Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

Journal of the Royal Society Interface

Volumn 11, Issue 98, 2014, Pages

  Dobrzyński, Maciej ^a   Nguyen, Lan K ^a   Birtwistle, Marc R ^a,c   Von Kriegsheim, Alexander ^a   Fernández, Alfonso Blanco ^a   Cheong, Alex ^a,b   Kolch, Walter ^a   Kholodenko, Boris N ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b ASTON UNIVERSITY   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Bimodality; Cell heterogeneity; Dose response; Signalling networks

Indexed keywords

CELLS; CYTOLOGY; MATHEMATICAL TRANSFORMATIONS; POPULATION DISTRIBUTION; PROTEINS;

BIMODALITY; CELL-TO-CELL VARIABILITY; CELL-TO-CELL VARIATION; DOSE RESPONSE; INPUT-OUTPUT CHARACTERISTICS; PROTEIN DISTRIBUTIONS; SIGNALLING NETWORK; THEORETICAL FRAMEWORK;

CELL SIGNALING;

GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR; DICARBOXYLIC AMINO ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXALYLGLYCINE; OXYGEN; PROTEIN;

ADAPTATION; ARTICLE; CALCULATION; CELL HETEROGENEITY; CELL KINETICS; CELL POPULATION; ENTROPY; FLOW CYTOMETRY; HCT116 CELL LINE; HUMAN; HUMAN CELL; HYPOXIA; INTRACELLULAR SIGNALING; MATHEMATICAL MODEL; OXYGEN CONSUMPTION; OXYGEN TENSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; ALGORITHM; CELL COMMUNICATION; CHEMISTRY; GENE EXPRESSION REGULATION; METABOLISM; SIGNAL TRANSDUCTION; THEORETICAL MODEL;

ALGORITHMS; AMINO ACIDS, DICARBOXYLIC; CELL COMMUNICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MODELS, THEORETICAL; OXYGEN; PROTEINS; SIGNAL TRANSDUCTION;

EID: 84905055041     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2014.0383     Document Type: Article

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