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Volumn 53, Issue 4, 2014, Pages 537-545

Pinocembrin protects SH-SY5Y cells against MPP+-induced neurotoxicity through the mitochondrial apoptotic pathway

Author keywords

Neuroprotection; Oxidative stress; Parkinson's disease; Pinocembrin

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; FLAVANONE DERIVATIVE; NEUROPROTECTIVE AGENT; PINOCEMBRINE; REACTIVE OXYGEN METABOLITE;

EID: 84905081060     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-0219-x     Document Type: Article
Times cited : (53)

References (57)
  • 1
    • 56949092585 scopus 로고    scopus 로고
    • Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis
    • Ahn KH, Kim YS, Kim SY, Huh Y, Park C, Jeong JW (2009) Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis. Neurosci Lett 449:93-97
    • (2009) Neurosci Lett , vol.449 , pp. 93-97
    • Ahn, K.H.1    Kim, Y.S.2    Kim, S.Y.3    Huh, Y.4    Park, C.5    Jeong, J.W.6
  • 3
    • 0343503019 scopus 로고    scopus 로고
    • Neurochemical changes induced by acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline and salsolinol in dopaminergic structures of rat brain
    • DOI 10.1016/S0306-4522(99)00533-3, PII S0306452299005333
    • Antkiewicz-Michaluk L, Romanska I, Papla I, Michaluk J, Bakalarz M, Vetulani J, Krygowska-Wajs A, Szczudlik A (2000) Neurochemical changes induced by acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline and salsolinol in dopaminergic structures of rat brain. Neuroscience 96:59-64 (Pubitemid 30103603)
    • (2000) Neuroscience , vol.96 , Issue.1 , pp. 59-64
    • Antkiewicz-Michaluk, L.1    Romanska, I.2    Papla, I.3    Michaluk, J.4    Bakalarz, M.5    Vetulani, J.6    Krygowska-Wajs, A.7    Szczudlik, A.8
  • 4
    • 84891360476 scopus 로고    scopus 로고
    • TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity
    • Arshad A, Chen X, Cong Z, Qing H, Deng Y (2014) TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol- induced cytotoxicity. Acta Biochim Biophys Sin (Shanghai) 46:22-30
    • (2014) Acta Biochim Biophys Sin (Shanghai) , vol.46 , pp. 22-30
    • Arshad, A.1    Chen, X.2    Cong, Z.3    Qing, H.4    Deng, Y.5
  • 5
    • 0038051345 scopus 로고    scopus 로고
    • Mitochondria, oxidative damage, and inflammation in Parkinson's disease
    • Beal MF (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann N Y Acad Sci 991:120-131
    • (2003) Ann N Y Acad Sci , vol.991 , pp. 120-131
    • Beal, M.F.1
  • 6
    • 0018121341 scopus 로고
    • Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones
    • Biedler JL, Roffler-Tarlov S, Schachner M, Freedman LS (1978) Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones. Cancer Res 38:3751-3757 (Pubitemid 9045201)
    • (1978) Cancer Research , vol.38 , Issue.11 I , pp. 3751-3757
    • Biedler, J.L.1    Roffler-Tarlov, S.2    Schachner, M.3    Freedman, L.S.4
  • 7
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • DOI 10.1016/S0301-0082(01)00003-X, PII S030100820100003X
    • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM (2001) Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65:135-172 (Pubitemid 32524182)
    • (2001) Progress in Neurobiology , vol.65 , Issue.2 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.-F.4    Benabid, A.-L.5    Sadoul, R.6    Verna, J.-M.7
  • 8
    • 25444480003 scopus 로고    scopus 로고
    • Programmed cell death via mitochondria: Different modes of dying
    • DOI 10.1007/s10541-005-0105-4
    • Bras M, Queenan B, Susin SA (2005) Programmed cell death via mitochondria: different modes of dying. Biochemistry (Mosc) 70:231-239 (Pubitemid 40512332)
    • (2005) Biochemistry (Moscow) , vol.70 , Issue.2 , pp. 231-239
    • Bras, M.1    Queenan, B.2    Susin, S.A.3
  • 9
    • 84878930078 scopus 로고    scopus 로고
    • PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: Implication for Parkinson's disease
    • Brown D, Tamas A, Reglodi D, Tizabi Y (2013) PACAP protects against salsolinol-induced toxicity in dopaminergic SH-SY5Y cells: implication for Parkinson's disease. J Mol Neurosci 50:600-607
    • (2013) J Mol Neurosci , vol.50 , pp. 600-607
    • Brown, D.1    Tamas, A.2    Reglodi, D.3    Tizabi, Y.4
  • 11
    • 0032951125 scopus 로고    scopus 로고
    • + opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism
    • DOI 10.1016/S0925-4439(98)00083-0, PII S0925443998000830
    • Cassarino DS, Parks JK, Parker WD Jr, Bennett JP Jr (1999) The parkinsonian neurotoxin MPP+ opens the mitochondrial permeability transition pore and releases cytochrome c in isolated mitochondria via an oxidative mechanism. Biochim Biophys Acta 1453:49-62 (Pubitemid 29065457)
    • (1999) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1453 , Issue.1 , pp. 49-62
    • Cassarino, D.S.1    Parks, J.K.2    Parker Jr., W.D.3    Bennett Jr., J.P.4
  • 13
    • 0013670404 scopus 로고    scopus 로고
    • Free radicals and MPTP-induced selective destruction of substantia nigra compacta neurons
    • Chiueh CC, Rauhala P (1998) Free radicals and MPTP-induced selective destruction of substantia nigra compacta neurons. Adv Pharmacol 42:796-800
    • (1998) Adv Pharmacol , vol.42 , pp. 796-800
    • Chiueh, C.C.1    Rauhala, P.2
  • 14
    • 0035116226 scopus 로고    scopus 로고
    • +, oxidant and specific neurotoxicants shares the common molecular mechanism
    • DOI 10.1046/j.1471-4159.2001.00096.x
    • Chun HS, Gibson GE, DeGiorgio LA, Zhang H, Kidd VJ, Son JH (2001) Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. J Neurochem 76:1010-1021 (Pubitemid 32167374)
    • (2001) Journal of Neurochemistry , vol.76 , Issue.4 , pp. 1010-1021
    • Chun, H.S.1    Gibson, G.E.2    Degiorgio, L.A.3    Zhang, H.4    Kidd, V.J.5    Son, J.H.6
  • 15
    • 33645929088 scopus 로고    scopus 로고
    • Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: Implications for Parkinson's disease
    • Copeland RL Jr, Leggett YA, Kanaan YM, Taylor RE, Tizabi Y (2005) Neuroprotective effects of nicotine against salsolinol-induced cytotoxicity: implications for Parkinson's disease. Neurotox Res 8:289-293
    • (2005) Neurotox Res , vol.8 , pp. 289-293
    • Copeland Jr., R.L.1    Leggett, Y.A.2    Kanaan, Y.M.3    Taylor, R.E.4    Tizabi, Y.5
  • 16
    • 34548635103 scopus 로고    scopus 로고
    • Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity
    • Copeland RL Jr, Das JR, Kanaan YM, Taylor RE, Tizabi Y (2007) Antiapoptotic effects of nicotine in its protection against salsolinol-induced cytotoxicity. Neurotox Res 12:61-69
    • (2007) Neurotox Res , vol.12 , pp. 61-69
    • Copeland Jr., R.L.1    Das, J.R.2    Kanaan, Y.M.3    Taylor, R.E.4    Tizabi, Y.5
  • 17
    • 70349898590 scopus 로고    scopus 로고
    • Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells
    • Das JR, Tizabi Y (2009) Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells. Neurotox Res 16:194-204
    • (2009) Neurotox Res , vol.16 , pp. 194-204
    • Das, J.R.1    Tizabi, Y.2
  • 18
    • 33847042812 scopus 로고    scopus 로고
    • Linking selective vulnerability to cell death mechanisms in Parkinson's disease
    • Dickson DW (2007) Linking selective vulnerability to cell death mechanisms in Parkinson's disease. Am J Pathol 170:16-19
    • (2007) Am J Pathol , vol.170 , pp. 16-19
    • Dickson, D.W.1
  • 19
    • 0037418614 scopus 로고    scopus 로고
    • Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease
    • DOI 10.1016/S0378-4274(02)00428-9, PII S0378427402004289
    • Eberhardt O, Schulz JB (2003) Apoptotic mechanisms and antiapoptotic therapy in the MPTP model of Parkinson's disease. Toxicol Lett 139:135-151 (Pubitemid 36298972)
    • (2003) Toxicology Letters , vol.139 , Issue.2-3 , pp. 135-151
    • Eberhardt, O.1    Schulz, J.B.2
  • 21
    • 0033104442 scopus 로고    scopus 로고
    • Characterization and time course of MPP+-induced apoptosis in human SH- SY5Y neuroblastoma cells
    • DOI 10.1002/(SICI)1097-4547(19990301)55:5<620
    • Fall CP, Bennett JP Jr (1999) Characterization and time course of MPP+-induced apoptosis in human SH-SY5Y neuroblastoma cells. J Neurosci Res 55:620-628 (Pubitemid 29117620)
    • (1999) Journal of Neuroscience Research , vol.55 , Issue.5 , pp. 620-628
    • Fall, C.P.1    Bennett Jr., J.P.2
  • 22
    • 0027988493 scopus 로고
    • Induction of adenylate cyclase sensitive dopamine D2-receptors in retinoic acid induced differentiated human neuroblastoma SHSY-5Y cells
    • Farooqui SM (1994) Induction of adenylate cyclase sensitive dopamine D2-receptors in retinoic acid induced differentiated human neuroblastoma SHSY-5Y cells. Life Sci 55:1887-1893
    • (1994) Life Sci , vol.55 , pp. 1887-1893
    • Farooqui, S.M.1
  • 24
    • 0037064274 scopus 로고    scopus 로고
    • +)- and nerve growth factor-induced changes in pro- and anti-apoptotic signaling pathways in SH-SY5Y neuroblastoma cells
    • DOI 10.1016/S0006-8993(02)03216-X, PII S000689930203216X
    • Halvorsen EM, Dennis J, Keeney P, Sturgill TW, Tuttle JB, Bennett JB Jr (2002) Methylpyridinium (MPP(+))- and nerve growth factor-induced changes in pro- and anti-apoptotic signaling pathways in SH-SY5Y neuroblastoma cells. Brain Res 952:98-110 (Pubitemid 35279492)
    • (2002) Brain Research , vol.952 , Issue.1 , pp. 98-110
    • Halvorsen, E.M.1    Dennis, J.2    Keeney, P.M.3    Sturgill, T.W.4    Tuttle, J.B.5    Bennett Jr., J.P.6
  • 25
    • 20944441667 scopus 로고    scopus 로고
    • Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease
    • DOI 10.1159/000085382
    • Houghton PJ, Howes MJ (2005) Natural products and derivatives affecting neurotransmission relevant to Alzheimer's and Parkinson's disease. Neurosignals 14:6-22 (Pubitemid 40868980)
    • (2005) NeuroSignals , vol.14 , Issue.1-2 , pp. 6-22
    • Houghton, P.J.1    Howes, M.-J.2
  • 26
    • 0028171676 scopus 로고
    • 1-Methyl-4-phenylpyridinium (MPP+)-induced cell death in PC12 cells: Inhibitory effects of several drugs
    • Itano Y, Kitamura Y, Nomura Y (1994) 1-Methyl-4-phenylpyridinium (MPP+)-induced cell death in PC12 cells: inhibitory effects of several drugs. Neurochem Int 25:419-424
    • (1994) Neurochem Int , vol.25 , pp. 419-424
    • Itano, Y.1    Kitamura, Y.2    Nomura, Y.3
  • 27
    • 0026635461 scopus 로고
    • Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease
    • The Royal Kings and Queens Parkinson's Disease Research Group
    • Jenner P, Dexter DT, Sian J, Schapira AH, Marsden CD (1992) Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group. Ann Neurol 32(Suppl):S82-S87
    • (1992) Ann Neurol , vol.32 , Issue.SUPPL.
    • Jenner, P.1    Dexter, D.T.2    Sian, J.3    Schapira, A.H.4    Marsden, C.D.5
  • 28
    • 0027323932 scopus 로고
    • Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells
    • DOI 10.1016/0896-6273(93)90187-V
    • Kaplan DR, Matsumoto K, Lucarelli E, Thiele CJ (1993) Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Eukaryotic Signal Transduction Group. Neuron 11:321-331 (Pubitemid 23250349)
    • (1993) Neuron , vol.11 , Issue.2 , pp. 321-331
    • Kaplan, D.R.1    Matsumoto, K.2    Lucarelli, E.3    Thiele, C.J.4
  • 29
    • 70449639679 scopus 로고    scopus 로고
    • Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity
    • Kim IS, Koppula S, Park PJ, Kim EH, Kim CG, Choi WS, Lee KH, Choi DK (2009) Chrysanthemum morifolium Ramat (CM) extract protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. J Ethnopharmacol 126:447-454
    • (2009) J Ethnopharmacol , vol.126 , pp. 447-454
    • Kim, I.S.1    Koppula, S.2    Park, P.J.3    Kim, E.H.4    Kim, C.G.5    Choi, W.S.6    Lee, K.H.7    Choi, D.K.8
  • 30
    • 0023210581 scopus 로고
    • Toxins and Parkinson's disease: MPTP parkinsonism in humans and animals
    • Kopin IJ (1987) Toxins and Parkinson's disease: MPTP parkinsonism in humans and animals. Adv Neurol 45:137-144
    • (1987) Adv Neurol , vol.45 , pp. 137-144
    • Kopin, I.J.1
  • 31
    • 0023911192 scopus 로고
    • MPTP toxicity: Implications for research in Parkinson's disease
    • Kopin IJ, Markey SP (1988) MPTP toxicity: implications for research in Parkinson's disease. Annu Rev Neurosci 11:81-96 (Pubitemid 18081034)
    • (1988) Annual Review of Neuroscience , vol.11 , pp. 81-96
    • Kopin, I.J.1    Markey, S.P.2
  • 33
    • 0031753043 scopus 로고    scopus 로고
    • 1-methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis
    • Leist M, Volbracht C, Fava E, Nicotera P (1998) 1-Methyl-4- phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. Mol Pharmacol 54:789-801 (Pubitemid 28523171)
    • (1998) Molecular Pharmacology , vol.54 , Issue.5 , pp. 789-801
    • Leist, M.1    Volbracht, C.2    Fava, E.3    Nicotera, P.4
  • 34
    • 84866305795 scopus 로고    scopus 로고
    • Pinocembrin protects against beta-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis
    • Liu R, Wu CX, Zhou D, Yang F, Tian S, Zhang L, Zhang TT, Du GH (2012) Pinocembrin protects against beta-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis. BMC Med 10:105
    • (2012) BMC Med , vol.10 , pp. 105
    • Liu, R.1    Wu, C.X.2    Zhou, D.3    Yang, F.4    Tian, S.5    Zhang, L.6    Zhang, T.T.7    Du, G.H.8
  • 35
    • 0034624017 scopus 로고    scopus 로고
    • The Parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation: A novel mechanism of toxicity
    • DOI 10.1074/jbc.M005385200
    • Lotharius J, O'Malley KL (2000) The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. J Biol Chem 275:38581-38588 (Pubitemid 32009186)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.49 , pp. 38581-38588
    • Lotharius, J.1    O'Malley, K.L.2
  • 36
    • 0033557640 scopus 로고    scopus 로고
    • Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons
    • Lotharius J, Dugan LL, O'Malley KL (1999) Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci Off J Soc Neurosci 19:1284-1293 (Pubitemid 29088911)
    • (1999) Journal of Neuroscience , vol.19 , Issue.4 , pp. 1284-1293
    • Lotharius, J.1    Dugan, L.L.2    O'Malley, K.L.3
  • 37
    • 0031043805 scopus 로고    scopus 로고
    • A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigrostriatal system of the human brain
    • DOI 10.1016/S0304-3940(97)13389-4, PII S0304394097133894
    • Maruyama W, Sobue G, Matsubara K, Hashizume Y, Dostert P, Naoi M (1997) A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigro-striatal system of the human brain. Neurosci Lett 223:61-64 (Pubitemid 27093020)
    • (1997) Neuroscience Letters , vol.223 , Issue.1 , pp. 61-64
    • Maruyama, W.1    Sobue, G.2    Matsubara, K.3    Hashizume, Y.4    Dostert, P.5    Naoi, M.6
  • 38
    • 16544388655 scopus 로고    scopus 로고
    • Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2- propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells
    • DOI 10.1016/j.lfs.2003.12.001, PII S0024320504002036
    • Maruyama W, Yi H, Takahashi T, Shimazu S, Ohde H, Yoneda F, Iwasa K, Naoi M (2004) Neuroprotective function of R-(-)-1-(benzofuran-2-yl)-2- propylaminopentane, [R-(-)-BPAP], against apoptosis induced by N-methyl(R)salsolinol, an endogenous dopaminergic neurotoxin, in human dopaminergic neuroblastoma SH-SY5Y cells. Life Sci 75:107-117 (Pubitemid 38501768)
    • (2004) Life Sciences , vol.75 , Issue.1 , pp. 107-117
    • Maruyama, W.1    Yi, H.2    Takahashi, T.3    Shimazu, S.4    Ohde, H.5    Yoneda, F.6    Iwasa, K.7    Naoi, M.8
  • 39
    • 0029015251 scopus 로고
    • Presence of N-methyl-norsalsolinol in the CSF: Correlations with dopamine metabolites of patients with Parkinson's disease
    • Moser A, Scholz J, Nobbe F, Vieregge P, Bohme V, Bamberg H (1995) Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease. J Neurol Sci 131:183-189
    • (1995) J Neurol Sci , vol.131 , pp. 183-189
    • Moser, A.1    Scholz, J.2    Nobbe, F.3    Vieregge, P.4    Bohme, V.5    Bamberg, H.6
  • 40
    • 39049179635 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of Parkinson's disease: Neurotoxins, causative genes, and inflammatory cytokines
    • Nagatsu T, Sawada M (2006) Cellular and molecular mechanisms of Parkinson's disease: neurotoxins, causative genes, and inflammatory cytokines. Cell Mol Neurobiol 26:781-802
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 781-802
    • Nagatsu, T.1    Sawada, M.2
  • 41
    • 0346154811 scopus 로고    scopus 로고
    • Dopamine-Derived Salsolinol Derivatives as Endogenous Monoamine Oxidase Inhibitors: Occurrence, Metabolism and Function in Human Brains
    • DOI 10.1016/S0161-813X(03)00099-8
    • Naoi M, Maruyama W, Nagy GM (2004) Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains. Neurotoxicology 25:193-204 (Pubitemid 38044181)
    • (2004) NeuroToxicology , vol.25 , Issue.1-2 , pp. 193-204
    • Naoi, M.1    Maruyama, W.2    Nagy, G.M.3
  • 42
    • 0033971898 scopus 로고    scopus 로고
    • Mitochondria and neuronal survival
    • Nicholls DG, Budd SL (2000) Mitochondria and neuronal survival. Physiol Rev 80:315-360 (Pubitemid 30060567)
    • (2000) Physiological Reviews , vol.80 , Issue.1 , pp. 315-360
    • Nicholls, D.G.1    Budd, S.L.2
  • 43
    • 34249671789 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and molecular pathways of disease
    • DOI 10.1016/j.yexmp.2006.09.008, PII S0014480006001328
    • Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83:84-92 (Pubitemid 46842959)
    • (2007) Experimental and Molecular Pathology , vol.83 , Issue.1 , pp. 84-92
    • Pieczenik, S.R.1    Neustadt, J.2
  • 44
    • 0027454020 scopus 로고
    • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium
    • Pifl C, Giros B, Caron MG (1993) Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. J Neurosci 13:4246-4253 (Pubitemid 23299947)
    • (1993) Journal of Neuroscience , vol.13 , Issue.10 , pp. 4246-4253
    • Pifl, C.1    Giros, B.2    Caron, M.G.3
  • 45
    • 0031895005 scopus 로고    scopus 로고
    • Mechanisms of MPTP toxicity
    • Przedborski S, Jackson-Lewis V (1998) Mechanisms of MPTP toxicity. Mov Disord 13(Suppl 1):35-38
    • (1998) Mov Disord , vol.13 , Issue.SUPPL. 1 , pp. 35-38
    • Przedborski, S.1    Jackson-Lewis, V.2
  • 46
    • 0022516015 scopus 로고
    • Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism
    • Ramsay RR, Salach JI, Dadgar J, Singer TP (1986) Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Biochem Biophys Res Commun 135:269-275 (Pubitemid 16063998)
    • (1986) Biochemical and Biophysical Research Communications , vol.135 , Issue.1 , pp. 269-275
    • Ramsay, R.R.1    Salach, J.I.2    Dadgar, J.3    Singer, T.P.4
  • 47
    • 84883171429 scopus 로고    scopus 로고
    • Pinocembrin: A novel natural compound with versatile pharmacological and biological activities
    • Rasul A, Millimouno FM, Ali EW, Ali M, Li J, Li X (2013) Pinocembrin: a novel natural compound with versatile pharmacological and biological activities. Biomed Res Int 2013:379850
    • (2013) Biomed Res Int , vol.2013 , pp. 379850
    • Rasul, A.1    Millimouno, F.M.2    Ali, E.W.3    Ali, M.4    Li, J.5    Li, X.6
  • 48
    • 0015926907 scopus 로고
    • Tetrahydroisoquinoline alkaloids: In vivo metabolites of L-dopa in man
    • Sandler M, Carter SB, Hunter KR, Stern GM (1973) Tetrahydroisoquinoline alkaloids: in vivo metabolites of L-dopa in man. Nature 241:439-443
    • (1973) Nature , vol.241 , pp. 439-443
    • Sandler, M.1    Carter, S.B.2    Hunter, K.R.3    Stern, G.M.4
  • 49
    • 0031589740 scopus 로고    scopus 로고
    • Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors
    • DOI 10.1016/S0006-8993(97)01034-2, PII S0006899397010342
    • Seaton TA, Cooper JM, Schapira AH (1997) Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors. Brain Res 777:110-118 (Pubitemid 28015738)
    • (1997) Brain Research , vol.777 , Issue.1-2 , pp. 110-118
    • Seaton, T.A.1    Cooper, J.M.2    Schapira, A.H.V.3
  • 50
    • 0025116342 scopus 로고
    • Mechanism of the neurotoxicity of MPTP. An update
    • DOI 10.1016/0014-5793(90)81315-F
    • Singer TP, Ramsay RR (1990) Mechanism of the neurotoxicity of MPTP. An update. FEBS Lett 274:1-8 (Pubitemid 20378107)
    • (1990) FEBS Letters , vol.274 , Issue.1-2 , pp. 1-8
    • Singer, T.P.1    Ramsay, R.R.2
  • 51
    • 0031036391 scopus 로고    scopus 로고
    • Evidence for generation of oxidative stress in brain by MPTP: In vitro and in vivo studies in mice
    • DOI 10.1016/S0006-8993(96)01271-1, PII S0006899396012711
    • Sriram K, Pai KS, Boyd MR, Ravindranath V (1997) Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res 749:44-52 (Pubitemid 27096453)
    • (1997) Brain Research , vol.749 , Issue.1 , pp. 44-52
    • Sriram, K.1    Pai, K.S.2    Boyd, M.R.3    Ravindranath, V.4
  • 52
    • 0033958942 scopus 로고    scopus 로고
    • 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism
    • DOI 10.1016/S0006-8993(99)02272-6, PII S0006899399022726
    • Storch A, Kaftan A, Burkhardt K, Schwarz J (2000) 1-Methyl-6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism. Brain Res 855:67-75 (Pubitemid 30067695)
    • (2000) Brain Research , vol.855 , Issue.1 , pp. 67-75
    • Storch, A.1    Kaftan, A.2    Burkhardt, K.3    Schwarz, J.4
  • 53
    • 18344395117 scopus 로고    scopus 로고
    • Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: Studies using heterologous expression systems of the dopamine transporter
    • DOI 10.1016/S0006-2952(01)00922-4, PII S0006295201009224
    • Storch A, Ott S, Hwang YI, Ortmann R, Hein A, Frenzel S, Matsubara K, Ohta S, Wolf HU, Schwarz J (2002) Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter. Biochem Pharmacol 63:909-920 (Pubitemid 34243004)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.5 , pp. 909-920
    • Storch, A.1    Ott, S.2    Hwang, Y.-I.3    Ortmann, R.4    Hein, A.5    Frenzel, S.6    Matsubara, K.7    Ohta, S.8    Wolf, H.-U.9    Schwarz, J.10
  • 54
    • 0028576861 scopus 로고
    • Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system
    • Takahashi T, Deng Y, Maruyama W, Dostert P, Kawai M, Naoi M (1994) Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4- tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system. J Neural Transm Gen Sect 98:107-118
    • (1994) J Neural Transm Gen Sect , vol.98 , pp. 107-118
    • Takahashi, T.1    Deng, Y.2    Maruyama, W.3    Dostert, P.4    Kawai, M.5    Naoi, M.6
  • 55
    • 67651111698 scopus 로고    scopus 로고
    • Acteoside protects human neuroblastoma SH-SY5Y cells against beta-amyloid-induced cell injury
    • Wang H, Xu Y, Yan J, Zhao X, Sun X, Zhang Y, Guo J, Zhu C (2009) Acteoside protects human neuroblastoma SH-SY5Y cells against beta-amyloid-induced cell injury. Brain Res 1283:139-147
    • (2009) Brain Res , vol.1283 , pp. 139-147
    • Wang, H.1    Xu, Y.2    Yan, J.3    Zhao, X.4    Sun, X.5    Zhang, Y.6    Guo, J.7    Zhu, C.8
  • 56
    • 77957949839 scopus 로고    scopus 로고
    • Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells
    • Wang HQ, Sun XB, Xu YX, Zhao H, Zhu QY, Zhu CQ (2010) Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. Brain Res 1360:159-167
    • (2010) Brain Res , vol.1360 , pp. 159-167
    • Wang, H.Q.1    Sun, X.B.2    Xu, Y.X.3    Zhao, H.4    Zhu, Q.Y.5    Zhu, C.Q.6
  • 57
    • 0031036872 scopus 로고    scopus 로고
    • Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
    • DOI 10.1126/science.275.5303.1129
    • Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275:1129-1132 (Pubitemid 27097312)
    • (1997) Science , vol.275 , Issue.5303 , pp. 1129-1132
    • Yang, J.1    Liu, X.2    Bhalla, K.3    Kim, C.N.4    Ibrado, A.M.5    Cai, J.6    Peng, T.-I.7    Jones, D.P.8    Wang, X.9


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