Microwave-assisted solid-phase synthesis of peptoids

Organic Letters

Volumn 4, Issue 23, 2002, Pages 4057-4058

  Olivos, Hernando J ^a   Alluri, Prasanna G ^a   Reddy, M Muralidhar ^a   Salony, Derek ^a   Kodadek, Thomas ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PEPTIDE; PEPTOID;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; MICROWAVE RADIATION; RADIATION EXPOSURE; SYNTHESIS;

AMINO ACID SEQUENCE; INDICATORS AND REAGENTS; MICROWAVES; PEPTIDES; PEPTOIDS;

EID: 0037078825     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0267578     Document Type: Article

References (14)

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14. General Procedure. In a typical experiment, the Rink resin (50 mg, substitution of 0.73 mmol/g) was placed in a standard glass peptide synthesis vessel, swollen in DMF, and deprotected with 20% piperidine in DMF for 20 min at room temperature. After washing with DMF, 2 M solutions of bromoacetic acid and DIC (1 mL each) were added to the vessel and placed inside a beaker in the center of a Whirlpool 1000-W microwave oven (model MT1130SG). The vessel was heated at a power setting of 10% for 15 s. Then the vessel was gently shaken for several seconds, and the microwave process was repeated one more time. After washing with DMF, a 1 M solution of the amine (2 mL) was added, the mixure was heated at a power setting of 10% for 15 s and shaken, and the microwave process was repeated one more time. Then the beads were washed with DMF and prepared for the formation of the next residue. See Supporting Information for more details.