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Volumn 111, Issue 30, 2014, Pages 11007-11012

Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated α-synuclein

Author keywords

Chemical biology; Drug discovery; Helical mimetic

Indexed keywords

CHEMICAL BIOLOGY; DRUG DISCOVERY; HELICAL MIMETIC;

EID: 84904961684     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320556111     Document Type: Article
Times cited : (52)

References (65)
  • 2
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
    • Arkin MR, Wells JA (2004) Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream. Nat Rev Drug Discov 3(4):301- 317.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.4 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 3
    • 37249004920 scopus 로고    scopus 로고
    • Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
    • DOI 10.1038/nature06526, PII NATURE06526
    • Wells JA, McClendon CL (2007) Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 450(7172):1001-1009. (Pubitemid 350273630)
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1001-1009
    • Wells, J.A.1    McClendon, C.L.2
  • 4
    • 0346727128 scopus 로고    scopus 로고
    • Therapeutic approaches to protein-misfolding diseases
    • DOI 10.1038/nature02265
    • Cohen FE, Kelly JW (2003) Therapeutic approaches to protein-misfolding diseases. Nature 426(6968):905-909. (Pubitemid 38056884)
    • (2003) Nature , vol.426 , Issue.6968 , pp. 905-909
    • Cohen, F.E.1    Kelly, J.W.2
  • 5
    • 38549169530 scopus 로고    scopus 로고
    • The two faces of protein misfolding: Gain- and loss-of-function in neurodegenerative diseases
    • DOI 10.1038/sj.emboj.7601930, PII 7601930
    • Winklhofer KF, Tatzelt J, Haass C (2008) The two faces of protein misfolding: Gain- and loss-of-function in neurodegenerative diseases. EMBO J 27(2):336-349. (Pubitemid 351161650)
    • (2008) EMBO Journal , vol.27 , Issue.2 , pp. 336-349
    • Winklhofer, K.F.1    Tatzelt, J.2    Haass, C.3
  • 6
    • 33846020543 scopus 로고    scopus 로고
    • Small molecule pharmacological chaperones: From thermodynamic stabilization to pharmaceutical drugs
    • DOI 10.1016/j.bbapap.2006.08.012, PII S157096390600286X
    • Arakawa T, Ejima D, Kita Y, Tsumoto K (2006) Small molecule pharmacological chaperones: From thermodynamic stabilization to pharmaceutical drugs. Biochim Biophys Acta 1764(11):1677-1687. (Pubitemid 46053854)
    • (2006) Biochimica et Biophysica Acta - Proteins and Proteomics , vol.1764 , Issue.11 , pp. 1677-1687
    • Arakawa, T.1    Ejima, D.2    Kita, Y.3    Tsumoto, K.4
  • 7
    • 50149112642 scopus 로고    scopus 로고
    • Protein misfolding in conformational disorders: Rescue of folding defects and chemical chaperoning
    • Leandro P, Gomes CM (2008) Protein misfolding in conformational disorders: Rescue of folding defects and chemical chaperoning. Mini Rev Med Chem 8(9):901-911.
    • (2008) Mini Rev Med Chem , vol.8 , Issue.9 , pp. 901-911
    • Leandro, P.1    Gomes, C.M.2
  • 8
    • 70350347721 scopus 로고    scopus 로고
    • What are pharmacological chaperones and why are they interesting?
    • Ringe D, Petsko GA (2009) What are pharmacological chaperones and why are they interesting? J Biol 8(9):80.
    • (2009) J Biol , vol.8 , Issue.9 , pp. 80
    • Ringe, D.1    Petsko, G.A.2
  • 10
    • 61449104961 scopus 로고    scopus 로고
    • Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques
    • Brenke R, et al. (2009) Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques. Bioinformatics 25(5):621-627.
    • (2009) Bioinformatics , vol.25 , Issue.5 , pp. 621-627
    • Brenke, R.1
  • 11
    • 67650979223 scopus 로고    scopus 로고
    • Detection of ligand binding hot spots on protein surfaces via fragment-based methods: Application to DJ-1 and glucocerebrosidase
    • Landon MR, et al. (2009) Detection of ligand binding hot spots on protein surfaces via fragment-based methods: Application to DJ-1 and glucocerebrosidase. J Comput Aided Mol Des 23(8):491-500.
    • (2009) J Comput Aided Mol des , vol.23 , Issue.8 , pp. 491-500
    • Landon, M.R.1
  • 12
    • 8144220031 scopus 로고    scopus 로고
    • Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations
    • Pey AL, et al. (2004) Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations. Hum Mutat 24(5):388- 399.
    • (2004) Hum Mutat , vol.24 , Issue.5 , pp. 388-399
    • Pey, A.L.1
  • 14
    • 77949272212 scopus 로고    scopus 로고
    • Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses
    • Connelly S, Choi S, Johnson SM, Kelly JW, Wilson IA (2010) Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. Curr Opin Struct Biol 20(1):54-62.
    • (2010) Curr Opin Struct Biol , vol.20 , Issue.1 , pp. 54-62
    • Connelly, S.1    Choi, S.2    Johnson, S.M.3    Kelly, J.W.4    Wilson, I.A.5
  • 16
    • 76149106544 scopus 로고    scopus 로고
    • Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix
    • Henchey LK, et al. (2010) Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix. J Am Chem Soc 132(3):941-943.
    • (2010) J Am Chem Soc , vol.132 , Issue.3 , pp. 941-943
    • Henchey, L.K.1
  • 17
    • 33645390844 scopus 로고    scopus 로고
    • An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction
    • Mills NL, Daugherty MD, Frankel AD, Guy RK (2006) An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction. J Am Chem Soc 128(11):3496-3497.
    • (2006) J Am Chem Soc , vol.128 , Issue.11 , pp. 3496-3497
    • Mills, N.L.1    Daugherty, M.D.2    Frankel, A.D.3    Guy, R.K.4
  • 18
    • 84875436143 scopus 로고    scopus 로고
    • Inhibition of α-helix-mediated protein-protein interactions using designed molecules
    • Azzarito V, Long K, Murphy NS, Wilson AJ (2013) Inhibition of α-helix-mediated protein-protein interactions using designed molecules. Nat Chem 5(3):161-173.
    • (2013) Nat Chem , vol.5 , Issue.3 , pp. 161-173
    • Azzarito, V.1    Long, K.2    Murphy, N.S.3    Wilson, A.J.4
  • 19
    • 77952541448 scopus 로고    scopus 로고
    • Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics
    • Cummings CG, Hamilton AD (2010) Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. Curr Opin Chem Biol 14(3):341-346.
    • (2010) Curr Opin Chem Biol , vol.14 , Issue.3 , pp. 341-346
    • Cummings, C.G.1    Hamilton, A.D.2
  • 20
    • 79960524751 scopus 로고    scopus 로고
    • High-throughput screening for modulators of protein-protein interactions: Use of photonic crystal biosensors and complementary technologies
    • Heeres JT, Hergenrother PJ (2011) High-throughput screening for modulators of protein-protein interactions: Use of photonic crystal biosensors and complementary technologies. Chem Soc Rev 40(8):4398-4410.
    • (2011) Chem Soc Rev , vol.40 , Issue.8 , pp. 4398-4410
    • Heeres, J.T.1    Hergenrother, P.J.2
  • 22
    • 57549092075 scopus 로고    scopus 로고
    • Contemporary strategies for the stabilization of peptides in the alpha-helical conformation
    • Henchey LK, Jochim AL, Arora PS (2008) Contemporary strategies for the stabilization of peptides in the alpha-helical conformation. Curr Opin Chem Biol 12(6):692-697.
    • (2008) Curr Opin Chem Biol , vol.12 , Issue.6 , pp. 692-697
    • Henchey, L.K.1    Jochim, A.L.2    Arora, P.S.3
  • 23
    • 79959492294 scopus 로고    scopus 로고
    • Design and structure of stapled peptides binding to estrogen receptors
    • Phillips C, et al. (2011) Design and structure of stapled peptides binding to estrogen receptors. J Am Chem Soc 133(25):9696-9699.
    • (2011) J Am Chem Soc , vol.133 , Issue.25 , pp. 9696-9699
    • Phillips, C.1
  • 24
    • 34247362490 scopus 로고    scopus 로고
    • Foldamers as versatile frameworks for the design and evolution of function
    • DOI 10.1038/nchembio876, PII NCHEMBIO876
    • Goodman CM, Choi S, Shandler S, DeGrado WF (2007) Foldamers as versatile frameworks for the design and evolution of function. Nat Chem Biol 3(5):252-262. (Pubitemid 46628637)
    • (2007) Nature Chemical Biology , vol.3 , Issue.5 , pp. 252-262
    • Goodman, C.M.1    Choi, S.2    Shandler, S.3    DeGrado, W.F.4
  • 25
    • 57349134690 scopus 로고    scopus 로고
    • Foldamers with heterogeneous backbones
    • Horne WS, Gellman SH (2008) Foldamers with heterogeneous backbones. Acc Chem Res 41(10):1399-1408.
    • (2008) Acc Chem Res , vol.41 , Issue.10 , pp. 1399-1408
    • Horne, W.S.1    Gellman, S.H.2
  • 26
    • 57149097169 scopus 로고    scopus 로고
    • Beta-peptidic peptidomimetics
    • Seebach D, Gardiner J (2008) Beta-peptidic peptidomimetics. Acc Chem Res 41(10):1366-1375.
    • (2008) Acc Chem Res , vol.41 , Issue.10 , pp. 1366-1375
    • Seebach, D.1    Gardiner, J.2
  • 27
    • 33244473080 scopus 로고    scopus 로고
    • Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions
    • DOI 10.1021/ja056344c
    • Hara T, Durell SR, Myers MC, Appella DH (2006) Probing the structural requirements of peptoids that inhibit HDM2-p53 interactions. J Am Chem Soc 128(6):1995-2004. (Pubitemid 43277340)
    • (2006) Journal of the American Chemical Society , vol.128 , Issue.6 , pp. 1995-2004
    • Hara, T.1    Durell, S.R.2    Myers, M.C.3    Appella, D.H.4
  • 30
    • 77950253384 scopus 로고    scopus 로고
    • Oligooxopiperazines as nonpeptidic alpha-helix mimetics
    • Tosovská P, Arora PS (2010) Oligooxopiperazines as nonpeptidic alpha-helix mimetics. Org Lett 12(7):1588-1591.
    • (2010) Org Lett , vol.12 , Issue.7 , pp. 1588-1591
    • Tosovská, P.1    Arora, P.S.2
  • 31
    • 34848921166 scopus 로고    scopus 로고
    • Synthesis of pyridazine-based scaffolds as alpha-helix mimetics
    • Volonterio A, Moisan L, Rebek J, Jr (2007) Synthesis of pyridazine-based scaffolds as alpha-helix mimetics. Org Lett 9(19):3733-3736.
    • (2007) Org Lett , vol.9 , Issue.19 , pp. 3733-3736
    • Volonterio, A.1    Moisan, L.2    Rebek Jr., J.3
  • 32
    • 45849130968 scopus 로고    scopus 로고
    • Synthesis and structure of 1,4-dipiperazino benzenes: Chiral terphenyl-type peptide helix mimetics
    • Maity P, König B (2008) Synthesis and structure of 1,4-dipiperazino benzenes: Chiral terphenyl-type peptide helix mimetics. Org Lett 10(7):1473-1476.
    • (2008) Org Lett , vol.10 , Issue.7 , pp. 1473-1476
    • Maity, P.1    König, B.2
  • 35
    • 79952523293 scopus 로고    scopus 로고
    • The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious
    • Popowicz GM, Dömling A, Holak TA (2011) The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Angew Chem Int Ed Engl 50(12):2680-2688.
    • (2011) Angew Chem Int Ed Engl , vol.50 , Issue.12 , pp. 2680-2688
    • Popowicz, G.M.1    Dömling, A.2    Holak, T.A.3
  • 36
    • 70350192270 scopus 로고    scopus 로고
    • Novel amphiphilic alpha-helix mimetics based on a bis-benzamide scaffold
    • Marimganti S, Cheemala MN, Ahn JM (2009) Novel amphiphilic alpha-helix mimetics based on a bis-benzamide scaffold. Org Lett 11(19):4418-4421.
    • (2009) Org Lett , vol.11 , Issue.19 , pp. 4418-4421
    • Marimganti, S.1    Cheemala, M.N.2    Ahn, J.M.3
  • 37
    • 84863946626 scopus 로고    scopus 로고
    • Amphiphilic α-helix mimetics based on a benzoylurea scaffold
    • Thompson S, Hamilton AD (2012) Amphiphilic α-helix mimetics based on a benzoylurea scaffold. Org Biomol Chem 10(30):5780-5782.
    • (2012) Org Biomol Chem , vol.10 , Issue.30 , pp. 5780-5782
    • Thompson, S.1    Hamilton, A.D.2
  • 38
    • 84879999898 scopus 로고    scopus 로고
    • Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold
    • Jung KY, et al. (2013) Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold. Org Lett 15(13):3234-3237.
    • (2013) Org Lett , vol.15 , Issue.13 , pp. 3234-3237
    • Jung, K.Y.1
  • 39
    • 69249156893 scopus 로고    scopus 로고
    • Inhibition of a viral enzyme by a small-molecule dimer disruptor
    • Shahian T, et al. (2009) Inhibition of a viral enzyme by a small-molecule dimer disruptor. Nat Chem Biol 5(9):640-646.
    • (2009) Nat Chem Biol , vol.5 , Issue.9 , pp. 640-646
    • Shahian, T.1
  • 40
    • 67849119649 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions
    • Shaginian A, et al. (2009) Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. J Am Chem Soc 131(15):5564-5572.
    • (2009) J Am Chem Soc , vol.131 , Issue.15 , pp. 5564-5572
    • Shaginian, A.1
  • 41
    • 79851497821 scopus 로고    scopus 로고
    • Novel pyrrolopyrimidine-based α-helix mimetics: Cell-permeable inhibitors of protein-protein interactions
    • Lee JH, et al. (2011) Novel pyrrolopyrimidine-based α-helix mimetics: Cell-permeable inhibitors of protein-protein interactions. J Am Chem Soc 133(4):676-679.
    • (2011) J Am Chem Soc , vol.133 , Issue.4 , pp. 676-679
    • Lee, J.H.1
  • 43
    • 33749532845 scopus 로고    scopus 로고
    • High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry
    • DOI 10.1021/ja063722k
    • Joo SH, Xiao Q, Ling Y, Gopishetty B, Pei D (2006) High-throughput sequence determination of cyclic peptide library members by partial Edman degradation/mass spectrometry. J Am Chem Soc 128(39):13000-13009. (Pubitemid 44527779)
    • (2006) Journal of the American Chemical Society , vol.128 , Issue.39 , pp. 13000-13009
    • Joo, S.H.1    Xiao, Q.2    Ling, Y.3    Gopishetty, B.4    Pei, D.5
  • 44
    • 78149417856 scopus 로고    scopus 로고
    • A simple strategy for the construction of combinatorial cyclic peptoid libraries
    • Lee JH, Meyer AM, Lim HS (2010) A simple strategy for the construction of combinatorial cyclic peptoid libraries. Chem Commun (Camb) 46(45):8615-8617.
    • (2010) Chem Commun (Camb) , vol.46 , Issue.45 , pp. 8615-8617
    • Lee, J.H.1    Meyer, A.M.2    Lim, H.S.3
  • 45
    • 80054752348 scopus 로고    scopus 로고
    • Design and facile solid-phase synthesis of conformationally constrained bicyclic peptoids
    • Lee JH, Kim HS, Lim HS (2011) Design and facile solid-phase synthesis of conformationally constrained bicyclic peptoids. Org Lett 13(19):5012- 5015.
    • (2011) Org Lett , vol.13 , Issue.19 , pp. 5012-5015
    • Lee, J.H.1    Kim, H.S.2    Lim, H.S.3
  • 46
    • 84856400291 scopus 로고    scopus 로고
    • A biomimetic polyketide-inspired approach to small-molecule ligand discovery
    • Aquino C, et al. (2012) A biomimetic polyketide-inspired approach to small-molecule ligand discovery. Nat Chem 4(2):99-104.
    • (2012) Nat Chem , vol.4 , Issue.2 , pp. 99-104
    • Aquino, C.1
  • 47
    • 75149135954 scopus 로고    scopus 로고
    • Seamless bead to microarray screening: Rapid identification of the highest affinity protein ligands from large combinatorial libraries
    • Astle JM, et al. (2010) Seamless bead to microarray screening: Rapid identification of the highest affinity protein ligands from large combinatorial libraries. Chem Biol 17(1):38-45.
    • (2010) Chem Biol , vol.17 , Issue.1 , pp. 38-45
    • Astle, J.M.1
  • 48
    • 77249176182 scopus 로고    scopus 로고
    • Rethinking screening
    • Kodadek T (2010) Rethinking screening. Nat Chem Biol 6(3):162-165.
    • (2010) Nat Chem Biol , vol.6 , Issue.3 , pp. 162-165
    • Kodadek, T.1
  • 50
    • 0037014692 scopus 로고    scopus 로고
    • A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries
    • DOI 10.1021/ja026421t
    • Liu R, Marik J, Lam KS (2002) A novel peptide-based encoding system for "one-bead one-compound" peptidomimetic and small molecule combinatorial libraries. J Am Chem Soc 124(26):7678-7680. (Pubitemid 34733779)
    • (2002) Journal of the American Chemical Society , vol.124 , Issue.26 , pp. 7678-7680
    • Liu, R.1    Marik, J.2    Lam, K.S.3
  • 51
    • 56349106981 scopus 로고    scopus 로고
    • Encoded combinatorial libraries for the construction of cyclic peptoid microarrays
    • Kwon YU, Kodadek T (2008) Encoded combinatorial libraries for the construction of cyclic peptoid microarrays. Chem Commun (Camb) (44):5704-5706.
    • (2008) Chem Commun (Camb) , Issue.44 , pp. 5704-5706
    • Kwon, Y.U.1    Kodadek, T.2
  • 52
    • 0026726041 scopus 로고
    • Peptoids: A modular approach to drug discovery
    • Simon RJ, et al. (1992) Peptoids: A modular approach to drug discovery. Proc Natl Acad Sci USA 89(20):9367-9371.
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.20 , pp. 9367-9371
    • Simon, R.J.1
  • 53
    • 17844376473 scopus 로고    scopus 로고
    • Expedient synthesis and design strategies for new peptoid construction
    • DOI 10.1021/ol0502984
    • Gorske BC, Jewell SA, Guerard EJ, Blackwell HE (2005) Expedient synthesis and design strategies for new peptoid construction. Org Lett 7(8):1521-1524. (Pubitemid 40585921)
    • (2005) Organic Letters , vol.7 , Issue.8 , pp. 1521-1524
    • Gorske, B.C.1    Jewell, S.A.2    Guerard, E.J.3    Blackwell, H.E.4
  • 58
    • 77955891885 scopus 로고    scopus 로고
    • The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
    • Stewart ML, Fire E, Keating AE, Walensky LD (2010) The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nat Chem Biol 6(8):595-601.
    • (2010) Nat Chem Biol , vol.6 , Issue.8 , pp. 595-601
    • Stewart, M.L.1    Fire, E.2    Keating, A.E.3    Walensky, L.D.4
  • 59
    • 72449187503 scopus 로고    scopus 로고
    • Prodrug approaches for enhancing the bioavailability of drugs with low solubility
    • Müller CE (2009) Prodrug approaches for enhancing the bioavailability of drugs with low solubility. Chem Biodivers 6(11):2071-2083.
    • (2009) Chem Biodivers , vol.6 , Issue.11 , pp. 2071-2083
    • Müller, C.E.1
  • 61
    • 33749841522 scopus 로고    scopus 로고
    • The aggregation and fibrillation of alpha-synuclein
    • Fink AL (2006) The aggregation and fibrillation of alpha-synuclein. Acc Chem Res 39(9):628-634.
    • (2006) Acc Chem Res , vol.39 , Issue.9 , pp. 628-634
    • Fink, A.L.1
  • 62
    • 0029904487 scopus 로고    scopus 로고
    • NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
    • DOI 10.1021/bi961799n
    • Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT, Jr (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35(43):13709-13715. (Pubitemid 26363912)
    • (1996) Biochemistry , vol.35 , Issue.43 , pp. 13709-13715
    • Weinreb, P.H.1    Zhen, W.2    Poon, A.W.3    Conway, K.A.4    Lansbury Jr., P.T.5
  • 63
    • 80052398365 scopus 로고    scopus 로고
    • α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    • Bartels T, Choi JG, Selkoe DJ (2011) α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477(7362):107-110.
    • (2011) Nature , vol.477 , Issue.7362 , pp. 107-110
    • Bartels, T.1    Choi, J.G.2    Selkoe, D.J.3
  • 64
    • 80055078029 scopus 로고    scopus 로고
    • A soluble α-synuclein construct forms a dynamic tetramer
    • Wang W, et al. (2011) A soluble α-synuclein construct forms a dynamic tetramer. Proc Natl Acad Sci USA 108(43):17797-17802.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.43 , pp. 17797-17802
    • Wang, W.1


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