Spatial distribution and acute anti-inflammatory effects of Methylprednisolone after sustained local delivery to the contused spinal cord

Biomaterials

Volumn 29, Issue 12, 2008, Pages 1967-1975

  Chvatal, Stacie A ^a   Kim, Young Tae ^a   Bratt Leal, Andres M ^a   Lee, Hyunjung ^a   Bellamkonda, Ravi V ^a  

^a Emory University   (United States)

Author keywords

Drug delivery; Hydrogel; Nanoparticle

Indexed keywords

METHYLPREDNISOLONE (MP); SPINAL CORD;

BIODEGRADABILITY; DRUG DELIVERY; HYDROGELS; PATIENT MONITORING;

BIOMEDICAL ENGINEERING;

AGAROSE; CADAVERINE; CALPAIN; INDUCIBLE NITRIC OXIDE SYNTHASE; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; NANOPARTICLE; POLYGLACTIN; TEXAS RED CADAVERINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIODEGRADABILITY; CONJUGATION; CONTUSION; CORTICOSTEROID THERAPY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ENCAPSULATION; HYDROGEL; MACROPHAGE; MALE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD INJURY; SYSTEMIC THERAPY;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; MALE; METHYLPREDNISOLONE; RATS; RATS, SPRAGUE-DAWLEY; SEPHAROSE; SPINAL CORD INJURIES; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

RATTUS;

EID: 39749107214     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.01.002     Document Type: Article

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