메뉴 건너뛰기




Volumn 14, Issue 5, 2014, Pages 419-433

Co-formulation of P-glycoprotein substrate and inhibitor in nanocarriers: An emerging strategy for cancer chemotherapy

Author keywords

Anticancer drugs; Co formulation; Multi drug resistance; Nanocarriers; P glycoprotein inhibitor

Indexed keywords

ABC TRANSPORTER; CHITOSAN; CURCUMIN; CYTOCHROME P450; DENDRIMER; DOFEQUIDAR; DOXORUBICIN; ELACRIDAR; ERYTHROMYCIN; GLYCOPROTEIN P INHIBITOR; KETOCONAZOLE; LIDOCAINE; LIPOSOME; LIPUSU; MAGNETIC NANOPARTICLE; MULTIDRUG RESISTANCE PROTEIN; NANOCARRIER; NANOPARTICLE; QUERCETIN; SMALL INTERFERING RNA; SOLID LIPID NANOPARTICLE; STEARIC ACID; TAMOXIFEN; UNCLASSIFIED DRUG; VERAPAMIL; VINCRISTINE; VINCRISTINE SULFATE; ZOSUQUIDAR; ANTINEOPLASTIC AGENT; DRUG CARRIER;

EID: 84904722192     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/1568009614666140407112034     Document Type: Article
Times cited : (45)

References (81)
  • 1
    • 70350393672 scopus 로고    scopus 로고
    • Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation
    • Bansal, T.; Akhtar, N.; Jaggi, M.; Khar, R. K.; Talegaonkar, S. Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation. Drug Discov. Today 2009, 14(21), 1067-1074.
    • (2009) Drug Discov. Today , vol.14 , Issue.21 , pp. 1067-1074
    • Bansal, T.1    Akhtar, N.2    Jaggi, M.3    Khar, R.K.4    Talegaonkar, S.5
  • 2
    • 84865738692 scopus 로고    scopus 로고
    • Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance
    • Creixell, M.; Peppas, N. A. Co-delivery of siRNA and therapeutic agents using nanocarriers to overcome cancer resistance. Nano Today 2012, 7, 367-379.
    • (2012) Nano Today , vol.7 , pp. 367-379
    • Creixell, M.1    Peppas, N.A.2
  • 3
    • 84890736388 scopus 로고    scopus 로고
    • Advances in P-glycoprotein-based approaches for delivering anticancer drugs: Pharmacokinetic perspective and clinical relevance
    • Saneja, A.; Khare, V.; Alam, N.; Dubey, R. D.; Gupta, P. N. Advances in P-glycoprotein-based approaches for delivering anticancer drugs: pharmacokinetic perspective and clinical relevance. Expert Opin. Drug Deliv. 2014, 11(1), 121-138.
    • (2014) Expert Opin. Drug Deliv. , vol.11 , Issue.1 , pp. 121-138
    • Saneja, A.1    Khare, V.2    Alam, N.3    Dubey, R.D.4    Gupta, P.N.5
  • 4
    • 33645830172 scopus 로고
    • A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
    • Juliano, R. L.; Ling, V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim. Biophys. Acta. 1976, 455(1), 152-162.
    • (1976) Biochim. Biophys. Acta. , vol.455 , Issue.1 , pp. 152-162
    • Juliano, R.L.1    Ling, V.2
  • 5
    • 84862615963 scopus 로고    scopus 로고
    • Delivery of P-glycoprotein substrates using chemosensitizers and nanotechnology for selective and efficient therapeutic outcomes
    • Montesinos, R. N.; Beduneau, A.; Pellequer, Y.; Lamprecht, A. Delivery of P-glycoprotein substrates using chemosensitizers and nanotechnology for selective and efficient therapeutic outcomes. J. Control. Release 2012, 161, 50-61.
    • (2012) J. Control. Release , vol.161 , pp. 50-61
    • Montesinos, R.N.1    Beduneau, A.2    Pellequer, Y.3    Lamprecht, A.4
  • 6
    • 33846419807 scopus 로고    scopus 로고
    • How can we best use structural information on P-glycoprotein to design inhibitors? Pharmacol
    • McDevitt, C. A.; Callaghan, R. How can we best use structural information on P-glycoprotein to design inhibitors? Pharmacol. Ther. 2007, 113(2), 429-441.
    • (2007) Pharmacol. Ther. , vol.113 , Issue.2 , pp. 429-441
    • McDevitt, C.A.1    Callaghan, R.2
  • 7
    • 84876817977 scopus 로고    scopus 로고
    • P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: Current status and future perspectives
    • Binkhathlan, Z.; Lavasanifar, A. P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives. Curr. Cancer Drug Targets 2013, 13(3), 326-346.
    • (2013) Curr. Cancer Drug Targets , vol.13 , Issue.3 , pp. 326-346
    • Binkhathlan, Z.1    Lavasanifar, A.2
  • 8
    • 84871919918 scopus 로고    scopus 로고
    • Oral delivery of anticancer drugs III: Formulation using drug delivery systems
    • Mazzaferro, S.; Bouchemal, K.; Ponchel, G. Oral delivery of anticancer drugs III: Formulation using drug delivery systems. Drug Discov. Today 2013, 18(1-2), 99-104.
    • (2013) Drug Discov. Today , vol.18 , Issue.1-2 , pp. 99-104
    • Mazzaferro, S.1    Bouchemal, K.2    Ponchel, G.3
  • 9
    • 84865480687 scopus 로고    scopus 로고
    • Nanotechnology-based combinational drug delivery: An emerging approach for cancer therapy
    • Parhi, P.; Mohanty, C.; Sahoo, S. K. Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy. Drug Discov. Today 2012, 17, 1044-1052.
    • (2012) Drug Discov. Today , vol.17 , pp. 1044-1052
    • Parhi, P.1    Mohanty, C.2    Sahoo, S.K.3
  • 10
    • 0042167430 scopus 로고    scopus 로고
    • Pglycoprotein inhibitors and their screening: A perspective from bioavailability enhancement
    • Varma, M. V. S.; Ashokraj, Y.; Dey, C. S.; Panchagnula, R. Pglycoprotein inhibitors and their screening: a perspective from bioavailability enhancement. Pharmacol. Res. 2003, 48(4), 347-359.
    • (2003) Pharmacol. Res. , vol.48 , Issue.4 , pp. 347-359
    • Varma, M.V.S.1    Ashokraj, Y.2    Dey, C.S.3    Panchagnula, R.4
  • 12
    • 1642523162 scopus 로고    scopus 로고
    • Polymorphisms in human MDR1 (P-glycoprotein): Recent advances and clinical relevance
    • Marzolini, C.; Paus, E.; Buclin, T.; Kim, R. B. Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance. Clin. Pharmacol. Ther. 2004, 75(1), 13-33.
    • (2004) Clin. Pharmacol. Ther. , vol.75 , Issue.1 , pp. 13-33
    • Marzolini, C.1    Paus, E.2    Buclin, T.3    Kim, R.B.4
  • 13
    • 84857558058 scopus 로고    scopus 로고
    • In vitroand in vivorelevance of the p-glycoprotein probe substrates in drug discovery and development: Focus on rhodamine 123, digoxin and talinolol
    • Ana, F.; Gilberto, A.; Falcao, A. In vitroand in vivorelevance of the p-glycoprotein probe substrates in drug discovery and development: focus on rhodamine 123, digoxin and talinolol. J. Bioequ. Bioavail. 2011, 2, 1-23.
    • (2011) J. Bioequ. Bioavail. , vol.2 , pp. 1-23
    • Ana, F.1    Gilberto, A.2    Falcao, A.3
  • 14
    • 0028342805 scopus 로고
    • Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: Evidence against direct drug extrusion from the plasma membrane
    • Altenberg, G. A.; Vanoye, C. G.; Horton, J. K.; Reuss, L. Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane. Proc. Natl. Acad. Sci. USA 1994, 91(11), 4654-4657.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , Issue.11 , pp. 4654-4657
    • Altenberg, G.A.1    Vanoye, C.G.2    Horton, J.K.3    Reuss, L.4
  • 15
    • 0026580336 scopus 로고
    • Is the multidrug transporter a flippase?
    • Higgins, C. F.; Gottesman, M. M. Is the multidrug transporter a flippase? Trend. Biochem. Sci. 1992, 17(1), 18-21.
    • (1992) Trend. Biochem. Sci. , vol.17 , Issue.1 , pp. 18-21
    • Higgins, C.F.1    Gottesman, M.M.2
  • 16
    • 0025193531 scopus 로고
    • Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells
    • Raviv, Y.; Pollard, H. B.; Bruggemann, E. P.; Pastan, I.; Gottesman, M. M. Photosensitized labeling of a functional multidrug transporter in living drug-resistant tumor cells. J. Biol. Chem. 1990, 265(7), 3975-3980.
    • (1990) J. Biol. Chem. , vol.265 , Issue.7 , pp. 3975-3980
    • Raviv, Y.1    Pollard, H.B.2    Bruggemann, E.P.3    Pastan, I.4    Gottesman, M.M.5
  • 18
    • 84867883248 scopus 로고    scopus 로고
    • Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans
    • Jin, M. S.; Oldham, M. L.; Zhang, Q.; Chen, J. Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans. Nature 2012, 490(7421), 566-569.
    • (2012) Nature , vol.490 , Issue.7421 , pp. 566-569
    • Jin, M.S.1    Oldham, M.L.2    Zhang, Q.3    Chen, J.4
  • 20
    • 84900449189 scopus 로고    scopus 로고
    • Refined structures of mouse Pglycoprotein
    • Li, J.; Jaimes, K. F.; Aller, S. G. Refined structures of mouse Pglycoprotein. Protein Sci. 2013, 23(1), 34-46.
    • (2013) Protein Sci. , vol.23 , Issue.1 , pp. 34-46
    • Li, J.1    Jaimes, K.F.2    Aller, S.G.3
  • 21
    • 84900772381 scopus 로고    scopus 로고
    • In; Andreas Bernkop-Schnürch, Ed.; Springer
    • Foger, F. In: Oral Delivery of Macromolecular Drugs; Andreas Bernkop-Schnürch, Ed.; Springer, 2009; pp. 123-136.
    • (2009) Oral Delivery of Macromolecular Drugs , pp. 123-136
    • Foger, F.1
  • 22
    • 69949106198 scopus 로고    scopus 로고
    • Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy
    • Bansal, T.; Jaggi, M.; Khar, R.; Talegaonkar, S. Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy. J. Pharm. Pharm. Sci. 2009, 12(1), 46-78.
    • (2009) J. Pharm. Pharm. Sci. , vol.12 , Issue.1 , pp. 46-78
    • Bansal, T.1    Jaggi, M.2    Khar, R.3    Talegaonkar, S.4
  • 23
    • 79955469557 scopus 로고    scopus 로고
    • Involvement of P-glycoprotein and CYP 3A4 in the enhancement of etoposide bioavailability by a piperine analogue
    • Najar, I. A.; Sharma, S. C.; Singh, G. D.; Koul, S.; Gupta, P. N.; Javed, S.; Johri, R. K. Involvement of P-glycoprotein and CYP 3A4 in the enhancement of etoposide bioavailability by a piperine analogue. Chem. Biol. Int. 2011, 190(2), 84-90.
    • (2011) Chem. Biol. Int. , vol.190 , Issue.2 , pp. 84-90
    • Najar, I.A.1    Sharma, S.C.2    Singh, G.D.3    Koul, S.4    Gupta, P.N.5    Javed, S.6    Johri, R.K.7
  • 25
    • 5144221545 scopus 로고    scopus 로고
    • Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder
    • Chearwae, W.; Anuchapreeda, S.; Nandigama, K.; Ambudkar, S. V.; Limtrakul, P. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem. Pharmacol. 2004, 68(10), 2043-2052.
    • (2004) Biochem. Pharmacol. , vol.68 , Issue.10 , pp. 2043-2052
    • Chearwae, W.1    Anuchapreeda, S.2    Nandigama, K.3    Ambudkar, S.V.4    Limtrakul, P.5
  • 26
    • 79953767571 scopus 로고    scopus 로고
    • Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy
    • Wu, C. P.; Ohnuma, S.; Ambudkar, S. V. Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy. Curr. Pharm. Biotechnol. 2011, 12(4), 609-620.
    • (2011) Curr. Pharm. Biotechnol. , vol.12 , Issue.4 , pp. 609-620
    • Wu, C.P.1    Ohnuma, S.2    Ambudkar, S.V.3
  • 27
    • 84874081668 scopus 로고    scopus 로고
    • The effects of flavonoids on the ABC transporters: Consequences for the pharmacokinetics of substrate drugs
    • Li, Y.; Paxton, J. W. The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs. Expert Opin. Drug. Metab. Toxicol. 2013, 9(3), 267-285.
    • (2013) Expert Opin. Drug. Metab. Toxicol. , vol.9 , Issue.3 , pp. 267-285
    • Li, Y.1    Paxton, J.W.2
  • 28
    • 39749084704 scopus 로고    scopus 로고
    • Development of inhibitors of ATP-binding cassette drug transporters-present status and challenges
    • Shukla, S.; Wu, C. P.; Ambudkar, S. V. Development of inhibitors of ATP-binding cassette drug transporters-present status and challenges. Expert Opin. Drug. Metab. Toxicol. 2008, 4(2), 205-223.
    • (2008) Expert Opin. Drug. Metab. Toxicol. , vol.4 , Issue.2 , pp. 205-223
    • Shukla, S.1    Wu, C.P.2    Ambudkar, S.V.3
  • 29
    • 79953035086 scopus 로고    scopus 로고
    • PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
    • Acharya, S.; Sahoo, S. K. PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. Adv. Drug Deliv. Rev. 2011, 63(3), 170-183.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , Issue.3 , pp. 170-183
    • Acharya, S.1    Sahoo, S.K.2
  • 30
    • 84888197706 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing 'Generally Recognized As Safe' (GRAS) nanopharmaceuticals: A review
    • Sosnik, A. Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing 'Generally Recognized As Safe' (GRAS) nanopharmaceuticals: A review. Adv. Drug Deliv. Rev. 2013, 65(13), 1828-1851.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , Issue.13 , pp. 1828-1851
    • Sosnik, A.1
  • 31
    • 77953235847 scopus 로고    scopus 로고
    • Vitamin E TPGS P-glycoprotein inhibition mechanism: Influence on conformational flexibility, intracellular ATP levels, and role of time and site of access
    • Collnot, E. M.; Baldes, C.; Schaefer, U. F.; Edgar, K. J.; Wempe, M. F.; Lehr, C. M. Vitamin E TPGS P-glycoprotein inhibition mechanism: influence on conformational flexibility, intracellular ATP levels, and role of time and site of access. Mol. Pharm. 2010, 7(3), 642-651.
    • (2010) Mol. Pharm. , vol.7 , Issue.3 , pp. 642-651
    • Collnot, E.M.1    Baldes, C.2    Schaefer, U.F.3    Edgar, K.J.4    Wempe, M.F.5    Lehr, C.M.6
  • 32
    • 34250822863 scopus 로고    scopus 로고
    • Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: Influence on ATPase activity and membrane fluidity
    • Collnot, E. M.; Baldes, C.; Wempe, M. F.; Kappl, R.; Hattermann, J. R.; Hyatt, J. A.; Edgar, K. J.; Schaefer, U. F.; Lehr, C. M. Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity. Mol. Pharm. 2007, 4(3), 465-474.
    • (2007) Mol. Pharm. , vol.4 , Issue.3 , pp. 465-474
    • Collnot, E.M.1    Baldes, C.2    Wempe, M.F.3    Kappl, R.4    Hattermann, J.R.5    Hyatt, J.A.6    Edgar, K.J.7    Schaefer, U.F.8    Lehr, C.M.9
  • 33
    • 84904751251 scopus 로고    scopus 로고
    • Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance
    • Zhu, H.; Chen, H.; Zeng, X.; Wang, Z.; Zhang, X.; Wu, Y.; Gao, Y.; Zhang, J.; Liu, K.; Liu, R. Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance. Biomaterials 2013, 1-10.
    • (2013) Biomaterials , pp. 1-10
    • Zhu, H.1    Chen, H.2    Zeng, X.3    Wang, Z.4    Zhang, X.5    Wu, Y.6    Gao, Y.7    Zhang, J.8    Liu, K.9    Liu, R.10
  • 34
    • 0038061535 scopus 로고    scopus 로고
    • Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines
    • Lo, Y. l. Relationships between the hydrophilic-lipophilic balance values of pharmaceutical excipients and their multidrug resistance modulating effect in Caco-2 cells and rat intestines. J. Control. Release 2003, 90(1), 37-48.
    • (2003) J. Control. Release , vol.90 , Issue.1 , pp. 37-48
    • Lo, Y.L.1
  • 35
    • 36248980358 scopus 로고    scopus 로고
    • The effects of pharmaceutical excipients on drug disposition
    • Buggins, T. R.; Dickinson, P. A.; Taylor, G. The effects of pharmaceutical excipients on drug disposition. Adv. Drug Deliv. Rev. 2007, 59(15), 1482-1503.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , Issue.15 , pp. 1482-1503
    • Buggins, T.R.1    Dickinson, P.A.2    Taylor, G.3
  • 36
    • 33847341135 scopus 로고    scopus 로고
    • Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: In vitro/In vivocase studies
    • Constantinides, P. P.; Wasan, K. M. Lipid formulation strategies for enhancing intestinal transport and absorption of P-glycoprotein (P-gp) substrate drugs: In vitro/In vivocase studies. J. Pharm. Sci. 2007, 96(2), 235-248.
    • (2007) J. Pharm. Sci. , vol.96 , Issue.2 , pp. 235-248
    • Constantinides, P.P.1    Wasan, K.M.2
  • 37
    • 85028127551 scopus 로고    scopus 로고
    • Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs
    • Lu, Y.; Park, K. Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs. Int. J. Pharm. 2013, 453, 198-214.
    • (2013) Int. J. Pharm. , vol.453 , pp. 198-214
    • Lu, Y.1    Park, K.2
  • 38
    • 84874669561 scopus 로고    scopus 로고
    • Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability
    • Sane, R.; Mittapalli, R. K.; Elmquist, W. F. Development and evaluation of a novel microemulsion formulation of elacridar to improve its bioavailability. J. Pharm. Sci. 2013, 102, 1343-1354.
    • (2013) J. Pharm. Sci. , vol.102 , pp. 1343-1354
    • Sane, R.1    Mittapalli, R.K.2    Elmquist, W.F.3
  • 39
    • 0032742140 scopus 로고    scopus 로고
    • Doxorubicin encapsulated in sterically stabilized liposomes exhibits renal and biliary clearance properties that are independent of valspodar (PSC 833) under conditions that significantly inhibit nonencapsulated drug excretion
    • Krishna, R.; McIntosh, N.; Riggs, K. W.; Mayer, L. D. Doxorubicin encapsulated in sterically stabilized liposomes exhibits renal and biliary clearance properties that are independent of valspodar (PSC 833) under conditions that significantly inhibit nonencapsulated drug excretion. Clin. Cancer Res. 1999, 5(10), 2939-2947.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.10 , pp. 2939-2947
    • Krishna, R.1    McIntosh, N.2    Riggs, K.W.3    Mayer, L.D.4
  • 40
    • 0345504156 scopus 로고    scopus 로고
    • Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug-resistant solid tumors by co-administering valspodar (PSC 833) with sterically stabilized liposomal doxorubicin
    • Krishna, R.; St-Louis, M.; Mayer, L. D. Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug-resistant solid tumors by co-administering valspodar (PSC 833) with sterically stabilized liposomal doxorubicin. Int. J. Cancer 2000, 85(1), 131-141.
    • (2000) Int. J. Cancer , vol.85 , Issue.1 , pp. 131-141
    • Krishna, R.1    St-Louis, M.2    Mayer, L.D.3
  • 41
    • 0344012523 scopus 로고    scopus 로고
    • Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability
    • Gao, P.; Rush, B. D.; Pfund, W. P.; Huang, T.; Bauer, J. M.; Morozowich, W.; Kuo, M. S.; Hageman, M. J. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J. Pharm. Sci. 2003, 92(12), 2386-2398.
    • (2003) J. Pharm. Sci. , vol.92 , Issue.12 , pp. 2386-2398
    • Gao, P.1    Rush, B.D.2    Pfund, W.P.3    Huang, T.4    Bauer, J.M.5    Morozowich, W.6    Kuo, M.S.7    Hageman, M.J.8
  • 42
    • 84855800458 scopus 로고    scopus 로고
    • Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats
    • Park, J. H.; Park, J. H.; Hur, H. J.; Woo, J. S.; Lee, H. J. Effects of silymarin and formulation on the oral bioavailability of paclitaxel in rats. Eur. J. Pharm. Sci. 2012, 45(3), 296-301.
    • (2012) Eur. J. Pharm. Sci. , vol.45 , Issue.3 , pp. 296-301
    • Park, J.H.1    Park, J.H.2    Hur, H.J.3    Woo, J.S.4    Lee, H.J.5
  • 43
  • 44
    • 79959776093 scopus 로고    scopus 로고
    • Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin
    • Xiong, X. B.; Lavasanifar, A. Traceable multifunctional micellar nanocarriers for cancer-targeted co-delivery of MDR-1 siRNA and doxorubicin. ACS nano 2011, 5(6), 5202-5213.
    • (2011) ACS nano , vol.5 , Issue.6 , pp. 5202-5213
    • Xiong, X.B.1    Lavasanifar, A.2
  • 46
    • 84878296177 scopus 로고    scopus 로고
    • Oral delivery of anticancer drugs: Challenges and opportunities
    • Thanki, K.; Gangwal, R.; Sangamwar, A. T.; Jain, S. Oral delivery of anticancer drugs: challenges and opportunities. J. Control. Release 2013, 170(1), 15-40.
    • (2013) J. Control. Release , vol.170 , Issue.1 , pp. 15-40
    • Thanki, K.1    Gangwal, R.2    Sangamwar, A.T.3    Jain, S.4
  • 47
    • 40549125358 scopus 로고    scopus 로고
    • Natural and synthetic polymers as inhibitors of drug efflux pumps
    • Werle, M. Natural and synthetic polymers as inhibitors of drug efflux pumps. Pharm. Res. 2008, 25(3), 500-511.
    • (2008) Pharm. Res. , vol.25 , Issue.3 , pp. 500-511
    • Werle, M.1
  • 48
    • 0344560656 scopus 로고    scopus 로고
    • Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles
    • Emilienne Soma, C.; Dubernet, C.; Bentolila, D.; Benita, S.; Couvreur, P. Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles. Biomaterials 2000, 21(1), 1-7.
    • (2000) Biomaterials , vol.21 , Issue.1 , pp. 1-7
    • Emilienne Soma, C.1    Dubernet, C.2    Bentolila, D.3    Benita, S.4    Couvreur, P.5
  • 49
    • 67349243616 scopus 로고    scopus 로고
    • Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance
    • Patil, Y.; Sadhukha, T.; Ma, L.; Panyam, J. Nanoparticle-mediated simultaneous and targeted delivery of paclitaxel and tariquidar overcomes tumor drug resistance. J. Control. Release 2009, 136(1), 21-29.
    • (2009) J. Control. Release , vol.136 , Issue.1 , pp. 21-29
    • Patil, Y.1    Sadhukha, T.2    Ma, L.3    Panyam, J.4
  • 50
    • 78049498597 scopus 로고    scopus 로고
    • Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma
    • Song, X. R.; Zheng, Y.; He, G.; Yang, L.; Luo, Y. F.; He, Z. Y.; Li, S. Z.; Li, J. M.; Yu, S.; Luo, X. Development of PLGA nanoparticles simultaneously loaded with vincristine and verapamil for treatment of hepatocellular carcinoma. J. Pharm. Sci. 2010, 99(12), 4874-4879.
    • (2010) J. Pharm. Sci. , vol.99 , Issue.12 , pp. 4874-4879
    • Song, X.R.1    Zheng, Y.2    He, G.3    Yang, L.4    Luo, Y.F.5    He, Z.Y.6    Li, S.Z.7    Li, J.M.8    Yu, S.9    Luo, X.10
  • 51
    • 79958271282 scopus 로고    scopus 로고
    • Co-formulation of doxorubicin and curcumin in poly(D, L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells
    • Misra, R.; Sahoo, S. K. Co-formulation of doxorubicin and curcumin in poly(D, L-lactide-co-glycolide) nanoparticles suppresses the development of multidrug resistance in K562 cells. Mol. Pharm. 2011, 8(3), 852-66.
    • (2011) Mol. Pharm. , vol.8 , Issue.3 , pp. 852-866
    • Misra, R.1    Sahoo, S.K.2
  • 52
    • 84862808031 scopus 로고    scopus 로고
    • Reversion of multidrug resistance by coencapsulation of doxorubicin and curcumin in chitosan/poly (butyl cyanoacrylate) nanoparticles
    • Duan, J.; Mansour, H. M.; Zhang, Y.; Deng, X.; Chen, Y.; Wang, J.; Pan, Y.; Zhao, J. Reversion of multidrug resistance by coencapsulation of doxorubicin and curcumin in chitosan/poly (butyl cyanoacrylate) nanoparticles. Int. J. Pharm. 2012, 426(1), 193-201.
    • (2012) Int. J. Pharm. , vol.426 , Issue.1 , pp. 193-201
    • Duan, J.1    Mansour, H.M.2    Zhang, Y.3    Deng, X.4    Chen, Y.5    Wang, J.6    Pan, Y.7    Zhao, J.8
  • 53
    • 77955485060 scopus 로고    scopus 로고
    • Systemic administration of polymeric nanoparticleencapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer
    • Bisht, S.; Mizuma, M.; Feldmann, G.; Ottenhof, N. A.; Hong, S.-M.; Pramanik, D.; Chenna, V.; Karikari, C.; Sharma, R.; Goggins, M. G. Systemic administration of polymeric nanoparticleencapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol. Cancer Ther. 2010, 9(8), 2255-2264.
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.8 , pp. 2255-2264
    • Bisht, S.1    Mizuma, M.2    Feldmann, G.3    Ottenhof, N.A.4    Hong, S.-M.5    Pramanik, D.6    Chenna, V.7    Karikari, C.8    Sharma, R.9    Goggins, M.G.10
  • 55
    • 84883581837 scopus 로고    scopus 로고
    • Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: Implications on oral Bioavailability, antitumor efficacy, and drug-Induced toxicity
    • Jain, A. K.; Thanki, K.; Jain, S. Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral Bioavailability, antitumor efficacy, and drug-Induced toxicity. Mol. Pharm. 2013, 10(9), 3459-3474.
    • (2013) Mol. Pharm. , vol.10 , Issue.9 , pp. 3459-3474
    • Jain, A.K.1    Thanki, K.2    Jain, S.3
  • 56
    • 0030598260 scopus 로고    scopus 로고
    • Biodegradation of solid lipid nanoparticles as a function of lipase incubation time
    • Muller, R. H.; Ruhl, D. R.; Runge, S. A. Biodegradation of solid lipid nanoparticles as a function of lipase incubation time. Int. J. Pharm. 1996, 144(1), 115-121.
    • (1996) Int. J. Pharm. , vol.144 , Issue.1 , pp. 115-121
    • Muller, R.H.1    Ruhl, D.R.2    Runge, S.A.3
  • 57
    • 37849185909 scopus 로고    scopus 로고
    • Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymerlipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer
    • Wong, H. L.; Bendayan, R.; Rauth, A. M.; Wu, X. Y. Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymerlipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer. J. Control. Release 2006, 116(3), 275-284.
    • (2006) J. Control. Release , vol.116 , Issue.3 , pp. 275-284
    • Wong, H.L.1    Bendayan, R.2    Rauth, A.M.3    Wu, X.Y.4
  • 59
    • 51649111253 scopus 로고    scopus 로고
    • Reversal in multidrug resistance by magnetic nanoparticle of Fe3O4loaded with adriamycin and tetrandrine in K562/A02 leukemic cells
    • Chen, B.; Sun, Q.; Wang, X.; Gao, F.; Dai, Y.; Yin, Y.; Ding, J.; Gao, C.; Cheng, J.; Li, J. Reversal in multidrug resistance by magnetic nanoparticle of Fe3O4loaded with adriamycin and tetrandrine in K562/A02 leukemic cells. Int. J. Nanomedicine 2008, 3(2), 277-286.
    • (2008) Int. J. Nanomedicine , vol.3 , Issue.2 , pp. 277-286
    • Chen, B.1    Sun, Q.2    Wang, X.3    Gao, F.4    Dai, Y.5    Yin, Y.6    Ding, J.7    Gao, C.8    Cheng, J.9    Li, J.10
  • 60
    • 43249096164 scopus 로고    scopus 로고
    • Dual agents loaded PLGA nanoparticles: Systematic study of particle size and drug entrapment efficiency
    • Song, X.; Zhao, Y.; Hou, S.; Xu, F.; Zhao, R.; He, J.; Cai, Z.; Li, Y.; Chen, Q. Dual agents loaded PLGA nanoparticles: systematic study of particle size and drug entrapment efficiency. Eur. J. Pharm. Biopharm. 2008, 69(2), 445-453.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , Issue.2 , pp. 445-453
    • Song, X.1    Zhao, Y.2    Hou, S.3    Xu, F.4    Zhao, R.5    He, J.6    Cai, Z.7    Li, Y.8    Chen, Q.9
  • 61
    • 84867366635 scopus 로고    scopus 로고
    • Liposomal paclitaxel formulations
    • Koudelka, S.; Turanek, J. Liposomal paclitaxel formulations. J. Control. Release 2012, 163, 322-334.
    • (2012) J. Control. Release , vol.163 , pp. 322-334
    • Koudelka, S.1    Turanek, J.2
  • 62
    • 34548482374 scopus 로고    scopus 로고
    • Stealth liposomes: Review of the basic science, rationale, and clinical applications, existing and potential
    • Immordino, M. L.; Dosio, F.; Cattel, L. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int. J. Nanomedicine 2006, 1(3), 297-315.
    • (2006) Int. J. Nanomedicine , vol.1 , Issue.3 , pp. 297-315
    • Immordino, M.L.1    Dosio, F.2    Cattel, L.3
  • 63
    • 19644369801 scopus 로고    scopus 로고
    • In vitrocytotoxicity of Stealth liposomes coencapsulating doxorubicin and verapamil on doxorubicin-resistant tumor cells
    • Wang, J.; Goh, B.; Lu, W.; Zhang, Q.; Chang, A.; Liu, X. Y.; Tan, T. M. C.; Lee, H. In vitrocytotoxicity of Stealth liposomes coencapsulating doxorubicin and verapamil on doxorubicin-resistant tumor cells. Biol. Pharma. Bull. 2005, 28(5), 822-828.
    • (2005) Biol. Pharma. Bull. , vol.28 , Issue.5 , pp. 822-828
    • Wang, J.1    Goh, B.2    Lu, W.3    Zhang, Q.4    Chang, A.5    Liu, X.Y.6    Tan, T.M.C.7    Lee, H.8
  • 64
    • 28444437067 scopus 로고    scopus 로고
    • Pharmacokinetics of intravenously administered stealth liposomal doxorubicin modulated with verapamil in rats
    • Wang, J. C.; Liu, X. Y.; Lu, W.-L.; Change Qiang Zhang, A.; Goh, B. C.; Lee, H. S. Pharmacokinetics of intravenously administered stealth liposomal doxorubicin modulated with verapamil in rats. Eur. J. Pharm. Biopharm. 2006, 62(1), 44-51.
    • (2006) Eur. J. Pharm. Biopharm. , vol.62 , Issue.1 , pp. 44-51
    • Wang, J.C.1    Liu, X.Y.2    Lu, W.-L.3    Change Qiang Zhang, A.4    Goh, B.C.5    Lee, H.S.6
  • 65
    • 34848911993 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil
    • Wu, J.; Lu, Y.; Lee, A.; Pan, X.; Yang, X.; Zhao, X.; Lee, R. J. Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil. J. Pharm. Pharm. Sci. 2007, 10(3), 350-357.
    • (2007) J. Pharm. Pharm. Sci. , vol.10 , Issue.3 , pp. 350-357
    • Wu, J.1    Lu, Y.2    Lee, A.3    Pan, X.4    Yang, X.5    Zhao, X.6    Lee, R.J.7
  • 66
    • 67249130759 scopus 로고    scopus 로고
    • Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals
    • Du, J.; Lu, W.-L.; Ying, X.; Liu, Y.; Du, P.; Tian, W.; Men, Y.; Guo, J.; Zhang, Y.; Li, R. J. Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals. Mol. Pharm. 2009, 6(3), 905-917.
    • (2009) Mol. Pharm. , vol.6 , Issue.3 , pp. 905-917
    • Du, J.1    Lu, W.-L.2    Ying, X.3    Liu, Y.4    Du, P.5    Tian, W.6    Men, Y.7    Guo, J.8    Zhang, Y.9    Li, R.J.10
  • 67
    • 78649961648 scopus 로고    scopus 로고
    • Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats
    • Pang, Z.; Feng, L.; Hua, R.; Chen, J.; Gao, H.; Pan, S.; Jiang, X.; Zhang, P. Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats. Mol. Pharm. 2010, 7(6), 1995-2005.
    • (2010) Mol. Pharm. , vol.7 , Issue.6 , pp. 1995-2005
    • Pang, Z.1    Feng, L.2    Hua, R.3    Chen, J.4    Gao, H.5    Pan, S.6    Jiang, X.7    Zhang, P.8
  • 68
    • 0037047627 scopus 로고    scopus 로고
    • Polymer vesicles
    • Discher, D. E.; Eisenberg, A. Polymer vesicles. Science 2002, 297(5583), 967-973.
    • (2002) Science , vol.297 , Issue.5583 , pp. 967-973
    • Discher, D.E.1    Eisenberg, A.2
  • 70
    • 80051785398 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes
    • Patel, N. R.; Rathi, A.; Mongayt, D.; Torchilin, V. P. Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes. Int. J. Pharm. 2011, 416(1), 296-299.
    • (2011) Int. J. Pharm. , vol.416 , Issue.1 , pp. 296-299
    • Patel, N.R.1    Rathi, A.2    Mongayt, D.3    Torchilin, V.P.4
  • 71
    • 82255193872 scopus 로고    scopus 로고
    • Liposome formulation of coencapsulated vincristine and quercetin enhanced antitumor activity in a trastuzumab-insensitive breast tumor xenograft model
    • Wong, M.-Y.; Chiu, G. N. C. Liposome formulation of coencapsulated vincristine and quercetin enhanced antitumor activity in a trastuzumab-insensitive breast tumor xenograft model. Nanomedicine 2011, 7(6), 834-840.
    • (2011) Nanomedicine , vol.7 , Issue.6 , pp. 834-840
    • Wong, M.-Y.1    Chiu, G.N.C.2
  • 72
    • 84868089602 scopus 로고    scopus 로고
    • Co-delivery of doxorubicin and PSC 833 (valspodar) by stealth nanoliposomes for efficient overcoming of multidrug resistance
    • Bajelan, E.; Haeri, A.; Vali, A. M.; Ostad, S. N.; Dadashzadeh, S. Co-delivery of doxorubicin and PSC 833 (valspodar) by stealth nanoliposomes for efficient overcoming of multidrug resistance. J. Pharm. Pharm. Sci. 2012, 15(4), 568-582.
    • (2012) J. Pharm. Pharm. Sci. , vol.15 , Issue.4 , pp. 568-582
    • Bajelan, E.1    Haeri, A.2    Vali, A.M.3    Ostad, S.N.4    Dadashzadeh, S.5
  • 73
    • 56749158194 scopus 로고    scopus 로고
    • Lipopeptide with a RGDK tetrapeptide sequence can selectively target genes to proangiogenic α5β1 integrin receptor and mouse tumor vasculature
    • Pramanik, D.; Majeti, B. K.; Mondal, G.; Karmali, P. P.; Sistla, R.; Ramprasad, O. G.; Srinivas, G.; Pande, G.; Chaudhuri, A. Lipopeptide with a RGDK tetrapeptide sequence can selectively target genes to proangiogenic α5β1 integrin receptor and mouse tumor vasculature. J. Med. Chem. 2008, 51(22), 7298-7302.
    • (2008) J. Med. Chem. , vol.51 , Issue.22 , pp. 7298-7302
    • Pramanik, D.1    Majeti, B.K.2    Mondal, G.3    Karmali, P.P.4    Sistla, R.5    Ramprasad, O.G.6    Srinivas, G.7    Pande, G.8    Chaudhuri, A.9
  • 74
    • 84890245521 scopus 로고    scopus 로고
    • Simultaneous delivery of doxorubicin and curcumin encapsulated in liposomes of pegylated RGDK-lipopeptide to tumor vasculature
    • Barui, S.; Saha, S.; Mondal, G.; Haseena, S.; Chaudhuri, A. Simultaneous delivery of doxorubicin and curcumin encapsulated in liposomes of pegylated RGDK-lipopeptide to tumor vasculature. Biomaterials 2014, 35(5), 1643-1656.
    • (2014) Biomaterials , vol.35 , Issue.5 , pp. 1643-1656
    • Barui, S.1    Saha, S.2    Mondal, G.3    Haseena, S.4    Chaudhuri, A.5
  • 75
    • 80053609978 scopus 로고    scopus 로고
    • Synergistic effect of folatemediated targeting and verapamil-mediated P-gp inhibition with paclitaxel-polymer micelles to overcome multi-drug resistance
    • Wang, F.; Zhang, D.; Zhang, Q.; Chen, Y.; Zheng, D.; Hao, L.; Duan, C.; Jia, L.; Liu, G.; Liu, Y. Synergistic effect of folatemediated targeting and verapamil-mediated P-gp inhibition with paclitaxel-polymer micelles to overcome multi-drug resistance. Biomaterials 2011, 32(35), 9444-9456.
    • (2011) Biomaterials , vol.32 , Issue.35 , pp. 9444-9456
    • Wang, F.1    Zhang, D.2    Zhang, Q.3    Chen, Y.4    Zheng, D.5    Hao, L.6    Duan, C.7    Jia, L.8    Liu, G.9    Liu, Y.10
  • 76
    • 84861812126 scopus 로고    scopus 로고
    • PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells
    • Sarisozen, C.; Vural, I.; Levchenko, T.; Hincal, A. A.; Torchilin, V. P. PEG-PE-based micelles co-loaded with paclitaxel and cyclosporine A or loaded with paclitaxel and targeted by anticancer antibody overcome drug resistance in cancer cells. Drug Deliv. 2012, 19(4), 169-176.
    • (2012) Drug Deliv. , vol.19 , Issue.4 , pp. 169-176
    • Sarisozen, C.1    Vural, I.2    Levchenko, T.3    Hincal, A.A.4    Torchilin, V.P.5
  • 77
    • 84870152480 scopus 로고    scopus 로고
    • Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance
    • Sarisozen, C.; Vural, I.; Levchenko, T.; Hincal, A. A.; Torchilin, V. P. Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance. Drug Deliv. 2012, 19(8), 363-370.
    • (2012) Drug Deliv. , vol.19 , Issue.8 , pp. 363-370
    • Sarisozen, C.1    Vural, I.2    Levchenko, T.3    Hincal, A.A.4    Torchilin, V.P.5
  • 78
    • 84880814226 scopus 로고    scopus 로고
    • Smart pH-Sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram
    • Duan, X.; Xiao, J.; Yin, Q.; Zhang, Z.; Yu, H.; Mao, S.; Li, Y. Smart pH-Sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram. ACS nano 2013, 7(7), 5858-5869.
    • (2013) ACS nano , vol.7 , Issue.7 , pp. 5858-5869
    • Duan, X.1    Xiao, J.2    Yin, Q.3    Zhang, Z.4    Yu, H.5    Mao, S.6    Li, Y.7
  • 79
    • 67249106291 scopus 로고    scopus 로고
    • Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells
    • Ganta, S.; Amiji, M. Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol. Pharm. 2009, 6(3), 928-939.
    • (2009) Mol. Pharm. , vol.6 , Issue.3 , pp. 928-939
    • Ganta, S.1    Amiji, M.2
  • 80
    • 84904727606 scopus 로고    scopus 로고
    • Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: Part I. formulation development, statistical optimization, and in vitrocharacterization
    • Jain, A. K.; Thanki, K.; Jain, S. Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: part I. formulation development, statistical optimization, and in vitrocharacterization. Pharm. Res. 2013, 1-23.
    • (2013) Pharm. Res. , pp. 1-23
    • Jain, A.K.1    Thanki, K.2    Jain, S.3
  • 81
    • 84895927068 scopus 로고    scopus 로고
    • Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: Part II in vivopharmacokinetics, antitumor efficacy and hepatotoxicity
    • Jain, A. K.; Thanki, K.; Jain, S., Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: part II in vivopharmacokinetics, antitumor efficacy and hepatotoxicity. Pharm. Res. 2013, 1-13.
    • (2013) Pharm. Res. , pp. 1-13
    • Jain, A.K.1    Thanki, K.2    Jain, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.