Stem Cell Based Strategies for Spinal Cord Injury Repair

Advances in Experimental Medicine and Biology

Volumn 760, Issue , 2012, Pages 16-24

  Reeves, Alexa ^a   Keirstead, Hans S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Human Embryonic Stem Cell; Neural Stem Cell; Spinal Cord Injury; Spinal Muscular Atrophy; Stem Cell

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYTOKINE; KRUPPEL LIKE FACTOR 4; MYC PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; NEUROTROPHIN RECEPTOR P75; OCTAMER TRANSCRIPTION FACTOR 4; ORGANIC CATION TRANSPORTER 3; TRANSCRIPTION FACTOR SOX2;

ALLODYNIA; BONE MARROW DERIVED MONONUCLEAR CELL; CARCINOGENESIS; CELL DIFFERENTIATION; HUMAN; HUMAN EMBRYONIC STEM CELL; INDUCED PLURIPOTENT STEM CELL; MESENCHYMAL STEM CELL; MOTOR NEURON PROGENITOR CELL; NEURAL STEM CELL; OLIGODENDROCYTE PRECURSOR CELL; PRIORITY JOURNAL; SAFETY PROCEDURE; SPINAL CORD INJURY; STEM CELL; STEM CELL TRANSPLANTATION; UMBILICAL CORD BLOOD CELL; METHODOLOGY; NERVE REGENERATION; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SPINAL CORD;

HUMANS; NERVE REGENERATION; SPINAL CORD; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION;

EID: 84872823325     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4090-1_2     Document Type: Chapter

References (68)

1. Sekhon LH, Fehlings MG. Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine 2001; 26(24 Suppl):S2-S12.
2. Schoenfeld AJ, McCriskin B, Hsiao M et al. Incidence and epidemiology of spinal cord injury within a closed American population: the United States military (2000-2009). Spinal Cord 2011; 49(8):874-9.
3. Dodwell ER, Kwon BK, Hughes Bet al. Spinal column and spinal cord injuries in mountain bikers: a 13-year review. Am J Sports Med 2010; 38(8):1647-1652.
4. Fehlings MG, Wilson JR. Timing of surgical intervention in spinal trauma: what does the evidence indicate? Spine 2010; 35(21 Suppl):S159-S160.
5. Biering-S0fensen F, Bickenbach JE, Masry EI WS etaI.ISCoS-WHO collaboration. International Perspectives of Spinal Cord Injury (IPSCI) report. Spinal Cord 2011; 49(6):679-83.
6. Nayak MS, Kim Y, Goldman M et al. Cellular therapies in motor neuron diseases. Biochim Biophys Acta 2006; 1762(11-12):1128-1138.
7. Lin VW, Cardenas DD. Spinal cord medicine. Demos Medical Pub 2003; 1043.
8. Sendtner M. Therapy development in spinal muscular atrophy. Nat Neurosci 2010; 13(7):795-799.
9. Ebert AD, Yu J, Rose FF et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009; 457(7227):277-280.
10. Jaenisch R, Young R. Stem cells, the molecular circuitry of pi uri potency and nuclear reprogramming. Cell 2008; 132(4):567-582.
11. Park I, Zhao R, West JA et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008; 451(7175):141-146.
12. Takahashi K, Tanabe K, Dhnuki M et al. Induction of pi uripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131(5):861-872.
13. Wyatt TJ, Keirstead HS. Stem cell-derived neurotrophic support for the neuromuscular junction in spinal muscular atrophy. Expert Dpin Bioi Ther 2010; 10(11):1587-1594.
14. Niibe K, Kawamura Y, Araki D et al. Purified mesenchymal stem cells are an efficient source for iPS cell induction. PLoS ONE 2011; 6(3):e17610.
15. Doi A, Park I, Wen B et al. Differential methylation of tissue-and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 2009; 41(12):1350-1353.
16. Okita K, Matsumura Y, Sato Yet al. A more eflicient method to generate integration-free human iPS cells. Nat Methods 2011; 8(5):409-12.
17. Stadtfeld M, Nagaya M, Utikal J et al. Induced pluripotent stem cells generated without viral integration. Science 2008; 322(5903):945-949.
18. Yamanaka S. A fresh look at iPS cells. Cell 2009; 137(1): 13-17.
19. Tsuji O, Miura K, Okada Y et al. Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci USA 2010; 107(28):12704-12709.
20. Iwanami A, Kaneko S, Nakamura M et al. Transplantation of human neural stem cells for spinal cord injury in primates. J Neurosci Res 2005; 80(2): 182-190.
21. Yamane J, Nakamura M, Iwanami A et al. Transplantation of galectin-l-expressing human neural stem cells into the injured spinal cord of adult common marmosets. J Neurosci Res 2010; 88(7):1394-1405.
22. Snyder EY, Deitcher DL, Walsh C et al. Muitipotent neural cell lines can engraft and participate in development of mouse cerebellum. Cell 1992; 68(1 ):33-51.
23. Lois C, Alvarez-Buylla A. Proliferating subventricular zone cells in the adult mammalian forebrain can diflerentiate into neurons and glia. Proc Nat! Acad Sci USA 1993; 90(5):2074-2077.
24. Mayer-Proschel M, Kalyani A.I, Mujtaba T et al. Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells. Neuron 1997; 19(4):773-785.
25. Shi I, Marinovich A, Barres BA. Purification and characterization of adult oligodendrocyte precursor cells from the rat optic nerve. J Neurosci 1998; 18(12):4627-4636.
26. Caldwell MA, He X, Wilkie N et al. Growth factors regulate the survival and fate of cells derived from human neurospheres. Nat Biotechnol2001; 19(5):475-479.
27. Nunes MC, Roy NS, Keyoung HM et al. Identification and isolation of multi potential neural progenitor cells from the subcortical white matter ofthe adult human brain. Nat Med 2003; 9(4):439-447.
28. L1adò J, Haenggeli C, Maragakis NJ et al. Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Mol Cell Neurosci 2004; 27(3):322-331.
29. Lu P, Jones LL, Snyder EY et al. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp Neuro12003; 181(2):115-129.
30. Doetsch F, Caille I, Lim DA et al. Subventricular zone astrocytes are neural stem cells in the adultmammalian brain. Cell 1999; 97(6):703-716.
31. Wright LS, Prowse KR, Wallace K et al. Human progenitor cells isolated from the developing cortex undergo decreased neurogenesis and eventual senescence following expansion in vitro. Exp Cell Res 2006; 312(11):2107-2120.
32. Einstein O, Karussis D, Grigoriadis N et al. Intraventricular transplantation of neural precursor cell spheres attenuates acute experimental allergic encephalomyelitis. Mol Cell Neurosci 2003; 24(4):1074-1082.
33. Ben-Hur T, Einstein O, Mizrachi-Kol R et al. Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 2003; 41(1):73-80.
34. Pluchino S, Quattrini A, Brambilla E et al. Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 2003; 422(6933):688-694.
35. Bulte JWM, Ben-Hur T, Miller BR et al. MR microscopy ofmagnetically labeled neurospheres transplanted into the Lewis EAE rat brain. Magn Reson Med 2003; 50(1):201-205.
36. Yoon SH, Shim YS, Park YH et al. Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase �I/II clinical trial. Stem Cells 2007; 25(8):2066-2073.
37. Callera F, do Nascimento RX. Delivery of autologous bone marrow precursor cells into the spinal cord via lumbar puncture technique in patients with spinal cord injury: a preliminary safety study. Exp Hematol 2006; 34(2): 130-131.
38. Akiyama Y, Radtke C, Kocsis.JD. Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J Neurosci 2002; 22(15):6623-6630.
39. Koda M, 0kada S, Nakayama T et al. Hematopoietic stem cell and marrow stromal cell for spinal cord injury in mice. Neuroreport2005; 16(16):1763-1767.
40. Hofstetter CP, Holmstrom NAY, Lilja JA et al. Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed diflerentiation improves outcome. Nat Neurosci 2005; 8(3):346-353.
41. Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105(4):1815-1822.
42. Song S, Kamath S, Mosquera D et al. Expression of brain natriuretic peptide by human bone marrow stromal cells. Exp Neuro12004; 185(1):191-197.
43. Lu P, Jones LL, Tuszynski MH. BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol 2005; 191(2):344-360.
44. Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998; 282(5391):1145-1147.
45. Coutts M, Keirstead HS. Stem cells for the treatment of spinal cord injury. Exp Neuro12008; 209(2):368-377.
46. Billon N, Jolicoeur C, Raff M. Generation and characterization of oligodendrocytes from lineage-selectable embryonic stem cells in vitro. Methods Mol Bioi 2006; 330: 15-32.
47. Finley MF, Kulkarni N, Huettner.IE. Synapse formation and establishment of neuronal polarity by PI9 embryonic carcinoma cells and embryonic stem cells. J Neurosci 1996; 16(3): 1056-1065.
48. Deshpande M, Kim Y, Martinez T et al. Recovery from paralysis in adult rats using embryonic stem cells Ann Neuro12006; 60(1):32-44.
49. Carpenter MK, Inokuma MS, Denham I et al. Enrichment of neurons and neural precursors from human embryonic stem cells. Exp Neuro12001; 172(2):383-397.
50. Li X, Du Z, Zarnowska ED et al. Specification of motoneurons from human embryonic stem cells. Nat Biotecbnol2005; 23(2):215-221.
51. Keirstead HS, Nistor G, Bernal G et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. JNeurosci2005; 25( 19):4694-4705.
52. Rossi SL, Nistor G, Wyatt T et al. Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord. PLoS ONE. 2010; 5(7):e1l852.
53. Schultz SS, Lucas PA. Human stem cells isolated from adult skeletal muscle differentiate into neural phenotypes. JNeurosci Methods 2006; 152(1-2):144-155.
54. Woodbury D, Schwarz EJ, Prockop DJ et al. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000; 61(4):364-370.
55. Lee SH, Lumelsky N, Studer L et al. Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol2000; 18(6):675-679.
56. Nistor G, Haque N, Carpenter M et al. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation-2004-Glia-Wiley Online Library. Glia 2005.
57. Zhang YW, Denham.I, Thies RS. Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors. Stem Cells Dev 2006; 15(6):943-952.
58. Dreyfus CF, Dai X, Lercher LD et al. Expression ofneurotrophins in the adult spinal cord in vivo..I Neurosci Res 1999; 56(1):1-7.
59. Corti S, Nizzardo M, Nardini M et al. Embryonic stem cell-derived neural stem cells improve spinal muscular atrophy phenotype in mice. Brain 2010; 133(Pt 2):465-481.
60. Grumbles RM, Sesodia S, Wood PM et al. Neurotrophic factors improve motoneuron survival and function of muscle reinnervated by embryonic neurons. J Neuropathol Exp Neurol 2009; 68(7):736-746.
61. Rossi SL, Keirstead HS. Stem cells and spinal cord regeneration. Current Opinion in Biotechnology 2009; 20( 5): 552-562.
62. Sharp J, Keirstead H. Therapeutic applications ofoligodendrocyte precursors derived from human embryonic stem cells. Current Opinion in Biotechnology 2007; 18(5):434-440.
63. Salazar DL, Uchida N, Hamers FPT et al. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS ONE 2010; 5(8):eI2272.
64. Fawcett JW, Curt A, Steeves JD et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 2007; 45(3): 190-205.
65. Steeves JD, Lammertse D, Curt A et al. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord 2007; 45(3):206-221.
66. Tuszynski MH, Steeves JD, Fawcett JW et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics. Spinal Cord 2007; 45(3):222-231.
67. Lammertse D, Tuszynski MH, Steeves JD et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design. Spinal Cord 2007; 45(3):232-242.
68. Hofstetter CP, Holmstrom NA, Lilja JA et al. Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci 2005; 8:346-353.