Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals

CNS and Neurological Disorders - Drug Targets

Volumn 11, Issue 1, 2012, Pages 40-49

  Menon, Preeti Kumaran ^a   Muresanu, Dafin Fior ^b   Sharma, Aruna ^a   Mössler, Herbert ^c   Sharma, Hari Shanker ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c EVER Neuro Pharma   (Austria)

Author keywords

Aluminum; Blood spinal cord barrier; Brain derived neurotrophic factor; Cerebrolysin; Ciliary neurotrophic factor; Copper; Glial cell line derived neurotrophic factor; Nanoparticles; Neuronal injuries; Neurotrophic factors; Silver; Spinal cord edema; Spinal cord injury; Spinal cord pathology

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CEREBROLYSIN; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LAZAROID; METAL NANOPARTICLE; METHYLPREDNISOLONE; NERVE GROWTH FACTOR; PROTIRELIN; SILVER NANOPARTICLE;

BLOOD BRAIN BARRIER; BLOOD SPINAL CORD BARRIER; DRUG EFFICACY; GLIA CELL; INTOXICATION; NEUROPROTECTION; NONHUMAN; PERMEABILITY BARRIER; REVIEW; SPINAL CORD; SPINAL CORD DISEASE; SPINAL CORD EDEMA; SPINAL CORD INJURY; WATER CONTENT;

EID: 84860342265     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/187152712799960781     Document Type: Review

References (58)

1. Post, M.W.; Brinkhof, M.W.; von Elm, E.; Boldt, C.; Brach, M.; Fekete, C.; Eriks-Hoogland, I.; Curt, A.; Stucki, G.; SwiSCI study group. Design of the Swiss Spinal Cord Injury Cohort Study. Am. J. Phys. Med. Rehabil., 2011, 90(11 Suppl 2), S5-S16.
2. Sharma, H.S.; Sharma, A. Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2012, 4(2), 184-203
3. Bains, M.; Hall, E.D. Antioxidant therapies in traumatic brain and spinal cord injury. Biochim. Biophys. Acta, 2011, [Epub ahead of print]
4. Fehlings MG, Vawda R. Cellular treatments for spinal cord injury: the time is right for clinical trials. Neurotherapeutics, 2011, 8(4), 704-720.
5. Sharma, H.S. Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection. J. Neural Transm., 2011, 118(1), 155-176.
6. Sharma, H.S. Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr. Pharm. Des., 2005, 11(11), 1353-1389.
7. Sharma, H.S. In: Blood-Central Nervous System Barriers: The Gateway to Neurodegeneration, Neuroprotection and Neuroregeneration; Lajtha, A.; Banik, N.; Ray, S.K., Eds.; Handbook of Neurochemistry and Molecular Neurobiology: Brain and Spinal Cord Trauma; Springer Verlag, Berlin, Heidelberg, New York, 2009, pp. 363-457.
8. Sharma, H.S.; Sharma, A. In: Breakdown Of The Blood-Brain Barrier In Stress Alters Cognitive Dysfunction And Induces Brain Pathology. New Perspective For Neuroprotective Strategies. Ritsner, M., Ed.; Brain Protection in Schizophrenia, Mood and Cognitive Disorders, 2010; Springer-Verlag, Berlin, New York, 2010, pp. 243-304.
9. Sharma, H.S.; Westman, J. The Blood-Spinal Cord and Brain Barriers in Health and Disease; Academic Press, San Diego, 2004, pp. 1-617.
10. Stålberg, E.; Sharma, H.S.; Olsson, Y. Spinal Cord Monitoring. Basic Principles, Regeneration, Pathophysiology and Clinical Aspects; Springer, Wien, New York, 1998, pp. 1-527.
11. Sharma, H.S. New perspectives for the treatment options in spinal cord injury. Expert Opin. Pharmacother., 2008, 9(16), 2773-2800.
12. Sharma, H.S.; Lundstedt, T.; Flärdh, M.; Skottner, A.; Wiklund, L. Neuroprotective effects of melanocortins in CNS injury. Curr. Pharm. Des., 2007, 13(19), 1929-1941.
13. Sharma, H.S. Neurotrophic factors in combination: a possible new therapeutic strategy to influence pathophysiology of spinal cord injury and repair mechanisms. Curr. Pharm. Des., 2007, 13(18), 1841-1874.
14. Sharma, H.S. Pathophysiology Of The Blood-Spinal Cord Barrier In Traumatic Injury. In: Sharma, H.S.; Westman, J., Eds.; The Blood-Spinal Cord and Brain Barriers in Health and Disease; Elsevier Academic Press, San Diego, 2004, pp. 437-518.
15. Noble, L.J.; Mautes, A.E.; Hall, J.J. Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat. J. Comp. Neurol., 1996, 376(4), 542-556.
16. Gómez-González, B.; Larios, H.M.; Escobar, A. Increased transvascular transport of WGA-peroxidase after chronic perinatal stress in the hippocampal microvasculature of the rat. Int. J. Dev. Neurosci., 2011, 29(8), 839-846.
17. Sharma, H.S.; Miclescu, A.; Wiklund, L. Cardiac arrest-induced regional blood-brain barrier breakdown, edema formation and brain pathology: a light and electron microscopic study on a new model for neurodegeneration and neuroprotection in porcine brain. J. Neural Transm., 2011, 118(1), 87-114.
18. Johanson, C.; Stopa, E.; Baird, A.; Sharma, H. Traumatic brain injury and recovery mechanisms: peptide modulation of periventricular neurogenic regions by the choroid plexus-CSF nexus. J. Neural Transm., 2011, 118(1), 115-133.
19. Gong, G.; Yuan, L.B.; Hu, L.; Wu, W.; Yin, L.; Hou, J.L.; Liu, Y.H.; Zhou, L.S. Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1. Acta Pharmacol. Sin., 2011, doi: 10.1038/aps.2011.151.
20. Bao, F.; Omana, V.; Brown, A.; Weaver, L. The systemic inflammatory response after spinal cord injury in the rat is decreased by alpha4 beta1 integrin blockade. J. Neurotrauma, 2011, [Epub ahead of print]
21. Bao, F.; Brown, A.; Dekaban, G.A.; Omana, V.; Weaver, L.C. CD11d integrin blockade reduces the systemic inflammatory response syndrome after spinal cord injury. Exp. Neurol., 2011, 231(2), 272-283.
22. Kuboyama, K.; Tsuda, M.; Tsutsui, M.; Toyohara, Y.; Tozaki- Saitoh, H.; Shimokawa, H.; Yanagihara, N.; Inoue, K. Reduced spinal microglial activation and neuropathic pain after nerve injury in mice lacking all three nitric oxide synthases. Mol. Pain, 2011, 7, 50.
23. Sharma, H.S.; Westman, J.; Olsson, Y.; Alm, P. Involvement of nitric oxide in acute spinal cord injury: an immunocytochemical study using light and electron microscopy in the rat. Neurosci. Res., 1996, 24(4), 373-384.
24. Sharma, H.S.; Sjöquist, P.O.; Mohanty, S.; Wiklund, L. Post-injury treatment with a new antioxidant compound H-290/51 attenuates spinal cord trauma-induced c-fos expression, motor dysfunction, edema formation, and cell injury in the rat. Acta Neurochir. Suppl., 2006, 96, 322-328.
25. Sharma, H.S.; Gordh, T.; Wiklund, L.; Mohanty, S.; Sjöquist, P.O. Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat. J. Neural Transm., 2006, 113(4), 521-536.
26. Sharma, H.S.; Sjöquist, P.O.; Alm, P. A new antioxidant compound H-290151 attenuates spinal cord injury induced expression of constitutive and inducible isoforms of nitric oxide synthase and edema formation in the rat. Acta Neurochir. Suppl., 2003, 86, 415-420.
27. Sharma, H.S.; Winkler, T.; Stålberg, E.; Gordh, T.; Alm, P.; Westman, J. Topical application of TNF-alpha antiserum attenuates spinal cord trauma induced edema formation, microvascular permeability disturbances and cell injury in the rat. Acta Neurochir. Suppl., 2003, 86, 407-413.
28. Sharma, H.S.; Lundstedt, T.; Flärdh, M.; Westman, J.; Post, C.; Skottner, A. Low molecular weight compounds with affinity to melanocortin receptors exert neuroprotection in spinal cord injury-- an experimental study in the rat. Acta Neurochir. Suppl., 2003, 86, 399-405.
29. Sharma, H.S.; Westman, J.; Cervós-Navarro, J.; Nyberg, F. Role of neurochemicals in brain edema and cell changes following hyperthermic brain injury in the rat. Acta Neurochir. Suppl., 1997, 70, 269-274.
30. Sharma, H.S.; Westman, J.; Nyberg, F.; Cervos-Navarro, J.; Dey, P.K. Role of serotonin and prostaglandins in brain edema induced by heat stress. An experimental study in the young rat. Acta Neurochir. Suppl. (Wien.), 1994, 60, 65-70.
31. Sharma, H.S.; Westman, J.; Nyberg, F. Pathophysiology of brain edema and cell changes following hyperthermic brain injury. Prog. Brain Res., 1998, 115, 351-412.
32. Sharma, H.S.; Alm, P.; Westman, J. Nitric oxide and carbon monoxide in the brain pathology of heat stress. Prog. Brain Res., 1998, 115, 297-333.
33. Sharma, H.S.; Westman, J.; Cervós-Navarro, J.; Dey, P.K.; Nyberg, F. Opioid receptor antagonists attenuate heat stress-induced reduction in cerebral blood flow, increased blood-brain barrier permeability, vasogenic edema and cell changes in the rat. Ann. NY Acad. Sci., 1997, 813, 559-571.
34. Sharma, H.S. Selected combination of neurotrophins potentiate neuroprotection and functional recovery following spinal cord injury in the rat. Acta Neurochir. Suppl., 2010, 106, 295-300.
35. Sharma, H.S.; Johanson, C.E. Intracerebroventricularly administered neurotrophins attenuate blood cerebrospinal fluid barrier breakdown and brain pathology following whole-body hyperthermia: an experimental study in the rat using biochemical and morphological approaches. Ann. NY Acad. Sci., 2007, 1122, 112-129.
36. Sharma, H.S. A select combination of neurotrophins enhances neuroprotection and functional recovery following spinal cord injury. Ann. NY Acad. Sci., 2007, 1122, 95-111.
37. Nyberg, F.; Sharma, H.S. Repeated topical application of growth hormone attenuates blood-spinal cord barrier permeability and edema formation following spinal cord injury: an experimental study in the rat using Evans blue, ([125])I-sodium and lanthanum tracers. Amino Acids, 2002, 23(1-3), 231-239.
38. Winkler, T.; Sharma, H.S.; Stålberg, E.; Badgaiyan, R.D.; Westman, J.; Nyberg, F. Growth hormone attenuates alterations in spinal cord evoked potentials and cell injury following trauma to the rat spinal cord. An experimental study using topical application of rat growth hormone. Amino Acids, 2000, 19(1), 363-371.
39. Sharma, H.S.; Muresanu, D.F.; Patnaik, R.; Stan, A.D.; Vacaras, V.; Perju-Dumbrav, L.; Alexandru, B.; Buzoianu, A.; Opincariu, I.; Menon, P.K.; Sharma, A. Superior neuroprotective effects of cerebrolysin in heat stroke following chronic intoxication of Cu or Ag engineered nanoparticles. A comparative study with other neuroprotective agents using biochemical and morphological approaches in the rat. J. Nanosci. Nanotechnol., 2011, 11(9), 7549-7569.
40. Sharma, H.S.; Patnaik, R.; Sharma, A. Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat. J. Nanosci. Nanotechnol., 2010, 10(12), 7931-7945.
41. Sharma, H.S.; Sharma, A.; Hussain, S.; Schlager, J.; Sjöquist, P.O.; Muresanu, D. A new antioxidant compound H-290/51 attenuates nanoparticle induced neurotoxicity and enhances neurorepair in hyperthermia. Acta Neurochir. Suppl., 2010, 106, 351-357.
42. Sharma, H.S.; Ali, S.F.; Hussain, S.M.; Schlager, J.J.; Sharma, A. Influence of engineered nanoparticles from metals on the bloodbrain barrier permeability, cerebral blood flow, brain edema and neurotoxicity. An experimental study in the rat and mice using biochemical and morphological approaches. J. Nanosci. Nanotechnol., 2009, 9(8), 5055-5072.
43. Sharma, H.S.; Patnaik, R.; Sharma, A.; Sjöquist, P.O.; Lafuente, J.V. Silicon dioxide nanoparticles (SiO2, 40-50 nm) exacerbate pathophysiology of traumatic spinal cord injury and deteriorate functional outcome in the rat. An experimental study using pharmacological and morphological approaches. J. Nanosci. Nanotechnol., 2009, 9(8), 4970-4980.
44. Sharma, H.S.; Muresanu, D.F.; Sharma, A.; Patnaik, R.; Lafuente, J.V. Chapter 9 - Nanoparticles influence pathophysiology of spinal cord injury and repair. Prog. Brain Res., 2009, 180, 154-180.
45. Sharma, H.S.; Sharma, A. Nanoparticles aggravate heat stress induced cognitive deficits, blood-brain barrier disruption, edema formation and brain pathology. Prog. Brain Res., 2007, 162, 245-273.
46. Sharma, H.S.; Ali, S.F.; Tian, Z.R.; Hussain, S.M.; Schlager, J.J.; Sjöquist, P.O.; Sharma, A.; Muresanu, D.F. Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H- 290/51. J. Nanosci. Nanotechnol., 2009, 9(8), 5073-5090.
47. Sharma, H.S.; Ali, S.; Tian, Z.R.; Patnaik, R; Patnaik, S.; Lek, P.; Sharma, A.; Lundstedt, T. Nano-drug delivery and neuroprotection in spinal cord injury. J. Nanosci. Nanotechnol., 2009, 9(8), 5014-5037.
48. Sharma, H.S.; Ali, S.F.; Dong, W.; Tian, Z.R.; Patnaik, R.; Patnaik, S.; Sharma, A.; Boman, A.; Lek, P.; Seifert, E.; Lundstedt, T. Drug delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord. Ann. NY Acad. Sci., 2007, 1122, 197-218.
49. Sharma, H.S.; Ali, S.F.; Patnaik, R.; Zimmermann-Meinzingen, S.; Sharma, A.; Muresanu, D.F. Cerebrolysin attenuates heat shock protein (HSP 72 KD) expression in the rat spinal cord following morphine dependence and withdrawal: possible new therapy for pain management. Curr. Neuropharmacol., 2011, 9(1), 223-235.
50. Sharma, H.S.; Muresanu, D.; Sharma, A.; Zimmermann- Meinzingen, S. Cerebrolysin treatment attenuates heat shock protein overexpression in the brain following heat stress: an experimental study using immunohistochemistry at light and electron microscopy in the rat. Ann. NY Acad. Sci., 2010, 1199, 138-148.
51. Sharma, H.S.; Zimmermann-Meinzingen, S.; Johanson, C.E. Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change, brain pathology, and functional deficits following traumatic brain injury in the rat. Ann. NY Acad. Sci., 2010, 1199, 125-137.
52. Muresanu, D.F.; Zimmermann-Meinzingen, S.; Sharma, H.S. Chronic hypertension aggravates heat stress-induced brain damage: possible neuroprotection by cerebrolysin. Acta Neurochir. Suppl., 2010, 106, 327-333.
53. Sharma, H.S.; Zimmermann-Meinzingen, S.; Sharma, A.; Johanson, C.E. Cerebrolysin attenuates blood-brain barrier and brain pathology following whole body hyperthermia in the rat. Acta Neurochir. Suppl., 2010, 106, 321-325.
54. Sharma, H.S; Westman, J.; Olsson, Y.; Johansson, O.; Dey, P.K. Increased 5-hydroxytryptamine immunoreactivity in traumatized spinal cord. An experimental study in the rat. Acta Neuropathol., 1990, 80(1), 12-17.
55. Sharma, H.S.; Olsson, Y. Edema formation and cellular alterations following spinal cord injury in the rat and their modification with p-chlorophenylalanine. Acta Neuropathol., 1990, 79(6), 604-610.
56. Olsson, Y.; Sharma, H.S.; Pettersson, C.A. Effects of pchlorophenylalanine on microvascular permeability changes in spinal cord trauma. An experimental study in the rat using 131Isodium and lanthanum tracers. Acta Neuropathol., 1990, 79(6), 595-603.
57. Guide for the Care and Use of Laboratory Animals - 2011, 8th Edition, National Research Council of the National Academies, The National Academic Press, Washington DC, www.nap.eduhttp://oacu.od.nih.gov/regs/index.htm [Accessed on: May 25, 2011].
58. Menon, P.K. Effects of Cerebrolysin, a Mixture of Neurotrophins on Spinal Cord Injury in Relation to Nanoparticles Treatment. Master's Thesis, Uppsala University, Biotechnology Program; Sharma, H.S., supervisor; Uppsala, Sweden, 2011, pp. 1-28.