Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Ji, Weidong ^a   Yang, Mei ^b   Praggastis, Alexandra ^c   Li, Yonghao ^d   Zhou, Huanjiao Jenny ^e   He, Yun ^a   Ghazvinian, Roxanne ^c   Cincotta, Dylan J ^c   Rice, Kevin P ^c   Min, Wang ^a,e  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c Colby College   (United States)

^d SUN YAT SEN UNIVERSITY   (China)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BIS(METHYLSULFONYL) 1 (2 CHLOROETHYL) HYDRAZINE; 1,2 BIS(METHYLSULFONYL) 1 [(METHYLAMINO)CARBONYL]HYDRAZINE; APOPTOSIS SIGNAL REGULATING KINASE 1; CARMUSTINE; CYSTEINE; DRUG ANALOG; LAROMUSTINE; METHYL ISOCYANATE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN 14 3 3; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN; THIOREDOXIN 1; THIOREDOXIN REDUCTASE 1; UNCLASSIFIED DRUG; 1,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYL)HYDRAZINE; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; HYDRAZINE DERIVATIVE; ISOCYANIC ACID DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE 1; SULFONAMIDE; TXN PROTEIN, HUMAN; TXNRD1 PROTEIN, HUMAN;

ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARBAMOYLATION; CATALYSIS; CELL DEATH; CELL LYSATE; CONTROLLED STUDY; DISSOCIATION; DRUG STRUCTURE; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NECROPTOSIS; NONHUMAN; PROTEIN PROTEIN INTERACTION; TUMOR VASCULARIZATION; WHOLE CELL; ANGIOGENESIS; ANIMAL; BIOCATALYSIS; BOVINE; CELL CULTURE; DRUG EFFECTS; IMMUNOBLOTTING; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOCATALYSIS; CARBAMATES; CATTLE; CELL DEATH; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; HYDRAZINES; IMMUNOBLOTTING; ISOCYANATES; MAP KINASE KINASE KINASE 5; MITOGEN-ACTIVATED PROTEIN KINASE 8; NEOVASCULARIZATION, PHYSIOLOGIC; SIGNAL TRANSDUCTION; SULFONAMIDES; THIOREDOXIN REDUCTASE 1; THIOREDOXINS;

EID: 84904893458     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103224     Document Type: Article

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