Capsaicin induces "Brite" phenotype in differentiating 3T3-L1 preadipocytes

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Baboota, Ritesh K ^a   Singh, Dhirendra P ^a   Sarma, Siddhartha M ^a   Kaur, Jaspreet ^b   Sandhir, Rajat ^c   Boparai, Ravneet K ^c   Kondepudi, Kanthi K ^a   Bishnoi, Mahendra ^a  

^a NATIONAL AGRI FOOD BIOTECHNOLOGY INSTITUTE   (India)

^b PANJAB UNIVERSITY   (India)

^c PANJAB UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CAPSAICIN; CAPSAZEPINE; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESINIFERATOXIN; ADIPOCYTOKINE; BIOLOGICAL MARKER; TRPV1 PROTEIN, MOUSE; VANILLOID RECEPTOR;

3T3 CELL LINE; ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRITE CELL; BROWN ADIPOSE TISSUE; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENOME ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; LIPID DIET; LIPID STORAGE; LOCOMOTION; MALE; MARKER GENE; NONHUMAN; NUTRIGENOMICS; OBESITY; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PPARGAMMA GENE; PROADIPOCYTE; RAT; TRPV1 GENE; WHITE ADIPOSE TISSUE; ANALOGS AND DERIVATIVES; ANIMAL; BODY WEIGHT; BROWN ADIPOCYTE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENETICS; LIPID METABOLISM; METABOLISM; MOTOR ACTIVITY; MOUSE; PAIN THRESHOLD; SECRETION (PROCESS);

3T3-L1 CELLS; ADIPOCYTES; ADIPOCYTES, BROWN; ADIPOGENESIS; ADIPOKINES; ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CAPSAICIN; CELL DIFFERENTIATION; DIET, HIGH-FAT; GENE EXPRESSION REGULATION; LIPID METABOLISM; MICE; MOTOR ACTIVITY; PAIN THRESHOLD; PHENOTYPE; PPAR GAMMA; TRPV CATION CHANNELS;

EID: 84904962630     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103093     Document Type: Article

References (52)

1. Kawada T, Watanabe T, Takaishi T, Tanaka T, Iwai K (1986) Capsaicin-induced beta-adrenergic action on energy metabolism in rats: influence of capsaicin on oxygen consumption, the respiratory quotient, and substrate utilization. Proc Soc Exp Biol Med 183: 250-256. (Pubitemid 17183831)
2. Yoshioka M, St-Pierre S, Suzuki M, Tremblay A (1998) Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr 80: 503-510. (Pubitemid 29060531)
3. Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, et al. (2007) Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res 100: 1063-1070. Epub 2007 Mar 1068.
4. Ludy MJ, Moore GE, Mattes RD (2012) The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 37: 103-121.
5. Clegg ME, Golsorkhi M, Henry CJ (2013) Combined medium-chain triglyceride and chili feeding increases diet-induced thermogenesis in normal-weight humans. Eur J Nutr 52: 1579-1585.
6. Chavez M, Kelly L, York DA, Berthoud HR (1997) Chemical lesion of visceral afferents causes transient overconsumption of unfamiliar high-fat diets in rats. Am J Physiol 272: R1657-1663.
7. Motter AL, Ahern GP (2008) TRPV1-null mice are protected from diet-induced obesity. FEBS Lett 582: 2257-2262.
8. Marshall NJ, Liang L, Bodkin J, Dessapt-Baradez C, Nandi M, et al. (2013) A role for TRPV1 in influencing the onset of cardiovascular disease in obesity. Hypertension 61: 246-252.
9. Kobayashi Y, Nakano Y, Kizaki M, Hoshikuma K, Yokoo Y, et al. (2001) Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med 67: 628-633. (Pubitemid 32929573)
10. Schwarz NA, Spillane M, La Bounty P, Grandjean PW, Leutholtz B, et al. (2013) Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-intense exercise. Nutrition research (New York, NY).
11. Kawabata F, Inoue N, Masamoto Y, Matsumura S, Kimura W, et al. (2009) Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice. Bioscience, biotechnology, and biochemistry 73: 2690-2697.
12. Yoneshiro T, Aita S, Kawai Y, Iwanaga T, Saito M (2012) Nonpungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am J Clin Nutr 95: 845-850.
13. Bishnoi M, Bosgraaf CA, Premkumar LS (2011) Preservation of acute pain and efferent functions following intrathecal resiniferatoxin-induced analgesia in rats. J Pain. 12(9):991-1003.
14. Premkumar LS (2010) Targeting TRPV1 as an Alternative Approach to Narcotic Analgesics to Treat Chronic Pain Conditions AAPS J. 12(3): 361-370.
15. Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, et al. (2001) Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nature medicine 7: 1128-1132. (Pubitemid 33010021)
16. Romanatto T, Roman EA, Arruda AP, Denis RG, Solon C, et al. (2009) Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. The Journal of biological chemistry 284: 36213-36222.
17. Bonet ML, Oliver P, Palou A (2013) Pharmacological and nutritional agents promoting browning of white adipose tissue. Biochimica et biophysica acta 1831: 969-985.
18. Vernochet C, Peres SB, Davis KE, McDonald ME, Qiang L, et al. (2009) C/EBPalpha and the corepressors CtBP1 and CtBP2 regulate repression of select visceral white adipose genes during induction of the brown phenotype in white adipocytes by peroxisome proliferator-activated receptor gamma agonists. Molecular and cellular biology 29: 4714-4728.
19. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, et al. (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 151: 96-110.
20. Sukumar P, Sedo A, Li J, Wilson LA, O'Regan D, et al. (2012) Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin. Circulation research 111: 191-200.
21. 2+-dependent desensitization of TRPV1 channel targets the receptor to lysosomes for degradation. The Journal of biological chemistry 287: 19462-19471.
22. Lee MS, Kim CT, Kim IH, Kim Y (2011) Effects of capsaicin on lipid catabolism in 3T3-L1 adipocytes. Phytotherapy research: PTR 25: 935-939.
23. Hsu CL, Yen GC (2007) Effects of capsaicin on induction of apoptosis and inhibition of adipogenesis in 3T3-L1 cells. Journal of agricultural and food chemistry 55: 1730-1736.
24. Park JY, Kawada T, Han IS, Kim BS, Goto T, et al. (2004) Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism. FEBS Letters 572: 266-270. (Pubitemid 39092547)
25. Kim CS, Park WH, Park JY, Kang JH, Kim MO, et al. (2004) Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells. J Med Food. 7: 267-73.
26. Kang JH, Kim CS, Han IS, Kawada T, Yu R (2007) Capsaicin, a spicy component of hot peppers, modulates adipokine gene expression and protein release from obese-mouse adipose tissues and isolated adipocytes, and suppresses the inflammatory responses of adipose tissue macrophages. FEBS Letters 587: 4389-96. (Pubitemid 47368195)
27. Yu C, Markan K, Temple KA, Deplewski D, Brady MJ, et al. (2005) The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. The Journal of biological chemistry 280: 13600-13605. (Pubitemid 40517253)
28. Wang F, Tong Q (2009) SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Molecular biology of the cell 20: 801-808.
29. Tong Q, Dalgin G, Xu H, Ting CN, Leiden JM, et al. (2000) Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290: 134-138.
30. Banerjee SS, Feinberg MW, Watanabe M, Gray S, Haspel RL, et al. (2003) The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. The Journal of biological chemistry 278: 2581-2584. (Pubitemid 36801336)
31. Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science 289: 950-953. (Pubitemid 30659947)
32. Christodoulides C, Lagathu C, Sethi JK, Vidal-Puig A (2009) Adipogenesis and WNT signalling. Trends in endocrinology and metabolism: TEM 20: 16-24.
33. Wang Y, Zhao L, Smas C, Sul HS (2010) Pref-1 interacts with fibronectin to inhibit adipocyte differentiation. Molecular and cellular biology 30: 3480-3492.
34. Li H, Fong C, Chen Y, Cai G, Yang M (2010) Beta-adrenergic signals regulate adipogenesis of mouse mesenchymal stem cells via cAMP/PKA pathway. Molecular and cellular endocrinology 323: 201-207.
35. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770. (Pubitemid 28485436)
36. Berg AH, Combs TP, Scherer PE (2002) ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends in endocrinology and metabolism: TEM 13: 84-89. (Pubitemid 36740452)
37. Zhang B, Berger J, Hu E, Szalkowski D, White-Carrington S, et al. (1996) Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol. Endocrinol. 10, 1457-1466. (Pubitemid 26423234)
38. Chandrasekar B, Patel DN, Mummidi S, Kim JW, Clark RA, et al. (2008) Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. The Journal of biological chemistry 283: 4200-4209.
39. Lihn AS, Bruun JM, He G, Pedersen SB, Jensen PF, et al. (2004) Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects. Molecular and cellular endocrinology 219: 9-15. (Pubitemid 38638516)
40. Bruun JM, Pedersen SB, Kristensen K, Richelsen B (2002) Effects of proinflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Molecular and cellular endocrinology 190: 91-99. (Pubitemid 34464102)
41. Lira FS, Rosa JC, Pimentel GD, Seelaender M, Damaso AR, et al. (2012) Both adiponectin and interleukin-10 inhibit LPS-induced activation of the NF-kappaB pathway in 3T3-L1 adipocytes. Cytokine 57: 98-106.
42. Lappas M, Permezel M, Rice GE (2005) Leptin and adiponectin stimulate the release of proinflammatory cytokines and prostaglandins from human placenta and maternal adipose tissue via nuclear factor-kappaB, peroxisomal proliferator-activated receptor-gamma and extracellularly regulated kinase 1/2. Endocrinology 146: 3334-3342. (Pubitemid 41058105)
43. Cheng X, Folco EJ, Shimizu K, Libby P (2012) Adiponectin induces proinflammatory programs in human macrophages and CD4+ T cells. The Journal of biological chemistry 287: 36896-36904.
44. Ajuwon KM, Spurlock ME (2005) Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. American journal of physiology Regulatory, integrative and comparative physiology 288: R1220-1225. (Pubitemid 40593705)
45. Kang JH, Tsuyoshi G, Han IS, Kawada T, Kim YM, et al. (2010) Dietary Capsaicin Reduces Obesity-induced Insulin Resistance and Hepatic Steatosis in Obese Mice Fed a High-fat Diet. Obesity, 18: 780-787.
46. Jeffry JA, Yu SQ, Sikand P, Parihar A, Evans MS, et al. (2009) Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia. PLoS One. 15;4(9):e7021.
47. Romanovsky AA, Almeida MC, Garami A, Steiner AA, Norman MH, et al. (2009) The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev 61: 228-261.
48. Yang MT, Fu J, Wang YK, Desai RA, Chen CS (2011) Assaying stem cell mechanobiology on microfabricated elastomeric substrates with geometrically modulated rigidity. Nature protocols 6: 187-213.
49. Bishnoi M, Bosgraaf CA, Premkumar LS (2011) Preservation of Acute Pain and Efferent Functions Following Intrathecal Resiniferatoxin-Induced Analgesia in Rats. The Journal of Pain 12: 991-1003.
50. Safieh-Garabedian B, Oz M, Bey RM, Shamaa F, Ashoor A, et al. (2013) Involvement of the alpha7-nicotinic acetylcholine receptors in the anti-inflammatory action of the thymulin-related peptide (PAT). Neuroscience 250: 455-66.
51. Gaur V, Kumar A (2010) Behavioral, biochemical and cellular correlates in the protective effect of sertraline against transient global ischemia induced behavioral despair: possible involvement of nitric oxide-cyclic guanosine monophosphate study pathway. Brain Res Bull 82: 57-64.
52. Gonzalez LE, Andrews N, File SE (1996) 5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze. Brain Res 732: 145-153. (Pubitemid 26305299)