Increased intracellular drug accumulation and complete chemosensitization achieved in multidrug-resistant solid tumors by co- administering valspodar (PSC 833) with sterically stabilized liposomal doxorubicin

International Journal of Cancer

Volumn 85, Issue 1, 2000, Pages 131-141

  Krishna, Rajesh ^a,b,c   St Louis, Maryse ^b   Mayer, Lawrence D ^a,b  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; LIPOSOME; VALSPODAR;

ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHEMOSENSITIVITY; DRUG FORMULATION; DRUG POTENTIATION; DRUG SENSITIVITY; ENCAPSULATION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; SOLID TUMOR; XENOGRAFT;

ANIMALS; CARCINOMA; CELL DIVISION; CYCLOSPORINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INTRACELLULAR FLUID; LIPOSOMES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, SCID; NEOPLASM TRANSPLANTATION; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 0345504156     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000101)85:1<131::AID-IJC23>3.0.CO;2-R     Document Type: Article

References (23)

1. ANDERSEN, A., WARREN, D.J. and STORDAL, L., A sensitive and simple high-performance liquid chromatographic method for the determination of doxorubicin and its metabolites in plasma. Ther. Drug Monit., 15, 455-458 (1993).
2. BALLY, M.B., MAYER, L.D., HOPE, M.J. and NAYAR, R., Pharmacodynamics of liposomal drug carriers: methodological considerations. In: G. Gregoriadis (ed.), Liposome technology, Vol. III, Interactions of liposomes with biological milieu, pp. 27-41. CRC Press, Boca Raton, FL, (1993).
3. BOOTE, D.J., DENNIS, I.F., TWENTYMAN, P.R., OSBORNE, R.J., LABURTE, C., HENSEL, S., SMYTH, J.F., BRAMPTON, M.H. and BLEEHEN, N.M., Phase I study of etoposide with PSC-833 as a modulator of multidrug resistance in patients with cancer. J. clin. Oncol., 14, 610-618 (1996).
4. BOOTH, C.L., BROUWER, K.R. and BROUWER, K.L.R., Effect of multidrug resistance modulators on the hepatobiliary disposition of doxorubicin in the isolated perfused rat liver. Cancer Res., 58, 3641-3648 (1998).
5. DERKSEN, J.T.P., MORSELT, H.W.M. and SCHERPHOF, G.L., Processing of different liposome markers after in vitro uptake of immunoglobulin-coated liposomes by rat liver macrophages. Biochim. biophys. Acta, 931, 33-40 (1987).
6. GATMAITAN, Z. and ARIAS, I., Structure and function of P-glycoprotein in normal liver and small intestine. Adv. Pharmacol., 24, 77-96 (1993).
7. GIBALDI, M., and PERRIER, D., Pharmacokinetics, Marcel Dekker, New York (1982).
8. KELLER, R.P., ALTERMATT, H.J., DONATSCH, P., ZIHLMANN. H., LAISSUE, J.A. and HIESTAND, P.C., Pharmacologic interactions between the resistance-modifying cyclosporine SDZ PSC 833 and etoposide (VP 16-213) enhance in vivo cytostatic activity and toxicity. Int. J. Cancer, 51, 433-438 (1992a).
9. KELLER, R.P., ALTERMATT, H.J., NOOTER, K., POSCHMANN, G., LAISSUE, J.A., BOLLINGER, P. and HIESTAND, P.C., SDZ PSC 833, a non-immunosuppressive cyclosporine: its potency in overcoming P-glycoprotein mediated multidrug resistance of murine leukemia. Int. J. Cancer, 50, 593-597 (1992b).
10. KRISHNA, R. and MAYER, L.D., Liposomal doxorubicin circumvents toxicities associated with non-encapsulated drug-PSC 833 interactions, resulting in effective therapy of multidrug resistant solid tumors. Cancer Res., 57, 5246-5253 (1997).
11. MDRI: ascites models of human breast cancer. Brit. J. Cancer, 73, 154-161 (1996).
12. MAYER, L.D. and ST-ONGE, G., Determination of free and liposome-associated doxorubicin and vincristine levels in plasma under equilibrium conditions employing ultrafiltration technique. Anal. Biochem., 232, 149-157 (1995).
13. MAYER, L.D., TAI, L.C.L., KO, D.S.C., MASIN, D., GINSBERG, R.S., CULLIS, P.R. and BALLY, M.B., Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice. Cancer Res., 49, 5922-5930 (1989).
14. MILLER, T., DAHLBERG, S. and GROGAN, T., Southwest Oncology Group clinical trials of chemosensitizers in non-Hodgkin's lymphomas. Anticancer Drugs, 5, 73 (1994).
15. NOOTER, K., OOSTRUM, R. and DEURLOO, J., Effects of verapamil on the pharmacokinetics of daunomycin in the rat. Cancer Chemother. Pharmacol., 20, 176-178 (1987).
16. PAPAHADJOPOULOS, D., ALLEN, T.M., GABIZON, A., MAYHEW, E., MATTHAY, K., HUANG, S.K., LEE, K.D., WOODLE, M.C., LASIC, D.D., REDEMANN, C. and MARTIN, F.C., Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. nat. Acad. Sci. (Wash.), 88, 11460-11464 (1991).
17. SARRIS, A.H. and 13 OTHERS, Cyclosporin A does not reverse clinical resistance to paclitaxel in patients with relapsed non-Hodgkin's lymphoma. J. clin. Oncol., 14, 233-239 (1996).
18. SCHERPHOF, G.L., ROERDINK, F., DIJKSTRA, J., ELLENS, H., DE ZANGER, R. and WISSE, E., Uptake of liposomes by rat and mouse hepatocytes and Kupffer cells. Biol. Cell., 47, 47 (1983).
19. SPEEG, K.V. and MALDONADO, A.L., Effect of the nonimmunosuppressive cyclosporin analog SDZ PSC-833 on colchicine and doxorubicin biliary secretion by the rat in vivo. Cancer Chemother. Pharmacol., 34, 133-136 (1994).
20. SPEEG, K.V., MALDONADO, A.L., LIACI, J. and MUIRHEAD, D., Effect of cyclosporine on colchicine secretion by a liver canalicular transporter studied in vivo. Hepatology, 15, 899-903 (1992).
21. VRIGNAUD, P., LONDOS-GAGLIARDI, D. and ROBERT, J., Hepatic metabolism of doxorubicin in mice and rats. Europ. J. Drug Metab., Pharmacokinetics, 11, 101-105 (1986).
22. WISHART, G.C., BISSETT, D., PAUL, J., JODRELL, D., HARNETT, A., HABESHAW, T., KERR, D.J., MACHAM, M.A., SOUKOP, M. and LEONARD, R.C., Quinidine as a resistance modulator of epirubicin in advanced breast cancer: mature results of a placebo-controlled trial. J. clin. Oncol., 12, 1771-1777 (1994).
23. WU, N.Z., BRAUN, R.D., GABER, M.H., LIN, G.M., ONG, E.T., SHAN, S., PAPAHADJOPOULOS, D. and DEWHIRST, M.W., Simultaneous measurement of liposome extravasation and content release in tumors. Microcirculation, 4, 83-101 (1997).