-
1
-
-
34248590470
-
Mitophagy: Thelife-or-death dichotomy includes yeast
-
Abeliovich H. 2007. Mitophagy: Thelife-or-death dichotomy includes yeast. Autophagy 3: 275-277.
-
(2007)
Autophagy
, vol.3
, pp. 275-277
-
-
Abeliovich, H.1
-
2
-
-
0038156122
-
The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation
-
Aerbajinai W, Giattina M, Lee YT, Raffeld M, Miller JL. 2003. The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. Blood 102: 712-717.
-
(2003)
Blood
, vol.102
, pp. 712-717
-
-
Aerbajinai, W.1
Giattina, M.2
Lee, Y.T.3
Raffeld, M.4
Miller, J.L.5
-
3
-
-
77955448361
-
ATM engages the TSC2/mTORC1 signaling node to regulate autophagy
-
Alexander A, Kim J, Walker CL. 2010. ATM engages the TSC2/mTORC1 signaling node to regulate autophagy. Autophagy 6: 672-673.
-
(2010)
Autophagy
, vol.6
, pp. 672-673
-
-
Alexander, A.1
Kim, J.2
Walker, C.L.3
-
4
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, Mazure NM. 2009. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 29: 2570-2581.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
Pouyssegur, J.6
Mazure, N.M.7
-
5
-
-
77956419439
-
Ketones and lactate fuel tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
-
Bonuccelli G, Tsirigos A, Whitaker-Menezes D, Pavlides S, Pestell RG, Chiavarina B, Frank PG, Flomenberg N, Howell A, Martinez-Outschoorn UE, et al. 2010. Ketones and lactate fuel tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 9: 3506-3514.
-
(2010)
Cell Cycle
, vol.9
, pp. 3506-3514
-
-
Bonuccelli, G.1
Tsirigos, A.2
Whitaker-Menezes, D.3
Pavlides, S.4
Pestell, R.G.5
Chiavarina, B.6
Frank, P.G.7
Flomenberg, N.8
Howell, A.9
Martinez-Outschoorn, U.E.10
-
6
-
-
84868019043
-
Cancer cell metabolism: One hallmark, many faces
-
Cantor JR, Sabatini DM. 2012. Cancer cell metabolism: One hallmark, many faces. Cancer Discov 2: 881-898.
-
(2012)
Cancer Discov
, vol.2
, pp. 881-898
-
-
Cantor, J.R.1
Sabatini, D.M.2
-
7
-
-
84862886876
-
Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
-
Capparelli C, Guido C, Whitaker-Menezes D, Bonuccelli G, Balliet R, Pestell TG, Goldberg AF, Pestell RG, Howell A, Sneddon S, et al. 2012. Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 11: 2285-2302.
-
(2012)
Cell Cycle
, vol.11
, pp. 2285-2302
-
-
Capparelli, C.1
Guido, C.2
Whitaker-Menezes, D.3
Bonuccelli, G.4
Balliet, R.5
Pestell, T.G.6
Goldberg, A.F.7
Pestell, R.G.8
Howell, A.9
Sneddon, S.10
-
8
-
-
79960356284
-
Autophagy contributes to resistance of tumor cells to ionizing radiation
-
Chaachouay H, Ohneseit P, Toulany M, Kehlbach R, Multhoff G, Rodemann HP. 2011. Autophagy contributes to resistance of tumor cells to ionizing radiation. Radiother Oncol 99: 287-292.
-
(2011)
Radiother Oncol
, vol.99
, pp. 287-292
-
-
Chaachouay, H.1
Ohneseit, P.2
Toulany, M.3
Kehlbach, R.4
Multhoff, G.5
Rodemann, H.P.6
-
9
-
-
77950886468
-
Methods for detecting autophagy and determining autophagy-induced cell death
-
Chen Y, Azad MB, Gibson SB. 2010. Methods for detecting autophagy and determining autophagy-induced cell death. Can J Physiol Pharmacol 88: 285-295.
-
(2010)
Can J Physiol Pharmacol
, vol.88
, pp. 285-295
-
-
Chen, Y.1
Azad, M.B.2
Gibson, S.B.3
-
10
-
-
80051706047
-
Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells
-
Chen YS, Song HX, Lu Y, Li X, Chen T, Zhang Y, Xue JX, Liu H, Kan B, Yang G, et al. 2011. Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells. Dis Esophagus 24: 437-443.
-
(2011)
Dis Esophagus
, vol.24
, pp. 437-443
-
-
Chen, Y.S.1
Song, H.X.2
Lu, Y.3
Li, X.4
Chen, T.5
Zhang, Y.6
Xue, J.X.7
Liu, H.8
Kan, B.9
Yang, G.10
-
11
-
-
57749089665
-
Caspasemediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells
-
Cho DH, Jo YK, Hwang JJ, Lee YM, Roh SA, Kim JC. 2009. Caspasemediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells. Cancer Lett 274: 95-100.
-
(2009)
Cancer Lett
, vol.274
, pp. 95-100
-
-
Cho, D.H.1
Jo, Y.K.2
Hwang, J.J.3
Lee, Y.M.4
Roh, S.A.5
Kim, J.C.6
-
12
-
-
84877628647
-
Autophagy in human health and disease
-
Choi AM, Ryter SW, Levine B. 2013a. Autophagy in human health and disease. N Engl J Med 368: 651-662.
-
(2013)
N Engl J Med
, vol.368
, pp. 651-662
-
-
Choi, A.M.1
Ryter, S.W.2
Levine, B.3
-
13
-
-
84877609568
-
Autophagy in human health and disease
-
Choi AM, Ryter SW, Levine B. 2013b. Autophagy in human health and disease. N Engl J Med 368: 1845-1846.
-
(2013)
N Engl J Med
, vol.368
, pp. 1845-1846
-
-
Choi, A.M.1
Ryter, S.W.2
Levine, B.3
-
14
-
-
0000189281
-
Cellular differentiation in the kidneys of newborn mice studies with the electron microscope
-
Clark SL Jr. 1957. Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J Biophys Biochem Cytol 3: 349-362.
-
(1957)
J Biophys Biochem Cytol
, vol.3
, pp. 349-362
-
-
Clark Jr., S.L.1
-
15
-
-
3042562282
-
Pivotal role of the cell death factor BNIP3 in ceramideinduced autophagic cell death in malignant glioma cells
-
Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S. 2004. Pivotal role of the cell death factor BNIP3 in ceramideinduced autophagic cell death in malignant glioma cells. Cancer Res 64: 4286-4293.
-
(2004)
Cancer Res
, vol.64
, pp. 4286-4293
-
-
Daido, S.1
Kanzawa, T.2
Yamamoto, A.3
Takeuchi, H.4
Kondo, Y.5
Kondo, S.6
-
16
-
-
67649607465
-
Autophagy, immunity, and microbial adaptations
-
Deretic V, Levine B. 2009. Autophagy, immunity, and microbial adaptations . Cell Host Microbe 5: 527-549.
-
(2009)
Cell Host Microbe
, vol.5
, pp. 527-549
-
-
Deretic, V.1
Levine, B.2
-
17
-
-
77950252174
-
Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1
-
Djavaheri-Mergny M, Maiuri MC, Kroemer G. 2010. Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene 29: 1717-1719.
-
(2010)
Oncogene
, vol.29
, pp. 1717-1719
-
-
Djavaheri-Mergny, M.1
Maiuri, M.C.2
Kroemer, G.3
-
18
-
-
80052381384
-
Seeing is believing: The impact of electron microscopy on autophagy research
-
Eskelinen EL, Reggiori F, Baba M, Kovacs AL, Seglen PO. 2011. Seeing is believing: the impact of electron microscopy on autophagy research. Autophagy 7: 935-956.
-
(2011)
Autophagy
, vol.7
, pp. 935-956
-
-
Eskelinen, E.L.1
Reggiori, F.2
Baba, M.3
Kovacs, A.L.4
Seglen, P.O.5
-
19
-
-
80052606545
-
High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas
-
Giatromanolaki A, Koukourakis MI, Koutsopoulos A, Chloropoulou P, Liberis V, Sivridis E. 2011. High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas. Gynecol Oncol 123: 147-151.
-
(2011)
Gynecol Oncol
, vol.123
, pp. 147-151
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Koutsopoulos, A.3
Chloropoulou, P.4
Liberis, V.5
Sivridis, E.6
-
20
-
-
84865335195
-
Metabolic reprogramming of cancer-associated fibroblasts by TGF-beta drives tumor growth: Connecting TGF-beta signaling with Warburg-like cancer metabolism and L-lactate production
-
Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Ando S, Martinez-Outschoorn U, et al. 2012. Metabolic reprogramming of cancer-associated fibroblasts by TGF-beta drives tumor growth: Connecting TGF-beta signaling with Warburg-like cancer metabolism and L-lactate production. Cell Cycle 11: 3019-3035.
-
(2012)
Cell Cycle
, vol.11
, pp. 3019-3035
-
-
Guido, C.1
Whitaker-Menezes, D.2
Capparelli, C.3
Balliet, R.4
Lin, Z.5
Pestell, R.G.6
Howell, A.7
Aquila, S.8
Ando, S.9
Martinez-Outschoorn, U.10
-
21
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, et al. 2011. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis . Genes Dev 25: 460-470.
-
(2011)
Genes Dev
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
Karsli-Uzunbas, G.6
Kamphorst, J.J.7
Chen, G.8
Lemons, J.M.9
Karantza, V.10
-
22
-
-
44949230260
-
N-acetylphytosphingosine enhances the radiosensitivity of lung cancer cell line NCI-H460
-
Han Y, Kim K, Shim JY, Park C, Song JY, Yun YS. 2008. N-acetylphytosphingosine enhances the radiosensitivity of lung cancer cell line NCI-H460. Mol Cells 25: 224-230.
-
(2008)
Mol Cells
, vol.25
, pp. 224-230
-
-
Han, Y.1
Kim, K.2
Shim, J.Y.3
Park, C.4
Song, J.Y.5
Yun, Y.S.6
-
23
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, et al. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889.
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
Yokoyama, M.7
Mishima, K.8
Saito, I.9
Okano, H.10
-
24
-
-
75649114258
-
Autophagy in immunity against intracellular bacteria
-
Huang J, Brumell JH. 2009. Autophagy in immunity against intracellular bacteria. Curr Top Microbiol Immunol 335: 189-215.
-
(2009)
Curr Top Microbiol Immunol
, vol.335
, pp. 189-215
-
-
Huang, J.1
Brumell, J.H.2
-
25
-
-
79959874238
-
The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella
-
Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T. 2011. The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. Mol Biol Cell 22: 2290-2300.
-
(2011)
Mol Biol Cell
, vol.22
, pp. 2290-2300
-
-
Kageyama, S.1
Omori, H.2
Saitoh, T.3
Sone, T.4
Guan, J.L.5
Akira, S.6
Imamoto, F.7
Noda, T.8
Yoshimori, T.9
-
26
-
-
79952628267
-
The Beclin 1 network regulates autophagy and apoptosis
-
Kang R, Zeh HJ, Lotze MT, Tang D. 2011. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18: 571-580.
-
(2011)
Cell Death Differ
, vol.18
, pp. 571-580
-
-
Kang, R.1
Zeh, H.J.2
Lotze, M.T.3
Tang, D.4
-
27
-
-
13944256602
-
Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3
-
Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. 2005. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 24: 980-991.
-
(2005)
Oncogene
, vol.24
, pp. 980-991
-
-
Kanzawa, T.1
Zhang, L.2
Xiao, L.3
Germano, I.M.4
Kondo, Y.5
Kondo, S.6
-
28
-
-
56449111580
-
Surgical management of hip fractures: An evidence-based review of the literature II: Intertrochanteric fractures
-
Kaplan K, Miyamoto R, Levine BR, Egol KA, Zuckerman JD. 2008. Surgical management of hip fractures: An evidence-based review of the literature. II: Intertrochanteric fractures. J Am Acad Orthop Surg 16: 665-673.
-
(2008)
J Am Acad Orthop Surg
, vol.16
, pp. 665-673
-
-
Kaplan, K.1
Miyamoto, R.2
Levine, B.R.3
Egol, K.A.4
Zuckerman, J.D.5
-
29
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J, Kundu M, Viollet B, Guan KL. 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13: 132-141.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
30
-
-
84862295360
-
Guidelines for the use and interpretation of assays for monitoring autophagy
-
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al. 2012. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8: 445-544.
-
(2012)
Autophagy
, vol.8
, pp. 445-544
-
-
Klionsky, D.J.1
Abdalla, F.C.2
Abeliovich, H.3
Abraham, R.T.4
Acevedo-Arozena, A.5
Adeli, K.6
Agholme, L.7
Agnello, M.8
Agostinis, P.9
Aguirre-Ghiso, J.A.10
-
31
-
-
79955398591
-
Otto Warburg s contributions to current concepts of cancer metabolism
-
Koppenol WH, Bounds PL, Dang CV. 2011. Otto Warburg s contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325-337.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
32
-
-
84883521392
-
The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia
-
Koritzinsky M, Wouters BG. 2013. The roles of reactive oxygen species and autophagy in mediating the tolerance of tumor cells to cycling hypoxia. Semin Radiat Oncol 23: 252-261.
-
(2013)
Semin Radiat Oncol
, vol.23
, pp. 252-261
-
-
Koritzinsky, M.1
Wouters, B.G.2
-
33
-
-
77957993522
-
Beclin 1 over-and underexpression in colorectal cancer: Distinct patterns relate to prognosis and tumour hypoxia
-
Koukourakis MI, Giatromanolaki A, Sivridis E, Pitiakoudis M, Gatter KC, Harris AL. 2010. Beclin 1 over-and underexpression in colorectal cancer: Distinct patterns relate to prognosis and tumour hypoxia. Br J Cancer 103: 1209-1214.
-
(2010)
Br J Cancer
, vol.103
, pp. 1209-1214
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Pitiakoudis, M.4
Gatter, K.C.5
Harris, A.L.6
-
34
-
-
11144245626
-
Therole of autophagy during the early neonatal starvation period
-
Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T, Mizushima N. 2004. Therole of autophagy during the early neonatal starvation period. Nature 432: 1032-1036.
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
35
-
-
78751672975
-
Autophagy in immunity and inflammation
-
Levine B, Mizushima N, Virgin HW. 2011. Autophagy in immunity and inflammation. Nature 469: 323-335.
-
(2011)
Nature
, vol.469
, pp. 323-335
-
-
Levine, B.1
Mizushima, N.2
Virgin, H.W.3
-
36
-
-
54449091476
-
CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
-
Liakou CI, Kamat A, Tang DN, Chen H, Sun J, Troncoso P, Logothetis C, Sharma P. 2008. CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci USA 105: 14987-14992.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14987-14992
-
-
Liakou, C.I.1
Kamat, A.2
Tang, D.N.3
Chen, H.4
Sun, J.5
Troncoso, P.6
Logothetis, C.7
Sharma, P.8
-
37
-
-
78649308481
-
The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells
-
Lian J, Karnak D, Xu L. 2010. The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy 6: 1201-1203.
-
(2010)
Autophagy
, vol.6
, pp. 1201-1203
-
-
Lian, J.1
Karnak, D.2
Xu, L.3
-
38
-
-
33846204370
-
UVRAG: A new player in autophagy and tumor cell growth
-
Liang C, Feng P, Ku B, Oh BH, Jung JU. 2007. UVRAG: A new player in autophagy and tumor cell growth. Autophagy 3: 69-71.
-
(2007)
Autophagy
, vol.3
, pp. 69-71
-
-
Liang, C.1
Feng, P.2
Ku, B.3
Oh, B.H.4
Jung, J.U.5
-
39
-
-
33745751085
-
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
-
Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. 2006. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 8: 688-699.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 688-699
-
-
Liang, C.1
Feng, P.2
Ku, B.3
Dotan, I.4
Canaani, D.5
Oh, B.H.6
Jung, J.U.7
-
40
-
-
46449120732
-
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
-
Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, et al. 2008. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 10: 776-787.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 776-787
-
-
Liang, C.1
Lee, J.S.2
Inn, K.S.3
Gack, M.U.4
Li, Q.5
Roberts, E.A.6
Vergne, I.7
Deretic, V.8
Feng, P.9
Akazawa, C.10
-
41
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. 1999. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
42
-
-
34547132328
-
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3
-
Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. 2007. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem 282: 18573-18583.
-
(2007)
J Biol Chem
, vol.282
, pp. 18573-18583
-
-
Marino, G.1
Salvador-Montoliu, N.2
Fueyo, A.3
Knecht, E.4
Mizushima, N.5
Lopez-Otin, C.6
-
43
-
-
84864667633
-
Bcl-2:Beclin 1 complex: Multiple, mechanisms regulating autophagy/apoptosis toggle switch
-
Marquez RT, Xu L. 2012. Bcl-2:Beclin 1 complex: Multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res 2: 214-221.
-
(2012)
Am J Cancer Res
, vol.2
, pp. 214-221
-
-
Marquez, R.T.1
Xu, L.2
-
44
-
-
79961101955
-
Cancer cells metabolically fertilize the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: Implications for PET imaging of human tumors
-
Martinez-Outschoorn UE, Lin Z, Trimmer C, Flomenberg N, Wang C, Pavlides S, Pestell RG, Howell A, Sotgia F, Lisanti MP. 2011. Cancer cells metabolically fertilize the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: Implications for PET imaging of human tumors. Cell Cycle 10: 2504-2520.
-
(2011)
Cell Cycle
, vol.10
, pp. 2504-2520
-
-
Martinez-Outschoorn, U.E.1
Lin, Z.2
Trimmer, C.3
Flomenberg, N.4
Wang, C.5
Pavlides, S.6
Pestell, R.G.7
Howell, A.8
Sotgia, F.9
Lisanti, M.P.10
-
45
-
-
77954162846
-
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
-
Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes D, Daumer KM, Lin Z, Witkiewicz AK, et al. 2010. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 9: 3256-3276.
-
(2010)
Cell Cycle
, vol.9
, pp. 3256-3276
-
-
Martinez-Outschoorn, U.E.1
Balliet, R.M.2
Rivadeneira, D.B.3
Chiavarina, B.4
Pavlides, S.5
Wang, C.6
Whitaker-Menezes, D.7
Daumer, K.M.8
Lin, Z.9
Witkiewicz, A.K.10
-
46
-
-
64049086758
-
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
-
Matsunaga K, Saitoh T, Tabata K, Omori H, Satoh T, Kurotori N, Maejima I, Shirahama-Noda K, Ichimura T, Isobe T, et al. 2009. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol 11: 385-396.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 385-396
-
-
Matsunaga, K.1
Saitoh, T.2
Tabata, K.3
Omori, H.4
Satoh, T.5
Kurotori, N.6
Maejima, I.7
Shirahama-Noda, K.8
Ichimura, T.9
Isobe, T.10
-
47
-
-
59249095218
-
Methods for monitoring autophagy using GFPLC3 transgenic mice
-
Mizushima N. 2009. Methods for monitoring autophagy using GFPLC3 transgenic mice. Methods Enzymol 452: 13-23.
-
(2009)
Methods Enzymol
, vol.452
, pp. 13-23
-
-
Mizushima, N.1
-
48
-
-
75749122303
-
Methods in mammalian autophagy research
-
Mizushima N, Yoshimori T, Levine B. 2010. Methods in mammalian autophagy research. Cell 140: 313-326.
-
(2010)
Cell
, vol.140
, pp. 313-326
-
-
Mizushima, N.1
Yoshimori, T.2
Levine, B.3
-
49
-
-
8344247016
-
Autophagy defends cells against invading group A Streptococcus
-
Nakagawa I, Amano A, Mizushima N, Yamamoto A, Yamaguchi H, Kamimoto T, Nara A, Funao J, Nakata M, Tsuda K, et al. 2004. Autophagy defends cells against invading group A Streptococcus. Science 306: 1037-1040.
-
(2004)
Science
, vol.306
, pp. 1037-1040
-
-
Nakagawa, I.1
Amano, A.2
Mizushima, N.3
Yamamoto, A.4
Yamaguchi, H.5
Kamimoto, T.6
Nara, A.7
Funao, J.8
Nakata, M.9
Tsuda, K.10
-
50
-
-
34250828455
-
Proteomic analysis of membrane-associated proteins from rat liver autophagosomes
-
Overbye A, Fengsrud M, Seglen PO. 2007. Proteomic analysis of membrane-associated proteins from rat liver autophagosomes. Autophagy 3: 300-322.
-
(2007)
Autophagy
, vol.3
, pp. 300-322
-
-
Overbye, A.1
Fengsrud, M.2
Seglen, P.O.3
-
51
-
-
77956399968
-
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
-
Pavlides S, Tsirigos A, Migneco G, Whitaker-Menezes D, Chiavarina B, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, et al. 2010. The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism. Cell Cycle 9: 3485-3505.
-
(2010)
Cell Cycle
, vol.9
, pp. 3485-3505
-
-
Pavlides, S.1
Tsirigos, A.2
Migneco, G.3
Whitaker-Menezes, D.4
Chiavarina, B.5
Flomenberg, N.6
Frank, P.G.7
Casimiro, M.C.8
Wang, C.9
Pestell, R.G.10
-
52
-
-
84880133893
-
The use of electron microscopy for the detection of autophagy in human atherosclerosis
-
Perrotta I. 2013. The use of electron microscopy for the detection of autophagy in human atherosclerosis. Micron 50: 7-13.
-
(2013)
Micron
, vol.50
, pp. 7-13
-
-
Perrotta, I.1
-
53
-
-
78149475088
-
Regulation of mammalian autophagy in physiology and pathophysiology
-
Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, et al. 2010. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 90: 1383-1435.
-
(2010)
Physiol Rev
, vol.90
, pp. 1383-1435
-
-
Ravikumar, B.1
Sarkar, S.2
Davies, J.E.3
Futter, M.4
Garcia-Arencibia, M.5
Green-Thompson, Z.W.6
Jimenez-Sanchez, M.7
Korolchuk, V.I.8
Lichtenberg, M.9
Luo, S.10
-
54
-
-
74949118681
-
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
-
Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, et al. 2010. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest 120: 127-141.
-
(2010)
J Clin Invest
, vol.120
, pp. 127-141
-
-
Rouschop, K.M.1
Van Den Beucken, T.2
Dubois, L.3
Niessen, H.4
Bussink, J.5
Savelkouls, K.6
Keulers, T.7
Mujcic, H.8
Landuyt, W.9
Voncken, J.W.10
-
55
-
-
47049100413
-
Essential role for Nix in autophagic maturation of erythroid cells
-
Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. 2008. Essential role for Nix in autophagic maturation of erythroid cells. Nature 454: 232-235.
-
(2008)
Nature
, vol.454
, pp. 232-235
-
-
Sandoval, H.1
Thiagarajan, P.2
Dasgupta, S.K.3
Schumacher, A.4
Prchal, J.T.5
Chen, M.6
Wang, J.7
-
56
-
-
84887018838
-
The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia
-
Schaaf MB, Cojocari D, Keulers TG, Jutten B, Starmans MH, de Jong MC, Begg AC, Savelkouls KG, Bussink J, Vooijs M, et al. 2013. The autophagy associated gene, ULK1, promotes tolerance to chronic and acute hypoxia. Radiother Oncol 108: 529-534.
-
(2013)
Radiother Oncol
, vol.108
, pp. 529-534
-
-
Schaaf, M.B.1
Cojocari, D.2
Keulers, T.G.3
Jutten, B.4
Starmans, M.H.5
De Jong, M.C.6
Begg, A.C.7
Savelkouls, K.G.8
Bussink, J.9
Vooijs, M.10
-
57
-
-
34250825929
-
Oxidation as a post-translational modification that regulates autophagy
-
Scherz-Shouval R, Shvets E, Elazar Z. 2007a. Oxidation as a post-translational modification that regulates autophagy. Autophagy 3: 371-373.
-
(2007)
Autophagy
, vol.3
, pp. 371-373
-
-
Scherz-Shouval, R.1
Shvets, E.2
Elazar, Z.3
-
58
-
-
34247186472
-
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
-
Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. 2007b. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26: 1749-1760.
-
(2007)
EMBO J
, vol.26
, pp. 1749-1760
-
-
Scherz-Shouval, R.1
Shvets, E.2
Fass, E.3
Shorer, H.4
Gil, L.5
Elazar, Z.6
-
59
-
-
37649017266
-
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
-
Schweers RL, Zhang J, Randall MS, Loyd MR, Li W, Dorsey FC, Kundu M, Opferman JT, Cleveland JL, Miller JL, et al. 2007. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci USA 104: 19500-19505.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19500-19505
-
-
Schweers, R.L.1
Zhang, J.2
Randall, M.S.3
Loyd, M.R.4
Li, W.5
Dorsey, F.C.6
Kundu, M.7
Opferman, J.T.8
Cleveland, J.L.9
Miller, J.L.10
-
60
-
-
84877329400
-
Angiogenic growth factor axis in autophagy regulation
-
Stanton MJ, Dutta S, Polavaram NS, Roy S, Muders MH, Datta K. 2013a. Angiogenic growth factor axis in autophagy regulation. Autophagy 9: 789-790.
-
(2013)
Autophagy
, vol.9
, pp. 789-790
-
-
Stanton, M.J.1
Dutta, S.2
Polavaram, N.S.3
Roy, S.4
Muders, M.H.5
Datta, K.6
-
61
-
-
84871980877
-
Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance
-
Stanton MJ, Dutta S, Zhang H, Polavaram NS, Leontovich AA, Honscheid P, Sinicrope FA, Tindall DJ, Muders MH, Datta K. 2013b. Autophagy control by the VEGF-C/NRP-2 axis in cancer and its implication for treatment resistance. Cancer Res 73: 160-171.
-
(2013)
Cancer Res
, vol.73
, pp. 160-171
-
-
Stanton, M.J.1
Dutta, S.2
Zhang, H.3
Polavaram, N.S.4
Leontovich, A.A.5
Honscheid, P.6
Sinicrope, F.A.7
Tindall, D.J.8
Muders, M.H.9
Datta, K.10
-
62
-
-
34848899280
-
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
-
Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mule JJ, et al. 2007. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis . Nat Cell Biol 9: 1142-1151.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
Coppola, D.2
Matsushita, N.3
Cualing, H.D.4
Sun, M.5
Sato, Y.6
Liang, C.7
Jung, J.U.8
Cheng, J.Q.9
Mule, J.J.10
-
63
-
-
79955377420
-
Autophagy-deficient mice develop multiple liver tumors
-
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K, Mizushima N. 2011. Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25: 795-800.
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
Komatsu, M.2
Hara, T.3
Sakamoto, A.4
Kishi, C.5
Waguri, S.6
Eishi, Y.7
Hino, O.8
Tanaka, K.9
Mizushima, N.10
-
64
-
-
34548235820
-
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy
-
Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF. 2007. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol 27: 6229-6242.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 6229-6242
-
-
Tracy, K.1
Dibling, B.C.2
Spike, B.T.3
Knabb, J.R.4
Schumacker, P.5
Macleod, K.F.6
-
65
-
-
79957644595
-
Sensitizing effect of 3-methyladenine on radiation-induced cytotoxicity in radio-resistant HepG2 cell in vitro and in tumor xenografts
-
Tseng HC, Liu WS, Tyan YS, Chiang HC, Kuo WH, Chou FP. 2011. Sensitizing effect of 3-methyladenine on radiation-induced cytotoxicity in radio-resistant HepG2 cell in vitro and in tumor xenografts. Chem Biol Interact 192: 201-208.
-
(2011)
Chem Biol Interact
, vol.192
, pp. 201-208
-
-
Tseng, H.C.1
Liu, W.S.2
Tyan, Y.S.3
Chiang, H.C.4
Kuo, W.H.5
Chou, F.P.6
-
66
-
-
2442668926
-
Hereditary early-onset Parkinson s disease caused by mutations in PINK1
-
Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, et al. 2004. Hereditary early-onset Parkinson s disease caused by mutations in PINK1. Science 304: 1158-1160.
-
(2004)
Science
, vol.304
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
Del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
-
67
-
-
53549132786
-
Beclin 1 bridges autophagy, apoptosis and differentiation
-
Wang J. 2008. Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy 4: 947-948.
-
(2008)
Autophagy
, vol.4
, pp. 947-948
-
-
Wang, J.1
-
68
-
-
84869147050
-
Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation
-
Wang RC, Wei Y, An Z, Zou Z, Xiao G, Bhagat G, White M, Reichelt J, Levine B. 2012. Akt-mediated regulation of autophagy and tumorigenesis through Beclin 1 phosphorylation. Science 338: 956-959.
-
(2012)
Science
, vol.338
, pp. 956-959
-
-
Wang, R.C.1
Wei, Y.2
An, Z.3
Zou, Z.4
Xiao, G.5
Bhagat, G.6
White, M.7
Reichelt, J.8
Levine, B.9
-
69
-
-
84858604270
-
Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
-
Ward PS, Thompson CB. 2012. Metabolic reprogramming: A cancer hallmark even warburg did not anticipate. Cancer Cell 21: 297-308.
-
(2012)
Cancer Cell
, vol.21
, pp. 297-308
-
-
Ward, P.S.1
Thompson, C.B.2
-
70
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson WR, Hay MP. 2011. Targeting hypoxia in cancer therapy. Nat Rev Cancer 11: 393-410.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
71
-
-
78649636176
-
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
-
Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I, Roelandt R, De Rycke R, Verspurten J, Declercq W, et al. 2010. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 1: e18.
-
(2010)
Cell Death Dis
, vol.1
-
-
Wirawan, E.1
Vande Walle, L.2
Kersse, K.3
Cornelis, S.4
Claerhout, S.5
Vanoverberghe, I.6
Roelandt, R.7
De Rycke, R.8
Verspurten, J.9
Declercq, W.10
-
72
-
-
84873030827
-
Expression and signifi cance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer
-
Xu LW, Qian M, Jia RP, Xu Z, Wu JP, Li WC, Huang WB, Chen XG. 2012. Expression and signifi cance of microsomal prostaglandin synthase-1 (mPGES-1) and Beclin-1 in the development of prostate cancer. Asian Pac J Cancer Prev 13: 1639-1644.
-
(2012)
Asian Pac J Cancer Prev
, vol.13
, pp. 1639-1644
-
-
Xu, L.W.1
Qian, M.2
Jia, R.P.3
Xu, Z.4
Wu, J.P.5
Li, W.C.6
Huang, W.B.7
Chen, X.G.8
-
73
-
-
58149392999
-
Role of apoptosis-regulating signal kinase 1 in innate immune responses by Mycobacterium bovis bacillus Calmette-Guerin
-
Yuk JM, Shin DM, Yang CS, Kim KH, An SJ, Rho J, Park JK, Jo EK. 2009. Role of apoptosis-regulating signal kinase 1 in innate immune responses by Mycobacterium bovis bacillus Calmette-Guerin. Immunol Cell Biol 87: 100-107.
-
(2009)
Immunol Cell Biol
, vol.87
, pp. 100-107
-
-
Yuk, J.M.1
Shin, D.M.2
Yang, C.S.3
Kim, K.H.4
An, S.J.5
Rho, J.6
Park, J.K.7
Jo, E.K.8
-
74
-
-
70349331678
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
-
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, et al. 2009. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 325: 1555-1559.
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
Schmidt, K.7
Willson, J.K.8
Markowitz, S.9
Zhou, S.10
-
75
-
-
65949083995
-
Cell biology: Another way to get rid of fat
-
Zechner R, Madeo F. 2009. Cell biology: Another way to get rid of fat. Nature 458: 1118-1119.
-
(2009)
Nature
, vol.458
, pp. 1118-1119
-
-
Zechner, R.1
Madeo, F.2
-
76
-
-
67549101188
-
Role of BNIP3 and NIX in cell death, autophagy, and mitophagy
-
Zhang J, Ney PA. 2009. Role of BNIP3 and NIX in cell death, autophagy, and mitophagy. Cell Death Differ 16: 939-946.
-
(2009)
Cell Death Differ
, vol.16
, pp. 939-946
-
-
Zhang, J.1
Ney, P.A.2
-
77
-
-
79953230490
-
Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis
-
Zhu Y, Zhao L, Liu L, Gao P, Tian W, Wang X, Jin H, Xu H, Chen Q. 2010. Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein Cell 1: 468-477.
-
(2010)
Protein Cell
, vol.1
, pp. 468-477
-
-
Zhu, Y.1
Zhao, L.2
Liu, L.3
Gao, P.4
Tian, W.5
Wang, X.6
Jin, H.7
Xu, H.8
Chen, Q.9
-
78
-
-
78651359429
-
Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy
-
Zhuang W, Li B, Long L, Chen L, Huang Q, Liang ZQ. 2011. Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy. Brain Res 1371: 7-15.
-
(2011)
Brain Res
, vol.1371
, pp. 7-15
-
-
Zhuang, W.1
Li, B.2
Long, L.3
Chen, L.4
Huang, Q.5
Liang, Z.Q.6
|