Nanovector-mediated drug delivery for spinal cord injury treatment

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 6, Issue 5, 2014, Pages 506-515

  Caron, Ilaria ^a   Papa, Simonetta ^a   Rossi, Filippo ^b   Forloni, Gianluigi ^a   Veglianese, Pietro ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b POLITECNICO DI MILANO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DELIVERY; MOLECULAR BIOLOGY; SECONDARY RECOVERY;

BENEFICIAL EFFECTS; CLINICAL TREATMENTS; CONFLICT OF INTEREST; CONFLICTS OF INTEREST; FINANCIAL SUPPORT; SPINAL CORD INJURIES (SCI); TARGETED TREATMENT; THERAPEUTIC INTERVENTION;

PATIENT REHABILITATION;

2 HYDROXYETHYL METHACRYLATE; ADENOVIRUS VECTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CHITOSAN; CHONDROITIN ABC LYASE; DENDRIMER; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HYALURONIC ACID; MACROGOL; METHYLPREDNISOLONE; MINOCYCLINE; NANOCARRIER; NANOPARTICLE; NANOVECTOR; NANOWIRE; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; PLATELET DERIVED GROWTH FACTOR A; POLYAMIDOAMINE; PROTEOCHONDROITIN SULFATE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SCATTER FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; NEUROPROTECTIVE AGENT;

ARTICLE; BLOOD SPINAL CORD BARRIER; CELL DIFFERENTIATION; CELL MIGRATION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; GLIA CELL; GRAFT SURVIVAL; HALF LIFE TIME; HEMATOPOIETIC STEM CELL; HUMAN; HYDROGEL; MACROPHAGE; MICELLE; MICROGLIA; NERVE FIBER; NERVE POTENTIAL; NERVE REGENERATION; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; OXIDATIVE STRESS; PERMEABILITY BARRIER; PHAGOCYTOSIS; PRIORITY JOURNAL; REMYELINIZATION; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; SUSTAINED DRUG RELEASE; ANIMAL; BIOLOGICAL THERAPY; CELL CULTURE; DISEASE MODEL; SPINAL CORD INJURIES;

ANIMALS; CELL- AND TISSUE-BASED THERAPY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; HUMANS; NANOPARTICLES; NEUROPROTECTIVE AGENTS; SPINAL CORD INJURIES;

EID: 84904900390     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1276     Document Type: Article

References (75)

1. Lee BB, Cripps RA, Fitzharris M, Wing PC. The global map for traumatic spinal cord injury epidemiology: update 2011, global incidence rate. Spinal Cord 2014, 52:110-116.
2. Silva NA, Sousa N, Reis RL, Salgado AJ. From basics to clinical: a comprehensive review on spinal cord injury. Prog Neurobiol 2014, 114:25-57.
3. Plunet W, Kwon BK, Tetzlaff W. Promoting axonal regeneration in the central nervous system by enhancing the cell body response to axotomy. J Neurosci Res 2002, 68:1-6.
4. Hagg T, Oudega M. Degenerative and spontaneous regenerative processes after spinal cord injury. J Neurotrauma 2006, 23:264-280.
5. Awad BI, Carmody MA, Steinmetz MP. Potential role of growth factors in the management of spinal cord injury. World Neurosurg 2013. doi: 10.1016/j.wneu.2013.01.042.
6. Yiu G, He Z. Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 2006, 7:617-627.
7. Nash M, Pribiag H, Fournier AE, Jacobson C. Central nervous system regeneration inhibitors and their intracellular substrates. Mol Neurobiol 2009, 40:224-235.
8. Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci 2004, 5:146-156.
9. Carulli D, Laabs T, Geller HM, Fawcett JW. Chondroitin sulfate proteoglycans in neural development and regeneration. Curr Opin Neurobiol 2005, 15:116-120.
10. Cregg JM, DePaul MA, Filous AR, Lang BT, Tran A, Silver J. Functional regeneration beyond the glial scar. Exp Neurol 2014, 253:197-207.
11. Yuan YM, He C. The glial scar in spinal cord injury and repair. Neurosci Bull 2013, 29:421-435.
12. Benowitz LI, Popovich PG. Inflammation and axon regeneration. Curr Opin Neurol 2011, 24:577-583.
13. Donnelly DJ, Popovich PG. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol 2008, 209:378-388.
14. Trivedi A, Olivas AD, Noble-Haeusslein LJ. Inflammation and spinal cord injury: infiltrating leukocytes as determinants of injury and repair processes. Clin Neurosci Res 2006, 6:283-292.
15. Chan CC. Inflammation: beneficial or detrimental after spinal cord injury? Recent Pat CNS Drug Discov 2008, 3:189-199.
16. Zhang N, Yin Y, Xu SJ, Wu YP, Chen WS. Inflammation & apoptosis in spinal cord injury. Indian J Med Res 2012, 135:287-296.
17. Kwon BK, Okon E, Hillyer J, Mann C, Baptiste D, Weaver LC, Fehlings MG, Tetzlaff W. A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. J Neurotrauma 2011, 28:1545-1588.
18. Yoon C, Tuszynski MH. Frontiers of spinal cord and spine repair: experimental approaches for repair of spinal cord injury. Adv Exp Med Biol 2012, 760:1-15.
19. Rossi F, Perale G, Papa S, Forloni G, Veglianese P. Current options for drug delivery to the spinal cord. Expert Opin Drug Deliv 2013, 10:385-396.
20. Lawson EF, Wallace MS. Advances in intrathecal drug delivery. Curr Opin Anaesthesiol 2012, 25:572-576.
21. Belverud S, Mogilner A, Schulder M. Intrathecal pumps. Neurotherapeutics 2008, 5:114-122.
22. Slaughter BV, Khurshid SS, Fisher OZ, Khademhosseini A, Peppas NA. Hydrogels in regenerative medicine. Adv Mater 2009, 21:3307-3329.
23. Perale G, Rossi F, Santoro M, Peviani M, Papa S, Llupi D, Torriani P, Micotti E, Previdi S, Cervo L, et al. Multiple drug delivery hydrogel system for spinal cord injury repair strategies. J Control Release 2012, 159:271-280.
24. Perale G, Rossi F, Sundstrom E, Bacchiega S, Masi M, Forloni G, Veglianese P. Hydrogels in spinal cord injury repair strategies. ACS Chem Neurosci 2011, 2:336-345.
25. Macaya D, Spector M. Injectable hydrogel materials for spinal cord regeneration: a review. Biomed Mater 2012, 7:012001.
26. Haggerty AE, Oudega M. Biomaterials for spinal cord repair. Neurosci Bull 2013, 29:445-459.
27. Katz JS, Burdick JA. Hydrogel mediated delivery of trophic factors for neural repair. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2009, 1:128-139.
28. Piantino J, Burdick JA, Goldberg D, Langer R, Benowitz LI. An injectable, biodegradable hydrogel for trophic factor delivery enhances axonal rewiring and improves performance after spinal cord injury. Exp Neurol 2006, 201:359-367.
29. Lee H, McKeon RJ, Bellamkonda RV. Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. Proc Natl Acad Sci U S A 2010, 107:3340-3345.
30. Ansorena E, De Berdt P, Ucakar B, Simon-Yarza T, Jacobs D, Schakman O, Jankovski A, Deumens R, Blanco-Prieto MJ, Preat V, et al. Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury. Int J Pharm 2013, 455:148-158.
31. Kang CE, Baumann MD, Tator CH, Shoichet MS. Localized and sustained delivery of fibroblast growth factor-2 from a nanoparticle-hydrogel composite for treatment of spinal cord injury. Cells Tissues Organs 2013, 197:55-63.
32. Jain A, McKeon RJ, Brady-Kalnay SM, Bellamkonda RV. Sustained delivery of activated Rho GTPases and BDNF promotes axon growth in CSPG-rich regions following spinal cord injury. PLoS One 2011, 6:e16135.
33. Parr AM, Tator CH, Keating A. Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant 2007, 40:609-619.
34. Reeves A, Keirstead HS. Stem cell based strategies for spinal cord injury repair. Adv Exp Med Biol 2012, 760:16-24.
35. Li J, Lepski G. Cell transplantation for spinal cord injury: a systematic review. Biomed Res Int 2013, 2013:786475.
36. Antonic A, Sena ES, Lees JS, Wills TE, Skeers P, Batchelor PE, Macleod MR, Howells DW. Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies. PLoS Biol 2013, 11:e1001738.
37. Li X, Liu X, Cui L, Brunson C, Zhao W, Bhat NR, Zhang N, Wen X. Engineering an in situ crosslinkable hydrogel for enhanced remyelination. FASEB J 2013, 27:1127-1136.
38. Sykova E, Jendelova P, Urdzikova L, Lesny P, Hejcl A. Bone marrow stem cells and polymer hydrogels-two strategies for spinal cord injury repair. Cell Mol Neurobiol 2006, 26:1113-1129.
39. Straley KS, Foo CW, Heilshorn SC. Biomaterial design strategies for the treatment of spinal cord injuries. J Neurotrauma 2010, 27:1-19.
40. Hejcl A, Sedy J, Kapcalova M, Toro DA, Amemori T, Lesny P, Likavcanova-Masinova K, Krumbholcova E, Pradny M, Michalek J, et al. HPMA-RGD hydrogels seeded with mesenchymal stem cells improve functional outcome in chronic spinal cord injury. Stem Cells Dev 2010, 19:1535-1546.
41. Woerly S, Doan VD, Evans-Martin F, Paramore CG, Peduzzi JD. Spinal cord reconstruction using NeuroGel implants and functional recovery after chronic injury. J Neurosci Res 2001, 66:1187-1197.
42. Woerly S, Doan VD, Sosa N, de Vellis J, Espinosa-Jeffrey A. Prevention of gliotic scar formation by NeuroGel allows partial endogenous repair of transected cat spinal cord. J Neurosci Res 2004, 75:262-272.
43. Cho Y, Shi R, Borgens RB, Ivanisevic A. Repairing the damaged spinal cord and brain with nanomedicine. Small 2008, 4:1676-1681.
44. Kohane DS. Microparticles and nanoparticles for drug delivery. Biotechnol Bioeng 2007, 96:203-209.
45. Mout R, Moyano DF, Rana S, Rotello VM. Surface functionalization of nanoparticles for nanomedicine. Chem Soc Rev 2012, 41:2539-2544.
46. Liu Y, Wang CY, Kong XH, Wang HJ, Chang J, Zhang DP, Ban DX, Feng SQ. Novel multifunctional polyethylene glycol-transactivating-transduction protein-modified liposomes cross the blood-barrier after spinal cord spinal cord injury. J Drug Target 2010, 18:420-429.
47. Yoo JW, Mitragotri S. Polymer particles that switch shape in response to a stimulus. Proc Natl Acad Sci U S A 2010, 107:11205-11210.
48. Papa S, Ferrari R, De Paola M, Rossi F, Mariani A, Caron I, Sammali E, Peviani M, Dell'oro V, Colombo C, et al. Polymeric nanoparticle system to target activated microglia/macrophages in spinal cord injury. J Control Release 2013, 174C:15-26.
49. Papa S, Rossi F, Ferrari R, Mariani A, De Paola M, Caron I, Fiordaliso F, Bisighini C, Sammali E, Colombo C, et al. Selective nanovector mediated treatment of activated proinflammatory microglia/macrophages in spinal cord injury. ACS Nano 2013, 7:9881-9895.
50. Tyler JY, Xu XM, Cheng JX. Nanomedicine for treating spinal cord injury. Nanoscale 2013, 5:8821-8836.
51. Wu W, Lee SY, Wu X, Tyler JY, Wang H, Ouyang Z, Park K, Xu XM, Cheng JX. Neuroprotective ferulic acid (FA)-glycol chitosan (GC) nanoparticles for functional restoration of traumatically injured spinal cord. Biomaterials 2014, 35:2355-2364.
52. Takenaga M, Ishihara T, Ohta Y, Tokura Y, Hamaguchi A, Igarashi R, Mizushima T. Nano PGE1 promoted the recovery from spinal cord injury-induced motor dysfunction through its accumulation and sustained release. J Control Release 2010, 148:249-254.
53. Wang YC, Wu YT, Huang HY, Lin HI, Lo LW, Tzeng SF, Yang CS. Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials 2008, 29:4546-4553.
54. Kim YT, Caldwell JM, Bellamkonda RV. Nanoparticle-mediated local delivery of methylprednisolone after spinal cord injury. Biomaterials 2009, 30:2582-2590.
55. Chen CL, Chang SF, Lee D, Yang LY, Lee YH, Hsu CY, Lin SJ, Liaw J. Bioavailability effect of methylprednisolone by polymeric micelles. Pharm Res 2008, 25:39-47.
56. Menon PK, Muresanu DF, Sharma A, Mossler H, Sharma HS. Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 2012, 11:40-49.
57. Jain NK, Mishra V, Mehra NK. Targeted drug delivery to macrophages. Expert Opin Drug Deliv 2013, 10:353-367.
58. Baumann MD, Kang CE, Stanwick JC, Wang Y, Kim H, Lapitsky Y, Shoichet MS. An injectable drug delivery platform for sustained combination therapy. J Control Release 2009, 138:205-213.
59. Stanwick JC, Baumann MD, Shoichet MS. In vitro sustained release of bioactive anti-NogoA, a molecule in clinical development for treatment of spinal cord injury. Int J Pharm 2012, 426:284-290.
60. Baumann MD, Kang CE, Tator CH, Shoichet MS. Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury. Biomaterials 2010, 31:7631-7639.
61. Chvatal SA, Kim YT, Bratt-Leal AM, Lee H, Bellamkonda RV. Spatial distribution and acute anti-inflammatory effects of methylprednisolone after sustained local delivery to the contused spinal cord. Biomaterials 2008, 29:1967-1975.
62. Cho Y, Borgens RB. Polymer and nano-technology applications for repair and reconstruction of the central nervous system. Exp Neurol 2012, 233:126-144.
63. Shi Y, Kim S, Huff TB, Borgens RB, Park K, Shi R, Cheng JX. Effective repair of traumatically injured spinal cord by nanoscale block copolymer micelles. Nat Nanotechnol 2010, 5:80-87.
64. Borgens RB, Shi R, Bohnert D. Behavioral recovery from spinal cord injury following delayed application of polyethylene glycol. J Exp Biol 2002, 205:1-12.
65. Shi R, Borgens RB. Acute repair of crushed guinea pig spinal cord by polyethylene glycol. J Neurophysiol 1999, 81:2406-2414.
66. Tian ZR, Sharma A, Nozari A, Subramaniam R, Lundstedt T, Sharma HS. Nanowired drug delivery to enhance neuroprotection in spinal cord injury. CNS Neurol Disord Drug Targets 2012, 11:86-95.
67. Lunov O, Syrovets T, Loos C, Beil J, Delacher M, Tron K, Nienhaus GU, Musyanovych A, Mailander V, Landfester K, et al. Differential uptake of functionalized polystyrene nanoparticles by human macrophages and a monocytic cell line. ACS Nano 2011, 5:1657-1669.
68. Cerqueira SR, Silva BL, Oliveira JM, Mano JF, Sousa N, Salgado AJ, Reis RL. Multifunctionalized CMCht/PAMAM dendrimer nanoparticles modulate the cellular uptake by astrocytes and oligodendrocytes in primary cultures of glial cells. Macromol Biosci 2012, 12:591-597.
69. David S, Kroner A. Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci 2011, 12:388-399.
70. Cerqueira SR, Oliveira JM, Silva NA, Leite-Almeida H, Ribeiro-Samy S, Almeida A, Mano JF, Sousa N, Salgado AJ, Reis RL. Microglia response and in vivo therapeutic potential of methylprednisolone-loaded dendrimer nanoparticles in spinal cord injury. Small 2013, 9:738-749.
71. El-Ansary A, Al-Daihan S, Bacha AB, Kotb M. Toxicity of novel nanosized formulations used in medicine. Methods Mol Biol 2013, 1028:47-74.
72. Varma AK, Das A, Wallace G, Barry J, Vertegel AA, Ray SK, Banik NL. Spinal cord injury: a review of current therapy, future treatments, and basic science frontiers. Neurochem Res 2013, 38:895-905.
73. Hwang DH, Kim HM, Kang YM, Joo IS, Cho CS, Yoon BW, Kim SU, Kim BG. Combination of multifaceted strategies to maximize the therapeutic benefits of neural stem cell transplantation for spinal cord repair. Cell Transplant 2011, 20:1361-1379.
74. Ruzicka J, Romanyuk N, Hejcl A, Vetrik M, Hruby M, Cocks G, Cihlar J, Pradny M, Price J, Sykova E, et al. Treating spinal cord injury in rats with a combination of human fetal neural stem cells and hydrogels modified with serotonin. Acta Neurobiol Exp (Wars) 2013, 73:102-115.
75. Mothe AJ, Tam RY, Zahir T, Tator CH, Shoichet MS. Repair of the injured spinal cord by transplantation of neural stem cells in a hyaluronan-based hydrogel. Biomaterials 2013, 34:3775-3783.