Sensitizing effect of 3-methyladenine on radiation-induced cytotoxicity in radio-resistant HepG2 cells in vitro and in tumor xenografts

Chemico-Biological Interactions

Volumn 192, Issue 3, 2011, Pages 201-208

  Tseng, Hsien Chun ^a,b   Liu, Wen Shan ^b   Tyan, Yeu Sheng ^b   Chiang, Huei Ching ^b   Kuo, Wu Hsien ^c,d,e   Chou, Fen Pi ^a,e  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^d CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e HUALIEN ARMED FORCES GENERAL HOSPITAL   (Taiwan)

Author keywords

Autophagy; Liver cancer; Radio resistance

Indexed keywords

3 METHYLADENINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; ELECTRON MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; RADIOSENSITIVITY; RADIOSENSITIZATION; TUMOR XENOGRAFT; WESTERN BLOTTING;

ADENINE; ANIMALS; APOPTOSIS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; MUS MUSCULUS;

EID: 79957644595     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.03.011     Document Type: Article

References (38)

1. C.M. Lo, H. Ngan, W.K. Tso, C.L. Liu, C.M. Lam, R.T. Poon, S.T. Fan, J. Wong, Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma, Hepatology 35 (2002) 1164-1171. (Pubitemid 34454013)
2. R. Murakami, S. Yoshimatsu, Y. Yamashita, K. Sagara, A. Arakawa, M. Takahashi, Transcatheter hepatic subsegmental arterial chemoembolization therapy using iodized oil for small hepatocellular carcinomas. Correlation between lipiodol accumulation pattern and local recurrence, Acta. Radiol. 35 (1994) 576-580.
3. R. Murakami, S. Yoshimatsu, Y. Yamashita, T. Matsukawa, M. Takahashi, K. Sagara, Treatment of hepatocellular carcinoma: value of percutaneous microwave coagulation, AJR. Am. J. Roentgenol. 164 (1995) 1159-1164.
4. R. Tateishi, S. Shiina, T. Teratani, S. Obi, S. Sato, Y. Koike, T. Fujishima, H. Yoshida, T. Kawabe, M. Omata, Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases, Cancer 103 (2005) 1201-1209. (Pubitemid 40328091)
5. R. Toya, R. Murakami, Y. Baba, R. Nishimura, S. Morishita, O. Ikeda, K. Kawanaka, T. Beppu, S. Sugiyama, T. Sakamoto, Y. Yamashita, N. Oya, Conformal radiotherapy for portal vein tumor thrombosis of hepatocellular carcinoma, Radiother. Oncol. 84 (2007) 266-271.
6. M. Fuss, B.J. Salter, T.S. Herman, C.R. Thomas Jr., External beam radiation therapy for hepatocellular carcinoma: potential of intensity-modulated and image-guided radiation therapy, Gastroenterology 127 (2004) S206-S217. (Pubitemid 39423389)
7. H.P. Rodemann, Molecular radiation biology: perspectives for radiation oncology, Radiat. Oncol. 92 (2009) 293-298.
8. M. Verheij, H. Bartelink, Radiation-induced apoptosis, Cell Tissue Res. 301 (2000) 133-142. (Pubitemid 30459860)
9. S. Paglin, T. Hollister, T. Delohery, N. Hackett, M. McMahill, E. Sphicas, D. Domingo, J. Yahalom, A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles, Cancer Res. 61 (2001) 439-444.
10. B. Levin, J. Yuan, Autophagy in cell death: an innocent convict?, J Clin. Invest. 115 (2005) 2679-2688. (Pubitemid 41434392)
11. A. Kelekar, Autophagy, Ann. N. Y. Acad. Sci. 1066 (2005) 259-271.
12. E. Corcelle, M. Nebout, S. Bekri, N. Gauthier, P. Hofman, P. Poujeol, P. Fénichel, B. Mograbi, Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity, Cancer Res. 66 (2006) 686-6870.
13. M. Hoyer-Hansen, L. Bastholm, P. Szyniarowski, M. Campanella, G. Szabadkai, T. Farkas, K. Bianchi, N. Fehrenbacher, F. Elling, R. Rizzuto, I.S. Mathiasen, M. Jäättelä, Control of macroautophagy by calcium, calmoldulin-dependent kinase kinase-β, and Bcl-2, Mol. Cell 25 (2007) 193-205. (Pubitemid 46109606)
14. R. Scherz-Shouval, E. Shvets, E. Fass, H. Shorer, L. Gil, Z. Elazar, Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4, EMBO J. 26 (2007) 1749-1760. (Pubitemid 46624042)
15. M. Ogata, S. Hino, A. Saito, K. Morikawa, S. Kondo, S. Kanemoto, T. Murakami, M. Taniguchi, I. Tanii, K. Yoshinaga, S. Shiosaka, J.A. Hammarback, F. Urano, K. Imaizumi, Autophagy is activated for cell survival after endoplasmic reticulum stress, Mol. Cell. Biol. 26 (2006) 9220-9231. (Pubitemid 44904418)
16. K.W. Kim, M. Hwang, L. Moretti, J.J. Jaboin, Y.I. Cha, B. Lu, Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer, Autophagy 4 (2008) 659-668.
17. J.J. Lum, D.E. Bauer, M. Kong, M.H. Harris, C. Li, T. Lindsten, C.B. Thompson, Growth factor regulation of autophagy and cell survival in the absence of apoptosis, Cell 120 (2005) 237-248. (Pubitemid 40174766)
18. K. Degenhardt, R. Mathew, B. Beaudoin, K. Bray, D. Anderson, G. Chen, C. Mukherjee, Y. Shi, C. Gélinas, Y. Fan, D.A. Nelson, S. Jin, E. White, Autophagy promotes tumor cell survival and restricts necrosis, Inflammation, and tumorigenesis, Cancer Cell 10 (2006) 51-64.
19. R.K. Amaravadi, D. Yu, J.J. Lum, T. Bui, M.A. Christophorou, G.I. Evan, A. Thomas-Tikhonenko, C.B. Thompson, Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma, J. Clin. Invest. 117 (2007) 326-336.
20. T. Kanzawa, I.M. Germano, T. Komata, H. Ito, Y. Kondo, S. Kondo, Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells, Cell Death Differ. 11 (2004) 448-457. (Pubitemid 38489422)
21. K.C. Yao, T. Komata, Y. Kondo, T. Kanzawa, S. Kondo, I.M. Germano, Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy, J. Neurosurg. 98 (2003) 378-384. (Pubitemid 36151035)
22. A. Ertmer, V. Huber, S. Gilch, T. Yoshimori, V. Erfle, J. Duyster, H.P. Elsässer, H.M. Schätzl, The anticancer drug imatinib induces cellular autophagy, Leukemia 21 (2007) 936-942. (Pubitemid 46672069)
23. H. Takeuchi, T. Kanzawa, Y. Kondo, S. Kondo, Inhibition of platelet-derived growth factor signaling induces autophagy in malignant glioma cells, Br. J. Cancer 90 (2004) 1069-1075. (Pubitemid 38495830)
24. W. Bursch, A. Ellinger, H. Kienzl, L. Török, S. Pandey, M. Sikorska, R. Walker, R.S. Hermann, Active cell death induced by the anti-estrogens tamoxifen and ICI 164384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy, Carcinogenesis 17 (1996) 1595-1607. (Pubitemid 26280381)
25. N. Chen, V. Karantza, Autophagy as a therapeutic target in cancer, Cancer Biol. Therapy 11 (2011) 157-168.
26. C.E. Zois, M.I. Koukourakis, Radiation-induced autophagy in normal and cancer cells, Autophagy 5 (2009) 442-450.
27. X.M. Yin, W.X. Ding, W. Gao, Autophagy in the liver, Hepatology 47 (2008) 1773-1785. (Pubitemid 351702759)
28. D. Crighton, S. Wilkinson, J. O'Prey, N. Syed, P. Smith, P.R. Harrison, M. Gasco, O. Garrone, T. Crook, K.M. Ryan, DRAM, a p53-induced modulator of autophagy, is critical for apoptosis, Cell 126 (2006) 121-134.
29. F. Traganos, Z. Darzynkiewicz, Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations, Methods. Cell Biol. 41 (1994) 185-194.
30. E. Solary, S. Plenchette, O. Sordet, C. Rébé, P. Ducoroy, R. Filomenko, J.M. Bruey, N. Droin, L. Corcos, Modulation of apoptotic pathways triggered by cytotoxic agents, Therapie 56 (2001) 511-518. (Pubitemid 34027023)
31. A. Petiot, E. Ogier-Denis, E.F.C. Blommaart, A.J. Meijer, P. Codogno, Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells, J. Biol. Chem. 275 (2000) 992-998.
32. M.J. Abedin, D. Wang, M.A. McDonnell, U. Lehmann, A. Kelekar, Autophagy delays apoptotic cell death in breast cancer cells following DNA damage, Cell Death Differ. 22 (2006) 1-11.
33. J. Li, N. Hou, A. Faried, S. Tsutsumi, T. Takeuchi, H. Kuwano, Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells, Ann. Surg. Oncol. 16 (2009) 761-771.
34. J. Li, N. Hou, A. Faried, S. Tsutsumi, H. Kuwano, Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model, Eur. J. Cancer 46 (2010) 1900-1909.
35. D. Liu, Y. Yang, Q. Liu, J. Wang, Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells, Med. Oncol. 28 (2011) 105-111.
36. A. Apel, I. Herr, H. Schwarz, H.P. Rodemann, A. Mayer, Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy, Cancer Res. 68 (2008) 1485-1494. (Pubitemid 351346857)
37. S.L. Lomonaco, S. Finniss, C. Xiang, A. DeCarvalho, F. Umansky, S.N. Kalkanis, T. Mikkelsen, C. Brodie, The induction of autophagy by c-radiation contributes to the radioresistance of glioma stem cells, Int. J. Cancer 125 (2009) 717-722.
38. P.L. Peng, W.H. Kuo, H.C. Tseng, F.P. Chou, Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death, Int. J. Radiat. Oncol. Biol. Phys. 70 (2008) 529-542.