A dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl(R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigrostriatal system of the human brain

Neuroscience Letters

Volumn 223, Issue 1, 1997, Pages 61-64

  Maruyama, Wakako ^a,b   Sobue, Gen ^b   Matsubara, Kazuo ^c   Hashizume, Yoshio ^d   Dostert, Philippe ^e   Naoi, Makoto ^f  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c SHIMANE UNIVERSITY   (Japan)

^d AICHI MEDICAL UNIVERSITY   (Japan)

^e PFIZER INC   (United States)

^f NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

1,2 Dimethyl 6,7 dihydroxyisoquinolinium ion; Aging; Dopamine; N Methyl(R)salsolinol; Nigro striatal system; Parkinson's disease

Indexed keywords

1,2,3,4 TETRAHYDRO 6,7 DIHYDROXY 1,2 DIMETHYLISOQUINOLINE; DOPAMINE; N METHYLSALSOLINOL; NEUROTOXIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; NIGRONEOSTRIATAL SYSTEM; NORMAL HUMAN; PARKINSON DISEASE; PRIORITY JOURNAL;

EID: 0031043805     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)13389-4     Document Type: Article

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