Involvement of P-glycoprotein and CYP 3A4 in the enhancement of etoposide bioavailability by a piperine analogue

Chemico-Biological Interactions

Volumn 190, Issue 2-3, 2011, Pages 84-90

  Najar, I A ^a   Sharma, S C ^a   Singh, G D ^a   Koul, S ^a   Gupta, P N ^a   Javed, S ^b   Johri, R K ^a  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b HAMDARD UNIVERSITY   (India)

Author keywords

CYP 3A4; Etoposide; P glycoprotein; Piperine analogue

Indexed keywords

4 ETHYL 5 (3,4 METHYLENEDIOXYPHENYL) 2,4 PENTADIENOIC ACID PIPERIDINE; 7 METHOXYCOUMARIN O DEMETHYLASE; CYTOCHROME P450 3A4; ERYTHROMYCIN N DEMETHYLASE; ETHOXYRESORUFIN DEETHYLASE; ETOPOSIDE; GLYCOPROTEIN P; PIPERIDINE DERIVATIVE; RHODAMINE 123; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEETHYLATION; DEMETHYLATION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG STRUCTURE; DRUG TRANSPORT; FEMALE; INTESTINE ABSORPTION; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PLASMA CLEARANCE; RAT;

ABSORPTION; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL AVAILABILITY; CELL MEMBRANE PERMEABILITY; CYTOCHROME P-450 ENZYME SYSTEM; ETOPOSIDE; FEMALE; INTESTINAL MUCOSA; MALE; MICE; P-GLYCOPROTEIN; PIPERIDINES; RATS; RATS, WISTAR;

ANIMALIA; MUS; RATTUS;

EID: 79955469557     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.02.011     Document Type: Article

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