Expression and significance of microsomal prostaglandin synthase-1 (mPGES-1) and beclin-1 in the development of prostate cancer

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 4, 2012, Pages 1639-1644

  Xu, Lu Wei ^a   Qian, Ming ^a   Jia, Rui Peng ^a   Xu, Zheng ^a   Wu, Jian Ping ^a   Li, Wen Cheng ^a   Huang, Wen Bin ^a   Huang, Xing Guo ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

1; Beclin; E synthase; Microsomal prostaglandin; Prostatic neoplasms

Indexed keywords

4 (BENZO(B)THIOPHEN 2 YL) 3 BROMO 5 HYDROXYDIHYDROFURAN 2(3H) ONE; 4-(BENZO(B)THIOPHEN-2-YL)-3-BROMO-5-HYDROXYDIHYDROFURAN-2(3H)-ONE; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; ISOMERASE; MEMBRANE PROTEIN; PROSTAGLANDIN E SYNTHASE; THIOPHENE DERIVATIVE;

ADENOCARCINOMA; AGE; AGED; ANALYSIS OF VARIANCE; ARTICLE; CANCER GRADING; CANCER STAGING; CELL PROLIFERATION; CELL SURVIVAL; CHI SQUARE DISTRIBUTION; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; MALE; METABOLISM; MICROSOME; MIDDLE AGED; PATHOLOGY; PROSTATE; PROSTATE HYPERTROPHY; PROSTATE TUMOR; TUMOR CELL LINE; UPREGULATION;

4-BUTYROLACTONE; ADENOCARCINOMA; AGE FACTORS; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHI-SQUARE DISTRIBUTION; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; MALE; MEMBRANE PROTEINS; MICROSOMES; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; PROSTATE; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; THIOPHENES; UP-REGULATION;

EID: 84873030827     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.4.1639     Document Type: Article

References (38)

1. Banning A, Florian S, Deubel S, et al (2008). GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Antioxid Redox Signal, 10, 1491-500.
2. Beales IL, Ogunwobi OO (2010). Microsomal prostaglandin E synthase-1 inhibition blocks proliferation and enhances apoptosis in oesophageal adenocarcinoma cells without affecting endothelial prostacyclin production. Int J Cancer, 126, 2247-55.
3. Bhutia SK, Dash R, Das SK, et al (2010). Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiationassociated gene 7/interleukin-24. Cancer Res, 70, 3667-76.
4. Cheng Y, Qiu F, Ye YC, et al (2009). Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38- nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells. FEBS J, 276, 1291-306.
5. Cheng Y, Wang M, Yu Y, et al (2006). Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J Clin Invest, 116, 1391-9.
6. Ciechomska IA, Goemans GC, Skepper JN, Tolkovsky AM (2009). Bcl-2 complexed with Beclin-1 maintains full antiapoptotic function. Oncogene, 28, 2128-41.
7. Chen N, Karantza-Wadsworth V (2009). Role and regulation of autophagy in cancer. Biochim Biophys Acta, 1793, 1516-23.
8. Gao X, Zacharek A, Salkowski A, et al (1995). Loss of heterozygosity of the BRCA1 and other loci on chromosome 17q in human prostate cancer. Cancer Res, 55, 1002-5.
9. Hanaka H, Pawelzik SC, Johnsen JI, et al (2009). Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells. Proc Natl Acad Sci U S A, 106, 18757-62.
10. Hellerstedt BA, Pienta KJ (2002). The current state of hormonal therapy for prostate cancer. CA Cancer J Clin, 52, 154-79.
11. Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B (1999). Identification of human prostaglandin E synthase:a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A, 96, 7220-5.
12. Jain S, Chakraborty G, Raja R, Kale S, Kundu GC (2008). Prostaglandin E2 regulates tumor angiogenesis in prostate cancer. Cancer Res, 68, 7750-9.
13. Jia RP, Xu LW, Su Q, et al (2008). Cyclooxygenase-2 expression is dependent upon epidermal growth factor receptor expression or activation in androgen independent prostate cancer. Asian J Androl, 10, 758-64.
14. Kawata R, Hyo S, Araki M, Takenaka H (2010). Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 in head and neck squamous cell carcinoma. Auris Nasus Larynx, 37, 482-7.
15. Lalier L, Cartron PF, Pedelaborde F, et al (2007). Increase in PGE2 biosynthesis induces a Bax dependent apoptosis correlated to patients' survival in glioblastoma multiforme. Oncogene, 26, 4999-5009.
16. Lau KM, LaSpina M, Long J, Ho SM (2000). Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation. Cancer Res, 60, 3175-82.
17. Lee LM, Pan CC, Cheng CJ, Chi CW, Liu TY (2001). Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia. Anticancer Res, 21, 1291-4.
18. Liang XH, Kleeman LK, Jiang HH, et al (1998). Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol, 72, 8586-96.
19. Lian J, Karnak D, Xu L (2010). The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells. Autophagy, 6, 1201-3.
20. Lian J, Wu X, He F, et al (2011). A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ, 18, 60-71.
21. Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK (2009). Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway. Cancer Lett, 275, 54-60.
22. Madaan S, Abel PD, Chaudhary KS, et al (2000). Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications forprevention and treatment. BJU Int, 86, 736-41.
23. Miracco C, Cosci E, Oliveri et al (2007). Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours. Int J Oncol, 30, 429-36.
24. Myung SJ, Kim IH (2008). Role of prostaglandins in colon cancer. Korean J Gastroenterol, 51, 274-9.
25. Murakami M, Naraba H, Tanioka T, et al (2000). Regulation of prostaglandin E2 biosynthesis by inducible membraneassociated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem, 275, 32783-92.
26. Nakanishi M, Montrose DC, Clark P, et al (2008). Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. Cancer Res, 68, 3251-9.
27. Nakanishi M, Gokhale V, Meuillet EJ, Rosenberg DW (2010). mPGES-1 as a target for cancer suppression:A comprehensive invited review "Phospholipase A2 and lipid mediators". Biochimie, 92, 660-4.
28. Pattingre S, Levine B (2006). Bcl-2 inhibition of autophagy:a new route to cancer? Cancer Res, 66, 2885-8.
29. Pecchi E, Dallaporta M, Jean A, Thirion S, Troadec JD (2008). mPGES-1 knock-out mice are resistant to cancer-induced anorexia despite the absence of central mPGES-1 upregulation in wild-type anorexic mice. J Neuroimmunol, 199, 104-14.
30. Qu X, Yu J, Bhagat G, et al (2003). Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest, 112, 1809-20.
31. Rask K, Zhu Y, Wang W, Hedin L, Sundfeldt K (2006). Ovarian epithelial cancer:a role for PGE2-synthesis and signalling in malignant transformation and progression. Mol Cancer, 5, 62.
32. Samuelsson B, Morgenstern R, Jakobsson PJ (2007). Membrane prostaglandin E synthase-1, a novel therapeutic target. Pharmacol Rev, 59, 207-24.
33. Smith MR, Manola J, Kaufman DS, et al (2006). Celecoxib versus placebo for men with prostate cancer and a rising serum prostate-specific antigen after radical prostatectomy and/or radiation therapy. J Clin Oncol, 24, 2723-8.
34. Srivastava JK, Pandey M, Gupta S (2009). Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life Sci, 85, 663-9.
35. Takasu S, Tsukamoto T, Cao XY, et al (2008). Roles of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 expression and beta-catenin activationin gastric carcinogenesis in N-methyl-N-nitrosourea-treated K19- C2mE transgenic mice. Cancer Sci, 99, 2356-64.
36. Wang M, Zukas AM, Hui Y, et al (2006). Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proc Natl Acad Sci U S A, 103, 14507-12.
37. Wingo PA, Cardinez CJ, Landis SH, et al (2003). Long-term trends in cancer mortality in the United States, 1930-1998. Cancer, 97, 3133-275.
38. Wu D, Mennerich D, Arndt K, et al (2009). Comparison of microsomal prostaglandin E synthase-1 deletion and COX-2 inhibition in acute cardiac ischemia in mice. Prostaglandins Other Lipid Mediat, 90, 21-5.