Bimodal protein distributions in heterogeneous oscillating systems

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

Volumn 7605 LNBI, Issue , 2012, Pages 17-28

  Dobrzyński, Maciej ^a   Fey, Dirk ^a   Nguyen, Lan K ^a   Kholodenko, Boris N ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

bimodality; oscillations; protein distributions; signaling networks; stochasticity

Indexed keywords

BIMODAL DISTRIBUTION; BIMODALITY; BISTABLE DYNAMICS; CELL-TO-CELL VARIABILITY; KULLBACK LEIBLER DIVERGENCE; OSCILLATING SYSTEMS; OSCILLATIONS; PROTEIN ACTIVITY; SIGNALING CASCADES; SIGNALING NETWORKS; SIGNALING SYSTEMS; STOCHASTICITY; SUSTAINED OSCILLATIONS;

CELLS; COMPUTATIONAL METHODS; CYTOLOGY; SIGNALING;

PROTEINS;

EID: 84867850712     PISSN: 03029743     EISSN: 16113349     Source Type: Book Series    
DOI: 10.1007/978-3-642-33636-2_3     Document Type: Conference Paper

References (16)

1. Acar, M., Mettetal, J.T., van Oudenaarden, A.: Stochastic switching as a survival strategy in fluctuating environments. Nat. Genet. 40(4), 471-475 (2008)
2. Ackermann, M., Stecher, B., Freed, N.E., Songhet, P., Hardt, W.D., Doebeli, M.: Self-destructive cooperation mediated by phenotypic noise. Nature 454(7207), 987-990 (2008)
3. Blake, W.J., Balázsi, G., Kohanski, M.A., Isaacs, F.J., Murphy, K.F., Kuang, Y., Cantor, C.R., Walt, D.R., Collins, J.J.: Phenotypic consequences of promoter-mediated transcriptional noise. Molecular Cell 24(6), 853-865 (2006)
4. Das, M., Drake, T., Wiley, D.J., Buchwald, P., Vavylonis, D., Verde, F.: Oscillatory dynamics of Cdc42 GTPase in the control of polarized growth. Science 337(6091), 239-243 (2012)
5. Kuepfer, L., Peter, M., Sauer, U., Stelling, J.: Ensemble modeling for analysis of cell signaling dynamics. Nat. Biotechnol. 25(9), 1001-1006 (2007)
6. Miller, S., Childers, D.: Probability and Random Processes. With Applications to Signal Processing and Communications. Academic Press (January 2012)
7. Mirsky, H.P., Taylor, S.R., Harvey, R.A., Stelling, J., Doyle, F.J.: Distribution-based sensitivity metric for highly variable biochemical systems. IET Syst. Biol. 5(1), 50 (2011)
8. Niepel, M., Spencer, S.L., Sorger, P.K.: Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr. Opin. Chem. Biol. 13(5-6), 556-561 (2009)
9. Ochab-Marcinek, A., Tabaka, M.: Bimodal gene expression in noncooperative regulatory systems. PNAS 107(51), 22096-22101 (2010)
10. Ogunnaike, B.A.: Elucidating the digital control mechanism for DNA damage repair with the p53-Mdm2 system: single cell data analysis and ensemble modelling. J. R. Soc. Interface 3(6), 175-184 (2006)
11. Samoilov, M., Plyasunov, S., Arkin, A.P.: Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations. PNAS 102(7), 2310-2315 (2005)
12. Schliemann, M., Bullinger, E., Borchers, S., Allgöwer, F., Findeisen, R., Scheurich, P.: Heterogeneity reduces sensitivity of cell death for TNF-stimuli. BMC Syst. Biol. 5, 204 (2011)
13. Shahrezaei, V., Swain, P.S.: Analytical distributions for stochastic gene expression. PNAS 105(45), 17256-17261 (2008)
14. Sigal, A., Milo, R., Cohen, A., Geva-Zatorsky, N., Klein, Y., Liron, Y., Rosenfeld, N., Danon, T., Perzov, N., Alon, U.: Variability and memory of protein levels in human cells. Nature 444(7119), 643-646 (2006)
15. Spencer, S.L., Gaudet, S., Albeck, J.G., Burke, J.M., Sorger, P.K.: Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459(7245), 428-432 (2009)
16. Tsyganov, M.A., Kolch, W., Kholodenko, B.N.: The topology design principles that determine the spatiotemporal dynamics of G-protein cascades. Mol. Biosyst. 8(3), 730-743 (2012)