Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer

Journal of Clinical Oncology

Volumn 30, Issue 5, 2012, Pages 525-532

  Hou, Jian Mei ^a   Krebs, Matthew G ^a,b   Lancashire, Lee ^a   Sloane, Robert ^a   Backen, Alison ^a   Swain, Rajeeb K ^a   Priest, Lynsey J C ^a   Greystoke, Alastair ^a   Zhou, Cong ^a   Morris, Karen ^a   Ward, Tim ^a   Blackhall, Fiona H ^a,b   Dive, Caroline ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DACTINOMYCIN; EPITHELIAL CELL ADHESION MOLECULE; ETOPOSIDE; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN MCL 1; VINCRISTINE;

ADULT; AGED; ANOIKIS; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CANCER PROGNOSIS; CIRCULATING TUMOR CELL; CIRCULATING TUMOR MICROEMBOLI; FEMALE; HUMAN; HUMAN CELL; IMMUNOMAGNETIC SEPARATION; LUNG SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CARCINOMA, SMALL CELL; CELL PROLIFERATION; DISEASE-FREE SURVIVAL; EMBOLISM; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; KI-67 ANTIGEN; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASTIC CELLS, CIRCULATING; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS C-BCL-2; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL;

EID: 84856862054     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2010.33.3716     Document Type: Article

References (32)

1. Govindan R, Page N, Morgensztern D, et al: Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol 24:4539-4544, 2006 (Pubitemid 46630948)
2. Hou JM, Krebs M, Ward T, et al: Circulating tumor cells: Enumeration and beyond. Cancers 2:1236-1250, 2010
3. Cohen SJ, Punt CJ, Iannotti N, et al: Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 26:3213-3221, 2008
4. Cristofanilli M, Budd GT, Ellis MJ, et al: Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351:781-791, 2004 (Pubitemid 39095313)
5. de Bono JS, Scher HI, Montgomery RB, et al: Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res 14:6302-6309, 2008
6. Krebs MG, Sloane R, Priest L, et al: Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer. J Clin Oncol 29:1556-1563, 2011
7. Hou JM, Greystoke A, Lancashire L, et al: Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy. Am J Pathol 175:808-816, 2009
8. Hou JM, Krebs M, Ward T, et al: Circulating tumor cells as a window on metastasis biology in lung cancer. Am J Pathol 178:989-996, 2011
9. Sorensen M, Felip E: Small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 20:71-72, 2009 (suppl 4)
10. Riethdorf S, Fritsche H, Muller V, et al: Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: A validation study of the CellSearch system. Clin Cancer Res 13:920-928, 2007 (Pubitemid 46340368)
11. Kraan J, Sleijfer S, Strijbos MH, et al: External quality assurance of circulating tumor cell enumeration using the CellSearch((R)) system: A feasibility study. Cytometry B Clin Cytom 80:112-118, 2011
12. Kerr JF, Wyllie AH, Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257, 1972
13. Müller V, Stahmann N, Riethdorf S, et al: Circulating tumor cells in breast cancer: Correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. Clin Cancer Res 11:3678-3685, 2005 (Pubitemid 40685584)
14. Vona G, Sabile A, Louha M, et al: Isolation by size of epithelial tumor cells: A new method for the immunomorphological and molecular characterization of circulating tumor cells. Am J Pathol 156:57-63, 2000 (Pubitemid 30644439)
15. Miller R, Siegmund D: Maximally selected Chi square statistics. Biometrics 38:1011-1016, 1982 (Pubitemid 14272808)
16. McShane LM, Altman DG, Sauerbrei W, et al: REporting recommendations for tumour MARKer prognostic studies (REMARK). Eur J Cancer 41:1690-1696, 2005 (Pubitemid 41132629)
17. Zereu M, Vinholes JJ, Zettler CG: p53 and Bcl-2 protein expression and its relationship with prognosis in small-cell lung cancer. Clin Lung Cancer 4:298-302, 2003 (Pubitemid 36546415)
18. Krebs MG, Sloane R, Priest L, et al: Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer. J Clin Oncol 29:1556-1563, 2011
19. Allard WJ, Matera J, Miller MC, et al: Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res 10:6897-6904, 2004 (Pubitemid 39383039)
20. Blackhall FH, Shepherd FA: Small cell lung cancer and targeted therapies. Curr Opin Oncol 19:103-108, 2007 (Pubitemid 46204348)
21. Tahir SK, Yang X, Anderson MG, et al: Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737. Cancer Res 67:1176-1183, 2007
22. Johnson BE, Makuch RW, Simmons AD, et al: Myc family DNA amplification in small cell lung cancer patients' tumors and corresponding cell lines. Cancer Res 48:5163-5166, 1988
23. Soucek L, Evan GI: The ups and downs of Myc biology. Curr Opin Genet Dev 20:91-95, 2010
24. Brandt B, Junker R, Griwatz C, et al: Isolation of prostate-derived single cells and cell clusters from human peripheral blood. Cancer Res 56:4556-4561, 1996 (Pubitemid 26338045)
25. Kats-Ugurlu G, Roodink I, de Weijert M, et al: Circulating tumour tissue fragments in patients with pulmonary metastasis of clear cell renal cell carcinoma. J Pathol 219:287-293, 2009
26. Molnar B, Ladanyi A, Tanko L, et al: Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients. Clin Cancer Res 7:4080-4085, 2001 (Pubitemid 34044631)
27. Stott SL, Hsu CH, Tsukrov DI, et al: Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A 107:18392-18397, 2010
28. Fidler IJ: Metastasis: Quantitative analysis of distribution and fate of tumor embolilabeled with 125 I-5-iodo-2′-deoxyuridine. J Natl Cancer Inst 45:773-782, 1970
29. Liotta LA, Saidel MG, Kleinerman J: The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res 36:889-894, 1976
30. Frisch SM, Francis H: Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124:619-626, 1994 (Pubitemid 24064472)
31. Friedl P, Gilmour D: Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 10:445-457, 2009
32. Tsuji T, Ibaragi S, Shima K, et al: Epithelialmesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res 68:10377-10386, 2008