CCL2 (monocyte chemoattractant protein-1) in cancer bone metastases

Cancer and Metastasis Reviews

Volumn 25, Issue 4, 2006, Pages 611-619

  Craig, Matt J ^a   Loberg, Robert D ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Bone metastasis; Cancer; Chemokine; Chemokine receptor; Tumorigenesis

Indexed keywords

2 FLUOROETHYL N,N DIMETHYLCARBAMATE; 2 MORPHOLINO 8 PHENYLCHROMONE; CYCLOOXYGENASE 2 INHIBITOR; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

BLADDER CANCER; BONE DEVELOPMENT; BONE MARROW CELL; BONE METASTASIS; BREAST CANCER; DISEASE COURSE; ENDOTHELIUM CELL; HODGKIN DISEASE; HUMAN; KIDNEY CANCER; KNOCKOUT MOUSE; MULTIPLE MYELOMA; NONHUMAN; OSTEOCLAST; OSTEOCLASTOMA; PRIORITY JOURNAL; PROSTATE CANCER; REVIEW; TUMOR CELL;

ANIMALS; BONE MARROW; BONE NEOPLASMS; CHEMOKINE CCL2; HUMANS; OSTEOBLASTS; OSTEOCLASTS; RECEPTORS, CHEMOKINE;

EID: 33846073087     PISSN: 01677659     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10555-006-9027-x     Document Type: Review

References (59)

1. Paget, S. (1989). The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Reviews, 8(2), 98-101.
2. Loberg, R. D., Gayed, B. A., Olson, K. B., & Pienta, K. J. (2005). A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell-microenvironment interactions. Journal of Cellular Biochemistry, 96(3), 439-446.
3. Shah, R. B., Mehra, R., Chinnaiyan, A. M., Shen, R., Ghosh, D., Zhou, M., et al. (2004). Androgen-independent prostate cancer is a heterogeneous group of diseases: Lessons from a rapid autopsy program. Cancer Research, 64(24), 9209-9216.
4. Posner, L. J., Miligkos, T., Gilles, J. A., Carnes, D. L., Taddeo, D. R., & Graves, D. T. (1997). Monocyte chemoattractant protein-1 induces monocyte recruitment that is associated with an increase in numbers of osteoblasts. Bone, 21(4):321-327.
5. Zheng, M. H., Fan, Y., Smith, A., Wysocki, S., Papadimitriou, J. M., & Wood, D. J. (1998). Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: Possible involvement in CD68+ macrophage-like cell migration. Journal of Cellular Biochemistry, 70(1), 121-129.
6. Uguccioni, M., Loetscher, P., Forssmann, U., Dewald, B., Li, H., Lima, S. H., et al. (1996). Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Journal of Experimental Medicine, 183(5):2379-2384.
7. Schall, T. J. (1991). Biology of the RANTES/SIS cytokine family. Cytokine, 3(3):165-183.
8. Sarafi, M. N., Garcia-Zepeda, E. A., MacLean, J. A., Charo, I. F., & Luster, A. D. (1997). Murine monocyte chemoattractant protein (MCP)-5: A novel CC chemokine that is a structural and functional homologue of human MCP-1. Journal of Experimental Medicine, 185(1), 99-109.
9. Van Damme, J., Proost, P., Lenaerts, J. P., & Opdenakker, G. (1992). Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. Journal of Experimental Medicine, 176(1), 59-65.
10. Vanderkerken, K., Vande Broek, I., Eizirik, D. L., Van Valckenborgh, E., Asosingh, K., Van Riet, I., et al. (2002). Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells. Clinical & Experimental Metastasis, 19(1), 87-90.
11. Silvestris, F., Cafforio, P., Calvani, N., & Dammacco, F. (2004). Impaired osteoblastogenesis in myeloma bone disease: Role of upregulated apoptosis by cytokines and malignant plasma cells. British Journal of Haematology, 126(4), 475-486.
12. Leonard, E. J. (1997). Biological aspects of macrophage-stimulating protein (MSP) and its receptor. Ciba Foundation Symposium, 212, 183-191 (discussion 92-97).
13. Charo, I. F., Myers, S. J., Herman, A., Franci, C., Connolly, A. J., & Coughlin, S. R. (1994). Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proceedings of the National Academy of Science U.S.A., 91(7), 2752-2756.
14. Graves, D. T., Jiang, Y., & Valente, A. J. (1999). The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts. Frontier in Bioscience, 4, D571-D580.
15. Graves, D. T., Jiang, Y., & Valente, A. J. (1999). Regulated expression of MCP-1 by osteoblastic cells in vitro and in vivo. Histology and Histopathology, 14(4), 1347-1354.
16. Wong, L. M., Myers, S. J., Tsou, C. L., Gosling, J., Arai, H., & Charo, I. F. (1997). Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. Journal of Biological Chemistry, 272(2), 1038-1045.
17. Rollins, B. J. (1997). Chemokines. Blood, 90(3), 909-928.
18. Baggiolini, M., Dewald, B., & Moser, B. (1997). Human chemokines: An update. Annual Review of Immunology, 15, 675-705.
19. Loberg, R. D., Day, L. L., Harwood, J., Ying, C., St John, L. N., Giles, R., et al. (2006). CCL2 is a potent regulator of prostate cancer cell migration and proliferation. Neoplasia, 8(7), 578-586.
20. Silvestris, F., Cafforio, P., Tucci, M., Grinello, D., & Dammacco, F. (2003) Upregulation of osteoblast apoptosis by malignant plasma cells: A role in myeloma bone disease. Britist Journal of Haematology, 122(1), 39-52.
21. Arendt, B. K., Velazquez-Dones, A., Tschumper, R. C., Howell, K. G., Ansell, S. M., Witzig, T. E., & Jelinek, D. F. (2002). Interleukin 6 induces monocyte chemoattractant protein-1 expression in myeloma cells. Leukemia, 16(10), 2142-2147.
22. Vande Broek, I., Asosingh, K., Vanderkerken, K., Straetmans, N., Van Camp, B., & Van Riet, I. (2003). Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3. British Journal of Cancer, 88(6), 855-862.
23. Johrer, K., Janke, K., Krugmann, J., Fiegl, M., & Greil, R. (2004). Transendothelial migration of myeloma cells is increased by tumor necrosis factor (TNF)-alpha via TNF receptor 2 and autocrine up-regulation of MCP-1. Clinical Cancer Research, 10(6), 1901-1910.
24. Pellegrino, A., Ria, R., Di Pietro, G., Cirulli, T., Surico, G., Pennisi, A., Morabito, F., Ribatti, D., Vacca, A. (2005). Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells. British Journal of Haematology, 129(2), 248-256.
25. Soule, H. D., Vazguez, J., Long, A., Albert, S., & Brennan, M. (1973). A human cell line from a pleural effusion derived from a breast carcinoma. Journal of the National Cancer Institute, 51(5), 1409-1416.
26. Engel, L. W., Young, N. A., Tralka, T. S., Lippman, M. E., O'Brien, S. J., & Joyce, M. J. (1978). Establishment and characterization of three new continuous cell lines derived from human breast carcinomas. Cancer Research 38(10), 3352-3364.
27. Youngs, S. J., Ali, S. A., Taub, D. D., & Rees, R. C. (1997). Chemokines induce migrational responses in human breast carcinoma cell lines. International Journal of Cancer, 71(2):257-266.
28. Keydar, I., Chen, L., Karby, S., Weiss, F. R., Delarea, J., Radu, M., et al. (1975). Establishment and characterization of a cell line of human breast carcinoma origin. European Journal of Cancer, 15(5), 659-670.
29. Ueno, T., Toi, M., Saji, H., Muta, M., Bando, H., Kuroi, K., et al. (2000). Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clinical Cancer Research, 6(8), 3282-3289.
30. Saji, H., Koike, M., Yamori, T., Saji, S., Seiki, M., Matsushima, K., et al. (2001). Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma. Cancer, 92(5), 1085-1091.
31. Lebrecht, A., Grimm, C., Lantzsch, T., Ludwig, E., Hefler, L., Ulbrich, E., et al. (2004). Monocyte chemoattractant protein-1 serum levels in patients with breast cancer. Tumour Biology, 25(1-2), 14-17.
32. Ferrero, E., Fabbri, M., Poggi, A., Galati, G., Bernasconi, S., & Zocchi, M. R. (1998). Tumor-driven matrix invasion by infiltrating lymphocytes: Involvement of the alpha1 integrin I-domain. European Journal of Immunology, 28(8), 2530-2536.
33. Amann, B., Perabo, F. G., Wirger, A., Hugenschmidt, H., & Schultze-Seemann, W. (1998). Urinary levels of monocyte chemoattractant protein-1 correlate with tumour stage and grade in patients with bladder cancer. British Journal of Urology, 82(1), 118-121.
34. Luciani, M. G., Stoppacciaro, A., Peri, G., Mantovani, A., & Ruco, L. P. (1998). The monocyte chemotactic protein a (MCP-1) and interleukin 8 (IL-8) in Hodgkin's disease and in solid tumours. Molecular Pathology, 51(5):273-276.
35. Baier, P. K., Eggstein, S., Wolff-Vorbeck, G., Baumgartner, U., & Hopt, U. T. (2005). Chemokines in human colorectal carcinoma. Anticancer Research, 25(5), 3581-3584.
36. Lu, Y., Cai, Z., Galson, D. L., Xiao, G., Liu, Y., George, D. E., et al. (2006). Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion. Prostate, 66(12), 1311-1318.
37. Kim, M. S., Day, C. J., & Morrison, N. A. (2005). MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation. Journal of Biology Chemistry, 280(16), 16163-16169.
38. Kim, M. S., Day, C. J., Selinger, C. I., Magno, C. L., Stephens, S. R., & Morrison, N. A. (2006). MCP-1-induced human osteoclast-like cells are tartrate-resistant acid phosphatase, NFATc1, and calcitonin receptor-positive but require receptor activator of NFkappaB ligand for bone resorption. Journal of Biology Chemistry, 281(2), 1274-1285.
39. Kim, M. S., Magno, C. L., Day, C. J., & Morrison, N. A. (2006). Induction of chemokines and chemokine receptors CCR2b and CCR4 in authentic human osteoclasts differentiated with RANKL and osteoclast like cells differentiated by MCP-1 and RANTES. Journal of Cellular Biochemistry, 97(3), 512-518.
40. Muta, M., Matsumoto, G., Nakashima, E., & Toi, M. (2006). Mechanical analysis of tumor growth regression by the cyclooxygenase-2 inhibitor, DFU, in a Walker256 rat tumor model: importance of monocyte chemoattractant protein-1 modulation. Clinical Cancer Research, 12(1), 264-272.
41. Broxmeyer, H. E., Pelus, L. M., Kim, C. H., Hangoc, G., Cooper, S., & Hromas, R. (2006). Synergistic inhibition in vivo of bone marrow myeloid progenitors by myelosuppressive chemokines and chemokine-accelerated recovery of progenitors after treatment of mice with ara-C. Experimental Hematology, 34(8), 1069-1077.
42. Broxmeyer, H. E., Cooper, S., Hangoc, G., & Kim, C. H. (2005). Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. Stem Cells and Development, 14(2), 199-203.
43. Cashman, J. D., Eaves, C. J., Sarris, A. H., & Eaves, A. C. (1998). MCP-1, not MIP-1alpha, is the endogenous chemokine that cooperates with TGF-beta to inhibit the cycling of primitive normal but not leukemic (CML) progenitors in long-term human marrow cultures. Blood, 92(7), 2338-2344.
44. Xu, Y. X., Talati, B. R., Janakiraman, N., Chapman, R. A., & Gautam, S. C. (1999). Growth factors: Production of monocyte chemotactic protein-1 (MCP-1/JE) by bone marrow stromal cells: Effect on the migration and proliferation of hematopoietic progenitor cells. Hematology, 4(4), 345-356.
45. Kurihara, T., Warr, G., Loy, J., & Bravo, R. (1997). Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. Journal of Experimental Medicine, 186(10), 1757-1762.
46. Dzenko, K. A., Song, L., Ge, S., Kuziel, W. A., & Pachter, J. S. (2005). CCR2 expression by brain microvascular endothelial cells is critical for macrophage transendothelial migration in response to CCL2. Microvascular Research, 70(1-2), 53-64.
47. Yang, X., Lu, P., Ishida, Y., Kuziel, W. A., Fujii, C., & Mukaida, N. (2006). Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization. International Journal Cancer, 118(2), 335-345.
48. Huang, S., Singh, R. K., Xie, K., Gutman, M., Berry, K. K., Bucana, C. D., et al. (1994). Expression of the JE/MCP-1 gene suppresses metastatic potential in murine colon carcinoma cells. Cancer Immunology Immunotherapy, 39(4), 231-238.
49. Huang, S., Xie, K., Singh, R. K., Gutman, M., & Bar-Eli, M. (1995). Suppression of tumor growth and metastasis of murine renal adenocarcinoma by syngeneic fibroblasts genetically engineered to secrete the JE/MCP-1 cytokine. Journal of Interferon Cytokine Research, 15(7), 655-665.
50. Monti, P., Leone, B. E., Marchesi, F., Balzano, G., Zerbi, A., Scaltrini, F., et al. (2003). The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: Regulation of expression and potential mechanisms of antimalignant activity. Cancer Research, 63(21), 7451-7461.
51. Kozlow, W., & Guise, T. A. (2005). Breast cancer metastasis to bone: Mechanisms of osteolysis and implications for therapy. Journal of Mammary Gland Biology Neoplasia, 10(2), 169-180.
52. Ishikawa, M., Toki, H., Fujii, M., Yamamoto, H., Yumoto, Y., Awazu, R., et al. (1983). Clinical significance of the bone marrow examination in small cell carcinoma of the lung. Gan No Rinsho, 29(5), 399-402.
53. Iguchi, H., Yasuda, M., Matsuo, T., Sumii, T., & Funakoshi, A. (2004). Clinical features and management of pancreatic cancer with bone metastases. Nippon Shokakibyo Gakkai Zasshi, 101(8):872-878.
54. Rowland, G. N., Capen, C. C., Black, H. E., & Young, D. M. (1971). Microradiographic evaluation of bone and ultrastructure of C-cells and parathyroid glands of cows receiving parathyroid extract. Beitrage zur Pathologie, 144(4), 360-376.
55. Junker, K., Romics, I., Szendroi, A., Riesz, P., Moravek, P., Hindermann, W., et al. (2004). Genetic profile of bone metastases in renal cell carcinoma. European Urology, 45(3), 320-324.
56. Natsuizaka, M., Omura, T., Akaike, T., Kuwata, Y., Yamazaki, K., Sato, T., et al. (2005). Clinical features of hepatocellular carcinoma with extrahepatic metastases. Journal of Gastroenterology and Hepatology, 20(11), 1781-1787.
57. Mado, K., Ishii, Y., Mazaki, T., Ushio, M., Masuda, H., & Takayama, T. (2006). A case of bone metastasis of colon cancer that markedly responded to S-1/CPT-11 combination chemotherapy and became curable by resection. World Journal of Surgical Oncology, 4, 3.
58. Berge, T., & Lundberg, S. (1977). Cancer in Malmo 1958-1969. An autopsy study. Acta Pathologica et Microbiologica Scandinavica, Supplementum, 260, 1-235.
59. Drury, A. B., Palmer, P. H., & Highman, W. J. (1964). Carcinomatous metastasis to the vertebral bodies. Journal of Clinical Pathology, 17, 448-457.