Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner

Circulation Research

Volumn 90, Issue 12, 2002, Pages 1259-1266

  Liu, Yingmei ^a   Min, Wang ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Apoptosis signal regulating kinase 1; Thioredoxin; Tumor necrosis factor ; Ubiquitination

Indexed keywords

ADAPTOR PROTEIN; ADAPTOR PROTEIN TRAF2; APOPTOSIS SIGNAL REGULATING KINASE 1; CASPASE 3; CYSTEINE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; LIPOFECTAMINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; THIOREDOXIN; TUMOR NECROSIS FACTOR; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; AORTA; APOPTOSIS; ARTICLE; CARDIOVASCULAR DISEASE; CATTLE; CELL KILLING; CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN STABILITY; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; APOPTOSIS; CATTLE; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; HYDROGEN PEROXIDE; MAP KINASE KINASE KINASE 5; MAP KINASE KINASE KINASES; MODELS, BIOLOGICAL; MUTATION; OXIDANTS; OXIDATION-REDUCTION; PROTEINS; THIOREDOXIN; TNF RECEPTOR-ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITINS;

EID: 0037188936     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000022160.64355.62     Document Type: Article

References (34)

1. Signal transduction by the c-Jun N-terminal kinase (JNK): From inflammation to development
2. Signal transduction by the JNK group of MAP kinases
3. From receptors to stress-activated MAP kinases
4. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
5. Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx
6. Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells
7. Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation
8. Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3
9. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation
10. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
11. ASK1 is essential for JNK/SAPK activation by TRAF2
12. Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins
13. The role of the redox protein thioredoxin in cell growth and cancer
14. Thioredoxin
15. Thioredoxin and glutaredoxin systems
16. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
17. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction
18. Activation of apoptosis signal-regulating kinase 1 (ASK 1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
19. TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-κB and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways
20. Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways
21. Substrate targeting in the ubiquitin system
22. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
23. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
24. Apoptotic pathways: Paper wraps stone blunts scissors
25. The biochemistry of apoptosis
26. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell
27. TAK1 is a ubiquitin-dependent kinase of MKK and IKK
28. Activation of the IKB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
29. Solution structure of human thioredoxin in a mixed disulfide intermediate complex with its target peptide from the transcription factor NF-κB
30. A stable mixed disulfide between thioredoxin reductase and its substrate, thioredoxin: Preparation and characterization
31. Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma
32. Involvement of thioredoxin in rheumatoid arthritis: Its costimulatory roles in the TNF-α-induced production of IL-6 and IL-8 from cultured synovial fibroblasts
33. Apoptosis: A potential target for discovering novel therapies for cardiovascular diseases
34. Apoptosis in cardiac diseases: Stress- and mitogen-activated signaling pathways