Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

Brain Research

Volumn 1360, Issue , 2010, Pages 159-167

  Wang, Hong Quan ^a   Sun, Xiao Bo ^a   Xu, Yu Xia ^a   Zhao, Hong ^a   Zhu, Qin Yuan ^a   Zhu, Cui Qing ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Astaxanthin; Beta amyloid peptide; ERK; Heme oxygenase 1; Neuroprotection

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; AMYLOID BETA PROTEIN[25-35]; ASTAXANTHIN; ENZYME INHIBITOR; EXTRACELLULAR REGULATED KINASE 1; EXTRACELLULAR REGULATED KINASE 2; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZNPP;

APOPTOSIS; ARTICLE; CYTOTOXICITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMYLOID BETA-PEPTIDES; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CELL DEATH; CELL LINE; CELL SURVIVAL; FLAVONOIDS; HEME OXYGENASE-1; HUMANS; MATRIX METALLOPROTEINASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE FRAGMENTS; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES; UP-REGULATION; XANTHOPHYLLS;

EID: 77957949839     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.08.100     Document Type: Article

References (39)

1. A. Ahmad, H. Zhuang, and S. Doré Heme oxygenase-1 protects brain from acute excitotoxicity Neuroscience 141 2006 1703 1708
2. C. Andreadi, L. Howells, P. Atherfold, and M. Manson Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols Mol. Pharmacol. 69 2006 1033 1040
3. D. Butterfield beta-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease Chem. Res. Toxicol. 10 1997 495 506
4. V. Calabrese, A. Ravagna, C. Colombrita, G. Scapagnini, E. Guagliano, M. Calvani, D. Butterfield, and A. Giuffrida Stella Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2 J. Neurosci. Res. 79 2005 509 521
5. J. Chandra, A. Samali, and S. Orrenius Triggering and modulation of apoptosis by oxidative stress Free Radic. Biol. Med. 29 2000 323 333
6. C. Chang, C. Chen, J. Chiou, R. Peng, and C. Peng Astaxanthine secured apoptotic death of PC12 cells induced by beta-amyloid peptide 25-35: its molecular action targets J. Med. Food 13 2010 548 556
7. M. Ferrándiz, and I. Devesa Inducers of heme oxygenase-1 Curr. Pharm. Des. 14 2008 473 486
8. M. Guerin, M. Huntley, and M. Olaizola Haematococcus astaxanthin: applications for human health and nutrition Trends Biotechnol. 21 2003 210 216
9. T. Harkany, T. Hortobágyi, M. Sasvári, C. Kónya, B. Penke, P. Luiten, and C. Nyakas Neuroprotective approaches in experimental models of beta-amyloid neurotoxicity: relevance to Alzheimer's disease Prog. Neuropsychopharmacol. Biol. Psychiatry 23 1999 963 1008
10. H. Huang, T. Nguyen, and C. Pickett Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription J. Biol. Chem. 277 2002 42769 42774
11. G. Hussein, U. Sankawa, H. Goto, K. Matsumoto, and H. Watanabe Astaxanthin, a carotenoid with potential in human health and nutrition J. Nat. Prod. 69 2006 443 449
12. D. Hwang, K. Chae, T. Kang, J. Hwang, C. Lim, H. Kang, J. Goo, M. Lee, H. Lim, S. Min, J. Cho, J. Hong, C. Song, S. Paik, J. Cho, and Y. Kim Alterations in behavior, amyloid beta-42, caspase-3, and Cox-2 in mutant PS2 transgenic mouse model of Alzheimer's disease FASEB J. 16 2002 805 813
13. Y. Ikeda, S. Tsuji, A. Satoh, M. Ishikura, T. Shirasawa, and T. Shimizu Protective effects of astaxanthin on 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells J. Neurochem. 107 2008 1730 1740
14. A. Jazwa, and A. Cuadrado Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases Curr. Drug Targets 2010
15. K. Kanninen, T. Malm, H. Jyrkkänen, G. Goldsteins, V. Keksa-Goldsteine, H. Tanila, M. Yamamoto, S. Ylä-Herttuala, A. Levonen, and J. Koistinaho Nuclear factor erythroid 2-related factor 2 protects against beta amyloid Mol. Cell. Neurosci. 39 2008 302 313
16. M. Kobayashi, and M. Yamamoto Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation Antioxid. Redox Signal. 7 2005 385 394
17. J. Lai, Y. Jiang, X. He, J. Huang, and F. Chen Separation and determination of astaxanthin from microalgal and yeast samples by molecularly imprinted microspheres J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 804 2004 25 30
18. W. Le, W. Xie, and S. Appel Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury J. Neurosci. Res. 56 1999 652 658
19. J. Li, J. Hu, B. Shao, W. Zhou, Y. Cui, C. Dong, J. Ezoulin, X. Zhu, W. Ding, F. Heymans, and H. Chen Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation Cell Mol. Neurobiol. 2009
20. X. Liu, T. Shibata, S. Hisaka, and T. Osawa Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism Brain Res. 1254 2009 18 27
21. W. Ma, L. Yuan, H. Yu, B. Ding, Y. Xi, J. Feng, and R. Xiao Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by beta-amyloid peptides 25-35 in PC12 cells Int. J. Dev. Neurosci. 28 2010 289 295
22. D. Martin, A. Rojo, M. Salinas, R. Diaz, G. Gallardo, J. Alam, C. De Galarreta, and A. Cuadrado Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol J. Biol. Chem. 279 2004 8919 8929
23. M. McMahon, K. Itoh, M. Yamamoto, and J. Hayes Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression J. Biol. Chem. 278 2003 21592 21600
24. T. Nguyen, P. Sherratt, H. Huang, C. Yang, and C. Pickett Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26S proteasome J. Biol. Chem. 278 2003 4536 4541
25. J. Nunan, and D. Small Regulation of APP cleavage by alpha-, beta- and gamma-secretases FEBS Lett. 483 2000 6 10
26. Z. Oltvai, C. Milliman, and S. Korsmeyer Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell 74 1993 609 619
27. S. Park, H. Kim, E. Cho, B. Kwon, S. Phark, K. Hwang, and D. Sul Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation Food Chem. Toxicol. 46 2008 2881 2887
28. S. Ryter, J. Alam, and A. Choi Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications Physiol. Rev. 86 2006 583 650
29. Y. Shan, J. Pepe, T. Lu, K. Elbirt, R. Lambrecht, and H. Bonkovsky Induction of the heme oxygenase-1 gene by metalloporphyrins Arch. Biochem. Biophys. 380 2000 219 227
30. H. Shen, C. Kuo, J. Chou, A. Delvolve, S. Jackson, J. Post, A. Woods, B. Hoffer, Y. Wang, and B. Harvey Astaxanthin reduces ischemic brain injury in adult rats FASEB J. 2009
31. D. Stewart, E. Killeen, R. Naquin, S. Alam, and J. Alam Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium J. Biol. Chem. 278 2003 2396 2402
32. T. Takahashi, K. Morita, R. Akagi, and S. Sassa Heme oxygenase-1: a novel therapeutic target in oxidative tissue injuries Curr. Med. Chem. 11 2004 1545 1561
33. A. Takeda, Y. Itoyama, T. Kimpara, X. Zhu, J. Avila, B. Dwyer, G. Perry, and M. Smith Heme catabolism and heme oxygenase in neurodegenerative disease Antioxid. Redox Signal. 6 2004 888 894
34. E. Tamagno, G. Robino, A. Obbili, P. Bardini, M. Aragno, M. Parola, and O. Danni H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK Exp. Neurol. 180 2003 144 155
35. A. Tanaka, N. Hamada, Y. Fujita, T. Itoh, Y. Nozawa, M. Iinuma, and M. Ito A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation Bioorg. Med. Chem. 18 2010 3133 3139
36. D. Tripathi, and G. Jena Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: Role of Nrf2, p53, p38 and phase-II enzymes Mutat. Res. 696 2010 69 80
37. H. Wang, Y. Xu, J. Yan, X. Zhao, X. Sun, Y. Zhang, J. Guo, and C. Zhu Acteoside protects human neuroblastoma SH-SY5Y cells against beta-amyloid-induced cell injury Brain Res. 1283 2009 139 147
38. C. Wruck, M. Götz, T. Herdegen, D. Varoga, L. Brandenburg, and T. Pufe Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation Mol. Pharmacol. 73 2008 1785 1795
39. X. Xiao, H. Zhang, and X. Tang Huperzine A attenuates amyloid beta-peptide fragment 25-35-induced apoptosis in rat cortical neurons via inhibiting reactive oxygen species formation and caspase-3 activation J. Neurosci. Res. 67 2002 30 36