Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by laromustine, KS119, and KS119W

Chemical Research in Toxicology

Volumn 27, Issue 5, 2014, Pages 818-833

  Penketh, Philip G ^a   Shyam, Krishnamurthy ^a   Zhu, Rui ^a   Baumann, Raymond P ^a   Ishiguro, Kimiko ^a   Sartorelli, Alan C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 BIS(METHYLSULFONYL) 1 (2 CHLOROETHYL)HYDRAZINE; 2 CHLOROETHANOL; 90CE; ACETALDEHYDE; CARMUSTINE; ELECTROPHILE; ETHYLENE GLYCOL; HYDRAZINE DERIVATIVE; KS 119; KS 119W; LAROMUSTINE; NUCLEOPHILE; ORGANOPHOSPHATE; PHOSPHATE; UNCLASSIFIED DRUG; 1,2-BIS(METHYLSULFONYL)-1-(2-CHLOROETHYL)HYDRAZINE; 1,2-BIS(METHYLSULFONYL)-1--(2-CHLOROETHYL)-2-((1-(4-NITROPHENYL)ETHOXY)CARBONYL)HYDRAZINE; ANTINEOPLASTIC AGENT; DNA; INTERCALATING AGENT; PRODRUG; SULFONAMIDE;

ALKYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA CROSS LINKING; DRUG DECOMPOSITION; L1210 CELL LINE; MICHAEL ADDITION; NONHUMAN; ANIMAL; CHEMISTRY; METABOLISM; MOUSE; NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DNA; HYDRAZINES; INTERCALATING AGENTS; MICE; NEOPLASMS; PHOSPHATES; PRODRUGS; SULFONAMIDES;

EID: 84901017014     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx500004y     Document Type: Article

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