Injectable alginate hydrogel loaded with GDNF promotes functional recovery in a hemisection model of spinal cord injury

International Journal of Pharmaceutics

Volumn 455, Issue 1-2, 2013, Pages 148-158

  Ansorena, Eduardo ^a,b   De Berdt, Pauline ^a   Ucakar, Bernard ^a   Simón Yarza, Teresa ^b   Jacobs, Damien ^a   Schakman, Olivier ^a   Jankovski, Aleksandar ^a,c   Deumens, Ronald ^a   Blanco Prieto, Maria J ^b   Préat, Véronique ^a   Des Rieux, Anne ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF NAVARRA   (Spain)

^c UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

Author keywords

Alginate; GDNF; Injectable hydrogel; Microspheres; Spinal cord injury

Indexed keywords

ALGINIC ACID; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MICROSPHERE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL ENCAPSULATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; ENDOTHELIUM CELL; HYDROGEL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; NERVE CELL; NERVE FIBER GROWTH; NEURITE; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD HEMISECTION; SPINAL CORD INJURY; SPINAL CORD REGENERATION; STAINING; SUSTAINED DRUG RELEASE;

ALGINATE; GDNF; INJECTABLE HYDROGEL; MICROSPHERES; SPINAL CORD INJURY;

ALGINATES; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GAIT; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLUCURONIC ACID; HEXURONIC ACIDS; HYDROGEL; INJECTIONS; LACTIC ACID; MICROSPHERES; NEURITES; POLYGLYCOLIC ACID; RATS; RATS, LONG-EVANS; SPINAL CORD INJURIES;

EID: 84883859932     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.045     Document Type: Article

References (36)

1. Awad, B.I., Carmody, M.A., Steinmetz, M.P., 2013. Potential Role of Growth Factors in SCI Management. World Neurosurgery.
2. Behrstock, S., Ebert, A., McHugh, J., Vosberg, S., Moore, J., Schneider, B., Capowski, E., Hei, D., Kordower, J., Aebischer, P., Svendsen, C.N., 2006. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther. 13, 379-388.
3. Berger, J.V., Knaepen, L., Janssen, S.P., Jaken, R.J., Marcus, M.A., Joosten, E.A., Deumens, R., 2011. Cellular and molecular insights into neuropathy-induced pain hypersensitivity for mechanism-based treatment approaches. Brain Res. Rev. 67, 282-310.
4. Boucher, T.J., Okuse, K., Bennett, D.L., Munson, J.B., Wood, J.N., McMahon, S.B., 2000. Potent analgesic effects of GDNF in neuropathic pain states. Science 290, 124-127.
5. Cholas, R.H., Hsu, H.P., Spector, M., 2012. The reparative response to cross-linked collagen-based scaffolds in a rat spinal cord gap model. Biomaterials 33, 2050-2059.
6. Chou, A.K., Yang, L.C., Wu, P.C., Wong, W.T., Liu, G.S., Chen, J.T., Howng, S.L., Tai, M.H., 2005. Intrathecal gene delivery of glial cell line-derived neurotrophic factor ameliorated paraplegia in rats after spinal ischemia. Brain Research Molecular Brain Research 133, 198-207. (Pubitemid 40248410)
7. De Laporte, L., Yan, A.L., Shea, L.D., 2009a. Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury. Biomaterials 30, 2361-2368.
8. De Laporte, L., Yang, Y., Zelivyanskaya, M.L., Cummings, B.J., Anderson, A.J., Shea, L.D., 2009b. Plasmid releasing multiple channel bridges for transgene expression after spinal cord injury. Mol. Ther. 17, 318-326.
9. Deng, L.X., Hu, J., Liu, N., Wang, X., Smith, G.M., Wen, X., Xu, X.M., 2011. GDNF modifies reactive astrogliosis allowing robust axonal regeneration through Schwann cell-seeded guidance channels after spinal cord injury. Exp. Neurol. 229, 238-250.
10. Deumens, R., Van Gorp, S.F., Bozkurt, A., Beckmann, C., Fuhrmann, T., Montzka, K., Tolba, R., Kobayashi, E., Heschel, I., Weis, J., Brook, G.A., 2013. Motor outcome and allodynia are largely unaffected by novel olfactory ensheathing cell grafts to repair low-thoracic lesion gaps in the adult rat spinal cord. Behav. Brain Res. 237, 185-189.
11. Erdogan, B., Bavbek, M., Sahin, I.F., Caner, H., Ozen, O., Denkbas, E.B., Altinors, M.N., 2010. Fetal allogeneic umbilical cord cell transplantation improves motor function in spinal cord-injured rats. Turk. Neurosurg. 20, 286-294.
12. Garbayo, E., Ansorena, E., Lanciego, J.L., Aymerich, M.S., Blanco-Prieto, M.J., 2007. Purification of bioactive glycosylated recombinant glial cell line-derived neurotrophic factor. Int. J. Pharm. 344, 9-15. (Pubitemid 47464816)
13. Garbayo, E., Montero-Menei, C.N., Ansorena, E., Lanciego, J.L., Aymerich, M.S., Blanco-Prieto, M.J., 2009. Effective GDNF brain delivery using microspheres - a promising strategy for Parkinson's disease. J. Control. Release 135, 119-126.
14. Gerin, C.G., Madueke, I.C., Perkins, T., Hill, S., Smith, K., Haley, B., Allen, S.A., Garcia, R.P., Paunesku, T., Woloschak, G., 2011. Combination strategies for repair, plasticity, and regeneration using regulation of gene expression during the chronic phase after spinal cord injury. Synapse 65, 1255-1281.
15. Gunduz, O., Ahmad, Z., Stride, E., Edirisinghe, M., 2013. Continuous generation of ethyl cellulose drug delivery nanocarriers from microbubbles. Pharm. Res. 30, 225-237.
16. Hamers, F.P., Lankhorst, A.J., van Laar, T.J., Veldhuis, W.B., Gispen, W.H., 2001. Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries. J. Neurotrauma 18, 187-201. (Pubitemid 32173426)
17. Hill, S., Smith, K., Gerin, C.G., 2008. Metal repartition and expressed genes in spinal cord of rats. Journal of Undergraduate Research 154, 154 (US Department of Energy).
18. Iannotti, C., Ping Zhang, Y., Shields, C.B., Han, Y., Burke, D.A., Xu, X.M., 2004. A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Exp. Neurol. 189, 317-332. (Pubitemid 39232071)
19. Iwase, T., Jung, C.G., Bae, H., Zhang, M., Soliven, B., 2005. Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells. J. Neurochem. 94, 1488-1499. (Pubitemid 41324633)
20. Kalous, A., Osborne, P.B., Keast, J.R., 2009. Spinal cord compression injury in adult rats initiates changes in dorsal horn remodeling that may correlate with development of neuropathic pain. J. Comp. Neurol. 513, 668-684.
21. Kardon, G., 1998. Muscle and tendon morphogenesis in the avian hind limb. Development 125, 4019-4032. (Pubitemid 28515440)
22. Kataoka, K., Suzuki, Y., Kitada, M., Hashimoto, T., Chou, H., Bai, H., Ohta, M., Wu, S., Suzuki, K., Ide, C., 2004. Alginate enhances elongation of early regenerating axons in spinal cord of young rats. Tissue Eng. 10, 493-504. (Pubitemid 38580270)
23. Lu, P., Jones, L.L., Snyder, E.Y., Tuszynski, M.H., 2003. Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury. Exp. Neurol. 181, 115-129. (Pubitemid 36629234)
24. Macias, M.Y., Syring, M.B., Pizzi, M.A., Crowe, M.J., Alexanian, A.R., Kurpad, S.N., 2006. Pain with no gain: allodynia following neural stem cell transplantation in spinal cord injury. Exp. Neurol. 201, 335-348. (Pubitemid 44344226)
25. Mignion, L., Magat, J., Schakman, O., Marbaix, E., Gallez, B., Jordan, B.F., 2013. Hexafluorobenzene in comparison with perfluoro-15-crown-5-ether for repeated monitoring of oxygenation using 19F MRI in a mouse model. Magn. Reson. Med. 69, 248-254.
26. Prang, P., Muller, R., Eljaouhari, A., Heckmann, K., Kunz, W., Weber, T., Faber, C., Vroemen, M., Bogdahn, U., Weidner, N., 2006. The promotion of oriented axonal regrowth in the injured spinal cord by alginate-based anisotropic capillary hydrogels. Biomaterials 27, 3560-3569.
27. Sharma, H.S., 2006. Post-traumatic application of brain-derived neurotrophic factor and glia-derived neurotrophic factor on the rat spinal cord enhances neuroprotection and improves motor function. Acta Neurochir. Suppl. 96, 329-334.
28. Slaughter, B.V., Khurshid, S.S., Fisher, O.Z., Khademhosseini, A., Peppas, N.A., 2009. Hydrogels in regenerative medicine. Adv. Mater. 21, 3307-3329.
29. Stanwick, J.C., Baumann, M.D., Shoichet, M.S., 2012. Enhanced neurotrophin-3 bioactivity and release from a nanoparticle-loaded composite hydrogel. J. Control. Release 160, 666-675.
30. Tan, R., Niu, X., Gan, S., Feng, Q., 2009. Preparation and characterization of an injectable composite. J. Mater. Sci. Mater. Med. 20, 1245-1253.
31. Tobias, C.A., Han, S.S., Shumsky, J.S., Kim, D., Tumolo, M., Dhoot, N.O., Wheatley, M.A., Fischer, I., Tessler, A., Murray, M., 2005. Alginate encapsulated BDNF-producing fibroblast grafts permit recovery of function after spinal cord injury in the absence of immune suppression. J. Neurotrauma 22, 138-156.
32. Vrinten, D.H., Hamers, F.F., 2003. 'CatWalk' automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing. Pain 102, 203-209. (Pubitemid 36298877)
33. Wang, Y.C., Wu, Y.T., Huang, H.Y., Lin, H.I., Lo, L.W., Tzeng, S.F., Yang, C.S., 2008. Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials 29, 4546-4553.
34. Widenfalk, J., Lundstromer, K., Jubran, M., Brene, S., Olson, L., 2001. Neurotrophic factors and receptors in the immature and adult spinal cord after mechanical injury or kainic acid. J. Neurosci. 21, 3457-3475. (Pubitemid 32422810)
35. Zhang, L., Ma, Z., Smith, G.M., Wen, X., Pressman, Y., Wood, P.M., Xu, X.M., 2009. GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons. Glia 57, 1178-1191.
36. Zhao, L., Weir, M.D., Xu, H.H., 2010. An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering. Biomaterials 31, 6502-6510.