Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury

Biomaterials

Volumn 29, Issue 34, 2008, Pages 4546-4553

  Wang, Yu Chao ^a   Wu, Yi Ting ^a   Huang, Hsin Ying ^a   Lin, Hsin I ^b   Lo, Leu Wei ^a   Tzeng, Shun Fen ^b   Yang, Chung Shi ^a,c  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL CHI NAN UNIVERSITY   (Taiwan)

Author keywords

Glial cell line derived neurotrophic factor; Nanoparticles; Poly(lactic acid co glycolic acid); Size dependent delivery; Spinal cord injury

Indexed keywords

BODY FLUIDS; CELL CULTURE; FOOD PRESERVATION; HEALTH; INJECTION (OIL WELLS); LACTIC ACID; NANOPARTICLES; NANOSTRUCTURED MATERIALS; NANOSTRUCTURES; NEUROLOGY; ORGANIC ACIDS; PATIENT REHABILITATION; RATS; REPAIR;

BIODEGRADABLE NANOPARTICLES; BOVINE SERUM ALBUMIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HIND LIMBS; IN VITRO STUDIES; LOCAL ADMINISTRATION; NEURONAL FIBERS; NEURONAL SURVIVAL; NEUROTROPHIC FACTORS; POLY(LACTIC ACID-CO-GLYCOLIC ACID); POLY(LACTIC ACID-CO-GLYCOLIC ACID) (PLGA); SIZE-DEPENDENT DELIVERY; SPINAL CORD INJURIES; SPINAL CORD INJURY; SPINAL CORDS; SUSTAINED RELEASE; TISSUE REPAIRING;

DOSIMETRY;

BOVINE SERUM ALBUMIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; NANOPARTICLE; POLYGLACTIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIODEGRADABILITY; DRUG DELIVERY SYSTEM; FEMALE; GLIA CELL; GLIOSIS; LOCOMOTION; NANOENCAPSULATION; NERVE CELL; NERVE FIBER; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; SUSTAINED DRUG RELEASE;

ABSORBABLE IMPLANTS; ANIMALS; ASTROCYTES; CELLS, CULTURED; CONTUSIONS; DRUG ADMINISTRATION ROUTES; FEMALE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLYCOLATES; LOCOMOTION; NANOPARTICLES; NEURONS; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES;

BOVINAE; RATTUS;

EID: 52049108266     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2008.07.050     Document Type: Article

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