078-0432. CCR-11-0255.
    • (2011) Clinical Cancer Research , vol.17 , Issue.11 , pp. 3600-3618
    • Sieuwerts, A.M.1    Mostert, B.2    Bolt-de Vries, J.3    Peeters, D.4    De Jongh, F.E.5    Stouthard, J.M.6
  • 51
    • 84875999237 scopus 로고    scopus 로고
    • Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis
    • doi:10.1158/0008-5472.CAN-12-0326
    • Yokobori, T., Iinuma, H., Shimamura, T., Imoto, S., Sugimachi, K., Ishii, H., et al. (2013). Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. Cancer Research, 73(7), 2059-2069. doi:10.1158/0008-5472.CAN-12-0326.
    • (2013) Cancer Research , vol.73 , Issue.7 , pp. 2059-2069
    • Yokobori, T.1    Iinuma, H.2    Shimamura, T.3    Imoto, S.4    Sugimachi, K.5    Ishii, H.6
  • 52
    • 84860397754 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients
    • doi:10.1186/bcr2896
    • Kallergi, G., Papadaki, M. A., Politaki, E., Mavroudis, D., Georgoulias, V., & Agelaki, S. (2011). Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients. Breast Cancer Research, 13(3), R59. doi:10.1186/bcr2896.
    • (2011) Breast Cancer Research , vol.13 , Issue.3
    • Kallergi, G.1    Papadaki, M.A.2    Politaki, E.3    Mavroudis, D.4    Georgoulias, V.5    Agelaki, S.6
  • 53
    • 84864856297 scopus 로고    scopus 로고
    • Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck
    • doi:10.1371/journal.pone.0042048
    • Balasubramanian, P., Lang, J. C., Jatana, K. R., Miller, B., Ozer, E., Old, M., et al. (2012). Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck. PLoS ONE, 7(7), e42048. doi:10.1371/journal.pone.0042048.
    • (2012) PLoS ONE , vol.7 , Issue.7
    • Balasubramanian, P.1    Lang, J.C.2    Jatana, K.R.3    Miller, B.4    Ozer, E.5    Old, M.6
  • 54
    • 84896395959 scopus 로고    scopus 로고
    • New frontiers in circulating tumor cell analysis - A reference guide for biomolecular profiling towards translational clinical use
    • doi:10.1002/ijc.28516
    • Becker, T. M., Caixeiro, N. J., Lim, S. H., Tognela, A., Kienzle, N., Scott, K. F., et al. (2013). New frontiers in circulating tumor cell analysis - a reference guide for biomolecular profiling towards translational clinical use. International Journal of Cancer. doi:10.1002/ijc.28516.
    • (2013) International Journal of Cancer
    • Becker, T.M.1    Caixeiro, N.J.2    Lim, S.H.3    Tognela, A.4    Kienzle, N.5    Scott, K.F.6
  • 55
    • 84869231518 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer
    • doi:10.1158/1535-7163.MCT-12-0460
    • Giordano, A., Gao, H., Anfossi, S., Cohen, E., Mego, M., Lee, B. N., et al. (2012). Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. Molecular Cancer Therapeutics, 11(11), 2526-2534. doi:10.1158/1535-7163.MCT-12-0460.
    • (2012) Molecular Cancer Therapeutics , vol.11 , Issue.11 , pp. 2526-2534
    • Giordano, A.1    Gao, H.2    Anfossi, S.3    Cohen, E.4    Mego, M.5    Lee, B.N.6
  • 56
    • 83955165959 scopus 로고    scopus 로고
    • Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
    • doi:10.1002/ijc.26037
    • Mego, M., Mani, S. A., Lee, B. N., Li, C., Evans, K. W., Cohen, E. N., et al. (2012). Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: the effect of neoadjuvant therapy. International Journal of Cancer, 130(4), 808-816. doi:10.1002/ijc. 26037.
    • (2012) International Journal of Cancer , vol.130 , Issue.4 , pp. 808-816
    • Mego, M.1    Mani, S.A.2    Lee, B.N.3    Li, C.4    Evans, K.W.5    Cohen, E.N.6
  • 57
    • 84896498173 scopus 로고    scopus 로고
    • Universal marker and detection tool for human sarcoma circulating tumor cells
    • doi:10.1158/0008-5472.CAN-13-1739
    • Satelli, A., Mitra, A., Cutrera, J. J., Devarie, M., Xia, X., Ingram, D. R., et al. (2014). Universal marker and detection tool for human sarcoma circulating tumor cells. Cancer Research, 74(6), 1645-1650. doi:10.1158/0008- 5472.CAN-13-1739.
    • (2014) Cancer Research , vol.74 , Issue.6 , pp. 1645-1650
    • Satelli, A.1    Mitra, A.2    Cutrera, J.J.3    Devarie, M.4    Xia, X.5    Ingram, D.R.6
  • 59
    • 33846073087 scopus 로고    scopus 로고
    • CCL2 (monocyte chemoattractant protein-1) in cancer bone metastases
    • DOI 10.1007/s10555-006-9027-x, Special issue on Bone Metastasis and Cancer
    • Craig, M. J., & Loberg, R. D. (2006). CCL2 (monocyte chemoattractant protein-1) in cancer bone metastases. Cancer and Metastasis Reviews, 25(4), 611-619. doi:10.1007/s10555-006-9027-x. (Pubitemid 46071867)
    • (2006) Cancer and Metastasis Reviews , vol.25 , Issue.4 , pp. 611-619
    • Craig, M.J.1    Loberg, R.D.2
  • 60
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery, J. P. (2003). Epithelial-mesenchymal transitions in development and pathologies. Current Opinion in Cell Biology, 15(6), 740-746.
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.6 , pp. 740-746
    • Thiery, J.P.1
  • 61
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • DOI 10.1038/nrc865
    • Chambers, A. F., Groom, A. C., & MacDonald, I. C. (2002). Dissemination and growth of cancer cells in metastatic sites. Nature Reviews Cancer, 2(8), 563-572. doi:10.1038/nrc865. (Pubitemid 37328923)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.8 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 62
    • 2942538264 scopus 로고    scopus 로고
    • Dissecting the metastatic cascade
    • Pantel, K., & Brakenhoff, R. H. (2004). Dissecting the metastatic cascade. Nature Reviews Cancer, 4(6), 448-456. doi:10.1038/nrc1370. (Pubitemid 38745530)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.6 , pp. 448-456
    • Pantel, K.1    Brakenhoff, R.H.2
  • 63
    • 58149102321 scopus 로고    scopus 로고
    • Molecular basis of metastasis
    • doi:10.1056/NEJMra0805239
    • Chiang, A. C., & Massague, J. (2008). Molecular basis of metastasis. New England Journal of Medicine, 359(26), 2814-2823. doi:10.1056/NEJMra0805239.
    • (2008) New England Journal of Medicine , vol.359 , Issue.26 , pp. 2814-2823
    • Chiang, A.C.1    Massague, J.2
  • 64
    • 33750616197 scopus 로고    scopus 로고
    • Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype
    • DOI 10.1016/j.ccr.2006.10.002, PII S1535610806002868
    • Nierodzik, M. L., & Karpatkin, S. (2006). Thrombin induces tumor growth, metastasis, and angiogenesis: evidence for a thrombin-regulated dormant tumor phenotype. Cancer Cell, 10(5), 355-362. doi:10.1016/j.ccr.2006.10.002. (Pubitemid 44693468)
    • (2006) Cancer Cell , vol.10 , Issue.5 , pp. 355-362
    • Nierodzik, M.L.1    Karpatkin, S.2
  • 65
    • 79953313000 scopus 로고    scopus 로고
    • Estradiol modulates TGF-beta1 expression and its signaling pathway in thyroid stromal cells
    • doi:10.1016/j.mce.2011.02.001
    • Gantus, M. A., Alves, L. M., Stipursky, J., Souza, E. C., Teodoro, A. J., Alves, T. R., et al. (2011). Estradiol modulates TGF-beta1 expression and its signaling pathway in thyroid stromal cells. Molecular and Cellular Endocrinology, 337(1-2), 71-79. doi:10.1016/j.mce.2011.02.001.
    • (2011) Molecular and Cellular Endocrinology , vol.337 , Issue.1-2 , pp. 71-79
    • Gantus, M.A.1    Alves, L.M.2    Stipursky, J.3    Souza, E.C.4    Teodoro, A.J.5    Alves, T.R.6
  • 66
    • 84877865227 scopus 로고    scopus 로고
    • Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing
    • doi:10.1158/0008-5472.CAN-12-4140
    • Heitzer, E., Auer, M., Gasch, C., Pichler, M., Ulz, P., Hoffmann, E. M., et al. (2013). Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Research, 73(10), 2965-2975. doi:10.1158/0008-5472.CAN-12-4140.
    • (2013) Cancer Research , vol.73 , Issue.10 , pp. 2965-2975
    • Heitzer, E.1    Auer, M.2    Gasch, C.3    Pichler, M.4    Ulz, P.5    Hoffmann, E.M.6
  • 68
    • 84855224475 scopus 로고    scopus 로고
    • Genes differentially expressed in the peripheral zone compared to the transitional zone of the normal human prostate and their potential regulation by ETS factors
    • doi:10.3892/mmr.2011.628
    • Shaikhibrahim, Z., Lindstrot, A., Ellinger, J., Rogenhofer, S., Buettner, R., & Wernert, N. (2012). Genes differentially expressed in the peripheral zone compared to the transitional zone of the normal human prostate and their potential regulation by ETS factors. Molecular Medicine Reports, 5(1), 32-36. doi:10.3892/mmr.2011.628.
    • (2012) Molecular Medicine Reports , vol.5 , Issue.1 , pp. 32-36
    • Shaikhibrahim, Z.1    Lindstrot, A.2    Ellinger, J.3    Rogenhofer, S.4    Buettner, R.5    Wernert, N.6
  • 69
    • 84858121091 scopus 로고    scopus 로고
    • Differential expression of gastric MUC5AC in colonic epithelial cells: TFF3-wired IL1 beta/Akt crosstalk-induced mucosal immune response against Shigella dysenteriae infection
    • doi:10.1242/jcs.092148
    • Raja, S. B., Murali, M. R., Devaraj, H., & Devaraj, S. N. (2012). Differential expression of gastric MUC5AC in colonic epithelial cells: TFF3-wired IL1 beta/Akt crosstalk-induced mucosal immune response against Shigella dysenteriae infection. Journal of Cell Science, 125(Pt 3), 703-713. doi:10.1242/jcs.092148.
    • (2012) Journal of Cell Science , vol.125 , Issue.PART 3 , pp. 703-713
    • Raja, S.B.1    Murali, M.R.2    Devaraj, H.3    Devaraj, S.N.4
  • 70
    • 38549130224 scopus 로고    scopus 로고
    • A "class action" against the microenvironment: Do cancer cells cooperate in metastasis?
    • doi:10.1007/s10555-007-9103-x
    • Bidard, F. C., Pierga, J. Y., Vincent-Salomon, A., & Poupon, M. F. (2008). A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Cancer and Metastasis Reviews, 27(1), 5-10. doi:10.1007/s10555-007-9103-x.
    • (2008) Cancer and Metastasis Reviews , vol.27 , Issue.1 , pp. 5-10
    • Bidard, F.C.1    Pierga, J.Y.2    Vincent-Salomon, A.3    Poupon, M.F.4
  • 71
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • doi:10.1016/j.cell.2011.02.013
    • Hanahan, D., & Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell, 144(5), 646-674. doi:10.1016/j.cell.2011.02.013.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 72
    • 78149491523 scopus 로고    scopus 로고
    • Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin
    • doi:10.1186/bcr2586
    • Vanderlaag, K. E., Hudak, S., Bald, L., Fayadat-Dilman, L., Sathe, M., Grein, J., et al. (2010). Anterior gradient-2 plays a critical role in breast cancer cell growth and survival by modulating cyclin D1, estrogen receptor-alpha and survivin. Breast Cancer Research, 12(3), R32. doi:10.1186/bcr2586.
    • (2010) Breast Cancer Research , vol.12 , Issue.3
    • Vanderlaag, K.E.1    Hudak, S.2    Bald, L.3    Fayadat-Dilman, L.4    Sathe, M.5    Grein, J.6
  • 74
    • 34250829726 scopus 로고    scopus 로고
    • The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation
    • DOI 10.2353/ajpath.2007.060886
    • Auguste, P., Fallavollita, L., Wang, N., Burnier, J., Bikfalvi, A., & Brodt, P. (2007). The host inflammatory response promotes liver metastasis by increasing tumor cell arrest and extravasation. American Journal of Pathology, 170(5), 1781-1792. doi:10.2353/ajpath.2007.060886. (Pubitemid 47339320)
    • (2007) American Journal of Pathology , vol.170 , Issue.5 , pp. 1781-1792
    • Auguste, P.1    Fallavollita, L.2    Wang, N.3    Burnier, J.4    Bikfalvi, A.5    Brodt, P.6
  • 75
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • doi:10.1038/35077241
    • Liotta, L. A., & Kohn, E. C. (2001). The microenvironment of the tumour-host interface. Nature, 411(6835), 375-379. doi:10.1038/35077241.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 76
    • 84871926107 scopus 로고    scopus 로고
    • Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance - A study of the OVCAD consortium
    • doi:10.1016/j.ygyno.2012.09.021
    • Obermayr, E., Castillo-Tong, D. C., Pils, D., Speiser, P., Braicu, I., Van Gorp, T., et al. (2013). Molecular characterization of circulating tumor cells in patients with ovarian cancer improves their prognostic significance - a study of the OVCAD consortium. Gynecologic Oncology, 128(1), 15-21. doi:10.1016/j.ygyno.2012.09.021.
    • (2013) Gynecologic Oncology , vol.128 , Issue.1 , pp. 15-21
    • Obermayr, E.1    Castillo-Tong, D.C.2    Pils, D.3    Speiser, P.4    Braicu, I.5    Van Gorp, T.6
  • 77
    • 84874651590 scopus 로고    scopus 로고
    • Translating metastasis-related biomarkers to the clinic-progress and pitfalls
    • doi:10.1038/nrclinonc.2013.4
    • Bidard, F. C., Pierga, J. Y., Soria, J. C., & Thiery, J. P. (2013). Translating metastasis-related biomarkers to the clinic-progress and pitfalls. Nature Reviews Clinical Oncology, 10(3), 169-179. doi:10.1038/nrclinonc.2013.4.
    • (2013) Nature Reviews Clinical Oncology , vol.10 , Issue.3 , pp. 169-179
    • Bidard, F.C.1    Pierga, J.Y.2    Soria, J.C.3    Thiery, J.P.4
  • 78
    • 84860656658 scopus 로고    scopus 로고
    • Circulating tumor cells: Finding the needle in the haystack
    • Zhe, X., Cher, M. L., & Bonfil, R. D. (2011). Circulating tumor cells: finding the needle in the haystack. American Journal of Cancer Research, 1(6), 740-751.
    • (2011) American Journal of Cancer Research , vol.1 , Issue.6 , pp. 740-751
    • Zhe, X.1    Cher, M.L.2    Bonfil, R.D.3
  • 80
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • doi:10.1038/nm.2753
    • Peinado, H., Aleckovic, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., et al. (2012). Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nature Medicine, 18(6), 883-891. doi:10.1038/nm.2753.
    • (2012) Nature Medicine , vol.18 , Issue.6 , pp. 883-891
    • Peinado, H.1    Aleckovic, M.2    Lavotshkin, S.3    Matei, I.4    Costa-Silva, B.5    Moreno-Bueno, G.6
  • 81
    • 0025936182 scopus 로고
    • Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells
    • Pantel, K., Schlimok, G., Kutter, D., Schaller, G., Genz, T., Wiebecke, B., et al. (1991). Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells. Cancer Research, 51(17), 4712-4715.
    • (1991) Cancer Research , vol.51 , Issue.17 , pp. 4712-4715
    • Pantel, K.1    Schlimok, G.2    Kutter, D.3    Schaller, G.4    Genz, T.5    Wiebecke, B.6
  • 82
    • 0025447921 scopus 로고
    • Detection, characterization and tumorigenicity of disseminated tumor cells in human bone marrow
    • Schlimok, G., & Riethmuller, G. (1990). Detection, characterization and tumorigenicity of disseminated tumor cells in human bone marrow. Seminars in Cancer Biology, 1(3), 207-215.
    • (1990) Seminars in Cancer Biology , vol.1 , Issue.3 , pp. 207-215
    • Schlimok, G.1    Riethmuller, G.2
  • 83
    • 0029185862 scopus 로고
    • Early metastasis of human solid tumours: Expression of cell adhesion molecules
    • discussion 170-153, 174-156
    • Pantel, K., Schlimok, G., Angstwurm, M., Passlick, B., Izbicki, J. R., Johnson, J. P., et al. (1995). Early metastasis of human solid tumours: expression of cell adhesion molecules. Ciba Foundation Symposium, 189, 157-170. discussion 170-153, 174-156.
    • (1995) Ciba Foundation Symposium , vol.189 , pp. 157-170
    • Pantel, K.1    Schlimok, G.2    Angstwurm, M.3    Passlick, B.4    Izbicki, J.R.5    Johnson, J.P.6
  • 84
    • 70349280375 scopus 로고    scopus 로고
    • VEGFR1-activity-independent metastasis formation
    • doi:10.1038/nature08254. discussion E5
    • Dawson, M. R., Duda, D. G., Fukumura, D., & Jain, R. K. (2009). VEGFR1-activity-independent metastasis formation. Nature, 461(7262), E4. doi:10.1038/nature08254. discussion E5.
    • (2009) Nature , vol.461 , Issue.7262
    • Dawson, M.R.1    Duda, D.G.2    Fukumura, D.3    Jain, R.K.4
  • 86
    • 0033972059 scopus 로고    scopus 로고
    • Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: A new model for metastasis
    • DOI 10.1038/71429
    • Al-Mehdi, A. B., Tozawa, K., Fisher, A. B., Shientag, L., Lee, A., & Muschel, R. J. (2000). Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis. Nature Medicine, 6(1), 100-102. doi:10.1038/71429. (Pubitemid 30048535)
    • (2000) Nature Medicine , vol.6 , Issue.1 , pp. 100-102
    • Al-Mehdi, A.B.1    Tozawa, K.2    Fisher, A.B.3    Shientag, L.4    Lee, A.5    Muschel, R.J.6
  • 87
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • doi:10.1056/NEJMoa1113205
    • Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., et al. (2012). Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. New England Journal of Medicine, 366(10), 883-892. doi:10.1056/NEJMoa1113205.
    • (2012) New England Journal of Medicine , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3    Larkin, J.4    Endesfelder, D.5    Gronroos, E.6
  • 88
    • 84872048462 scopus 로고    scopus 로고
    • Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer
    • doi:10.1373/clinchem.2012.188557
    • Gasch, C., Bauernhofer, T., Pichler, M., Langer-Freitag, S., Reeh, M., Seifert, A. M., et al. (2013). Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer. Clinical Chemistry, 59(1), 252-260. doi:10.1373/clinchem. 2012.188557.
    • (2013) Clinical Chemistry , vol.59 , Issue.1 , pp. 252-260
    • Gasch, C.1    Bauernhofer, T.2    Pichler, M.3    Langer-Freitag, S.4    Reeh, M.5    Seifert, A.M.6
  • 89
    • 84863116159 scopus 로고    scopus 로고
    • Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors
    • doi:10.1200/JCO.2010.33.8889
    • Niikura, N., Liu, J., Hayashi, N., Mittendorf, E. A., Gong, Y., Palla, S. L., et al. (2012). Loss of human epidermal growth factor receptor 2 (HER2) expression in metastatic sites of HER2-overexpressing primary breast tumors. Journal of Clinical Oncology, 30 (6), 593-599. doi:10.1200/JCO.2010.33.8889.
    • (2012) Journal of Clinical Oncology , vol.30 , Issue.6 , pp. 593-599
    • Niikura, N.1    Liu, J.2    Hayashi, N.3    Mittendorf, E.A.4    Gong, Y.5    Palla, S.L.6
  • 90
    • 79951834210 scopus 로고    scopus 로고
    • PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer
    • doi:10.1158/1078-0432.CCR-10-1133
    • Dupont Jensen, J., Laenkholm, A. V., Knoop, A., Ewertz, M., Bandaru, R., Liu, W., et al. (2011). PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Clinical Cancer Research, 17(4), 667-677. doi:10.1158/1078-0432.CCR-10-1133.
    • (2011) Clinical Cancer Research , vol.17 , Issue.4 , pp. 667-677
    • Dupont Jensen, J.1    Laenkholm, A.V.2    Knoop, A.3    Ewertz, M.4    Bandaru, R.5    Liu, W.6


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